Minodronic acid_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.137777
PCLO piccolo presynaptic cytomatrix protein 0.118766
COL11A1 collagen, type XI, alpha 1 0.114839
HDAC9 histone deacetylase 9 0.11348
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.100671
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0828409
ADGRL2 adhesion G protein-coupled receptor L2 0.0686509
MYH9 myosin, heavy chain 9, non-muscle 0.0684294
PCDH9 protocadherin 9 0.0679514
SYT1 synaptotagmin I 0.0565249
PHF3 PHD finger protein 3 0.0542534
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0512244
FN1 fibronectin 1 0.0506432
SLC38A2 solute carrier family 38, member 2 0.0501833
THBS1 thrombospondin 1 0.0493997
MT2A metallothionein 2A 0.047571
NTM neurotrimin 0.0472086
ARHGAP24 Rho GTPase activating protein 24 0.0455371
TMSB4X thymosin beta 4, X-linked 0.045042
ANKRD33B ankyrin repeat domain 33B 0.0433399
DOCK5 dedicator of cytokinesis 5 0.0429749
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0424713
SOX5 SRY (sex determining region Y)-box 5 0.0421944
PCDH7 protocadherin 7 0.0419435
DST dystonin 0.0412106
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0388425
RPS27A ribosomal protein S27a 0.0383099
PDE4D phosphodiesterase 4D, cAMP-specific 0.0373299
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0370992
SRRM2 serine/arginine repetitive matrix 2 0.0370321
EP300 E1A binding protein p300 0.0368627
BBX bobby sox homolog (Drosophila) 0.0358671
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0344411
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0342888
ENO1 enolase 1, (alpha) 0.0340409
IVNS1ABP influenza virus NS1A binding protein 0.0339324
LRRC4C leucine rich repeat containing 4C 0.0328994
APP amyloid beta (A4) precursor protein 0.0321533
HYOU1 hypoxia up-regulated 1 0.0319617
TTC28 tetratricopeptide repeat domain 28 0.0311592
COL5A2 collagen, type V, alpha 2 0.0305828
RPL37 ribosomal protein L37 0.0303904
MBD5 methyl-CpG binding domain protein 5 0.0300779
TENM2 teneurin transmembrane protein 2 0.0299524
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0299389
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0294826
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0293627
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0292233
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0291653
USP24 ubiquitin specific peptidase 24 0.0291219
GPC3 glypican 3 0.0289642
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0289383
NRIP1 nuclear receptor interacting protein 1 0.0286057
COTL1 coactosin-like F-actin binding protein 1 0.028593
IGF1R insulin-like growth factor 1 receptor 0.0279404
RFPL4B ret finger protein-like 4B 0.0279229
NFIB nuclear factor I/B 0.0279171
COL3A1 collagen, type III, alpha 1 0.0278818
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.027478
ZEB2 zinc finger E-box binding homeobox 2 0.0273917
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.027322
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0272612
BABAM2 BRISC and BRCA1 A complex member 2 0.0271714
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0271045
OGA O-GlcNAcase 0.0269511
RPL31 ribosomal protein L31 0.0268202
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0268115
CORO1C coronin, actin binding protein, 1C 0.0266478
PDLIM5 PDZ and LIM domain 5 0.026646
NT5C2 5'-nucleotidase, cytosolic II 0.0264343
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0260873
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0260411
MYH10 myosin, heavy chain 10, non-muscle 0.0260033
WDPCP WD repeat containing planar cell polarity effector 0.0259667
ADNP activity-dependent neuroprotector homeobox 0.0259585
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0259235
ADGRV1 adhesion G protein-coupled receptor V1 0.0258058
ZNFX1 zinc finger, NFX1-type containing 1 0.0256771
RPS15A ribosomal protein S15a 0.0256226
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0254864
TRAK1 trafficking protein, kinesin binding 1 0.0254031
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0252643
GPHN gephyrin 0.0250256
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0249303
USP25 ubiquitin specific peptidase 25 0.0248694
CXCL8 chemokine (C-X-C motif) ligand 8 0.0247861
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0247616
FIGN fidgetin 0.0247363
UPP1 uridine phosphorylase 1 0.0247334
TXNRD1 thioredoxin reductase 1 0.0244042
BRWD3 bromodomain and WD repeat domain containing 3 0.0243521
SRSF4 serine/arginine-rich splicing factor 4 0.0243464
RNF13 ring finger protein 13 0.0242603
APLP2 amyloid beta (A4) precursor-like protein 2 0.0242259
NUP214 nucleoporin 214kDa 0.0242091
TGFB2 transforming growth factor, beta 2 0.024196
ZBTB20 zinc finger and BTB domain containing 20 0.0240722
EPB41 erythrocyte membrane protein band 4.1 0.0239002
TENM3 teneurin transmembrane protein 3 0.023843
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0236498

decreased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 -0.0993211
ATP5F1B ATP synthase F1 subunit beta -0.0689346
STRN3 striatin, calmodulin binding protein 3 -0.0653997
PFN1 profilin 1 -0.064682
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0634272
KDM5B lysine (K)-specific demethylase 5B -0.0595271
PGAP1 post-GPI attachment to proteins 1 -0.0575262
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0574303
MARCKS myristoylated alanine-rich protein kinase C substrate -0.056271
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0544978
NIPBL Nipped-B homolog (Drosophila) -0.0544475
PUM1 pumilio RNA-binding family member 1 -0.0538411
SRP54 signal recognition particle 54kDa -0.0537923
NOP58 NOP58 ribonucleoprotein -0.0535749
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0529283
ZFAND3 zinc finger, AN1-type domain 3 -0.0524161
MKI67 marker of proliferation Ki-67 -0.0513416
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0509207
PRTG protogenin -0.0495223
COL1A2 collagen, type I, alpha 2 -0.0495212
UBE2K ubiquitin-conjugating enzyme E2K -0.0489454
CADM2 cell adhesion molecule 2 -0.0489344
CKAP2 cytoskeleton associated protein 2 -0.045436
GARS1 glycyl-tRNA synthetase 1 -0.0448174
POTEF POTE ankyrin domain family, member F -0.0418827
PHIP pleckstrin homology domain interacting protein -0.0414898
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0414287
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0410589
KMT2E lysine (K)-specific methyltransferase 2E -0.0407235
THOC2 THO complex 2 -0.040651
MEF2A myocyte enhancer factor 2A -0.0404015
ZC3H15 zinc finger CCCH-type containing 15 -0.0401739
HSPB1 heat shock 27kDa protein 1 -0.0397424
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.0390018
RPS8 ribosomal protein S8 -0.038917
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0380626
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0378184
MTF2 metal response element binding transcription factor 2 -0.0375424
ERBIN erbb2 interacting protein -0.0374265
RPLP1 ribosomal protein, large, P1 -0.0371032
BTG3 BTG family, member 3 -0.0367354
CENPF centromere protein F, 350/400kDa -0.0366071
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0364255
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0362035
CCDC88A coiled-coil domain containing 88A -0.0361071
RDX radixin -0.035701
SMC3 structural maintenance of chromosomes 3 -0.0355796
CNRIP1 cannabinoid receptor interacting protein 1 -0.0355468
RYBP RING1 and YY1 binding protein -0.0355033
ARHGAP15 Rho GTPase activating protein 15 -0.0354937
OLA1 Obg-like ATPase 1 -0.0354103
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0351805
GNAS GNAS complex locus -0.0350712
PARD3B par-3 family cell polarity regulator beta -0.0349882
RBM25 RNA binding motif protein 25 -0.0344016
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0342623
ZFPM2 zinc finger protein, FOG family member 2 -0.0341193
ASTN2 astrotactin 2 -0.0339275
TMSB10 thymosin beta 10 -0.0324187
ZBTB35 zinc finger and BTB domain containing 35 -0.032283
ZFC3H1 zinc finger, C3H1-type containing -0.0321578
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0318271
YBX1 Y box binding protein 1 -0.0315811
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -0.0314613
COPA coatomer protein complex, subunit alpha -0.0311683
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0309408
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0308989
PEG10 paternally expressed 10 -0.0306893
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0304145
GLG1 golgi glycoprotein 1 -0.0300626
GLS2 glutaminase 2 (liver, mitochondrial) -0.0297857
DENND4C DENN/MADD domain containing 4C -0.0297096
RAD51B RAD51 paralog B -0.0296429
RPL5 ribosomal protein L5 -0.0293359
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 -0.0292713
UBB ubiquitin B -0.0289199
TOR1AIP2 torsin A interacting protein 2 -0.0289183
BRDT bromodomain, testis-specific -0.0287749
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -0.0287484
RPL35A ribosomal protein L35a -0.0286721
FBXO11 F-box protein 11 -0.028575
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0282269
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0281895
GOLGA4 golgin A4 -0.0281572
GOLPH3 golgi phosphoprotein 3 (coat-protein) -0.0281462
TNPO3 transportin 3 -0.0279134
FNDC3B fibronectin type III domain containing 3B -0.0279002
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.027891
TBL1X transducin (beta)-like 1X-linked -0.0276068
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0275756
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0275351
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0273321
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0269748
SNX3 sorting nexin 3 -0.026945
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.026867
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0267878
ADGRG6 adhesion G protein-coupled receptor G6 -0.0267522
SLC38A9 solute carrier family 38, member 9 -0.026692
PER1 period circadian clock 1 -0.0265249
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -0.0264002