Minodronic acid_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.106279
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0941696
TMSB4X thymosin beta 4, X-linked 0.0911315
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0839623
SQSTM1 sequestosome 1 0.0823364
AHNAK AHNAK nucleoprotein 0.0814447
SMAD3 SMAD family member 3 0.0767745
MACF1 microtubule-actin crosslinking factor 1 0.0748667
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0710999
TRIO trio Rho guanine nucleotide exchange factor 0.0670958
MYH9 myosin, heavy chain 9, non-muscle 0.0644375
RUNX1 runt-related transcription factor 1 0.0627294
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0608406
NAV2 neuron navigator 2 0.0607688
PLEC plectin 0.059762
KRT8 keratin 8, type II 0.0593503
CANX calnexin 0.0571007
EZR ezrin 0.0549888
RNF213 ring finger protein 213 0.0527385
KDM3A lysine (K)-specific demethylase 3A 0.0525188
FNDC3B fibronectin type III domain containing 3B 0.0503136
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0483376
TPT1 tumor protein, translationally-controlled 1 0.0480892
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.046727
KRT18 keratin 18, type I 0.0466238
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0466133
AFAP1 actin filament associated protein 1 0.0459502
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0453552
APP amyloid beta (A4) precursor protein 0.0449386
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0442577
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.043591
OGA O-GlcNAcase 0.0435211
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0432468
TPM4 tropomyosin 4 0.0431432
AFDN afadin, adherens junction formation factor 0.0431379
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.042813
SDC4 syndecan 4 0.0427331
DSPP dentin sialophosphoprotein 0.0419976
CTNND1 catenin (cadherin-associated protein), delta 1 0.0419878
EFNA5 ephrin-A5 0.0405825
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0397666
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0389327
SAMD12 sterile alpha motif domain containing 12 0.038877
LAMC2 laminin, gamma 2 0.0379816
HLA-B major histocompatibility complex, class I, B 0.0378119
NRIP1 nuclear receptor interacting protein 1 0.0374607
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0361259
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0358997
APLP2 amyloid beta (A4) precursor-like protein 2 0.0355938
INTS6 integrator complex subunit 6 0.0355044
ERRFI1 ERBB receptor feedback inhibitor 1 0.0351473
LPP LIM domain containing preferred translocation partner in lipoma 0.0350986
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0340217
ARHGAP5 Rho GTPase activating protein 5 0.0339811
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0337605
NAP1L1 nucleosome assembly protein 1-like 1 0.0337133
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.033442
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0334214
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0328963
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0326016
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0325372
ZFAND3 zinc finger, AN1-type domain 3 0.0323986
SLMAP sarcolemma associated protein 0.0321697
ANKRD10 ankyrin repeat domain 10 0.0318485
EIF4A2 eukaryotic translation initiation factor 4A2 0.0318152
PRELID2 PRELI domain containing 2 0.0318009
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0316413
SKAP2 src kinase associated phosphoprotein 2 0.0315474
PARD3 par-3 family cell polarity regulator 0.031203
JMJD1C jumonji domain containing 1C 0.0311776
ZNF292 zinc finger protein 292 0.031177
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0310622
FOXO3 forkhead box O3 0.031006
ARHGAP26 Rho GTPase activating protein 26 0.0307902
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0307299
USP9X ubiquitin specific peptidase 9, X-linked 0.0306042
SHB Src homology 2 domain containing adaptor protein B 0.030479
KIAA1671 KIAA1671 0.0304009
SP100 SP100 nuclear antigen 0.0300567
SVIL supervillin 0.0298416
NAMPT nicotinamide phosphoribosyltransferase 0.0295094
ANXA2 annexin A2 0.0294958
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0293864
PTMA prothymosin, alpha 0.0293007
SEPTIN9 septin 9 0.0293004
BZW1 basic leucine zipper and W2 domains 1 0.0292662
TNIP1 TNFAIP3 interacting protein 1 0.029032
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0289487
MTAP methylthioadenosine phosphorylase 0.0286178
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0282184
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.0279745
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0279721
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0275615
KPNB1 karyopherin (importin) beta 1 0.0272513
RBM39 RNA binding motif protein 39 0.0271865
EEF2 eukaryotic translation elongation factor 2 0.0267051
KRT17 keratin 17, type I 0.0266418
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0265389
TXNIP thioredoxin interacting protein 0.0264462
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0263748

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.117135
POTEF POTE ankyrin domain family, member F -0.0895481
HMGA1 high mobility group AT-hook 1 -0.0735529
FTH1 ferritin, heavy polypeptide 1 -0.0474712
MT2A metallothionein 2A -0.046011
MUC4 mucin 4, cell surface associated -0.044797
RASAL2 RAS protein activator like 2 -0.0414296
EGR1 early growth response 1 -0.0388897
TMSB10 thymosin beta 10 -0.0385779
CLDN4 claudin 4 -0.0362469
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0346338
IGFBP3 insulin-like growth factor binding protein 3 -0.0326664
VMP1 vacuole membrane protein 1 -0.0323884
RPS13 ribosomal protein S13 -0.0300536
IFI27 interferon, alpha-inducible protein 27 -0.028839
CCNL1 cyclin L1 -0.0286636
RPL35A ribosomal protein L35a -0.0252911
FTL ferritin, light polypeptide -0.0252368
LAMA4 laminin, alpha 4 -0.025083
RPS14 ribosomal protein S14 -0.024988
RPS8 ribosomal protein S8 -0.0247925
WWC1 WW and C2 domain containing 1 -0.0247124
IFITM3 interferon induced transmembrane protein 3 -0.0242542
PDLIM5 PDZ and LIM domain 5 -0.0233522
RPS6 ribosomal protein S6 -0.0233405
TGM2 transglutaminase 2 -0.023212
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0230369
C6ORF132 chromosome 6 open reading frame 132 -0.022773
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0226238
LAMA5 laminin, alpha 5 -0.0220223
RBMS2 RNA binding motif, single stranded interacting protein 2 -0.0218671
LMO7 LIM domain 7 -0.0216288
RPS29 ribosomal protein S29 -0.0215862
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0210664
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0209143
UGCG UDP-glucose ceramide glucosyltransferase -0.0207674
AKAP9 A kinase (PRKA) anchor protein 9 -0.0206965
SACK1A scaffolding CK1 anchoring protein A -0.0201109
LATS2 large tumor suppressor kinase 2 -0.0200535
PCBP2 poly(rC) binding protein 2 -0.0195493
DLC1 DLC1 Rho GTPase activating protein -0.0194208
PICALM phosphatidylinositol binding clathrin assembly protein -0.0194178
RPL21 ribosomal protein L21 -0.0190228
PFN1 profilin 1 -0.0188961
TAPBP TAP binding protein (tapasin) -0.0188386
LOC102724023 ES1 protein homolog, mitochondrial -0.0188144
OSMR oncostatin M receptor -0.0187415
ENO2 enolase 2 (gamma, neuronal) -0.0186976
PCDH1 protocadherin 1 -0.0182126
RPS23 ribosomal protein S23 -0.0181814
AREG amphiregulin -0.0181683
RPL36 ribosomal protein L36 -0.0181272
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0178504
PLPP6 phospholipid phosphatase 6 -0.0176541
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0172687
RPS12 ribosomal protein S12 -0.0170599
RPL28 ribosomal protein L28 -0.016222
MYO1E myosin IE -0.0160748
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0158562
JUP junction plakoglobin -0.0155295
WFDC2 WAP four-disulfide core domain 2 -0.0150411
KIF2A kinesin heavy chain member 2A -0.0148791
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0148163
SEC31A SEC31 homolog A (S. cerevisiae) -0.0147163
BCL2L1 BCL2-like 1 -0.0143631
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0138915
ERBIN erbb2 interacting protein -0.0138152
RPL31 ribosomal protein L31 -0.0137976
S100A11 S100 calcium binding protein A11 -0.0137881
MT1X metallothionein 1X -0.0137733
S100A10 S100 calcium binding protein A10 -0.0136089
LY6E lymphocyte antigen 6 complex, locus E -0.0135335
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0134126
IL1RAP interleukin 1 receptor accessory protein -0.0132988
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0132322
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -0.0132307
RCOR1 REST corepressor 1 -0.0131329
RPS19 ribosomal protein S19 -0.0130592
ASTN2 astrotactin 2 -0.0129479
TMEM259 transmembrane protein 259 -0.0129466
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -0.0127686
DIAPH1 diaphanous-related formin 1 -0.0127522
SRSF11 serine/arginine-rich splicing factor 11 -0.0126266
RPS17 ribosomal protein S17 -0.0126032
BAG6 BCL2-associated athanogene 6 -0.0125406
RAP2B RAP2B, member of RAS oncogene family -0.0125178
BTBD10 BTB (POZ) domain containing 10 -0.0124935
RPL27 ribosomal protein L27 -0.0124089
PNN pinin, desmosome associated protein -0.0123999
ISG15 ISG15 ubiquitin-like modifier -0.0123737
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -0.0123599
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.012115
ZNF644 zinc finger protein 644 -0.0121105
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0120558
FNBP4 formin binding protein 4 -0.0120278
RPS11 ribosomal protein S11 -0.0117476
PERP PERP, TP53 apoptosis effector -0.0116574
ANXA3 annexin A3 -0.0116431
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0115744
KLK10 kallikrein-related peptidase 10 -0.0115736