Minodronic acid_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.147564
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.140583
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.110708
EEF2 eukaryotic translation elongation factor 2 0.0999639
RPS3 ribosomal protein S3 0.0988044
MYH9 myosin, heavy chain 9, non-muscle 0.0885423
RPL3 ribosomal protein L3 0.0842539
RPS12 ribosomal protein S12 0.0803139
RPS6 ribosomal protein S6 0.0762161
RPL37A ribosomal protein L37a 0.0721578
RPL35 ribosomal protein L35 0.0711233
RPL7A ribosomal protein L7a 0.0693649
RPS8 ribosomal protein S8 0.0650141
ACTG1 actin gamma 1 0.0646718
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0586269
EEF1G eukaryotic translation elongation factor 1 gamma 0.056218
LOC112694756 uncharaterized LOC112694756 0.0515801
RPS17 ribosomal protein S17 0.04781
UPP1 uridine phosphorylase 1 0.047801
RPS29 ribosomal protein S29 0.0445522
RPS15A ribosomal protein S15a 0.0429232
RPLP2 ribosomal protein, large, P2 0.0410452
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0406386
SRRM2 serine/arginine repetitive matrix 2 0.039422
RPL8 ribosomal protein L8 0.0388937
RPL13A ribosomal protein L13a 0.0385131
RPL7 ribosomal protein L7 0.0383494
RPS4X ribosomal protein S4, X-linked 0.0375699
RPL4 ribosomal protein L4 0.0374184
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0368639
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0367444
RPS13 ribosomal protein S13 0.0365199
CALR calreticulin 0.0358071
PTMA prothymosin, alpha 0.0357491
TMSB10 thymosin beta 10 0.0357359
RPS5 ribosomal protein S5 0.0352251
RPL19 ribosomal protein L19 0.0346179
RPS27 ribosomal protein S27 0.0343146
PKM pyruvate kinase, muscle 0.0337151
NDRG1 N-myc downstream regulated 1 0.0337116
MCL1 myeloid cell leukemia 1 0.0336303
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0324105
RPL36 ribosomal protein L36 0.0318499
FLNA filamin A, alpha 0.0317003
RPS10 ribosomal protein S10 0.0313329
RPL26 ribosomal protein L26 0.0310727
HYOU1 hypoxia up-regulated 1 0.0309307
EGR1 early growth response 1 0.0300687
APLP2 amyloid beta (A4) precursor-like protein 2 0.0298306
SFTPA2 surfactant protein A2 0.029829
SGMS2 sphingomyelin synthase 2 0.0298033
RACK1 receptor for activated C kinase 1 0.0289709
FTL ferritin, light polypeptide 0.0287349
RPS11 ribosomal protein S11 0.0280526
RPS27A ribosomal protein S27a 0.027639
ENO1 enolase 1, (alpha) 0.0270519
RPL23 ribosomal protein L23 0.0269453
FRMD6 FERM domain containing 6 0.0262777
RPL28 ribosomal protein L28 0.0252991
SQSTM1 sequestosome 1 0.0252397
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0250991
CPNE1 copine I 0.0244855
EIF1 eukaryotic translation initiation factor 1 0.0235254
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0233703
SET SET nuclear proto-oncogene 0.0227773
ZSWIM6 zinc finger, SWIM-type containing 6 0.0226344
RPL5 ribosomal protein L5 0.0224793
TPM3 tropomyosin 3 0.0222252
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0221912
NONO non-POU domain containing, octamer-binding 0.0220175
H1-4 H1.4 linker histone, cluster member 0.0217998
RPS23 ribosomal protein S23 0.0213032
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0209368
RPSA ribosomal protein SA 0.0207381
GOLGB1 golgin B1 0.0206176
RPS19 ribosomal protein S19 0.0205518
RPL31 ribosomal protein L31 0.020532
RPL37 ribosomal protein L37 0.0204749
RPS15 ribosomal protein S15 0.0204263
AARS1 alanyl-tRNA synthetase 1 0.0201875
RPL11 ribosomal protein L11 0.019988
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0195755
TLN1 talin 1 0.019378
RPLP1 ribosomal protein, large, P1 0.0193627
IER2 immediate early response 2 0.0189421
RPL12 ribosomal protein L12 0.0189003
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0187715
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0187514
MRPL13 mitochondrial ribosomal protein L13 0.0187016
TNIP1 TNFAIP3 interacting protein 1 0.018697
RPL9 ribosomal protein L9 0.0183369
ANGPTL4 angiopoietin-like 4 0.0181708
TMED9 transmembrane emp24 protein transport domain containing 9 0.018155
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0177317
BRD2 bromodomain containing 2 0.017521
RPS18 ribosomal protein S18 0.016963
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0166528
PRELID3B PRELI domain containing 3B 0.0166191
PDIA4 protein disulfide isomerase family A, member 4 0.016407
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0162731

decreased expression

Symbol Name Standardized Value
DLC1 DLC1 Rho GTPase activating protein -0.139975
ZNF438 zinc finger protein 438 -0.117298
IFI16 interferon, gamma-inducible protein 16 -0.0931531
NAV3 neuron navigator 3 -0.0859789
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0764698
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0697101
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0665361
ANTXR2 anthrax toxin receptor 2 -0.0613957
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0613515
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0602241
ERBIN erbb2 interacting protein -0.0597397
PTK2 protein tyrosine kinase 2 -0.0594947
MT2A metallothionein 2A -0.0557583
ANKRD17 ankyrin repeat domain 17 -0.0555794
RBM25 RNA binding motif protein 25 -0.0547351
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0516258
LPP LIM domain containing preferred translocation partner in lipoma -0.051585
CALD1 caldesmon 1 -0.0505619
MTAP methylthioadenosine phosphorylase -0.0483443
TCF12 transcription factor 12 -0.0464508
PRRC2B proline-rich coiled-coil 2B -0.045571
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0449085
PBX3 pre-B-cell leukemia homeobox 3 -0.0430955
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0429396
IARS1 isoleucyl-tRNA synthetase 1 -0.0426054
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0425558
LAMB3 laminin, beta 3 -0.0423585
ARHGAP22 Rho GTPase activating protein 22 -0.0412343
RPL35A ribosomal protein L35a -0.0403797
ZEB1 zinc finger E-box binding homeobox 1 -0.0398074
RAB7A RAB7A, member RAS oncogene family -0.0389523
SRPK2 SRSF protein kinase 2 -0.0386857
KPNB1 karyopherin (importin) beta 1 -0.0382832
FRMD4A FERM domain containing 4A -0.0380669
NF1 neurofibromin 1 -0.0372663
BNC2 basonuclin 2 -0.0371122
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0367356
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0363002
TRIO trio Rho guanine nucleotide exchange factor -0.0361887
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0360376
HMGA1 high mobility group AT-hook 1 -0.0355848
UBE2K ubiquitin-conjugating enzyme E2K -0.0355487
TTR transthyretin -0.0353249
RAB3IP RAB3A interacting protein -0.0340318
ZFAND3 zinc finger, AN1-type domain 3 -0.0338755
JMJD1C jumonji domain containing 1C -0.0336233
NUDCD1 NudC domain containing 1 -0.0334249
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0332318
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0329917
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0328335
RIGI RNA sensor RIG-I -0.0321057
PDS5A PDS5 cohesin associated factor A -0.0315468
PCNX4 pecanex 4 -0.0313611
ZC3H12B zinc finger CCCH-type containing 12B -0.0312358
FUBP3 far upstream element (FUSE) binding protein 3 -0.031088
STC1 stanniocalcin 1 -0.0308541
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0305309
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0304803
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0300305
TM4SF1 transmembrane 4 L six family member 1 -0.0293785
ALCAM activated leukocyte cell adhesion molecule -0.0292247
TM9SF3 transmembrane 9 superfamily member 3 -0.0291863
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.028797
WAC WW domain containing adaptor with coiled-coil -0.0284042
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0283199
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0283056
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0281678
PRRC2C proline-rich coiled-coil 2C -0.0281553
TXNRD1 thioredoxin reductase 1 -0.0279851
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0279132
STK4 serine/threonine kinase 4 -0.0278511
PTBP2 polypyrimidine tract binding protein 2 -0.0271876
DIAPH3 diaphanous-related formin 3 -0.0269941
TPM4 tropomyosin 4 -0.0269122
WDR43 WD repeat domain 43 -0.026896
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.0261931
SNX14 sorting nexin 14 -0.0261078
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0260779
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0258246
C2CD2 C2 calcium-dependent domain containing 2 -0.0257346
FAF1 Fas (TNFRSF6) associated factor 1 -0.0256922
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0255812
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0254172
GNAS GNAS complex locus -0.0254128
BIRC6 baculoviral IAP repeat containing 6 -0.0253341
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0251525
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0247007
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0246431
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0245603
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0245005
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0244814
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0244643
CHD7 chromodomain helicase DNA binding protein 7 -0.0244501
NIPBL Nipped-B homolog (Drosophila) -0.0244294
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0244043
PUM2 pumilio RNA-binding family member 2 -0.0243193
BZW1 basic leucine zipper and W2 domains 1 -0.0242819
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0241891
PARD3 par-3 family cell polarity regulator -0.0241236
ZBTB20 zinc finger and BTB domain containing 20 -0.0238278