Minodronic acid_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.172227
MYH9 myosin, heavy chain 9, non-muscle 0.130875
ENO1 enolase 1, (alpha) 0.129003
NDRG1 N-myc downstream regulated 1 0.125937
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.10666
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0871588
RPS3 ribosomal protein S3 0.0788413
RPL37A ribosomal protein L37a 0.0749728
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0744636
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0675271
VGF VGF nerve growth factor inducible 0.0668913
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0625262
VEGFA vascular endothelial growth factor A 0.0620371
ACTG1 actin gamma 1 0.0612548
LOC112694756 uncharaterized LOC112694756 0.0606229
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0573581
MT2A metallothionein 2A 0.0555139
RPL37 ribosomal protein L37 0.0552843
ZFHX3 zinc finger homeobox 3 0.0542552
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0528765
RPL3 ribosomal protein L3 0.0525987
CHGB chromogranin B 0.0525327
RPL35 ribosomal protein L35 0.0514674
ASPH aspartate beta-hydroxylase 0.051197
STC1 stanniocalcin 1 0.0508479
INHBA inhibin, beta A 0.0497608
RPS12 ribosomal protein S12 0.0491657
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0483339
RPS8 ribosomal protein S8 0.0475687
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0455723
HYOU1 hypoxia up-regulated 1 0.0454157
RNF213 ring finger protein 213 0.0430897
PGK1 phosphoglycerate kinase 1 0.04271
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0425441
PTMA prothymosin, alpha 0.0422123
ERRFI1 ERBB receptor feedback inhibitor 1 0.0421661
PDE4D phosphodiesterase 4D, cAMP-specific 0.0414799
MCTP1 multiple C2 domains, transmembrane 1 0.0400258
APLP2 amyloid beta (A4) precursor-like protein 2 0.0399476
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0393408
FAT1 FAT atypical cadherin 1 0.0387754
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0386489
GRB10 growth factor receptor-bound protein 10 0.0382753
LIMCH1 LIM and calponin homology domains 1 0.0376659
MCL1 myeloid cell leukemia 1 0.0375638
SMC1A structural maintenance of chromosomes 1A 0.0375181
IFI6 interferon, alpha-inducible protein 6 0.0370384
SCG2 secretogranin II 0.0361797
FAM13A family with sequence similarity 13, member A 0.0361608
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0354319
CALR calreticulin 0.0350113
AKAP12 A kinase (PRKA) anchor protein 12 0.0349496
RPS27 ribosomal protein S27 0.0348559
EEF2 eukaryotic translation elongation factor 2 0.0343855
SIK2 salt-inducible kinase 2 0.0338756
ADAR adenosine deaminase, RNA-specific 0.033639
RUNX1 runt-related transcription factor 1 0.0331467
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0330089
KLHL29 kelch-like family member 29 0.0328994
RPL26 ribosomal protein L26 0.032732
TPM3 tropomyosin 3 0.032729
RPS17 ribosomal protein S17 0.0324925
RPL4 ribosomal protein L4 0.0324713
PAEP progestagen-associated endometrial protein 0.0324031
NUMA1 nuclear mitotic apparatus protein 1 0.0323316
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0321331
NCOR2 nuclear receptor corepressor 2 0.0320968
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0319811
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0315679
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0311675
RPS6 ribosomal protein S6 0.0310807
AHR aryl hydrocarbon receptor 0.0310685
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0308707
PKM pyruvate kinase, muscle 0.0307712
BACE2 beta-site APP-cleaving enzyme 2 0.0307537
SETX senataxin 0.0305511
SRRM2 serine/arginine repetitive matrix 2 0.0302822
NFIB nuclear factor I/B 0.030153
NANOS1 nanos homolog 1 (Drosophila) 0.0297089
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0294915
P4HB prolyl 4-hydroxylase, beta polypeptide 0.029069
ELL2 elongation factor, RNA polymerase II, 2 0.0288383
TOP1 topoisomerase (DNA) I 0.0287139
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0285236
LDHA lactate dehydrogenase A 0.0282858
NCKAP5 NCK-associated protein 5 0.0281384
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0279609
EXT1 exostosin glycosyltransferase 1 0.0275438
GOLGB1 golgin B1 0.0273101
PDE10A phosphodiesterase 10A 0.0272101
MYH10 myosin, heavy chain 10, non-muscle 0.0271545
MSN moesin 0.0271187
EEF1G eukaryotic translation elongation factor 1 gamma 0.0269617
SNAP25 synaptosomal-associated protein, 25kDa 0.026615
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0264565
PNN pinin, desmosome associated protein 0.026262
FNDC3B fibronectin type III domain containing 3B 0.0262492
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0262235
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0260959
EFNA5 ephrin-A5 0.0257936

decreased expression

Symbol Name Standardized Value
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0517535
GPHN gephyrin -0.0483981
TENM1 teneurin transmembrane protein 1 -0.0482967
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.047454
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.0467925
CALCA calcitonin-related polypeptide alpha -0.0465924
SINHCAF SIN3-HDAC complex associated factor -0.0429153
NALF1 NALCN channel auxiliary factor 1 -0.0413923
RIT2 Ras-like without CAAX 2 -0.0397796
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0374002
ADGRL2 adhesion G protein-coupled receptor L2 -0.0353283
NCAM1 neural cell adhesion molecule 1 -0.0335759
SLC35F4 solute carrier family 35, member F4 -0.0329417
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0321275
CCDC88A coiled-coil domain containing 88A -0.0319056
FGF14 fibroblast growth factor 14 -0.0318966
ARB2A ARB2 cotranscriptional regulator A -0.0316682
PDE4B phosphodiesterase 4B, cAMP-specific -0.0307257
GPC5 glypican 5 -0.0297687
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0296127
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0292618
BCL2 B-cell CLL/lymphoma 2 -0.029249
RAD21 RAD21 homolog (S. pombe) -0.0279288
PHF14 PHD finger protein 14 -0.0272189
GNAS GNAS complex locus -0.0268727
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0258655
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0258271
COL22A1 collagen, type XXII, alpha 1 -0.0256525
MIS18BP1 MIS18 binding protein 1 -0.0254655
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0253632
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0252703
DGKB diacylglycerol kinase, beta 90kDa -0.0244104
WAC WW domain containing adaptor with coiled-coil -0.0239582
MKI67 marker of proliferation Ki-67 -0.0234308
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0230966
SMC4 structural maintenance of chromosomes 4 -0.0223343
CAMTA1 calmodulin binding transcription activator 1 -0.0222127
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0221757
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0221093
TPM4 tropomyosin 4 -0.0220768
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) -0.0213613
ZBTB20 zinc finger and BTB domain containing 20 -0.0210753
RIMS2 regulating synaptic membrane exocytosis 2 -0.0207648
NOP58 NOP58 ribonucleoprotein -0.0206822
AGMO alkylglycerol monooxygenase -0.0206742
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.020346
DENND5B DENN/MADD domain containing 5B -0.0202672
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.019792
SASH1 SAM and SH3 domain containing 1 -0.0195823
CADM1 cell adhesion molecule 1 -0.0192735
DNAH5 dynein, axonemal, heavy chain 5 -0.0186302
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0184765
CENPF centromere protein F, 350/400kDa -0.0184262
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.018341
FUS FUS RNA binding protein -0.0177457
CYRIB CYFIP related Rac1 interactor B -0.0177087
AGBL4 ATP/GTP binding protein-like 4 -0.0176246
TENT5A terminal nucleotidyltransferase 5A -0.0175183
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0173461
UBB ubiquitin B -0.01722
TNRC6C trinucleotide repeat containing 6C -0.0171776
BCLAF1 BCL2-associated transcription factor 1 -0.0169147
KIAA0586 KIAA0586 -0.0168084
MMP26 matrix metallopeptidase 26 -0.0168011
WRN Werner syndrome, RecQ helicase-like -0.0166583
DNM1L dynamin 1-like -0.0165654
HELLS helicase, lymphoid-specific -0.0165516
CBX3 chromobox homolog 3 -0.0164381
ARHGAP24 Rho GTPase activating protein 24 -0.0163639
STXBP5L syntaxin binding protein 5-like -0.0163543
JAM3 junctional adhesion molecule 3 -0.0162457
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0160042
KPNB1 karyopherin (importin) beta 1 -0.0159807
BTBD7 BTB (POZ) domain containing 7 -0.0159133
ASXL1 additional sex combs like transcriptional regulator 1 -0.0158856
TTK TTK protein kinase -0.0158761
FBXL17 F-box and leucine-rich repeat protein 17 -0.0158668
CSNK1G3 casein kinase 1, gamma 3 -0.0157841
NSD3 nuclear receptor binding SET domain protein 3 -0.0157237
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -0.0157063
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0156521
PIAS1 protein inhibitor of activated STAT, 1 -0.0154945
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0154743
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 -0.0154249
CHD7 chromodomain helicase DNA binding protein 7 -0.0153597
FANCL Fanconi anemia, complementation group L -0.0152507
NFIA nuclear factor I/A -0.0152325
MATR3 matrin 3 -0.0151921
SRSF11 serine/arginine-rich splicing factor 11 -0.0151497
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0151011
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0150307
MARCHF6 membrane associated ring-CH-type finger 6 -0.0149477
TPX2 TPX2, microtubule-associated -0.0147469
STAU2 staufen double-stranded RNA binding protein 2 -0.0147202
PHIP pleckstrin homology domain interacting protein -0.0146948
PUM3 pumilio RNA binding family member 3 -0.0146406
PBX3 pre-B-cell leukemia homeobox 3 -0.014564
GATAD2B GATA zinc finger domain containing 2B -0.0144443
ADGRL3 adhesion G protein-coupled receptor L3 -0.014339
BMERB1 bMERB domain containing 1 -0.0142443