Minodronic acid_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Minodronic acid_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.189371
ANGPTL4 angiopoietin-like 4 0.135859
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.11134
AKAP12 A kinase (PRKA) anchor protein 12 0.110431
SFTPA2 surfactant protein A2 0.107915
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.10467
RPS3 ribosomal protein S3 0.104062
MYH9 myosin, heavy chain 9, non-muscle 0.0942711
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0867667
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0844734
TMSB10 thymosin beta 10 0.0835368
ENO1 enolase 1, (alpha) 0.0808966
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0802275
PTMA prothymosin, alpha 0.0734067
PGK1 phosphoglycerate kinase 1 0.067994
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0609816
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0598302
SQSTM1 sequestosome 1 0.0589005
MT2A metallothionein 2A 0.0575642
PLEC plectin 0.0574286
TM4SF1 transmembrane 4 L six family member 1 0.0573826
NAP1L1 nucleosome assembly protein 1-like 1 0.056862
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0551226
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0550463
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0521053
PKM pyruvate kinase, muscle 0.0514637
CCND1 cyclin D1 0.0514376
IFI6 interferon, alpha-inducible protein 6 0.0461768
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0458187
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0454971
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0451228
FLNA filamin A, alpha 0.045046
TPT1 tumor protein, translationally-controlled 1 0.044982
B2M beta-2-microglobulin 0.0442111
DST dystonin 0.0433521
ASPH aspartate beta-hydroxylase 0.0433425
RPS6 ribosomal protein S6 0.0432796
RPS12 ribosomal protein S12 0.0427627
RPL37A ribosomal protein L37a 0.0421197
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0418458
AHNAK AHNAK nucleoprotein 0.0416368
RPLP1 ribosomal protein, large, P1 0.0409128
HLA-B major histocompatibility complex, class I, B 0.0405621
RNF213 ring finger protein 213 0.0405316
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0395579
LDHA lactate dehydrogenase A 0.0392886
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0392002
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0388662
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0381136
RPS27A ribosomal protein S27a 0.0379845
NDRG1 N-myc downstream regulated 1 0.037504
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0370064
ACTN1 actinin, alpha 1 0.0368117
RACK1 receptor for activated C kinase 1 0.0365311
RPL23 ribosomal protein L23 0.0364935
FTL ferritin, light polypeptide 0.0361115
RRBP1 ribosome binding protein 1 0.0359115
EEF2 eukaryotic translation elongation factor 2 0.0348628
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0348188
ANXA2 annexin A2 0.0348158
RPL38 ribosomal protein L38 0.0347971
LMNA lamin A/C 0.0347446
TPI1 triosephosphate isomerase 1 0.0342849
ICAM1 intercellular adhesion molecule 1 0.033898
HSPA8 heat shock 70kDa protein 8 0.0336459
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0334725
PDE4D phosphodiesterase 4D, cAMP-specific 0.0332822
TNIP1 TNFAIP3 interacting protein 1 0.0330938
NONO non-POU domain containing, octamer-binding 0.0329362
CANX calnexin 0.0327961
FLNB filamin B, beta 0.0325
CTTN cortactin 0.0323874
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0323757
SEPTIN9 septin 9 0.0323035
RPS8 ribosomal protein S8 0.0319986
RPL19 ribosomal protein L19 0.0318302
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0316695
SMAD3 SMAD family member 3 0.0314952
MSN moesin 0.031075
FRMD4A FERM domain containing 4A 0.0308347
TPM3 tropomyosin 3 0.0307175
PLAT plasminogen activator, tissue 0.0304459
HMG20B high mobility group 20B 0.0302138
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0298323
RPLP2 ribosomal protein, large, P2 0.0296952
SET SET nuclear proto-oncogene 0.0292876
MACF1 microtubule-actin crosslinking factor 1 0.0290374
RPL11 ribosomal protein L11 0.0287307
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0286942
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0284744
PRELID2 PRELI domain containing 2 0.0279867
CTSB cathepsin B 0.0273746
NFE2L1 nuclear factor, erythroid 2-like 1 0.0267242
NRG3 neuregulin 3 0.0263257
LOC112694756 uncharaterized LOC112694756 0.0262983
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.026293
RPS13 ribosomal protein S13 0.0261922
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0259868
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0256269
CALR calreticulin 0.0254272

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.144746
LSAMP limbic system-associated membrane protein -0.0885005
FN1 fibronectin 1 -0.0467659
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0402678
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0397305
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0352615
GOLGA4 golgin A4 -0.0350598
SREBF2 sterol regulatory element binding transcription factor 2 -0.0347642
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0333665
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0320236
TENM1 teneurin transmembrane protein 1 -0.0318397
POTEF POTE ankyrin domain family, member F -0.0313875
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.030843
TSC22D2 TSC22 domain family, member 2 -0.0302029
RAB7A RAB7A, member RAS oncogene family -0.0299883
NLGN1 neuroligin 1 -0.0272818
GLS2 glutaminase 2 (liver, mitochondrial) -0.0260127
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0242327
CXCL8 chemokine (C-X-C motif) ligand 8 -0.024128
PCBP2 poly(rC) binding protein 2 -0.0221389
COG5 component of oligomeric golgi complex 5 -0.0213569
BIRC6 baculoviral IAP repeat containing 6 -0.0212813
ERBIN erbb2 interacting protein -0.0209579
GDAP2 ganglioside induced differentiation associated protein 2 -0.0187803
MARCHF1 membrane associated ring-CH-type finger 1 -0.0187549
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0184979
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0184905
VMP1 vacuole membrane protein 1 -0.0183362
KIF5C kinesin family member 5C -0.0181262
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0179307
RBM25 RNA binding motif protein 25 -0.0179143
GPHN gephyrin -0.0177963
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.017729
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0170878
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0167297
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0166967
CCNL1 cyclin L1 -0.0165859
STRN3 striatin, calmodulin binding protein 3 -0.0163622
EVI5 ecotropic viral integration site 5 -0.016261
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0160729
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0158826
SEC24A SEC24 family member A -0.0157996
HMGA1 high mobility group AT-hook 1 -0.0157245
AKAP9 A kinase (PRKA) anchor protein 9 -0.015669
MON2 MON2 homolog (S. cerevisiae) -0.0155994
LINC02798 long intergenic non-protein coding RNA 2798 -0.0155965
ZFYVE16 zinc finger, FYVE domain containing 16 -0.0155435
NBAS neuroblastoma amplified sequence -0.015405
SBF2 SET binding factor 2 -0.0152329
PUM2 pumilio RNA-binding family member 2 -0.0150576
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0149303
THOC2 THO complex 2 -0.014513
NOTCH2 notch 2 -0.014273
ARB2A ARB2 cotranscriptional regulator A -0.0142218
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0141424
DHFR dihydrofolate reductase -0.0139782
GSK3B glycogen synthase kinase 3 beta -0.0139243
FNIP1 folliculin interacting protein 1 -0.0138727
ATXN2 ataxin 2 -0.0138604
MEMO1 mediator of cell motility 1 -0.0138324
ANKRD17 ankyrin repeat domain 17 -0.0134268
KAZN kazrin, periplakin interacting protein -0.0134024
CLEC2D C-type lectin domain family 2, member D -0.0132765
ARL15 ADP-ribosylation factor-like 15 -0.0132723
TUT4 terminal uridylyl transferase 4 -0.013164
ZNF644 zinc finger protein 644 -0.0130996
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0130525
PCNX1 pecanex 1 -0.0130271
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0128473
AHCTF1 AT hook containing transcription factor 1 -0.0127361
FSTL5 follistatin-like 5 -0.0126859
AFTPH aftiphilin -0.0124848
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0124385
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0123617
ZNF207 zinc finger protein 207 -0.0123042
RNF145 ring finger protein 145 -0.0122634
FER fer (fps/fes related) tyrosine kinase -0.0122444
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0122073
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0121805
WDPCP WD repeat containing planar cell polarity effector -0.0121769
ATRN attractin -0.0121021
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0120962
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 -0.0120618
DNAH14 dynein, axonemal, heavy chain 14 -0.0119439
ARHGAP26 Rho GTPase activating protein 26 -0.0119239
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 -0.0118861
TUSC3 tumor suppressor candidate 3 -0.0118063
MARCHF7 membrane associated ring-CH-type finger 7 -0.0117944
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0117824
ATP13A3 ATPase type 13A3 -0.011774
NF1 neurofibromin 1 -0.0117087
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0117
TRIQK triple QxxK/R motif containing -0.011587
ULK4 unc-51 like kinase 4 -0.0115647
SRP54 signal recognition particle 54kDa -0.0115134
NKTR natural killer cell triggering receptor -0.0114975
SNX13 sorting nexin 13 -0.0114973
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0114846
RB1CC1 RB1-inducible coiled-coil 1 -0.0114223
STAU2 staufen double-stranded RNA binding protein 2 -0.0113182