Minodronic acid_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.208288
AHNAK AHNAK nucleoprotein 0.135441
EGFR epidermal growth factor receptor 0.120821
PRELID2 PRELI domain containing 2 0.0928841
TMSB4X thymosin beta 4, X-linked 0.0926059
PKM pyruvate kinase, muscle 0.0792327
EEF2 eukaryotic translation elongation factor 2 0.0754839
HDAC9 histone deacetylase 9 0.0751529
FLNB filamin B, beta 0.0739026
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0644775
VCL vinculin 0.0632978
RPL3 ribosomal protein L3 0.0612362
LOC112694756 uncharaterized LOC112694756 0.0584618
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0575315
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0572658
MYH9 myosin, heavy chain 9, non-muscle 0.054745
GLI3 GLI family zinc finger 3 0.0540523
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.05335
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0518458
PDGFC platelet derived growth factor C 0.0514996
ZEB1 zinc finger E-box binding homeobox 1 0.0509666
MYO5C myosin VC 0.0500987
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.049359
H1-4 H1.4 linker histone, cluster member 0.0486381
TPT1 tumor protein, translationally-controlled 1 0.0479958
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.047818
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0474958
GLI2 GLI family zinc finger 2 0.0464593
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0461045
DSCAM Down syndrome cell adhesion molecule 0.0460149
SMYD3 SET and MYND domain containing 3 0.0435422
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0426447
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0421042
ZNF608 zinc finger protein 608 0.0416837
RPL37A ribosomal protein L37a 0.0415058
RPL4 ribosomal protein L4 0.0412152
APP amyloid beta (A4) precursor protein 0.0410155
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0400844
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0398694
CPNE1 copine I 0.0394841
MACROD2 MACRO domain containing 2 0.0392026
CAMTA1 calmodulin binding transcription activator 1 0.0389362
HSPA8 heat shock 70kDa protein 8 0.0389142
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0380275
FOXP1 forkhead box P1 0.0370155
TM4SF1 transmembrane 4 L six family member 1 0.0362676
INTS6 integrator complex subunit 6 0.0359578
RPL19 ribosomal protein L19 0.0358922
ZNF217 zinc finger protein 217 0.0354577
RPL7A ribosomal protein L7a 0.0347509
PRPF38B pre-mRNA processing factor 38B 0.0347426
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0346851
EXT1 exostosin glycosyltransferase 1 0.0343311
ANXA1 annexin A1 0.0342354
RPS15A ribosomal protein S15a 0.0315401
SFTPA2 surfactant protein A2 0.0313743
KLF3 Kruppel-like factor 3 (basic) 0.0313269
TACC2 transforming, acidic coiled-coil containing protein 2 0.030535
DST dystonin 0.0304791
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0304567
EEF1G eukaryotic translation elongation factor 1 gamma 0.0302446
KLC1 kinesin light chain 1 0.0301828
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0301103
RPS3 ribosomal protein S3 0.0300636
TMEM65 transmembrane protein 65 0.0297911
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0294924
ATP9B ATPase, class II, type 9B 0.029328
RPL26 ribosomal protein L26 0.0291538
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0284095
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0281621
SRRM2 serine/arginine repetitive matrix 2 0.0272029
FER1L6 fer-1-like family member 6 0.0271732
HDLBP high density lipoprotein binding protein 0.0271291
TRERF1 transcriptional regulating factor 1 0.0270939
PARD3B par-3 family cell polarity regulator beta 0.0269853
NONO non-POU domain containing, octamer-binding 0.0267565
RPL13A ribosomal protein L13a 0.0267334
RPS23 ribosomal protein S23 0.026702
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0263025
SDK1 sidekick cell adhesion molecule 1 0.0261837
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.0260854
TAS2R14 taste receptor, type 2, member 14 0.0260564
CEP250 centrosomal protein 250kDa 0.0258651
IFI16 interferon, gamma-inducible protein 16 0.0256924
NUMA1 nuclear mitotic apparatus protein 1 0.0254991
PARD3 par-3 family cell polarity regulator 0.0253626
AHCYL2 adenosylhomocysteinase-like 2 0.0251274
SOX6 SRY (sex determining region Y)-box 6 0.0249548
NCEH1 neutral cholesterol ester hydrolase 1 0.0249077
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.02482
MACF1 microtubule-actin crosslinking factor 1 0.0247919
SAMD4A sterile alpha motif domain containing 4A 0.0247767
RPL35 ribosomal protein L35 0.0245907
RPS12 ribosomal protein S12 0.0244273
NAP1L1 nucleosome assembly protein 1-like 1 0.0244105
RPS13 ribosomal protein S13 0.0244019
ARGLU1 arginine and glutamate rich 1 0.0241086
TTC28 tetratricopeptide repeat domain 28 0.0241084
CPED1 cadherin-like and PC-esterase domain containing 1 0.0240872
ALMS1 Alstrom syndrome protein 1 0.0237109

decreased expression

Symbol Name Standardized Value
GOLGA4 golgin A4 -0.085972
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0856951
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.083521
POTEF POTE ankyrin domain family, member F -0.06634
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0654428
EVI5 ecotropic viral integration site 5 -0.0639407
CENPF centromere protein F, 350/400kDa -0.0581982
RPL35A ribosomal protein L35a -0.0567103
PTMA prothymosin, alpha -0.0544869
KPNB1 karyopherin (importin) beta 1 -0.0523568
ZNF292 zinc finger protein 292 -0.0471998
TFG TRK-fused gene -0.0450174
SMC4 structural maintenance of chromosomes 4 -0.0441744
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0439117
SMC3 structural maintenance of chromosomes 3 -0.0431124
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0424364
PCBP2 poly(rC) binding protein 2 -0.0414457
RBM25 RNA binding motif protein 25 -0.0411697
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0401855
RAB7A RAB7A, member RAS oncogene family -0.0399766
PFN1 profilin 1 -0.03986
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0398201
BIRC6 baculoviral IAP repeat containing 6 -0.0377446
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0371035
WSB1 WD repeat and SOCS box containing 1 -0.0365376
KMT2E lysine (K)-specific methyltransferase 2E -0.0350668
USP3 ubiquitin specific peptidase 3 -0.0347704
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0344177
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0332648
DLG1 discs, large homolog 1 (Drosophila) -0.0313965
TMEM41B transmembrane protein 41B -0.031355
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0309379
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0307681
MON2 MON2 homolog (S. cerevisiae) -0.0305671
SEPTIN7 septin 7 -0.0300949
ZMYM2 zinc finger, MYM-type 2 -0.0292963
TMEM87A transmembrane protein 87A -0.0291613
DSTN destrin (actin depolymerizing factor) -0.0284222
FNDC3B fibronectin type III domain containing 3B -0.0279594
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0279478
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0274136
IARS1 isoleucyl-tRNA synthetase 1 -0.0272952
CBX3 chromobox homolog 3 -0.0266369
GLS2 glutaminase 2 (liver, mitochondrial) -0.0261321
SRP54 signal recognition particle 54kDa -0.0258103
SBF2 SET binding factor 2 -0.0256675
HMGB1 high mobility group box 1 -0.0255661
RAB6A RAB6A, member RAS oncogene family -0.0253939
MIS18BP1 MIS18 binding protein 1 -0.0250983
FAM13A family with sequence similarity 13, member A -0.0250847
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.024959
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0247599
NF1 neurofibromin 1 -0.0247555
MXI1 MAX interactor 1, dimerization protein -0.0241672
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0240004
BRWD1 bromodomain and WD repeat domain containing 1 -0.0239777
ATN1 atrophin 1 -0.0239661
NAMPT nicotinamide phosphoribosyltransferase -0.0237439
VDAC1 voltage-dependent anion channel 1 -0.0237142
HSPA4L heat shock 70kDa protein 4-like -0.0236646
SEC24A SEC24 family member A -0.0236565
RPL27A ribosomal protein L27a -0.0232915
S100A6 S100 calcium binding protein A6 -0.0231899
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0231237
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0230989
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0229121
WDR45B WD repeat domain 45B -0.0229115
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0228719
RBMS2 RNA binding motif, single stranded interacting protein 2 -0.022704
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0225983
HELZ helicase with zinc finger -0.0225733
MKI67 marker of proliferation Ki-67 -0.0225632
B2M beta-2-microglobulin -0.0225585
MT2A metallothionein 2A -0.0225496
IGF2 insulin-like growth factor 2 -0.0225343
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0223769
DEK DEK proto-oncogene -0.0223409
NBAS neuroblastoma amplified sequence -0.0218688
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0218464
NEBL nebulette -0.0218048
RLF rearranged L-myc fusion -0.0217961
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0215799
NUP58 nucleoporin 58 -0.0214842
SETD5 SET domain containing 5 -0.0213572
RB1CC1 RB1-inducible coiled-coil 1 -0.0213513
THOC2 THO complex 2 -0.0212202
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0212038
ACBD3 acyl-CoA binding domain containing 3 -0.0211929
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0208897
NKTR natural killer cell triggering receptor -0.0208321
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0206615
TBK1 TANK-binding kinase 1 -0.0204176
KMT2C lysine (K)-specific methyltransferase 2C -0.0203963
MTDH metadherin -0.0202691
DIAPH3 diaphanous-related formin 3 -0.0201744
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0200766
PTBP2 polypyrimidine tract binding protein 2 -0.0200107
CCDC88A coiled-coil domain containing 88A -0.0198436
CCNL1 cyclin L1 -0.0198202
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0196183