Minodronic acid_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.22543
COL6A3 collagen, type VI, alpha 3 0.224613
TGFBI transforming growth factor, beta-induced, 68kDa 0.194708
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.169446
FN1 fibronectin 1 0.118957
TRIO trio Rho guanine nucleotide exchange factor 0.112077
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0980793
ERRFI1 ERBB receptor feedback inhibitor 1 0.0962866
HLA-B major histocompatibility complex, class I, B 0.0943937
VIM vimentin 0.0807782
CD44 CD44 molecule (Indian blood group) 0.0734892
TMSB10 thymosin beta 10 0.0734313
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0720812
B2M beta-2-microglobulin 0.0706038
KYNU kynureninase 0.0701976
EXT1 exostosin glycosyltransferase 1 0.0610505
TNIP1 TNFAIP3 interacting protein 1 0.0589687
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0578478
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0567827
COL5A1 collagen, type V, alpha 1 0.0554931
VEGFA vascular endothelial growth factor A 0.0551444
PRELID2 PRELI domain containing 2 0.0551119
AHNAK AHNAK nucleoprotein 0.0533473
SDC4 syndecan 4 0.0523754
PRSS23 protease, serine, 23 0.0521063
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0501882
ZSWIM6 zinc finger, SWIM-type containing 6 0.0499369
COL6A2 collagen, type VI, alpha 2 0.0497423
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0496697
CALR calreticulin 0.0488151
AKAP12 A kinase (PRKA) anchor protein 12 0.0482839
LOX lysyl oxidase 0.0459785
IGFBP7 insulin-like growth factor binding protein 7 0.044748
ASPH aspartate beta-hydroxylase 0.0444979
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0435867
EXOC4 exocyst complex component 4 0.042357
RUNX1 runt-related transcription factor 1 0.0422399
CANX calnexin 0.0418897
TPT1 tumor protein, translationally-controlled 1 0.0417686
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0416039
SFTPA2 surfactant protein A2 0.0410492
EFNA5 ephrin-A5 0.0409153
PTMA prothymosin, alpha 0.0406465
RAI14 retinoic acid induced 14 0.0402043
FBXL7 F-box and leucine-rich repeat protein 7 0.0401594
SAMD4A sterile alpha motif domain containing 4A 0.0376177
RPS12 ribosomal protein S12 0.0367604
SP100 SP100 nuclear antigen 0.0366084
ZBTB20 zinc finger and BTB domain containing 20 0.0359675
TMSB4X thymosin beta 4, X-linked 0.0358745
ALK anaplastic lymphoma receptor tyrosine kinase 0.0358231
FNDC3B fibronectin type III domain containing 3B 0.0351992
HYOU1 hypoxia up-regulated 1 0.0340327
SETBP1 SET binding protein 1 0.0338362
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0336537
RPS27A ribosomal protein S27a 0.0334232
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0323545
STC1 stanniocalcin 1 0.0321278
LOXL2 lysyl oxidase-like 2 0.0320966
TNS3 tensin 3 0.0319832
CAVIN1 caveolae associated protein 1 0.0318467
GLIS3 GLIS family zinc finger 3 0.0317886
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0317322
FAM13A family with sequence similarity 13, member A 0.0309854
CALD1 caldesmon 1 0.0306982
WWOX WW domain containing oxidoreductase 0.0305915
HIPK2 homeodomain interacting protein kinase 2 0.0305429
EEF2 eukaryotic translation elongation factor 2 0.0301002
MSN moesin 0.0299236
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0292722
MAP1B microtubule-associated protein 1B 0.0292139
LOC112694756 uncharaterized LOC112694756 0.02912
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0290412
MACF1 microtubule-actin crosslinking factor 1 0.0289655
INTS6 integrator complex subunit 6 0.028883
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0286483
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0286178
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0285965
SON SON DNA binding protein 0.0283948
VEGFC vascular endothelial growth factor C 0.0275441
PGK1 phosphoglycerate kinase 1 0.0275143
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0273983
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0273429
WNK1 WNK lysine deficient protein kinase 1 0.0272953
IQGAP1 IQ motif containing GTPase activating protein 1 0.0272013
PLEC plectin 0.0268169
MCL1 myeloid cell leukemia 1 0.0267679
VCL vinculin 0.0267633
HMGA2 high mobility group AT-hook 2 0.0266817
TXNIP thioredoxin interacting protein 0.0266418
MYLK myosin light chain kinase 0.02653
RASAL2 RAS protein activator like 2 0.0263976
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0263916
RPL3 ribosomal protein L3 0.0263031
PSD3 pleckstrin and Sec7 domain containing 3 0.0259656
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0259239
PKM pyruvate kinase, muscle 0.0259113
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.025738
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0257357
S100A10 S100 calcium binding protein A10 0.0256653

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0953752
FTH1 ferritin, heavy polypeptide 1 -0.0764111
IGFBP3 insulin-like growth factor binding protein 3 -0.0599261
RTN4 reticulon 4 -0.059911
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0543238
COL1A2 collagen, type I, alpha 2 -0.0543045
TENT5A terminal nucleotidyltransferase 5A -0.0483057
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0419024
KLF7 Kruppel-like factor 7 (ubiquitous) -0.041733
RNF145 ring finger protein 145 -0.0400865
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0398559
MARCHF6 membrane associated ring-CH-type finger 6 -0.0392355
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0382725
ACBD3 acyl-CoA binding domain containing 3 -0.0381806
SRP54 signal recognition particle 54kDa -0.0374385
KMT2E lysine (K)-specific methyltransferase 2E -0.0373957
FAM133B family with sequence similarity 133, member B -0.0369312
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0368765
SETD5 SET domain containing 5 -0.0361445
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0346899
COPA coatomer protein complex, subunit alpha -0.0336039
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0335283
DLG1 discs, large homolog 1 (Drosophila) -0.0330345
BRWD3 bromodomain and WD repeat domain containing 3 -0.0318722
EGR1 early growth response 1 -0.0307408
PCNX1 pecanex 1 -0.0291175
PICALM phosphatidylinositol binding clathrin assembly protein -0.0290196
CLTC clathrin, heavy chain (Hc) -0.0289408
MEF2A myocyte enhancer factor 2A -0.0286631
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.028091
ELL2 elongation factor, RNA polymerase II, 2 -0.0269751
UBE4B ubiquitination factor E4B -0.0268215
TM9SF4 transmembrane 9 superfamily protein member 4 -0.0265783
SCFD2 sec1 family domain containing 2 -0.0264767
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.026388
PDE10A phosphodiesterase 10A -0.0263612
CHD1 chromodomain helicase DNA binding protein 1 -0.026232
CLINT1 clathrin interactor 1 -0.0262079
POT1 protection of telomeres 1 -0.025998
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.025949
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.02582
MARCHF7 membrane associated ring-CH-type finger 7 -0.0256346
HM13 histocompatibility (minor) 13 -0.0254972
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0254352
GOLGA4 golgin A4 -0.0251567
RAP1B RAP1B, member of RAS oncogene family -0.0250019
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0249274
SPAG9 sperm associated antigen 9 -0.0243686
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0243062
NEK7 NIMA-related kinase 7 -0.0242055
ANXA5 annexin A5 -0.024109
TNPO3 transportin 3 -0.023925
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0234596
AGRN agrin -0.0232895
COPB1 coatomer protein complex, subunit beta 1 -0.0231885
IARS1 isoleucyl-tRNA synthetase 1 -0.0230962
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0227794
OAF OAF homolog (Drosophila) -0.0226373
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0225009
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0223548
ITCH itchy E3 ubiquitin protein ligase -0.0223433
TMEM123 transmembrane protein 123 -0.02226
FGFR2 fibroblast growth factor receptor 2 -0.022062
USPL1 ubiquitin specific peptidase like 1 -0.0220263
SEC23A Sec23 homolog A (S. cerevisiae) -0.0220173
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0219282
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0219192
NT5C2 5'-nucleotidase, cytosolic II -0.0218163
ZCCHC17 zinc finger, CCHC domain containing 17 -0.0217163
CRLS1 cardiolipin synthase 1 -0.0215667
MTREX Mtr4 exosome RNA helicase -0.0215038
C1D C1D nuclear receptor corepressor -0.021252
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0210713
GARS1 glycyl-tRNA synthetase 1 -0.0209768
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0208422
CAPN2 calpain 2, (m/II) large subunit -0.0208163
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0207653
TXNDC11 thioredoxin domain containing 11 -0.0207503
ZNF207 zinc finger protein 207 -0.0207455
HAPSTR1 HUWE1 associated protein modifying stress responses -0.0207131
SETX senataxin -0.020352
AK1 adenylate kinase 1 -0.0203439
PDIA6 protein disulfide isomerase family A, member 6 -0.0203294
ATP11B ATPase, class VI, type 11B -0.0202584
NRF1 nuclear respiratory factor 1 -0.0201114
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0198404
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0197997
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0196027
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0196015
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0195369
NUP54 nucleoporin 54kDa -0.0194917
TLK1 tousled-like kinase 1 -0.0193127
STYX serine/threonine/tyrosine interacting protein -0.0191878
OSBP oxysterol binding protein -0.0191762
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0190705
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0190649
NSD3 nuclear receptor binding SET domain protein 3 -0.0190013
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) -0.0189933
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.018975
SLFN5 schlafen family member 5 -0.0189624