Minodronic acid_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.138342
EXT1 exostosin glycosyltransferase 1 0.134182
SMAD3 SMAD family member 3 0.0892017
MYH9 myosin, heavy chain 9, non-muscle 0.0851633
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0778311
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0767923
TRIO trio Rho guanine nucleotide exchange factor 0.0628286
SFTPA2 surfactant protein A2 0.0570295
SVIL supervillin 0.0541075
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0540553
DST dystonin 0.0534487
GRB10 growth factor receptor-bound protein 10 0.0529935
LRMDA leucine rich melanocyte differentiation associated 0.0506428
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.049662
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0492116
SPTBN1 spectrin, beta, non-erythrocytic 1 0.045139
OSMR oncostatin M receptor 0.0442545
FNDC3B fibronectin type III domain containing 3B 0.0430286
TMEM156 transmembrane protein 156 0.0423604
MLPH melanophilin 0.0412223
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0408368
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.040412
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0400179
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0394112
RNF213 ring finger protein 213 0.0378902
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0377657
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0376598
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0370034
AHR aryl hydrocarbon receptor 0.0365947
LOC112694756 uncharaterized LOC112694756 0.0365611
ACTN4 actinin, alpha 4 0.0361521
AHNAK2 AHNAK nucleoprotein 2 0.0361225
KDM3A lysine (K)-specific demethylase 3A 0.0355808
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0353405
ZNF217 zinc finger protein 217 0.0352409
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0351848
H1-0 H1.0 linker histone 0.0350373
AHNAK AHNAK nucleoprotein 0.0349494
RASAL2 RAS protein activator like 2 0.0344889
PLEC plectin 0.0342351
SQSTM1 sequestosome 1 0.0334036
LTBP1 latent transforming growth factor beta binding protein 1 0.0330681
APP amyloid beta (A4) precursor protein 0.0327177
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0325935
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0323018
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0319744
VCL vinculin 0.0319143
LOXL2 lysyl oxidase-like 2 0.0316177
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0315347
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0311013
NTN4 netrin 4 0.0306073
ATXN1 ataxin 1 0.030591
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0303966
YBX3 Y box binding protein 3 0.0299004
IL6ST interleukin 6 signal transducer 0.0293897
PDLIM5 PDZ and LIM domain 5 0.0285593
FLNA filamin A, alpha 0.0284978
HSPA8 heat shock 70kDa protein 8 0.028444
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0281221
GLIS3 GLIS family zinc finger 3 0.0279497
MACF1 microtubule-actin crosslinking factor 1 0.0275538
RPH3AL rabphilin 3A-like (without C2 domains) 0.0274983
NPAS2 neuronal PAS domain protein 2 0.0271882
NRP1 neuropilin 1 0.0271446
LMNA lamin A/C 0.0268765
WWOX WW domain containing oxidoreductase 0.0268558
CORO1C coronin, actin binding protein, 1C 0.0267593
PDE4D phosphodiesterase 4D, cAMP-specific 0.0266101
TMEM131 transmembrane protein 131 0.0265527
EMP1 epithelial membrane protein 1 0.0265394
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0265138
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0264305
FHIT fragile histidine triad 0.0263943
ELL2 elongation factor, RNA polymerase II, 2 0.0262789
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0258464
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0258289
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0256766
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0255136
WWTR1 WW domain containing transcription regulator 1 0.0254247
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0251899
CD44 CD44 molecule (Indian blood group) 0.0249999
ATF3 activating transcription factor 3 0.0244891
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0240988
ITGA1 integrin, alpha 1 0.0240604
PTPRE protein tyrosine phosphatase, receptor type, E 0.0240512
TXNRD1 thioredoxin reductase 1 0.0238631
LHFPL2 lipoma HMGIC fusion partner-like 2 0.023623
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0235296
RAB10 RAB10, member RAS oncogene family 0.0234904
UBASH3B ubiquitin associated and SH3 domain containing B 0.0233875
SGMS2 sphingomyelin synthase 2 0.0230788
ZC3H12C zinc finger CCCH-type containing 12C 0.022965
DUSP10 dual specificity phosphatase 10 0.0228425
WNK1 WNK lysine deficient protein kinase 1 0.0227722
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0226734
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0226658
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0225491
MCTP2 multiple C2 domains, transmembrane 2 0.0224141
TTC28 tetratricopeptide repeat domain 28 0.022372
NUMA1 nuclear mitotic apparatus protein 1 0.0223576

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.182936
P4HB prolyl 4-hydroxylase, beta polypeptide -0.162493
FTH1 ferritin, heavy polypeptide 1 -0.135798
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0869766
NRG1 neuregulin 1 -0.0822273
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.081827
MRPS6 mitochondrial ribosomal protein S6 -0.0794016
PLIN2 perilipin 2 -0.0783705
PTMA prothymosin, alpha -0.0768633
ZFP36L1 ZFP36 ring finger protein-like 1 -0.071352
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0635203
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0607771
STC2 stanniocalcin 2 -0.0603243
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0595915
POTEF POTE ankyrin domain family, member F -0.0594281
CADM1 cell adhesion molecule 1 -0.0585279
GOLGA4 golgin A4 -0.0563227
VIM vimentin -0.0553393
S100A6 S100 calcium binding protein A6 -0.0540988
TMEM165 transmembrane protein 165 -0.0527702
IFI27 interferon, alpha-inducible protein 27 -0.051941
HILPDA hypoxia inducible lipid droplet-associated -0.0518024
HMGA1 high mobility group AT-hook 1 -0.0515508
NDRG1 N-myc downstream regulated 1 -0.0514837
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0491391
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0458315
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.044209
SPDYA speedy/RINGO cell cycle regulator family member A -0.0430228
RPS6 ribosomal protein S6 -0.0423882
PDIA3 protein disulfide isomerase family A, member 3 -0.0420307
TMSB10 thymosin beta 10 -0.0420248
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0398196
CANX calnexin -0.0390414
SOD2 superoxide dismutase 2, mitochondrial -0.0378942
AKAP9 A kinase (PRKA) anchor protein 9 -0.0367884
LOC102724023 ES1 protein homolog, mitochondrial -0.0360465
ARID4B AT rich interactive domain 4B (RBP1-like) -0.034896
CEP350 centrosomal protein 350kDa -0.0348637
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0343872
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0319042
SRP54 signal recognition particle 54kDa -0.0316182
FOSL1 FOS-like antigen 1 -0.0313017
RPL35A ribosomal protein L35a -0.0312739
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.031091
ZCCHC7 zinc finger, CCHC domain containing 7 -0.030749
ENO2 enolase 2 (gamma, neuronal) -0.0302684
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0301043
WASF2 WAS protein family, member 2 -0.0298131
HDGF hepatoma-derived growth factor -0.0294647
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.029156
RPS20 ribosomal protein S20 -0.0285998
BIRC3 baculoviral IAP repeat containing 3 -0.0284053
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 -0.0281131
HM13 histocompatibility (minor) 13 -0.0272489
LRRC23 leucine rich repeat containing 23 -0.0271703
IGFBP3 insulin-like growth factor binding protein 3 -0.0268203
VEGFA vascular endothelial growth factor A -0.0267132
CFB complement factor B -0.0263397
SUCO SUN domain containing ossification factor -0.0262928
S100A9 S100 calcium binding protein A9 -0.0262927
RACK1 receptor for activated C kinase 1 -0.0262618
PDIA6 protein disulfide isomerase family A, member 6 -0.0261435
MON2 MON2 homolog (S. cerevisiae) -0.0258853
BIRC6 baculoviral IAP repeat containing 6 -0.0258176
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.025687
TTC3 tetratricopeptide repeat domain 3 -0.0256367
KDM5B lysine (K)-specific demethylase 5B -0.0255279
GLG1 golgi glycoprotein 1 -0.0254926
LOX lysyl oxidase -0.0251924
POU2F2 POU class 2 homeobox 2 -0.0251184
ZNF292 zinc finger protein 292 -0.0249875
COG6 component of oligomeric golgi complex 6 -0.0249005
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0246299
CALR calreticulin -0.0246164
CTSD cathepsin D -0.0246151
GNAS GNAS complex locus -0.0245364
HSPB1 heat shock 27kDa protein 1 -0.0244328
HIPK2 homeodomain interacting protein kinase 2 -0.0243856
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0243752
INTS6 integrator complex subunit 6 -0.024112
SEC31A SEC31 homolog A (S. cerevisiae) -0.0240358
CALU calumenin -0.0237711
TRAM1 translocation associated membrane protein 1 -0.0236329
LCORL ligand dependent nuclear receptor corepressor-like -0.0233137
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0232901
PGM3 phosphoglucomutase 3 -0.0231997
PKM pyruvate kinase, muscle -0.023088
CDCP1 CUB domain containing protein 1 -0.0226455
B2M beta-2-microglobulin -0.0223284
RPL28 ribosomal protein L28 -0.0222231
FRY furry homolog (Drosophila) -0.0221517
HMGB3 high mobility group box 3 -0.0220893
RPS12 ribosomal protein S12 -0.0219955
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0219813
PFN1 profilin 1 -0.0218353
AHRR aryl-hydrocarbon receptor repressor -0.0217795
FTL ferritin, light polypeptide -0.0217349
ARF4 ADP-ribosylation factor 4 -0.0215999
ATN1 atrophin 1 -0.0214111
USP15 ubiquitin specific peptidase 15 -0.021351