Minodronic acid_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.12217
FTL ferritin, light polypeptide 0.0875514
RPS12 ribosomal protein S12 0.0806145
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0725645
RPS3 ribosomal protein S3 0.0700025
RPL37A ribosomal protein L37a 0.0688219
TMSB10 thymosin beta 10 0.068496
PTMA prothymosin, alpha 0.0633288
RPS6 ribosomal protein S6 0.0547523
MYH9 myosin, heavy chain 9, non-muscle 0.0525479
RPL31 ribosomal protein L31 0.0491362
RPL35 ribosomal protein L35 0.0478759
LDHA lactate dehydrogenase A 0.0470768
RPLP2 ribosomal protein, large, P2 0.046889
RPL12 ribosomal protein L12 0.0452933
B2M beta-2-microglobulin 0.0441404
RPS27A ribosomal protein S27a 0.04399
EZR ezrin 0.0413496
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.04076
RPL28 ribosomal protein L28 0.0403151
RPL13A ribosomal protein L13a 0.0393496
TXNIP thioredoxin interacting protein 0.0373294
RPS19 ribosomal protein S19 0.0370794
LOC112694756 uncharaterized LOC112694756 0.0368853
RPS11 ribosomal protein S11 0.0368329
RPS13 ribosomal protein S13 0.0359685
RPL19 ribosomal protein L19 0.0358348
RPS21 ribosomal protein S21 0.0354
RPS8 ribosomal protein S8 0.0353111
KRT8 keratin 8, type II 0.0343326
NDRG1 N-myc downstream regulated 1 0.0341417
RPS29 ribosomal protein S29 0.0327043
RPL11 ribosomal protein L11 0.0326451
CST3 cystatin C 0.0321742
RPL3 ribosomal protein L3 0.0319417
RPS17 ribosomal protein S17 0.0317662
LOC102724023 ES1 protein homolog, mitochondrial 0.0317652
RPL8 ribosomal protein L8 0.0312876
RPS27 ribosomal protein S27 0.0305834
RPL36 ribosomal protein L36 0.0291946
RPLP1 ribosomal protein, large, P1 0.0291341
PKM pyruvate kinase, muscle 0.0285309
RPS5 ribosomal protein S5 0.0280073
ESYT2 extended synaptotagmin-like protein 2 0.0275173
RPL37 ribosomal protein L37 0.0271346
RPL7A ribosomal protein L7a 0.0269994
SRRM2 serine/arginine repetitive matrix 2 0.0267916
TPT1 tumor protein, translationally-controlled 1 0.0254214
GSTP1 glutathione S-transferase pi 1 0.0253377
ENO1 enolase 1, (alpha) 0.0251331
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0246005
IFI6 interferon, alpha-inducible protein 6 0.0245218
KRT18 keratin 18, type I 0.0242753
EEF1G eukaryotic translation elongation factor 1 gamma 0.0238918
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0234107
RPS15A ribosomal protein S15a 0.0232455
IFITM3 interferon induced transmembrane protein 3 0.0226957
CENPF centromere protein F, 350/400kDa 0.0226165
RPL18 ribosomal protein L18 0.0223551
RPS15 ribosomal protein S15 0.022225
RPS23 ribosomal protein S23 0.0221579
FAT1 FAT atypical cadherin 1 0.0217184
MYH14 myosin, heavy chain 14, non-muscle 0.0213739
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0213001
NONO non-POU domain containing, octamer-binding 0.0212921
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0212591
HYOU1 hypoxia up-regulated 1 0.0212482
RPL26 ribosomal protein L26 0.0210694
RPL30 ribosomal protein L30 0.0206697
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0201326
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0200691
NUMA1 nuclear mitotic apparatus protein 1 0.019998
TNIP1 TNFAIP3 interacting protein 1 0.0195382
IFI27 interferon, alpha-inducible protein 27 0.0193307
P4HB prolyl 4-hydroxylase, beta polypeptide 0.019196
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0190714
CEMIP cell migration inducing protein, hyaluronan binding 0.018787
PGK1 phosphoglycerate kinase 1 0.0187533
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0186509
RPL23 ribosomal protein L23 0.0186424
RPL32 ribosomal protein L32 0.018464
RPL9 ribosomal protein L9 0.0182939
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0179121
CALR calreticulin 0.0178646
RPS4X ribosomal protein S4, X-linked 0.0177576
CD9 CD9 molecule 0.0177424
ACTG1 actin gamma 1 0.017738
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0176396
ADM adrenomedullin 0.0173117
DSPP dentin sialophosphoprotein 0.0172369
TUBB4B tubulin, beta 4B class IVb 0.0171711
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0168285
VIM vimentin 0.0167421
RPS16 ribosomal protein S16 0.0167311
WSB1 WD repeat and SOCS box containing 1 0.0166868
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0166663
NCKAP1 NCK-associated protein 1 0.0164981
RPS10 ribosomal protein S10 0.0162859
ZNF292 zinc finger protein 292 0.0162551
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 0.0162358

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.0879031
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0658967
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0622749
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0601133
BCL2L1 BCL2-like 1 -0.0583644
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0446196
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0422979
IFRD1 interferon-related developmental regulator 1 -0.04197
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0417666
MAML2 mastermind-like 2 (Drosophila) -0.0412223
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0405683
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.040269
TOP1 topoisomerase (DNA) I -0.0398372
CDK13 cyclin-dependent kinase 13 -0.0388122
NCOA3 nuclear receptor coactivator 3 -0.0387229
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0386927
TMEM123 transmembrane protein 123 -0.0308367
GNAS GNAS complex locus -0.0306849
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0297997
EPS8 epidermal growth factor receptor pathway substrate 8 -0.029297
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0287942
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0285713
PICALM phosphatidylinositol binding clathrin assembly protein -0.0284167
INTS6 integrator complex subunit 6 -0.0278493
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0277407
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0277273
ANKRD11 ankyrin repeat domain 11 -0.0275277
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.027404
ITCH itchy E3 ubiquitin protein ligase -0.0272765
NIPBL Nipped-B homolog (Drosophila) -0.0259168
MYO1E myosin IE -0.0254787
CEMIP2 cell migration inducing hyaluronidase 2 -0.0253051
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0252818
TPM4 tropomyosin 4 -0.0251161
NFIA nuclear factor I/A -0.0249247
SDK1 sidekick cell adhesion molecule 1 -0.0247278
AKAP12 A kinase (PRKA) anchor protein 12 -0.0247053
UBAP2 ubiquitin associated protein 2 -0.024581
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0243165
ZBTB38 zinc finger and BTB domain containing 38 -0.0242267
SAMD4A sterile alpha motif domain containing 4A -0.023773
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0223178
STAU1 staufen double-stranded RNA binding protein 1 -0.022086
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0219153
USP34 ubiquitin specific peptidase 34 -0.021622
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0214996
EHBP1 EH domain binding protein 1 -0.0214387
PATJ PATJ crumbs cell polarity complex component -0.0213297
CCND1 cyclin D1 -0.0210633
WAC WW domain containing adaptor with coiled-coil -0.0210279
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0209444
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0206529
NCEH1 neutral cholesterol ester hydrolase 1 -0.0206062
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0202386
UBE2H ubiquitin-conjugating enzyme E2H -0.0201874
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0200939
LRPPRC leucine-rich pentatricopeptide repeat containing -0.020022
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0196934
RAB7A RAB7A, member RAS oncogene family -0.0195773
PDLIM5 PDZ and LIM domain 5 -0.0193635
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0193262
ACTN4 actinin, alpha 4 -0.0191669
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.019158
LARP4B La ribonucleoprotein domain family, member 4B -0.0190568
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0190561
ADIPOR2 adiponectin receptor 2 -0.0190522
SETD2 SET domain containing 2 -0.0188432
TMCC1 transmembrane and coiled-coil domain family 1 -0.0187797
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0187036
LPP LIM domain containing preferred translocation partner in lipoma -0.0186593
MED13L mediator complex subunit 13-like -0.0185265
PITPNB phosphatidylinositol transfer protein, beta -0.0184212
JMJD1C jumonji domain containing 1C -0.0183518
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.018312
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0182789
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0182537
NF1 neurofibromin 1 -0.0182328
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0181343
TGFA transforming growth factor, alpha -0.0180782
RALY RALY heterogeneous nuclear ribonucleoprotein -0.018072
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0179197
ARHGAP12 Rho GTPase activating protein 12 -0.0178004
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0173889
FBXO11 F-box protein 11 -0.0171048
SENP5 SUMO1/sentrin specific peptidase 5 -0.0170947
MED13 mediator complex subunit 13 -0.016789
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0167263
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0165765
CLDN1 claudin 1 -0.0165536
ANKRD17 ankyrin repeat domain 17 -0.0164315
IARS1 isoleucyl-tRNA synthetase 1 -0.0164174
CANX calnexin -0.0164109
FAM107B family with sequence similarity 107, member B -0.0163721
PPARG peroxisome proliferator-activated receptor gamma -0.0163332
SMAD2 SMAD family member 2 -0.0161696
FNDC3A fibronectin type III domain containing 3A -0.0161643
DLG1 discs, large homolog 1 (Drosophila) -0.0160303
COG5 component of oligomeric golgi complex 5 -0.0159881
RCOR1 REST corepressor 1 -0.0158025
ARHGAP35 Rho GTPase activating protein 35 -0.015736