Minodronic acid_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 0.0809537
MYH9 myosin, heavy chain 9, non-muscle 0.0679943
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0651148
RPS12 ribosomal protein S12 0.056862
RPL37A ribosomal protein L37a 0.0545789
RPL3 ribosomal protein L3 0.0515592
FLOT1 flotillin 1 0.0487335
EGFR epidermal growth factor receptor 0.0442635
SEPTIN9 septin 9 0.0419241
CPOX coproporphyrinogen oxidase 0.0418036
RPS3 ribosomal protein S3 0.0394682
KRT18 keratin 18, type I 0.0372797
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0371806
AKAP12 A kinase (PRKA) anchor protein 12 0.0353699
LAMA4 laminin, alpha 4 0.0342088
RPS17 ribosomal protein S17 0.0332875
ITPKC inositol-trisphosphate 3-kinase C 0.0326966
RPLP2 ribosomal protein, large, P2 0.0305969
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0303991
RPL9 ribosomal protein L9 0.0301197
APLP2 amyloid beta (A4) precursor-like protein 2 0.0298286
SRRM2 serine/arginine repetitive matrix 2 0.0294942
RPL31 ribosomal protein L31 0.029419
HSPA8 heat shock 70kDa protein 8 0.0286765
RPS23 ribosomal protein S23 0.0285028
PDE4D phosphodiesterase 4D, cAMP-specific 0.0281532
ITGB4 integrin, beta 4 0.0276736
VEGFA vascular endothelial growth factor A 0.0276271
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0268708
MPRIP myosin phosphatase Rho interacting protein 0.026294
ASPH aspartate beta-hydroxylase 0.0244171
CALR calreticulin 0.0240676
LOC102724023 ES1 protein homolog, mitochondrial 0.0237886
VIM vimentin 0.0236103
EGR1 early growth response 1 0.0234936
EFNB2 ephrin-B2 0.0234219
EEF1G eukaryotic translation elongation factor 1 gamma 0.0232795
PLEC plectin 0.023068
HMGA2 high mobility group AT-hook 2 0.0228529
RPS10 ribosomal protein S10 0.0222807
MKI67 marker of proliferation Ki-67 0.0219532
RPS5 ribosomal protein S5 0.0218407
SLC38A2 solute carrier family 38, member 2 0.021729
MYH14 myosin, heavy chain 14, non-muscle 0.0216286
NOP56 NOP56 ribonucleoprotein 0.0207275
FHL2 four and a half LIM domains 2 0.0206811
KRT8 keratin 8, type II 0.020335
RPL7A ribosomal protein L7a 0.0199867
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0198254
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.019765
CD9 CD9 molecule 0.0195793
CCSER1 coiled-coil serine-rich protein 1 0.0194124
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0193013
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0186788
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0186135
RPL35 ribosomal protein L35 0.0182271
CENPF centromere protein F, 350/400kDa 0.0181713
DSPP dentin sialophosphoprotein 0.018105
DST dystonin 0.0178495
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0176342
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0175819
RPS13 ribosomal protein S13 0.0175032
ZNF827 zinc finger protein 827 0.0174562
ATXN1 ataxin 1 0.0169362
RPL27 ribosomal protein L27 0.0167689
EFNA5 ephrin-A5 0.0166249
SMAD3 SMAD family member 3 0.01661
EIF4B eukaryotic translation initiation factor 4B 0.0162449
NTSR1 neurotensin receptor 1 (high affinity) 0.0160989
RPS15A ribosomal protein S15a 0.0160583
DOCK5 dedicator of cytokinesis 5 0.0158049
MCL1 myeloid cell leukemia 1 0.0157566
EPHA2 EPH receptor A2 0.0157424
RPS18 ribosomal protein S18 0.0156348
RAN RAN, member RAS oncogene family 0.0156225
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0156127
SGMS2 sphingomyelin synthase 2 0.0156125
EPCAM epithelial cell adhesion molecule 0.0155738
H1-2 H1.2 linker histone, cluster member 0.0155399
ZHX2 zinc fingers and homeoboxes 2 0.0153997
SOX9 SRY (sex determining region Y)-box 9 0.0153716
ITGA6 integrin, alpha 6 0.0153423
H1-4 H1.4 linker histone, cluster member 0.0153293
RPSA ribosomal protein SA 0.0152484
RPS11 ribosomal protein S11 0.0151595
OCIAD2 OCIA domain containing 2 0.015038
SAMD4A sterile alpha motif domain containing 4A 0.0148761
NUMA1 nuclear mitotic apparatus protein 1 0.0147524
B2M beta-2-microglobulin 0.0147346
HIP1 huntingtin interacting protein 1 0.0146818
IGSF9B immunoglobulin superfamily, member 9B 0.0146154
WWOX WW domain containing oxidoreductase 0.0144524
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0143994
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.014381
PLAUR plasminogen activator, urokinase receptor 0.0142653
RPS8 ribosomal protein S8 0.0142342
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0142128
NFE2L1 nuclear factor, erythroid 2-like 1 0.0141093
RRM2 ribonucleotide reductase M2 0.0140788
RPS19 ribosomal protein S19 0.0140743

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.195482
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.11247
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0853748
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0828763
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0756542
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0728888
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0628685
LMO7 LIM domain 7 -0.0612858
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0590652
STRN3 striatin, calmodulin binding protein 3 -0.0574391
PDLIM5 PDZ and LIM domain 5 -0.0545241
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0543474
CD36 CD36 molecule (thrombospondin receptor) -0.0526382
PUM2 pumilio RNA-binding family member 2 -0.0514507
GARS1 glycyl-tRNA synthetase 1 -0.0500347
RPL35A ribosomal protein L35a -0.0497422
WDR43 WD repeat domain 43 -0.0491234
GOLGA4 golgin A4 -0.0490398
OXR1 oxidation resistance 1 -0.0483192
COG5 component of oligomeric golgi complex 5 -0.047002
WAC WW domain containing adaptor with coiled-coil -0.0465456
RNF145 ring finger protein 145 -0.044346
ESYT2 extended synaptotagmin-like protein 2 -0.0437707
ANXA2 annexin A2 -0.0437033
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0428075
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0421731
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0419288
USP3 ubiquitin specific peptidase 3 -0.0417333
LAMB3 laminin, beta 3 -0.0414928
KMT2C lysine (K)-specific methyltransferase 2C -0.0401329
OGA O-GlcNAcase -0.0400661
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0392253
TXNRD1 thioredoxin reductase 1 -0.0389465
BIRC6 baculoviral IAP repeat containing 6 -0.0380151
MED13 mediator complex subunit 13 -0.0369711
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0362623
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0358565
SBF2 SET binding factor 2 -0.0350736
RPS4X ribosomal protein S4, X-linked -0.0345686
PARD3 par-3 family cell polarity regulator -0.0345602
SERINC5 serine incorporator 5 -0.0343733
RBM39 RNA binding motif protein 39 -0.0343386
UBE3C ubiquitin protein ligase E3C -0.0336849
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0333452
RLF rearranged L-myc fusion -0.0332604
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0328634
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0328585
EIF1 eukaryotic translation initiation factor 1 -0.0322175
MATR3 matrin 3 -0.032209
OSBPL3 oxysterol binding protein-like 3 -0.032072
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0314917
SLMAP sarcolemma associated protein -0.0311908
TSC22D2 TSC22 domain family, member 2 -0.03066
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.030577
NCOR1 nuclear receptor corepressor 1 -0.030201
SLC38A1 solute carrier family 38, member 1 -0.030137
NEMF nuclear export mediator factor -0.030074
ECT2 epithelial cell transforming 2 -0.0296456
MARCHF6 membrane associated ring-CH-type finger 6 -0.029643
PHIP pleckstrin homology domain interacting protein -0.0294427
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0292174
RPLP0 ribosomal protein, large, P0 -0.0292009
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0291148
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0288442
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0288162
BRWD1 bromodomain and WD repeat domain containing 1 -0.0288104
OXSR1 oxidative stress responsive 1 -0.0283696
TMSB10 thymosin beta 10 -0.0279235
EZR ezrin -0.0276703
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0274956
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.02746
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0274516
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.027162
ZFAND3 zinc finger, AN1-type domain 3 -0.027118
KDM6A lysine (K)-specific demethylase 6A -0.0269878
TRA2A transformer 2 alpha homolog (Drosophila) -0.0268369
RAB1A RAB1A, member RAS oncogene family -0.0266694
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0266459
FOXJ3 forkhead box J3 -0.0266106
EREG epiregulin -0.0263131
RPS24 ribosomal protein S24 -0.0262285
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.026186
NPR2 natriuretic peptide receptor 2 -0.0261767
MT2A metallothionein 2A -0.0261031
MTDH metadherin -0.0259833
ARF1 ADP-ribosylation factor 1 -0.025773
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0256533
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0255996
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0254078
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0252996
ZMYM2 zinc finger, MYM-type 2 -0.0252045
GNAS GNAS complex locus -0.0251915
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0251501
CHD7 chromodomain helicase DNA binding protein 7 -0.0251329
XPO1 exportin 1 -0.0249436
RSL1D1 ribosomal L1 domain containing 1 -0.0248752
NOP58 NOP58 ribonucleoprotein -0.0248408
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.024685
ZNF207 zinc finger protein 207 -0.0246506
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0244466