Minodronic acid_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.156001
NAV2 neuron navigator 2 0.135777
RPS12 ribosomal protein S12 0.120019
RPS3 ribosomal protein S3 0.114187
RPL37A ribosomal protein L37a 0.102576
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.09822
TMSB10 thymosin beta 10 0.0820885
RPL35 ribosomal protein L35 0.0747326
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0677033
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0584504
NONO non-POU domain containing, octamer-binding 0.0575986
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0555657
WWOX WW domain containing oxidoreductase 0.0474722
RPL3 ribosomal protein L3 0.0463942
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0459156
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0431229
RAD51B RAD51 paralog B 0.0428374
PDE4D phosphodiesterase 4D, cAMP-specific 0.0423552
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0414706
TNS3 tensin 3 0.0411163
RPS15A ribosomal protein S15a 0.0404247
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0403632
MSN moesin 0.0403579
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0395266
NUMA1 nuclear mitotic apparatus protein 1 0.0392861
RPS23 ribosomal protein S23 0.0387454
MT2A metallothionein 2A 0.0383607
DST dystonin 0.0361145
RPS29 ribosomal protein S29 0.0354716
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.034457
RPS17 ribosomal protein S17 0.0340642
RPL13A ribosomal protein L13a 0.0340152
HDAC4 histone deacetylase 4 0.0339743
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.033939
SMC1A structural maintenance of chromosomes 1A 0.0337826
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.0336002
CPNE1 copine I 0.0332408
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0317865
PLEC plectin 0.0314125
NAP1L1 nucleosome assembly protein 1-like 1 0.031308
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0304645
PCLO piccolo presynaptic cytomatrix protein 0.0304039
RPL26 ribosomal protein L26 0.0302052
EEF1G eukaryotic translation elongation factor 1 gamma 0.0300997
ARGLU1 arginine and glutamate rich 1 0.0299726
ADGRL2 adhesion G protein-coupled receptor L2 0.0297294
ZNF638 zinc finger protein 638 0.0296866
DIAPH3 diaphanous-related formin 3 0.0293629
CSNK1A1 casein kinase 1, alpha 1 0.0292906
APLP2 amyloid beta (A4) precursor-like protein 2 0.0290147
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0288668
RPS8 ribosomal protein S8 0.0288244
ASPH aspartate beta-hydroxylase 0.0286891
RPL11 ribosomal protein L11 0.0285644
RPL36 ribosomal protein L36 0.0279338
ATXN1 ataxin 1 0.026691
RPS27A ribosomal protein S27a 0.0266803
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0265442
RPLP2 ribosomal protein, large, P2 0.0264913
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0259691
LOC112694756 uncharaterized LOC112694756 0.0252097
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0251522
MYH10 myosin, heavy chain 10, non-muscle 0.0249232
PRELID2 PRELI domain containing 2 0.0248252
EEF2 eukaryotic translation elongation factor 2 0.0247527
PCBP2 poly(rC) binding protein 2 0.0246472
CEMIP cell migration inducing protein, hyaluronan binding 0.0239815
CENPF centromere protein F, 350/400kDa 0.023782
H1-4 H1.4 linker histone, cluster member 0.0237314
EIF4A1 eukaryotic translation initiation factor 4A1 0.0234131
CEMIP2 cell migration inducing hyaluronidase 2 0.0231968
SET SET nuclear proto-oncogene 0.0231088
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0227378
NDRG1 N-myc downstream regulated 1 0.0225432
EXOC4 exocyst complex component 4 0.0223
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0221908
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0221209
RPSA ribosomal protein SA 0.0219032
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0218767
FHIT fragile histidine triad 0.0216928
RPS13 ribosomal protein S13 0.0212678
RPL28 ribosomal protein L28 0.0210694
ZNF292 zinc finger protein 292 0.0210423
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0209933
WSB1 WD repeat and SOCS box containing 1 0.020904
NOP56 NOP56 ribonucleoprotein 0.0208815
H1-2 H1.2 linker histone, cluster member 0.0208146
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0207948
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.020754
INCENP inner centromere protein antigens 135/155kDa 0.0207171
RPS11 ribosomal protein S11 0.0207034
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0207025
RPS27 ribosomal protein S27 0.0207002
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0205984
HYOU1 hypoxia up-regulated 1 0.0205403
CEP128 centrosomal protein 128kDa 0.0205149
SMC4 structural maintenance of chromosomes 4 0.0204121
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0202811
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0202745
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0200378

decreased expression

Symbol Name Standardized Value
RPL35A ribosomal protein L35a -0.109103
VCL vinculin -0.103223
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0980681
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0927626
ANXA2 annexin A2 -0.089359
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0807756
BCL2L1 BCL2-like 1 -0.0803179
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0801312
CCND1 cyclin D1 -0.0797752
TPT1 tumor protein, translationally-controlled 1 -0.0779388
TPM4 tropomyosin 4 -0.0662933
HMGA1 high mobility group AT-hook 1 -0.0659817
EZR ezrin -0.0624627
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0613072
AHNAK AHNAK nucleoprotein -0.0591345
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0574339
TMEM123 transmembrane protein 123 -0.0573782
AKAP12 A kinase (PRKA) anchor protein 12 -0.0563896
CANX calnexin -0.0533258
KPNB1 karyopherin (importin) beta 1 -0.0530941
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.052073
CDK6 cyclin-dependent kinase 6 -0.0509672
KRT18 keratin 18, type I -0.0481932
HSPH1 heat shock 105kDa/110kDa protein 1 -0.047487
SLC38A2 solute carrier family 38, member 2 -0.047124
MRPS6 mitochondrial ribosomal protein S6 -0.0465612
ITGA6 integrin, alpha 6 -0.0417857
RPS24 ribosomal protein S24 -0.041288
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0405907
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0405139
PERP PERP, TP53 apoptosis effector -0.0403795
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0400508
S100A6 S100 calcium binding protein A6 -0.039658
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0385071
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0381773
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0380171
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.037437
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0373072
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.036323
RPL34 ribosomal protein L34 -0.0353476
EIF1 eukaryotic translation initiation factor 1 -0.034029
EGR1 early growth response 1 -0.0337818
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0333711
HMGB1 high mobility group box 1 -0.0328419
CBX3 chromobox homolog 3 -0.030993
GOLGA4 golgin A4 -0.0308125
RPLP0 ribosomal protein, large, P0 -0.0307817
MYOF myoferlin -0.030517
IPO7 importin 7 -0.029893
CD9 CD9 molecule -0.0296175
LIMS1 LIM and senescent cell antigen-like domains 1 -0.029544
RPS6 ribosomal protein S6 -0.0287733
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0284845
IGF2 insulin-like growth factor 2 -0.0282878
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0282058
TUBA1B tubulin, alpha 1b -0.02807
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0277682
PTMA prothymosin, alpha -0.0267975
ANO1 anoctamin 1, calcium activated chloride channel -0.0266153
RPL39 ribosomal protein L39 -0.0266029
MED13 mediator complex subunit 13 -0.0264228
PDGFA platelet-derived growth factor alpha polypeptide -0.0263477
IGFBP3 insulin-like growth factor binding protein 3 -0.0261279
RPL27A ribosomal protein L27a -0.0259923
GNAS GNAS complex locus -0.0257515
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0255979
GTF2IRD1 GTF2I repeat domain containing 1 -0.0253646
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0253534
SEC31A SEC31 homolog A (S. cerevisiae) -0.0251921
ANXA3 annexin A3 -0.0250057
STAU1 staufen double-stranded RNA binding protein 1 -0.0246835
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0246748
SH3KBP1 SH3-domain kinase binding protein 1 -0.0246496
BPTF bromodomain PHD finger transcription factor -0.0246054
S100A4 S100 calcium binding protein A4 -0.024576
ITPRID2 ITPR interacting domain containing 2 -0.0242345
SENP5 SUMO1/sentrin specific peptidase 5 -0.0241226
GARS1 glycyl-tRNA synthetase 1 -0.0230836
ZBTB38 zinc finger and BTB domain containing 38 -0.0230502
IARS1 isoleucyl-tRNA synthetase 1 -0.0228508
HM13 histocompatibility (minor) 13 -0.0227525
NCEH1 neutral cholesterol ester hydrolase 1 -0.0226918
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0226624
ZBTB20 zinc finger and BTB domain containing 20 -0.0225991
CLIP2 CAP-GLY domain containing linker protein 2 -0.0225226
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0223383
FOSL1 FOS-like antigen 1 -0.0222862
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0221471
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0221306
SOX4 SRY (sex determining region Y)-box 4 -0.0221082
ZFR zinc finger RNA binding protein -0.0220902
CEP350 centrosomal protein 350kDa -0.0219467
SERINC5 serine incorporator 5 -0.0219338
LAMB3 laminin, beta 3 -0.0218201
KRT19 keratin 19, type I -0.0215124
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0215013
LAMA4 laminin, alpha 4 -0.0213954
RBP1 retinol binding protein 1, cellular -0.0212099
UBE2K ubiquitin-conjugating enzyme E2K -0.0209778
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0209195