| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/9865528 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Mirabegron relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | 0.74 |
| HELB | helicase (DNA) B | 0.65 |
| NCKAP1L | NCK-associated protein 1-like | 0.6 |
| MID2 | midline 2 | 0.58 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.57 |
| ZNF268 | zinc finger protein 268 | 0.49 |
| ACVR2A | activin A receptor, type IIA | 0.48 |
| PIP4P2 | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | 0.44 |
| S100PBP | S100P binding protein | 0.43 |
| RCAN1 | regulator of calcineurin 1 | 0.43 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | 0.41 |
| C17ORF80 | chromosome 17 open reading frame 80 | 0.39 |
| LRP4 | low density lipoprotein receptor-related protein 4 | 0.39 |
| TPM4 | tropomyosin 4 | 0.38 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.38 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.38 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.38 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | 0.37 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | 0.37 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.37 |
| PLA2G12A | phospholipase A2, group XIIA | 0.36 |
| ZNF714 | zinc finger protein 714 | 0.36 |
| KLHL24 | kelch-like family member 24 | 0.34 |
| JMJD8 | jumonji domain containing 8 | 0.34 |
| PEX26 | peroxisomal biogenesis factor 26 | 0.34 |
| SETD5 | SET domain containing 5 | 0.33 |
| FAM133A | family with sequence similarity 133, member A | 0.33 |
| SOX7 | SRY (sex determining region Y)-box 7 | 0.33 |
| ARHGEF37 | Rho guanine nucleotide exchange factor (GEF) 37 | 0.32 |
| ZNF593 | zinc finger protein 593 | 0.32 |
| MVB12B | multivesicular body subunit 12B | 0.32 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.31 |
| RPP21 | ribonuclease P/MRP 21kDa subunit | 0.31 |
| HLA-F | major histocompatibility complex, class I, F | 0.31 |
| CMC1 | C-x(9)-C motif containing 1 | 0.31 |
| TXNL4B | thioredoxin-like 4B | 0.3 |
| ABHD4 | abhydrolase domain containing 4 | 0.3 |
| SLC10A4 | solute carrier family 10, member 4 | 0.29 |
| RBMXL3 | RNA binding motif protein, X-linked-like 3 | 0.29 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.29 |
| PVR | poliovirus receptor | 0.29 |
| FAIM | Fas apoptotic inhibitory molecule | 0.29 |
| MOCS2 | molybdenum cofactor synthesis 2 | 0.29 |
| LEPROTL1 | leptin receptor overlapping transcript-like 1 | 0.29 |
| CENPI | centromere protein I | 0.28 |
| ATXN7L3B | ataxin 7-like 3B | 0.28 |
| IKZF5 | IKAROS family zinc finger 5 (Pegasus) | 0.27 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | 0.27 |
| ARHGEF19 | Rho guanine nucleotide exchange factor (GEF) 19 | 0.27 |
| NARF | nuclear prelamin A recognition factor | 0.27 |
| ZNF567 | zinc finger protein 567 | 0.27 |
| VSIR | V-set immunoregulatory receptor | 0.27 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.26 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | 0.26 |
| TMEM64 | transmembrane protein 64 | 0.26 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.26 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.26 |
| SPATA2 | spermatogenesis associated 2 | 0.26 |
| DIXDC1 | DIX domain containing 1 | 0.26 |
| SIMC1 | SUMO-interacting motifs containing 1 | 0.26 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.26 |
| ZNF263 | zinc finger protein 263 | 0.26 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.26 |
| GGT1 | gamma-glutamyltransferase 1 | 0.25 |
| RUNX2 | runt-related transcription factor 2 | 0.25 |
| PPP2R2B | protein phosphatase 2, regulatory subunit B, beta | 0.25 |
| DDX4 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 | 0.25 |
| FIZ1 | FLT3-interacting zinc finger 1 | 0.24 |
| PEX7 | peroxisomal biogenesis factor 7 | 0.24 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | 0.24 |
| PRXL2A | peroxiredoxin like 2A | 0.24 |
| RPS28 | ribosomal protein S28 | 0.24 |
| KPTN | kaptin (actin binding protein) | 0.24 |
| PXDN | peroxidasin | 0.24 |
| RARG | retinoic acid receptor, gamma | 0.24 |
| KLHL21 | kelch-like family member 21 | 0.24 |
| MAST1 | microtubule associated serine/threonine kinase 1 | 0.24 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.24 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.24 |
| LANCL3 | LanC lantibiotic synthetase component C-like 3 (bacterial) | 0.24 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | 0.23 |
| IPPK | inositol 1,3,4,5,6-pentakisphosphate 2-kinase | 0.23 |
| SULF2 | sulfatase 2 | 0.23 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.23 |
| TSPYL2 | TSPY-like 2 | 0.23 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | 0.23 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | 0.23 |
| HES1 | hes family bHLH transcription factor 1 | 0.23 |
| EREG | epiregulin | 0.23 |
| ERMARD | ER membrane-associated RNA degradation | 0.23 |
| ZNF57 | zinc finger protein 57 | 0.23 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | 0.23 |
| TWF1 | twinfilin actin binding protein 1 | 0.23 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.22 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 0.22 |
| RBMX2 | RNA binding motif protein, X-linked 2 | 0.22 |
| PRRX2 | paired related homeobox 2 | 0.22 |
| NOS3 | nitric oxide synthase 3 (endothelial cell) | 0.22 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VAV1 | vav 1 guanine nucleotide exchange factor | -1.1 |
| FGA | fibrinogen alpha chain | -0.89 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.8 |
| FN1 | fibronectin 1 | -0.79 |
| SLC35F3 | solute carrier family 35, member F3 | -0.76 |
| C4BPA | complement component 4 binding protein, alpha | -0.7 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.67 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | -0.62 |
| ZNF623 | zinc finger protein 623 | -0.59 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.57 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.56 |
| GAS2L1 | growth arrest-specific 2 like 1 | -0.55 |
| KRT8 | keratin 8, type II | -0.55 |
| EVL | Enah/Vasp-like | -0.55 |
| DOCK4 | dedicator of cytokinesis 4 | -0.52 |
| MED7 | mediator complex subunit 7 | -0.51 |
| RNF13 | ring finger protein 13 | -0.46 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.46 |
| CBR1 | carbonyl reductase 1 | -0.45 |
| PEX19 | peroxisomal biogenesis factor 19 | -0.44 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.44 |
| TPM1 | tropomyosin 1 (alpha) | -0.42 |
| TMSB10 | thymosin beta 10 | -0.42 |
| SF3B5 | splicing factor 3b, subunit 5, 10kDa | -0.41 |
| TMEM94 | transmembrane protein 94 | -0.4 |
| ZDHHC23 | zinc finger, DHHC-type containing 23 | -0.4 |
| C12ORF57 | chromosome 12 open reading frame 57 | -0.4 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.39 |
| SLC35F6 | solute carrier family 35, member F6 | -0.38 |
| ENO1 | enolase 1, (alpha) | -0.38 |
| PAH | phenylalanine hydroxylase | -0.37 |
| TLE5 | TLE family member 5, transcriptional modulator | -0.37 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.37 |
| SLC25A44 | solute carrier family 25, member 44 | -0.36 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.36 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.36 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -0.36 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.36 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.36 |
| NUCB2 | nucleobindin 2 | -0.35 |
| DERPC | DERPC proline and glycine rich nuclear protein | -0.35 |
| S100A14 | S100 calcium binding protein A14 | -0.35 |
| ARG2 | arginase 2 | -0.35 |
| ONECUT3 | one cut homeobox 3 | -0.35 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.35 |
| MED8 | mediator complex subunit 8 | -0.34 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | -0.34 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | -0.34 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.33 |
| LRP11 | low density lipoprotein receptor-related protein 11 | -0.33 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 | -0.32 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.32 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.32 |
| RNF17 | ring finger protein 17 | -0.32 |
| TMEM102 | transmembrane protein 102 | -0.32 |
| CFAP58 | cilia and flagella associated protein 58 | -0.32 |
| TMEM200A | transmembrane protein 200A | -0.32 |
| C7 | complement component 7 | -0.31 |
| ZMAT5 | zinc finger, matrin-type 5 | -0.31 |
| TAF1L | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | -0.31 |
| CAVIN2 | caveolae associated protein 2 | -0.31 |
| NKAPD1 | NKAP domain containing 1 | -0.31 |
| ZBED8 | zinc finger, BED-type containing 8 | -0.31 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.3 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.3 |
| B3GALNT2 | beta-1,3-N-acetylgalactosaminyltransferase 2 | -0.3 |
| GSKIP | GSK3B interacting protein | -0.3 |
| TMEM192 | transmembrane protein 192 | -0.29 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.29 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | -0.29 |
| STMN1 | stathmin 1 | -0.29 |
| TMC4 | transmembrane channel-like 4 | -0.29 |
| TTN | titin | -0.29 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.29 |
| SUCO | SUN domain containing ossification factor | -0.29 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.28 |
| MFAP3 | microfibrillar-associated protein 3 | -0.28 |
| SERF2 | small EDRK-rich factor 2 | -0.28 |
| LAMTOR4 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 | -0.28 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.28 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.27 |
| CALB2 | calbindin 2 | -0.27 |
| NUCB1 | nucleobindin 1 | -0.27 |
| ZNF566 | zinc finger protein 566 | -0.27 |
| FCHO1 | FCH domain only 1 | -0.27 |
| AURKAIP1 | aurora kinase A interacting protein 1 | -0.27 |
| PFDN4 | prefoldin subunit 4 | -0.27 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | -0.27 |
| ZBTB47 | zinc finger and BTB domain containing 47 | -0.27 |
| COX5B | cytochrome c oxidase subunit Vb | -0.26 |
| C12ORF4 | chromosome 12 open reading frame 4 | -0.26 |
| PRMT6 | protein arginine methyltransferase 6 | -0.26 |
| MIEN1 | migration and invasion enhancer 1 | -0.26 |
| LAMA3 | laminin, alpha 3 | -0.26 |
| MEGF8 | multiple EGF-like-domains 8 | -0.26 |
| PDE4DIP | phosphodiesterase 4D interacting protein | -0.26 |
| GEMIN8 | gem (nuclear organelle) associated protein 8 | -0.26 |
| NDUFS6 | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) | -0.26 |
| RNASE4 | ribonuclease, RNase A family, 4 | -0.26 |
