Mitochondrial iron-sulfur cluster assembly complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
External Link http://amigo.geneontology.org/amigo/term/GO:0099128
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251 proteins co-occuring with the Mitochondrial iron-sulfur cluster assembly complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ISCA2 iron-sulfur cluster assembly 2 2.62
ISCA1 iron-sulfur cluster assembly 1 2.575
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 2.47
ISCU iron-sulfur cluster assembly enzyme 2.447
LYRM4 LYR motif containing 4 2.407
GLRX5 glutaredoxin 5 2.373
NFS1 NFS1 cysteine desulfurase 2.361
FXN frataxin 2.266
LIAS lipoic acid synthetase 2.215
BOLA3 bolA family member 3 2.212
NFU1 NFU1 iron-sulfur cluster scaffold 2.193
FDX2 ferredoxin 2 2.187
GLRX3 glutaredoxin 3 2.105
HSCB HscB mitochondrial iron-sulfur cluster co-chaperone 2.09
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 2.044
ACO1 aconitase 1, soluble 1.863
FOXRED1 FAD-dependent oxidoreductase domain containing 1 1.86
FDXR ferredoxin reductase 1.827
CIAPIN1 cytokine induced apoptosis inhibitor 1 1.823
ACO2 aconitase 2, mitochondrial 1.746
NUBPL nucleotide binding protein-like 1.735
METTL17 methyltransferase like 17 1.688
CMTR2 cap methyltransferase 2 1.59
SSR1 signal sequence receptor, alpha 1.589
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 1.588
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 1.575
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 1.536
GLRX glutaredoxin (thioltransferase) 1.52
FDX1 ferredoxin 1 1.516
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 1.407
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.381
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 1.372
NDOR1 NADPH dependent diflavin oxidoreductase 1 1.364
PPP5C protein phosphatase 5, catalytic subunit 1.362
BOLA1 bolA family member 1 1.304
SFXN4 sideroflexin 4 1.279
IREB2 iron-responsive element binding protein 2 1.275
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 1.265
KDSR 3-ketodihydrosphingosine reductase 1.263
CISD1 CDGSH iron sulfur domain 1 1.26
PET100 PET100 homolog (S. cerevisiae) 1.246
COASY CoA synthase 1.237
GFER growth factor, augmenter of liver regeneration 1.235
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 1.228
GSTA3 glutathione S-transferase alpha 3 1.225
SLC49A4 solute carrier family 49 member 4 1.2
FECH ferrochelatase 1.191
ALAS1 5'-aminolevulinate synthase 1 1.186
SLC25A53 solute carrier family 25, member 53 1.172
GSX2 GS homeobox 2 1.172
PGAM5 phosphoglycerate mutase family member 5 1.171
SLC25A35 solute carrier family 25, member 35 1.168
MRPL36 mitochondrial ribosomal protein L36 1.156
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 1.131
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 1.127
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5 1.117
EPAS1 endothelial PAS domain protein 1 1.1
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 1.094
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4 1.085
SLC25A38 solute carrier family 25, member 38 1.085
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 1.081
DNAJC19 DnaJ (Hsp40) homolog, subfamily C, member 19 1.074
COX5B cytochrome c oxidase subunit Vb 1.071
SDHAF1 succinate dehydrogenase complex assembly factor 1 1.07
LDHD lactate dehydrogenase D 1.064
GLRX2 glutaredoxin 2 1.056
CISD2 CDGSH iron sulfur domain 2 1.053
CLIC4 chloride intracellular channel 4 1.032
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 1.027
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 1.008
OMA1 OMA1 zinc metallopeptidase 1.006
MRPS18C mitochondrial ribosomal protein S18C 0.992
DLAT dihydrolipoamide S-acetyltransferase 0.987
CBR4 carbonyl reductase 4 0.985
TFRC transferrin receptor 0.983
MRPL35 mitochondrial ribosomal protein L35 0.981
CIAO2A cytosolic iron-sulfur assembly component 2A 0.97
MTX3 metaxin 3 0.962
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 0.962
ALAS2 5'-aminolevulinate synthase 2 0.962
MRPL17 mitochondrial ribosomal protein L17 0.947
PET117 PET117 homolog (S. cerevisiae) 0.944
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 0.921
TOMM40L translocase of outer mitochondrial membrane 40 homolog (yeast)-like 0.919
NUBP2 nucleotide binding protein 2 0.919
SFXN5 sideroflexin 5 0.902
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 0.901
LIPJ lipase, family member J 0.899
MRPL16 mitochondrial ribosomal protein L16 0.897
DPH2 DPH2 homolog (S. cerevisiae) 0.894
MRPS36 mitochondrial ribosomal protein S36 0.893
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 0.889
FTH1 ferritin, heavy polypeptide 1 0.886
YME1L1 YME1-like 1 ATPase 0.876
TIMM29 translocase of inner mitochondrial membrane 29 0.876
MTFR1 mitochondrial fission regulator 1 0.876
SAMM50 SAMM50 sorting and assembly machinery component 0.876
ECHDC3 enoyl CoA hydratase domain containing 3 0.875
FUNDC1 FUN14 domain containing 1 0.862
FUNDC2 FUN14 domain containing 2 0.861
SDHAF4 succinate dehydrogenase complex assembly factor 4 0.853
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.851
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 0.85
MRPS6 mitochondrial ribosomal protein S6 0.85
MOCS1 molybdenum cofactor synthesis 1 0.841
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.834
DPH3 diphthamide biosynthesis 3 0.834
HSPE1 heat shock 10kDa protein 1 0.827
BOLA2B bolA family member 2B 0.825
LIX1 Lix1 homolog (chicken) 0.818
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.812
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa 0.806
GPX4 glutathione peroxidase 4 0.804
SLC38A1 solute carrier family 38, member 1 0.798
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.796
PARL presenilin associated, rhomboid-like 0.796
MRPL1 mitochondrial ribosomal protein L1 0.796
IL1RL1 interleukin 1 receptor-like 1 0.795
ERCC2 excision repair cross-complementation group 2 0.795
PGP phosphoglycolate phosphatase 0.794
SCUBE1 signal peptide, CUB domain, EGF-like 1 0.793
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.789
FTMT ferritin mitochondrial 0.787
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.779
PTDSS2 phosphatidylserine synthase 2 0.776
HIPK1 homeodomain interacting protein kinase 1 0.766
SLC25A51 solute carrier family 25, member 51 0.766
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) 0.76
GLS2 glutaminase 2 (liver, mitochondrial) 0.759
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.758
SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 0.758
CIAO2B cytosolic iron-sulfur assembly component 2B 0.756
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.752
HSPA1A heat shock 70kDa protein 1A 0.752
NUDT5 nudix (nucleoside diphosphate linked moiety X)-type motif 5 0.746
HSPA1B heat shock 70kDa protein 1B 0.741
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 0.74
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 0.737
PDPR pyruvate dehydrogenase phosphatase regulatory subunit 0.735
MCEE methylmalonyl CoA epimerase 0.735
ALOX12 arachidonate 12-lipoxygenase 0.734
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 0.733
PRDX3 peroxiredoxin 3 0.733
LYRM7 LYR motif containing 7 0.732
HAND1 heart and neural crest derivatives expressed 1 0.731
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.731
DHODH dihydroorotate dehydrogenase (quinone) 0.725
PHB2 prohibitin 2 0.723
ATP5PF ATP synthase peripheral stalk subunit F6 0.723
FMO4 flavin containing monooxygenase 4 0.717
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.714
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 0.714
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.712
SLC48A1 solute carrier family 48 (heme transporter), member 1 0.708
GCH1 GTP cyclohydrolase 1 0.708
ECHDC1 ethylmalonyl-CoA decarboxylase 1 0.705
ADSS1 adenylosuccinate synthase 1 0.699
ASCL4 achaete-scute family bHLH transcription factor 4 0.697
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.697
PRDX2 peroxiredoxin 2 0.692
CIAO1 cytosolic iron-sulfur assembly component 1 0.692
PNKD paroxysmal nonkinesigenic dyskinesia 0.691
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.686
PDHB pyruvate dehydrogenase (lipoamide) beta 0.682
RNF126 ring finger protein 126 0.682
LDLR low density lipoprotein receptor 0.68
COA3 cytochrome c oxidase assembly factor 3 0.675
EIF3L eukaryotic translation initiation factor 3, subunit L 0.667
SLC30A9 solute carrier family 30 (zinc transporter), member 9 0.664
CPT2 carnitine palmitoyltransferase 2 0.664
COX14 COX14 cytochrome c oxidase assembly factor 0.664
PRDX1 peroxiredoxin 1 0.664
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 0.662
BDH2 3-hydroxybutyrate dehydrogenase, type 2 0.655
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.651
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.648
TOMM34 translocase of outer mitochondrial membrane 34 0.647
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.641
ATP5MK ATP synthase membrane subunit k 0.64
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 0.64
EIF3K eukaryotic translation initiation factor 3, subunit K 0.637
C6ORF89 chromosome 6 open reading frame 89 0.637
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.636
SFXN1 sideroflexin 1 0.635
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.634
UQCRC1 ubiquinol-cytochrome c reductase core protein I 0.634
PUM3 pumilio RNA binding family member 3 0.634
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.63
ALOX12B arachidonate 12-lipoxygenase, 12R type 0.627
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 0.624
ACSF2 acyl-CoA synthetase family member 2 0.617
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 0.612
ACSL4 acyl-CoA synthetase long-chain family member 4 0.611
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.608
MRPL12 mitochondrial ribosomal protein L12 0.607
AMT aminomethyltransferase 0.607
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 0.606
AASDH aminoadipate-semialdehyde dehydrogenase 0.6
OLFML3 olfactomedin-like 3 0.597
COQ3 coenzyme Q3 methyltransferase 0.591
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae) 0.589
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 0.587
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) 0.585
STEAP3 STEAP family member 3, metalloreductase 0.584
SLIRP SRA stem-loop interacting RNA binding protein 0.583
ARL2BP ADP-ribosylation factor-like 2 binding protein 0.583
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 0.581
OGDHL oxoglutarate dehydrogenase-like 0.58
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 0.58
DERL3 derlin 3 0.579
LPCAT3 lysophosphatidylcholine acyltransferase 3 0.576
DERL2 derlin 2 0.575
TIMM21 translocase of inner mitochondrial membrane 21 homolog (yeast) 0.575
ALX4 ALX homeobox 4 0.574
GSX1 GS homeobox 1 0.57
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast) 0.566
DCPS decapping enzyme, scavenger 0.564
COQ4 coenzyme Q4 0.559
TMC6 transmembrane channel-like 6 0.559
ALOXE3 arachidonate lipoxygenase 3 0.554
EIF3I eukaryotic translation initiation factor 3, subunit I 0.552
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.551
TXN2 thioredoxin 2 0.551
EIF4A3 eukaryotic translation initiation factor 4A3 0.546
MTX2 metaxin 2 0.546
MIA3 melanoma inhibitory activity family, member 3 0.544
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.544
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa 0.54
COPE coatomer protein complex, subunit epsilon 0.54
MRPL13 mitochondrial ribosomal protein L13 0.538
PGK2 phosphoglycerate kinase 2 0.536
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 0.532
PPOX protoporphyrinogen oxidase 0.531
GSR glutathione reductase 0.529
NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 0.528
PYGM phosphorylase, glycogen, muscle 0.526
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 0.523
AUP1 ancient ubiquitous protein 1 0.522
CIAO3 cytosolic iron-sulfur assembly component 3 0.52
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 0.52
DTYMK deoxythymidylate kinase (thymidylate kinase) 0.517
PDPK1 3-phosphoinositide dependent protein kinase 1 0.516
MPC2 mitochondrial pyruvate carrier 2 0.51
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.509
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 0.509
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 0.508
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.506
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) 0.503
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.502
ROMO1 reactive oxygen species modulator 1 0.502
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 0.502