Mitotic Prometaphase Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles. (Gene Ontology, GO_0000236)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-68877
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Genes

203 proteins participating in the Mitotic Prometaphase pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
AHCTF1 AT hook containing transcription factor 1
AKAP9 A kinase (PRKA) anchor protein 9
ALMS1 Alstrom syndrome protein 1
AURKB aurora kinase B
B9D2 B9 protein domain 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CCNB1 cyclin B1
CCNB2 cyclin B2
CCP110 centriolar coiled coil protein 110kDa
CDC20 cell division cycle 20
CDCA5 cell division cycle associated 5
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPA centromere protein A
CENPC centromere protein C
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPH centromere protein H
CENPI centromere protein I
CENPJ centromere protein J
CENPK centromere protein K
CENPL centromere protein L
CENPM centromere protein M
CENPN centromere protein N
CENPO centromere protein O
CENPP centromere protein P
CENPQ centromere protein Q
CENPS-CORT CENPS-CORT readthrough
CENPT centromere protein T
CENPU centromere protein U
CEP131 centrosomal protein 131kDa
CEP135 centrosomal protein 135kDa
CEP152 centrosomal protein 152kDa
CEP164 centrosomal protein 164kDa
CEP192 centrosomal protein 192kDa
CEP250 centrosomal protein 250kDa
CEP290 centrosomal protein 290kDa
CEP41 centrosomal protein 41kDa
CEP43 centrosomal protein 43
CEP57 centrosomal protein 57kDa
CEP63 centrosomal protein 63kDa
CEP70 centrosomal protein 70kDa
CEP72 centrosomal protein 72kDa
CEP76 centrosomal protein 76kDa
CEP78 centrosomal protein 78kDa
CETN2 centrin, EF-hand protein, 2
CKAP5 cytoskeleton associated protein 5
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CLIP1 CAP-GLY domain containing linker protein 1
CNTRL centriolin
CSNK1D casein kinase 1, delta
CSNK1E casein kinase 1, epsilon
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
DCTN1 dynactin 1
DCTN2 dynactin 2 (p50)
DCTN3 dynactin 3 (p22)
DSN1 DSN1, MIS12 kinetochore complex component
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
EML4 echinoderm microtubule associated protein like 4
ERCC6L excision repair cross-complementation group 6-like
FIRRM FIGNL1 interacting regulator of recombination and mitosis
HAUS1 HAUS augmin-like complex, subunit 1
HAUS2 HAUS augmin-like complex, subunit 2
HAUS3 HAUS augmin-like complex, subunit 3
HAUS4 HAUS augmin-like complex, subunit 4
HAUS5 HAUS augmin-like complex, subunit 5
HAUS6 HAUS augmin-like complex, subunit 6
HAUS7 HAUS augmin-like complex, subunit 7
HAUS8 HAUS augmin-like complex, subunit 8
HDAC8 histone deacetylase 8
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
INCENP inner centromere protein antigens 135/155kDa
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIF18A kinesin family member 18A
KIF2A kinesin heavy chain member 2A
KIF2B kinesin family member 2B
KIF2C kinesin family member 2C
KNL1 kinetochore scaffold 1
KNTC1 kinetochore associated 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MIS12 MIS12 kinetochore complex component
MZT1 mitotic spindle organizing protein 1
MZT2A mitotic spindle organizing protein 2A
MZT2B mitotic spindle organizing protein 2B
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NDEL1 nudE neurodevelopment protein 1-like 1
NEDD1 neural precursor cell expressed, developmentally down-regulated 1
NEK2 NIMA-related kinase 2
NEK6 NIMA-related kinase 6
NEK7 NIMA-related kinase 7
NEK9 NIMA-related kinase 9
NINL ninein-like
NME7 NME/NM23 family member 7
NSL1 NSL1, MIS12 kinetochore complex component
NUDC nudC nuclear distribution protein
NUF2 NUF2, NDC80 kinetochore complex component
NUMA1 nuclear mitotic apparatus protein 1
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP160 nucleoporin 160kDa
NUP37 nucleoporin 37kDa
NUP43 nucleoporin 43kDa
NUP85 nucleoporin 85kDa
NUP98 nucleoporin 98kDa
ODF2 outer dense fiber of sperm tails 2
OFD1 oral-facial-digital syndrome 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PCM1 pericentriolar material 1
PCNT pericentrin
PDS5A PDS5 cohesin associated factor A
PDS5B PDS5 cohesin associated factor B
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PMF1 polyamine-modulated factor 1
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAD21 RAD21 homolog (S. pombe)
RANBP2 RAN binding protein 2
RANGAP1 Ran GTPase activating protein 1
RCC2 regulator of chromosome condensation 2
RPS27 ribosomal protein S27
SDCCAG8 serologically defined colon cancer antigen 8
SEC13 SEC13 homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SGO1 shugoshin 1
SGO2 shugoshin 2
SKA1 spindle and kinetochore associated complex subunit 1
SKA2 spindle and kinetochore associated complex subunit 2
SMC1A structural maintenance of chromosomes 1A
SMC2 structural maintenance of chromosomes 2
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SPC24 SPC24, NDC80 kinetochore complex component
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SSNA1 Sjogren syndrome nuclear autoantigen 1
STAG1 stromal antigen 1
STAG2 stromal antigen 2
TAOK1 TAO kinase 1
TUBA1A tubulin, alpha 1a
TUBA1B tubulin, alpha 1b
TUBA1C tubulin, alpha 1c
TUBA3C tubulin, alpha 3c
TUBA3E tubulin, alpha 3e
TUBA4A tubulin, alpha 4a
TUBA4B tubulin, alpha 4b
TUBA8 tubulin, alpha 8
TUBAL3 tubulin, alpha-like 3
TUBB tubulin, beta class I
TUBB1 tubulin, beta 1 class VI
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBB8 tubulin, beta 8 class VIII
TUBB8B tubulin beta 8B
TUBG1 tubulin, gamma 1
TUBG2 tubulin, gamma 2
TUBGCP2 tubulin, gamma complex associated protein 2
TUBGCP3 tubulin, gamma complex associated protein 3
TUBGCP4 tubulin, gamma complex associated protein 4
TUBGCP5 tubulin, gamma complex associated protein 5
TUBGCP6 tubulin, gamma complex associated protein 6
WAPL WAPL cohesin release factor
XPO1 exportin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ZW10 zw10 kinetochore protein
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein