Mitotic Spindle Checkpoint Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description A mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form. (Gene Ontology, GO_0071174)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-69618
Similar Terms
Downloads & Tools

Genes

111 proteins participating in the Mitotic Spindle Checkpoint pathway from the Reactome Pathways 2024 dataset.

Symbol Name
AHCTF1 AT hook containing transcription factor 1
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC11 anaphase promoting complex subunit 11
ANAPC15 anaphase promoting complex subunit 15
ANAPC16 anaphase promoting complex subunit 16
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
AURKB aurora kinase B
B9D2 B9 protein domain 2
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
BUB3 BUB3 mitotic checkpoint protein
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CDCA8 cell division cycle associated 8
CENPA centromere protein A
CENPC centromere protein C
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPH centromere protein H
CENPI centromere protein I
CENPK centromere protein K
CENPL centromere protein L
CENPM centromere protein M
CENPN centromere protein N
CENPO centromere protein O
CENPP centromere protein P
CENPQ centromere protein Q
CENPS-CORT CENPS-CORT readthrough
CENPT centromere protein T
CENPU centromere protein U
CKAP5 cytoskeleton associated protein 5
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CLIP1 CAP-GLY domain containing linker protein 1
DSN1 DSN1, MIS12 kinetochore complex component
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
ERCC6L excision repair cross-complementation group 6-like
INCENP inner centromere protein antigens 135/155kDa
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KIF18A kinesin family member 18A
KIF2A kinesin heavy chain member 2A
KIF2B kinesin family member 2B
KIF2C kinesin family member 2C
KNL1 kinetochore scaffold 1
KNTC1 kinetochore associated 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MIS12 MIS12 kinetochore complex component
NDC80 NDC80 kinetochore complex component
NDE1 nudE neurodevelopment protein 1
NDEL1 nudE neurodevelopment protein 1-like 1
NSL1 NSL1, MIS12 kinetochore complex component
NUDC nudC nuclear distribution protein
NUF2 NUF2, NDC80 kinetochore complex component
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP160 nucleoporin 160kDa
NUP37 nucleoporin 37kDa
NUP43 nucleoporin 43kDa
NUP85 nucleoporin 85kDa
NUP98 nucleoporin 98kDa
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PLK1 polo-like kinase 1
PMF1 polyamine-modulated factor 1
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RANBP2 RAN binding protein 2
RANGAP1 Ran GTPase activating protein 1
RCC2 regulator of chromosome condensation 2
RPS27 ribosomal protein S27
SEC13 SEC13 homolog (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SGO1 shugoshin 1
SGO2 shugoshin 2
SKA1 spindle and kinetochore associated complex subunit 1
SKA2 spindle and kinetochore associated complex subunit 2
SPC24 SPC24, NDC80 kinetochore complex component
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
TAOK1 TAO kinase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2S ubiquitin-conjugating enzyme E2S
XPO1 exportin 1
ZW10 zw10 kinetochore protein
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein