Mitoxantrone (dihydrochloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.203029
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.170993
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.143041
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.135569
MAP1B microtubule-associated protein 1B 0.131285
AKAP12 A kinase (PRKA) anchor protein 12 0.127977
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.106189
TPM4 tropomyosin 4 0.102904
CD44 CD44 molecule (Indian blood group) 0.0995708
CENPF centromere protein F, 350/400kDa 0.0903508
TPM3 tropomyosin 3 0.0899772
TRIO trio Rho guanine nucleotide exchange factor 0.0837093
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.077135
DST dystonin 0.0751072
MYH9 myosin, heavy chain 9, non-muscle 0.0641187
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0617332
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0617322
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0617143
CALR calreticulin 0.0616493
HDAC9 histone deacetylase 9 0.0599294
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0550339
GLIS3 GLIS family zinc finger 3 0.054521
RHOBTB3 Rho-related BTB domain containing 3 0.0542215
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.048767
CANX calnexin 0.0487435
PKM pyruvate kinase, muscle 0.0487332
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0475128
MSN moesin 0.0471981
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0463885
TMSB4X thymosin beta 4, X-linked 0.0448921
CDK6 cyclin-dependent kinase 6 0.0443728
PDIA3 protein disulfide isomerase family A, member 3 0.044247
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0438415
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0438342
DOCK5 dedicator of cytokinesis 5 0.0430478
ENO1 enolase 1, (alpha) 0.0429346
WWTR1 WW domain containing transcription regulator 1 0.0422921
ANXA2 annexin A2 0.0419315
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0416995
ASPH aspartate beta-hydroxylase 0.0416757
POTEF POTE ankyrin domain family, member F 0.0416452
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0413696
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0408177
COL3A1 collagen, type III, alpha 1 0.040714
SRRM2 serine/arginine repetitive matrix 2 0.0406342
LAMB1 laminin, beta 1 0.0405922
ERBIN erbb2 interacting protein 0.0403338
PTMA prothymosin, alpha 0.0399574
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0398977
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0391291
RTN4 reticulon 4 0.0389678
DSPP dentin sialophosphoprotein 0.0388419
S100A10 S100 calcium binding protein A10 0.0384246
MBNL1 muscleblind-like splicing regulator 1 0.0377506
COPA coatomer protein complex, subunit alpha 0.0377226
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0367371
TRIP12 thyroid hormone receptor interactor 12 0.0365085
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.036391
EZR ezrin 0.0358062
PBX3 pre-B-cell leukemia homeobox 3 0.0356583
ADAM9 ADAM metallopeptidase domain 9 0.0353656
SET SET nuclear proto-oncogene 0.0352411
GLS2 glutaminase 2 (liver, mitochondrial) 0.0350657
ELL2 elongation factor, RNA polymerase II, 2 0.0348101
SLIT2 slit homolog 2 (Drosophila) 0.0346591
JMJD1C jumonji domain containing 1C 0.0344807
PDLIM5 PDZ and LIM domain 5 0.034099
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0334712
YBX1 Y box binding protein 1 0.0332335
ITPRID2 ITPR interacting domain containing 2 0.0331331
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0329679
CLTC clathrin, heavy chain (Hc) 0.0328728
SPDL1 spindle apparatus coiled-coil protein 1 0.0324329
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.032233
TXNRD1 thioredoxin reductase 1 0.0321979
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0321541
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0317479
PCDH10 protocadherin 10 0.0317045
DCLK2 doublecortin-like kinase 2 0.0315694
TLN1 talin 1 0.0314271
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0313647
RAI14 retinoic acid induced 14 0.0313411
EEF2 eukaryotic translation elongation factor 2 0.0312105
VEGFC vascular endothelial growth factor C 0.0311845
ANXA5 annexin A5 0.0309991
ANO6 anoctamin 6 0.0307138
MYADM myeloid-associated differentiation marker 0.0302572
VMP1 vacuole membrane protein 1 0.0302498
LMO7 LIM domain 7 0.0302138
ERRFI1 ERBB receptor feedback inhibitor 1 0.0297896
BBS9 Bardet-Biedl syndrome 9 0.0297509
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0295546
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0293013
GOLGA4 golgin A4 0.0287792
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.028603
FAT1 FAT atypical cadherin 1 0.028575
SON SON DNA binding protein 0.0285063
CKAP5 cytoskeleton associated protein 5 0.0283158
PDIA6 protein disulfide isomerase family A, member 6 0.0282055
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0281749

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.192657
TMSB10 thymosin beta 10 -0.166357
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.120189
NDRG1 N-myc downstream regulated 1 -0.10858
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.106164
LOX lysyl oxidase -0.103633
ABI3BP ABI family, member 3 (NESH) binding protein -0.0965639
THBS2 thrombospondin 2 -0.0939072
AHNAK AHNAK nucleoprotein -0.0883405
IGFBP3 insulin-like growth factor binding protein 3 -0.0877265
HLA-B major histocompatibility complex, class I, B -0.0860109
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0753912
COL5A1 collagen, type V, alpha 1 -0.0724803
PLAT plasminogen activator, tissue -0.0660286
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0652789
MT2A metallothionein 2A -0.0622966
HLA-C major histocompatibility complex, class I, C -0.0584769
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0576748
FN1 fibronectin 1 -0.0547872
FBN1 fibrillin 1 -0.0526451
SAMD9 sterile alpha motif domain containing 9 -0.0505855
SOD2 superoxide dismutase 2, mitochondrial -0.0476971
MT1X metallothionein 1X -0.0469279
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0455889
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0425295
ZBTB20 zinc finger and BTB domain containing 20 -0.0421947
PDE4D phosphodiesterase 4D, cAMP-specific -0.0403626
RIGI RNA sensor RIG-I -0.0389349
RNF213 ring finger protein 213 -0.0386
SDK1 sidekick cell adhesion molecule 1 -0.0382806
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0375826
CSTB cystatin B (stefin B) -0.0371518
LMNA lamin A/C -0.0369225
TPT1 tumor protein, translationally-controlled 1 -0.0367472
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0365413
IFI16 interferon, gamma-inducible protein 16 -0.0350863
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0340451
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0337311
FRMD4A FERM domain containing 4A -0.0327588
COL8A1 collagen, type VIII, alpha 1 -0.0320991
COL1A2 collagen, type I, alpha 2 -0.0320506
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0316499
MRPS6 mitochondrial ribosomal protein S6 -0.0308311
AUTS2 autism susceptibility candidate 2 -0.0302609
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0300983
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0297006
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0282915
PRELID2 PRELI domain containing 2 -0.02808
PRSS23 protease, serine, 23 -0.0271107
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0269278
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0263833
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0263519
FNDC3A fibronectin type III domain containing 3A -0.0256632
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0250746
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.024646
OASL 2'-5'-oligoadenylate synthetase-like -0.0240687
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0238686
S100A6 S100 calcium binding protein A6 -0.0238407
PSD3 pleckstrin and Sec7 domain containing 3 -0.0236249
DENND1A DENN/MADD domain containing 1A -0.0227531
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0225732
IFIH1 interferon induced with helicase C domain 1 -0.0217703
OGA O-GlcNAcase -0.0216323
MX2 MX dynamin-like GTPase 2 -0.0215991
S100A4 S100 calcium binding protein A4 -0.0215474
COL7A1 collagen, type VII, alpha 1 -0.0215291
SLC39A11 solute carrier family 39, member 11 -0.0212448
WARS1 tryptophanyl-tRNA synthetase 1 -0.0210826
KDM4B lysine (K)-specific demethylase 4B -0.0208808
LY6E lymphocyte antigen 6 complex, locus E -0.0207404
XPC xeroderma pigmentosum, complementation group C -0.02062
LDHA lactate dehydrogenase A -0.0204807
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0201178
AEBP2 AE binding protein 2 -0.0200222
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0196844
TRIM22 tripartite motif containing 22 -0.0193959
DTNA dystrobrevin, alpha -0.0190076
CAV1 caveolin 1, caveolae protein, 22kDa -0.0189208
GANAB glucosidase, alpha; neutral AB -0.0188008
GNAS GNAS complex locus -0.0186327
AFF3 AF4/FMR2 family, member 3 -0.018291
ISG15 ISG15 ubiquitin-like modifier -0.0180719
COL6A2 collagen, type VI, alpha 2 -0.0180076
HOXD10 homeobox D10 -0.0179961
CCND1 cyclin D1 -0.017975
TAGLN2 transgelin 2 -0.0179329
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.017649
NT5C2 5'-nucleotidase, cytosolic II -0.0175793
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0175428
COL1A1 collagen, type I, alpha 1 -0.0175084
ARL4C ADP-ribosylation factor-like 4C -0.0174248
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0173673
KDM3A lysine (K)-specific demethylase 3A -0.017311
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0171294
ANKRD12 ankyrin repeat domain 12 -0.0169999
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0168942
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0167932
TCF25 transcription factor 25 (basic helix-loop-helix) -0.016772
H3-3B H3.3 histone B -0.0167516
TMEM263 transmembrane protein 263 -0.0167235