Mitoxantrone (dihydrochloride)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.212883
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.16794
PDE4D phosphodiesterase 4D, cAMP-specific 0.101614
MMP12 matrix metallopeptidase 12 0.0982466
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0845326
BIRC3 baculoviral IAP repeat containing 3 0.0771428
YAP1 Yes-associated protein 1 0.07675
DST dystonin 0.0744944
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0735944
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0719232
SMC4 structural maintenance of chromosomes 4 0.0701428
HMGA2 high mobility group AT-hook 2 0.0663361
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0639645
VMP1 vacuole membrane protein 1 0.0617936
NHSL1 NHS-like 1 0.0616429
ERRFI1 ERBB receptor feedback inhibitor 1 0.0605357
MKI67 marker of proliferation Ki-67 0.0587476
TAS2R14 taste receptor, type 2, member 14 0.0548958
ECT2 epithelial cell transforming 2 0.0516229
ADIPOR2 adiponectin receptor 2 0.0502131
USP34 ubiquitin specific peptidase 34 0.0498274
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0496037
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0495846
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0495192
PDGFC platelet derived growth factor C 0.0490266
CELF2 CUGBP, Elav-like family member 2 0.0488523
PCDH7 protocadherin 7 0.0474752
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0471648
MACF1 microtubule-actin crosslinking factor 1 0.0466831
CENPF centromere protein F, 350/400kDa 0.0465718
EDARADD EDAR-associated death domain 0.0460975
RRM2 ribonucleotide reductase M2 0.0456544
ASPH aspartate beta-hydroxylase 0.0451756
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0437918
ZSWIM6 zinc finger, SWIM-type containing 6 0.0436886
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0415046
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0414296
DIAPH3 diaphanous-related formin 3 0.0410502
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0393925
DPYD dihydropyrimidine dehydrogenase 0.0364619
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0364041
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0356607
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0346041
SPATS2 spermatogenesis associated, serine-rich 2 0.0345655
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0343548
ADGRG6 adhesion G protein-coupled receptor G6 0.0340394
CLTC clathrin, heavy chain (Hc) 0.0339114
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0337294
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.033517
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.03345
NSD2 nuclear receptor binding SET domain protein 2 0.0325019
CCSER1 coiled-coil serine-rich protein 1 0.0320905
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0320649
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0318988
CDK6 cyclin-dependent kinase 6 0.0317564
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0313953
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0311894
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0311532
CKAP5 cytoskeleton associated protein 5 0.030576
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0300566
DTNA dystrobrevin, alpha 0.0300136
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0290029
SLC38A2 solute carrier family 38, member 2 0.0286774
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0286183
MED13L mediator complex subunit 13-like 0.0282354
JMJD1C jumonji domain containing 1C 0.0281978
RAD51B RAD51 paralog B 0.0281584
TBC1D5 TBC1 domain family, member 5 0.0276839
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.027439
ATAD2 ATPase family, AAA domain containing 2 0.0273817
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0271382
CEP192 centrosomal protein 192kDa 0.0271293
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0270582
FAF1 Fas (TNFRSF6) associated factor 1 0.0268681
TENM3 teneurin transmembrane protein 3 0.0268069
TPX2 TPX2, microtubule-associated 0.0267084
WNK1 WNK lysine deficient protein kinase 1 0.0267072
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0265195
ATP11A ATPase, class VI, type 11A 0.0260561
ANXA1 annexin A1 0.0258386
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0258104
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0249866
MBNL1 muscleblind-like splicing regulator 1 0.0246594
NEBL nebulette 0.0246464
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0246292
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0238374
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.023733
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0236086
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0234471
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0233505
CEP128 centrosomal protein 128kDa 0.0231817
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.0231106
MED12L mediator complex subunit 12-like 0.0230836
SPIDR scaffolding protein involved in DNA repair 0.0230257
PRELID2 PRELI domain containing 2 0.0230206
GSK3B glycogen synthase kinase 3 beta 0.0229788
OSBPL8 oxysterol binding protein-like 8 0.0229459
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0228326
EPHA6 EPH receptor A6 0.022802
RSRC1 arginine/serine-rich coiled-coil 1 0.0226311

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16501
TMSB10 thymosin beta 10 -0.153912
TPI1 triosephosphate isomerase 1 -0.0891423
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0834485
FTL ferritin, light polypeptide -0.0823165
AREG amphiregulin -0.0804413
RPS12 ribosomal protein S12 -0.0733672
RPL23 ribosomal protein L23 -0.0717812
PTMA prothymosin, alpha -0.0675723
YBX3 Y box binding protein 3 -0.0659527
RPS19 ribosomal protein S19 -0.065445
RPS8 ribosomal protein S8 -0.0651535
RPL35A ribosomal protein L35a -0.0626781
RPS6 ribosomal protein S6 -0.0613313
MYL12B myosin, light chain 12B, regulatory -0.0583047
RPL26 ribosomal protein L26 -0.0544774
TPT1 tumor protein, translationally-controlled 1 -0.0516281
RPLP1 ribosomal protein, large, P1 -0.0501909
RPL34 ribosomal protein L34 -0.0483393
RPLP2 ribosomal protein, large, P2 -0.0483286
CNRIP1 cannabinoid receptor interacting protein 1 -0.0470845
RPS3 ribosomal protein S3 -0.0469704
RPL11 ribosomal protein L11 -0.0458501
RPL19 ribosomal protein L19 -0.0456892
VIM vimentin -0.0423584
RPS13 ribosomal protein S13 -0.0420931
RPL37 ribosomal protein L37 -0.041904
RPS21 ribosomal protein S21 -0.0403627
RPL12 ribosomal protein L12 -0.0386547
RPL9 ribosomal protein L9 -0.0385776
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0380287
RPS24 ribosomal protein S24 -0.037164
S100A6 S100 calcium binding protein A6 -0.0363346
RPS27A ribosomal protein S27a -0.036208
RPL31 ribosomal protein L31 -0.0355955
RPLP0 ribosomal protein, large, P0 -0.0349568
RACK1 receptor for activated C kinase 1 -0.0322933
RPS14 ribosomal protein S14 -0.0319639
RPL37A ribosomal protein L37a -0.0316444
RPS23 ribosomal protein S23 -0.0306698
RPL36 ribosomal protein L36 -0.0298596
RPS27 ribosomal protein S27 -0.029353
YBX1 Y box binding protein 1 -0.0291941
EIF1 eukaryotic translation initiation factor 1 -0.028724
ATP5F1E ATP synthase F1 subunit epsilon -0.0284732
RPS2 ribosomal protein S2 -0.0282598
RPL8 ribosomal protein L8 -0.0278975
RPS4X ribosomal protein S4, X-linked -0.0276013
RPS29 ribosomal protein S29 -0.027211
RPS15 ribosomal protein S15 -0.0271892
HMGA1 high mobility group AT-hook 1 -0.0271557
ATP5F1B ATP synthase F1 subunit beta -0.0260795
RPL27A ribosomal protein L27a -0.025947
EGR1 early growth response 1 -0.0255327
ACTG1 actin gamma 1 -0.0251388
RPL36A ribosomal protein L36a -0.0250256
GPX1 glutathione peroxidase 1 -0.0248294
RPL27 ribosomal protein L27 -0.0228273
RPS16 ribosomal protein S16 -0.0228159
RPL7 ribosomal protein L7 -0.0227175
HLA-A major histocompatibility complex, class I, A -0.0225311
RPS17 ribosomal protein S17 -0.0220711
NDUFA4 NDUFA4, mitochondrial complex associated -0.0220266
RPL38 ribosomal protein L38 -0.0219995
EEF1G eukaryotic translation elongation factor 1 gamma -0.021997
HSPB1 heat shock 27kDa protein 1 -0.0218404
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0216368
RPL32 ribosomal protein L32 -0.0216127
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0214984
PFN1 profilin 1 -0.0213262
H3-3B H3.3 histone B -0.0210593
PTMS parathymosin -0.0210041
S100A9 S100 calcium binding protein A9 -0.0209859
RPS10 ribosomal protein S10 -0.0204998
RPL5 ribosomal protein L5 -0.0197842
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0195807
RPS20 ribosomal protein S20 -0.0195316
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0193683
POTEF POTE ankyrin domain family, member F -0.0193677
RPS25 ribosomal protein S25 -0.0192595
FAM162A family with sequence similarity 162, member A -0.0191628
RPS11 ribosomal protein S11 -0.01916
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0189844
GNAS GNAS complex locus -0.0187911
HLA-B major histocompatibility complex, class I, B -0.0187472
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0182374
NACA nascent polypeptide-associated complex alpha subunit -0.0181963
RPL10A ribosomal protein L10a -0.0181701
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0181554
GCG glucagon -0.0181281
UQCRB ubiquinol-cytochrome c reductase binding protein -0.017729
RPL18 ribosomal protein L18 -0.0176566
TUBB6 tubulin, beta 6 class V -0.0175694
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0174877
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0173788
S100A10 S100 calcium binding protein A10 -0.0172496
RPL28 ribosomal protein L28 -0.0172331
RPL30 ribosomal protein L30 -0.0172207
TGM2 transglutaminase 2 -0.0167034
RPS5 ribosomal protein S5 -0.0166031