Mitoxantrone (dihydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZCCHC7 zinc finger, CCHC domain containing 7 0.110401
FRMD4A FERM domain containing 4A 0.0924538
GPC6 glypican 6 0.0895624
FNDC3B fibronectin type III domain containing 3B 0.0886115
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0826314
PLK2 polo-like kinase 2 0.0803185
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0718075
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0662602
TXNRD1 thioredoxin reductase 1 0.065347
ASPH aspartate beta-hydroxylase 0.0652223
TPM3 tropomyosin 3 0.0640663
HIPK2 homeodomain interacting protein kinase 2 0.0616528
MYH9 myosin, heavy chain 9, non-muscle 0.0612713
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0603175
DIAPH3 diaphanous-related formin 3 0.0593319
CENPF centromere protein F, 350/400kDa 0.0592225
VMP1 vacuole membrane protein 1 0.0532049
MBNL1 muscleblind-like splicing regulator 1 0.0503383
MSN moesin 0.0500596
CSF1 colony stimulating factor 1 (macrophage) 0.0476663
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0470534
VCAM1 vascular cell adhesion molecule 1 0.0466302
RND3 Rho family GTPase 3 0.0464768
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0460375
SOD2 superoxide dismutase 2, mitochondrial 0.045115
KYNU kynureninase 0.0446841
MBNL2 muscleblind-like splicing regulator 2 0.0439741
GOLGB1 golgin B1 0.0431038
KMT2C lysine (K)-specific methyltransferase 2C 0.0429001
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0427079
HDGF hepatoma-derived growth factor 0.0424444
GLIS3 GLIS family zinc finger 3 0.0424219
ESYT2 extended synaptotagmin-like protein 2 0.0423055
KTN1 kinectin 1 (kinesin receptor) 0.0420544
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0413863
TTC3 tetratricopeptide repeat domain 3 0.041251
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0412409
ADAM9 ADAM metallopeptidase domain 9 0.0407602
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0406073
BIRC6 baculoviral IAP repeat containing 6 0.0403591
BIRC3 baculoviral IAP repeat containing 3 0.0397711
TPM4 tropomyosin 4 0.0393531
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0391467
NFIB nuclear factor I/B 0.0391158
CLTC clathrin, heavy chain (Hc) 0.0389204
PDLIM5 PDZ and LIM domain 5 0.0388129
NRP2 neuropilin 2 0.0387767
MYADM myeloid-associated differentiation marker 0.037955
CKAP5 cytoskeleton associated protein 5 0.0377719
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0377123
UBA6 ubiquitin-like modifier activating enzyme 6 0.037467
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.037318
AKAP9 A kinase (PRKA) anchor protein 9 0.0369114
LPP LIM domain containing preferred translocation partner in lipoma 0.0367635
TRAM1 translocation associated membrane protein 1 0.0364307
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0364251
WAC WW domain containing adaptor with coiled-coil 0.0361014
SKAP2 src kinase associated phosphoprotein 2 0.035431
CANX calnexin 0.0352891
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0351371
CD44 CD44 molecule (Indian blood group) 0.0346614
SPAG9 sperm associated antigen 9 0.0346552
JAK1 Janus kinase 1 0.0343574
DSTN destrin (actin depolymerizing factor) 0.0343126
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0342237
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.033408
ANXA1 annexin A1 0.0330818
TPR translocated promoter region, nuclear basket protein 0.033005
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0328849
COPA coatomer protein complex, subunit alpha 0.0328357
GIGYF2 GRB10 interacting GYF protein 2 0.0320719
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0317547
ZFP36L1 ZFP36 ring finger protein-like 1 0.0313331
SPIDR scaffolding protein involved in DNA repair 0.0308313
PBX1 pre-B-cell leukemia homeobox 1 0.0306491
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0305491
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.030463
SRRM2 serine/arginine repetitive matrix 2 0.030437
EFNA5 ephrin-A5 0.0304014
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0303338
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0302144
CDK13 cyclin-dependent kinase 13 0.0300272
TPX2 TPX2, microtubule-associated 0.029963
CPAP centrosome assembly and centriole elongation protein 0.0294725
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0293635
SND1 staphylococcal nuclease and tudor domain containing 1 0.0293519
ADAM10 ADAM metallopeptidase domain 10 0.0292216
FAF1 Fas (TNFRSF6) associated factor 1 0.0288226
SUCO SUN domain containing ossification factor 0.0287568
CSPP1 centrosome and spindle pole associated protein 1 0.0287553
ELOVL5 ELOVL fatty acid elongase 5 0.028632
PDIA3 protein disulfide isomerase family A, member 3 0.0285703
DST dystonin 0.0285428
COG5 component of oligomeric golgi complex 5 0.0284573
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.02823
CHD9 chromodomain helicase DNA binding protein 9 0.0280991
ANLN anillin, actin binding protein 0.0280242
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0278821
FAM120A family with sequence similarity 120A 0.0276962
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0274573

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.168557
HLA-B major histocompatibility complex, class I, B -0.121191
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.117297
TPT1 tumor protein, translationally-controlled 1 -0.0989216
FTL ferritin, light polypeptide -0.0873956
RPL35A ribosomal protein L35a -0.0765838
RPL23 ribosomal protein L23 -0.0729849
RPL34 ribosomal protein L34 -0.0697954
NDRG1 N-myc downstream regulated 1 -0.0636738
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0612882
RPS24 ribosomal protein S24 -0.0607355
RPL26 ribosomal protein L26 -0.0582564
RPS19 ribosomal protein S19 -0.0555085
HLA-C major histocompatibility complex, class I, C -0.0553068
RPS4X ribosomal protein S4, X-linked -0.052278
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0510241
RPLP1 ribosomal protein, large, P1 -0.0499487
GDF15 growth differentiation factor 15 -0.0496346
RPS6 ribosomal protein S6 -0.0484682
RPL31 ribosomal protein L31 -0.0478455
IFI16 interferon, gamma-inducible protein 16 -0.0466426
RPS8 ribosomal protein S8 -0.0455941
RRBP1 ribosome binding protein 1 -0.0454945
RPL9 ribosomal protein L9 -0.0440646
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0436729
LOXL2 lysyl oxidase-like 2 -0.0424449
RPLP2 ribosomal protein, large, P2 -0.0424422
RPS21 ribosomal protein S21 -0.0421986
RPL12 ribosomal protein L12 -0.0418368
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0413257
OSMR oncostatin M receptor -0.0407832
B2M beta-2-microglobulin -0.0396919
CP ceruloplasmin (ferroxidase) -0.0396232
CD82 CD82 molecule -0.0387196
RPS20 ribosomal protein S20 -0.0386688
RPL30 ribosomal protein L30 -0.0376976
OSBPL3 oxysterol binding protein-like 3 -0.0376359
RPL28 ribosomal protein L28 -0.0375796
STAT1 signal transducer and activator of transcription 1, 91kDa -0.037518
RPL37A ribosomal protein L37a -0.0368611
GNAS GNAS complex locus -0.0363928
COTL1 coactosin-like F-actin binding protein 1 -0.0359132
RPS27A ribosomal protein S27a -0.0346734
LAMB3 laminin, beta 3 -0.0336093
FAM107B family with sequence similarity 107, member B -0.0332674
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0324846
HM13 histocompatibility (minor) 13 -0.0321397
RPL35 ribosomal protein L35 -0.0318391
RPL38 ribosomal protein L38 -0.0316498
S100A9 S100 calcium binding protein A9 -0.0311461
CCL2 chemokine (C-C motif) ligand 2 -0.0310546
MT2A metallothionein 2A -0.0306951
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0305818
S100A11 S100 calcium binding protein A11 -0.0296213
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0295539
RPL27 ribosomal protein L27 -0.0295006
CTSD cathepsin D -0.0292931
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0291842
RPL19 ribosomal protein L19 -0.0291829
S100A6 S100 calcium binding protein A6 -0.029119
IFI6 interferon, alpha-inducible protein 6 -0.0289704
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0286958
RPS17 ribosomal protein S17 -0.0286103
CADM1 cell adhesion molecule 1 -0.028505
S100A10 S100 calcium binding protein A10 -0.0285049
HMGB1 high mobility group box 1 -0.0283062
RPS12 ribosomal protein S12 -0.0282638
COL5A1 collagen, type V, alpha 1 -0.028212
NAP1L1 nucleosome assembly protein 1-like 1 -0.028166
FKBP10 FK506 binding protein 10, 65 kDa -0.0281095
RPS13 ribosomal protein S13 -0.0279449
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0276739
RTN4 reticulon 4 -0.0276717
TFPI2 tissue factor pathway inhibitor 2 -0.0275502
LOC112694756 uncharaterized LOC112694756 -0.0263139
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0262977
CD63 CD63 molecule -0.0261648
RPL11 ribosomal protein L11 -0.0260916
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0258796
VCL vinculin -0.0253665
RPL37 ribosomal protein L37 -0.0253629
PAX8 paired box 8 -0.0252841
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0251386
HLA-A major histocompatibility complex, class I, A -0.0248577
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0247695
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0246889
RPL36A ribosomal protein L36a -0.0246817
APOL1 apolipoprotein L, 1 -0.024467
APOL2 apolipoprotein L, 2 -0.0243543
ANKRD33B ankyrin repeat domain 33B -0.0242507
SEC61G Sec61 gamma subunit -0.024091
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0240813
IFI27 interferon, alpha-inducible protein 27 -0.0239672
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0238924
ARF1 ADP-ribosylation factor 1 -0.0238118
NDUFA4 NDUFA4, mitochondrial complex associated -0.0237503
OAZ1 ornithine decarboxylase antizyme 1 -0.0237028
RPS14 ribosomal protein S14 -0.023609
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.023076
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0227814