Mitoxantrone (dihydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.189137
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.13368
KYNU kynureninase 0.0994219
ZSWIM6 zinc finger, SWIM-type containing 6 0.0789622
VCL vinculin 0.0672809
ALCAM activated leukocyte cell adhesion molecule 0.0605554
ARHGAP26 Rho GTPase activating protein 26 0.0601185
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0571223
PDLIM5 PDZ and LIM domain 5 0.0525266
FNDC3B fibronectin type III domain containing 3B 0.0516245
VMP1 vacuole membrane protein 1 0.0505019
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0503858
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0468879
PDE10A phosphodiesterase 10A 0.0466468
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0437246
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0423557
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.041018
ELL2 elongation factor, RNA polymerase II, 2 0.0388479
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0386425
ECT2 epithelial cell transforming 2 0.0376605
AADAC arylacetamide deacetylase 0.0339103
EXT1 exostosin glycosyltransferase 1 0.0337464
NRIP1 nuclear receptor interacting protein 1 0.0331928
INTS6 integrator complex subunit 6 0.0329036
DOCK5 dedicator of cytokinesis 5 0.0326902
EPAS1 endothelial PAS domain protein 1 0.0320877
RNF145 ring finger protein 145 0.0317639
RHCG Rh family, C glycoprotein 0.0317357
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0316507
UBASH3B ubiquitin associated and SH3 domain containing B 0.0315564
WWOX WW domain containing oxidoreductase 0.0313257
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0307747
FAT1 FAT atypical cadherin 1 0.0307574
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0306912
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0295552
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0294013
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0284679
BMP6 bone morphogenetic protein 6 0.0282322
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0275434
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0273946
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0272952
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0268619
USP47 ubiquitin specific peptidase 47 0.0267757
GLIS3 GLIS family zinc finger 3 0.0265159
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0264658
AKAP13 A kinase (PRKA) anchor protein 13 0.0262408
MCTP1 multiple C2 domains, transmembrane 1 0.0249632
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0248792
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.0245776
MSN moesin 0.0245721
TGFBR1 transforming growth factor, beta receptor 1 0.024418
FNDC3A fibronectin type III domain containing 3A 0.0242464
MYH9 myosin, heavy chain 9, non-muscle 0.0241217
SMYD3 SET and MYND domain containing 3 0.0237485
NTN4 netrin 4 0.0236008
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0230946
LPP LIM domain containing preferred translocation partner in lipoma 0.022528
SLC38A2 solute carrier family 38, member 2 0.0216427
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0211205
DOCK4 dedicator of cytokinesis 4 0.0210722
PALLD palladin, cytoskeletal associated protein 0.0204367
LMO7 LIM domain 7 0.0202865
MED13L mediator complex subunit 13-like 0.0202357
IGF1R insulin-like growth factor 1 receptor 0.0202277
HMGA2 high mobility group AT-hook 2 0.0197774
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0197146
WWC1 WW and C2 domain containing 1 0.0196389
FRMD6 FERM domain containing 6 0.0194398
SMAD2 SMAD family member 2 0.0193634
VEGFC vascular endothelial growth factor C 0.0192466
SMOC1 SPARC related modular calcium binding 1 0.0190761
ZC3H12C zinc finger CCCH-type containing 12C 0.0190745
GPHN gephyrin 0.018919
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0188568
BICC1 BicC family RNA binding protein 1 0.0187157
GPATCH2L G patch domain containing 2-like 0.0186605
TRIO trio Rho guanine nucleotide exchange factor 0.0184873
PRELID2 PRELI domain containing 2 0.018275
CENPF centromere protein F, 350/400kDa 0.0182646
SMAD3 SMAD family member 3 0.0182129
MBNL1 muscleblind-like splicing regulator 1 0.0182051
ADGRG6 adhesion G protein-coupled receptor G6 0.0180919
NABP1 nucleic acid binding protein 1 0.0180615
PUM2 pumilio RNA-binding family member 2 0.017904
MAML3 mastermind-like 3 (Drosophila) 0.0177926
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0177289
RIMKLB ribosomal modification protein rimK-like family member B 0.0174891
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0174273
SAMD4A sterile alpha motif domain containing 4A 0.0172557
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0171885
SFPQ splicing factor proline/glutamine-rich 0.0171877
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0171874
HSPA8 heat shock 70kDa protein 8 0.0170287
ETNK1 ethanolamine kinase 1 0.01684
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0165425
PM20D1 peptidase M20 domain containing 1 0.016454
GRAMD1B GRAM domain containing 1B 0.0164069
TRIP12 thyroid hormone receptor interactor 12 0.0163644
TOP1 topoisomerase (DNA) I 0.0163184
KANK1 KN motif and ankyrin repeat domains 1 0.0162925

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.251653
IGFBP3 insulin-like growth factor binding protein 3 -0.197755
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.197082
NDRG1 N-myc downstream regulated 1 -0.191096
VIM vimentin -0.189678
AKAP12 A kinase (PRKA) anchor protein 12 -0.159095
ACTG1 actin gamma 1 -0.135051
RPS19 ribosomal protein S19 -0.109452
MT2A metallothionein 2A -0.0979984
CA12 carbonic anhydrase XII -0.0949655
RPS6 ribosomal protein S6 -0.0948216
EIF1 eukaryotic translation initiation factor 1 -0.0924413
S100A6 S100 calcium binding protein A6 -0.0916588
IGFBP4 insulin-like growth factor binding protein 4 -0.0910894
FTL ferritin, light polypeptide -0.0862166
TPT1 tumor protein, translationally-controlled 1 -0.0834695
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0819051
RPLP1 ribosomal protein, large, P1 -0.0810541
ANXA2 annexin A2 -0.076114
FTH1 ferritin, heavy polypeptide 1 -0.0737872
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0664088
PTMA prothymosin, alpha -0.0645645
RPS16 ribosomal protein S16 -0.0643597
FLNB filamin B, beta -0.0614359
MT1X metallothionein 1X -0.0610796
ANXA4 annexin A4 -0.0547748
LDHA lactate dehydrogenase A -0.0547418
GRB10 growth factor receptor-bound protein 10 -0.0537206
BASP1 brain abundant, membrane attached signal protein 1 -0.0535214
BTG1 B-cell translocation gene 1, anti-proliferative -0.0534413
KRT81 keratin 81, type II -0.0532572
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0523511
RNF213 ring finger protein 213 -0.0521718
RPL12 ribosomal protein L12 -0.0506665
RRBP1 ribosome binding protein 1 -0.0502699
ZMYND8 zinc finger, MYND-type containing 8 -0.0493405
RPL26 ribosomal protein L26 -0.0486482
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0465615
S100A10 S100 calcium binding protein A10 -0.0457472
RPS27A ribosomal protein S27a -0.0455198
RPL23 ribosomal protein L23 -0.0443204
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0440465
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0427387
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.042735
RIN2 Ras and Rab interactor 2 -0.0427254
PGK1 phosphoglycerate kinase 1 -0.0425167
RPS8 ribosomal protein S8 -0.0422491
RPS13 ribosomal protein S13 -0.0417215
AKR1C2 aldo-keto reductase family 1, member C2 -0.0415495
RPS24 ribosomal protein S24 -0.0408372
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0408223
RPL35A ribosomal protein L35a -0.0406951
TPM4 tropomyosin 4 -0.0402146
RPL37A ribosomal protein L37a -0.0400269
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0385577
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0385448
HLA-B major histocompatibility complex, class I, B -0.0377445
RPL31 ribosomal protein L31 -0.0375778
FA2H fatty acid 2-hydroxylase -0.0374678
RPLP2 ribosomal protein, large, P2 -0.0368792
RPS3 ribosomal protein S3 -0.0367628
RPL19 ribosomal protein L19 -0.0367077
POTEF POTE ankyrin domain family, member F -0.0361474
KPNB1 karyopherin (importin) beta 1 -0.0359336
B2M beta-2-microglobulin -0.0357231
OSMR oncostatin M receptor -0.0355893
UBC ubiquitin C -0.0354653
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0351897
AHNAK AHNAK nucleoprotein -0.0348551
LOC112694756 uncharaterized LOC112694756 -0.0346685
IFI6 interferon, alpha-inducible protein 6 -0.0338941
RPL8 ribosomal protein L8 -0.03325
RPLP0 ribosomal protein, large, P0 -0.0328432
ADM adrenomedullin -0.0328395
RPL34 ribosomal protein L34 -0.0323804
RPL28 ribosomal protein L28 -0.032345
RIGI RNA sensor RIG-I -0.0316395
LOXL2 lysyl oxidase-like 2 -0.0314209
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0312652
RPL36A ribosomal protein L36a -0.0311949
HMGA1 high mobility group AT-hook 1 -0.0310491
RPS11 ribosomal protein S11 -0.0307521
MAP1B microtubule-associated protein 1B -0.0307021
CD99 CD99 molecule -0.0306411
RPS14 ribosomal protein S14 -0.0305601
PYGL phosphorylase, glycogen, liver -0.0304607
TNS3 tensin 3 -0.0303593
ARL4C ADP-ribosylation factor-like 4C -0.0299203
RPS29 ribosomal protein S29 -0.0297647
ENO1 enolase 1, (alpha) -0.0295335
AHNAK2 AHNAK nucleoprotein 2 -0.0294689
LAMB3 laminin, beta 3 -0.0294478
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0293481
RPL37 ribosomal protein L37 -0.0293402
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0283151
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0283035
LMNA lamin A/C -0.0281871
RACK1 receptor for activated C kinase 1 -0.0276388
RPL32 ribosomal protein L32 -0.0274242
RPL38 ribosomal protein L38 -0.0274131