Mitoxantrone (dihydrochloride)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.160731
PRKG1 protein kinase, cGMP-dependent, type I 0.0574623
PDE10A phosphodiesterase 10A 0.0562907
PRELID2 PRELI domain containing 2 0.0517754
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0467705
THSD4 thrombospondin, type I, domain containing 4 0.0374781
ARID1B AT rich interactive domain 1B (SWI1-like) 0.036796
FNDC3B fibronectin type III domain containing 3B 0.0347699
FNIP1 folliculin interacting protein 1 0.0325019
GMDS GDP-mannose 4,6-dehydratase 0.0309095
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0308175
FBXL7 F-box and leucine-rich repeat protein 7 0.0307569
HMGA2 high mobility group AT-hook 2 0.0303526
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0284298
PDE4B phosphodiesterase 4B, cAMP-specific 0.0275278
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0273371
TRA2A transformer 2 alpha homolog (Drosophila) 0.0269855
TSHZ2 teashirt zinc finger homeobox 2 0.026649
PHF21A PHD finger protein 21A 0.0266137
MED13L mediator complex subunit 13-like 0.026352
YAP1 Yes-associated protein 1 0.0258248
ERBIN erbb2 interacting protein 0.0243591
HOXA3 homeobox A3 0.0238738
ARHGAP21 Rho GTPase activating protein 21 0.0236424
DSCAM Down syndrome cell adhesion molecule 0.0231533
ATG10 autophagy related 10 0.0231494
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.0223701
USP9X ubiquitin specific peptidase 9, X-linked 0.0221528
KDM6A lysine (K)-specific demethylase 6A 0.0216492
ZNF608 zinc finger protein 608 0.0215772
PDGFC platelet derived growth factor C 0.0211055
SPAG9 sperm associated antigen 9 0.0209834
ANO6 anoctamin 6 0.0199992
GPC6 glypican 6 0.0197333
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0192377
BOC BOC cell adhesion associated, oncogene regulated 0.0190152
SAMD4A sterile alpha motif domain containing 4A 0.0188821
AOPEP aminopeptidase O (putative) 0.0187758
ASPH aspartate beta-hydroxylase 0.0187388
EGFR epidermal growth factor receptor 0.0186628
MACF1 microtubule-actin crosslinking factor 1 0.0186588
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0185671
PTK2 protein tyrosine kinase 2 0.0184023
PARD3 par-3 family cell polarity regulator 0.0182321
ZNF678 zinc finger protein 678 0.0177708
BCOR BCL6 corepressor 0.0176529
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0175645
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0174852
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0172663
DOCK3 dedicator of cytokinesis 3 0.0172507
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0172443
KDM4C lysine (K)-specific demethylase 4C 0.0172388
TBC1D5 TBC1 domain family, member 5 0.0170207
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0169134
NSD3 nuclear receptor binding SET domain protein 3 0.0168739
ZNF292 zinc finger protein 292 0.0168089
TTC28 tetratricopeptide repeat domain 28 0.0165437
TENT4A terminal nucleotidyltransferase 4A 0.0162955
PUM2 pumilio RNA-binding family member 2 0.016266
DST dystonin 0.0161668
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0161066
SPIDR scaffolding protein involved in DNA repair 0.0160806
MYOF myoferlin 0.015999
FRMD6 FERM domain containing 6 0.0159433
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0157801
ZEB1 zinc finger E-box binding homeobox 1 0.0157792
RCOR1 REST corepressor 1 0.0156157
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0154548
GSE1 Gse1 coiled-coil protein 0.0153822
FGFR2 fibroblast growth factor receptor 2 0.0153529
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.0152159
ZNF516 zinc finger protein 516 0.0151518
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0149652
GSK3B glycogen synthase kinase 3 beta 0.0149562
DOCK7 dedicator of cytokinesis 7 0.0149151
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0147047
WAC WW domain containing adaptor with coiled-coil 0.0146274
UTRN utrophin 0.0146134
NCOA2 nuclear receptor coactivator 2 0.0144446
PRKD1 protein kinase D1 0.0143877
TNS3 tensin 3 0.0143318
NPTN neuroplastin 0.0143238
UBE2H ubiquitin-conjugating enzyme E2H 0.0141416
RAD51B RAD51 paralog B 0.0140305
SMAD6 SMAD family member 6 0.0138719
ATP11A ATPase, class VI, type 11A 0.0137864
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0137176
DMXL1 Dmx-like 1 0.0135708
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0135701
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0135689
TRIO trio Rho guanine nucleotide exchange factor 0.0135233
TSC22D2 TSC22 domain family, member 2 0.0135108
ZMIZ1 zinc finger, MIZ-type containing 1 0.0134787
PDE8A phosphodiesterase 8A 0.0133642
BTBD9 BTB (POZ) domain containing 9 0.0133367
PICALM phosphatidylinositol binding clathrin assembly protein 0.0132783
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0132753
CTIF CBP80/20-dependent translation initiation factor 0.0132679
PAPOLA poly(A) polymerase alpha 0.0131201
NBEA neurobeachin 0.0130972

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.328427
MGP matrix Gla protein -0.17062
PTMA prothymosin, alpha -0.152991
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.150052
RPS6 ribosomal protein S6 -0.117037
RPLP1 ribosomal protein, large, P1 -0.0973261
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0913954
RPS8 ribosomal protein S8 -0.0881119
PEG10 paternally expressed 10 -0.0863856
MEST mesoderm specific transcript -0.0852176
RPS24 ribosomal protein S24 -0.0839955
TMSB10 thymosin beta 10 -0.0829132
RPL23 ribosomal protein L23 -0.075639
RPL34 ribosomal protein L34 -0.0734213
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0726654
RPS23 ribosomal protein S23 -0.0686975
COL1A2 collagen, type I, alpha 2 -0.065793
RPLP2 ribosomal protein, large, P2 -0.0649743
RPS19 ribosomal protein S19 -0.0642805
RPL12 ribosomal protein L12 -0.0615505
ACTG1 actin gamma 1 -0.0610015
RPL35A ribosomal protein L35a -0.0604506
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0598073
RPS14 ribosomal protein S14 -0.0583744
RACK1 receptor for activated C kinase 1 -0.0576616
RPS13 ribosomal protein S13 -0.0556606
RPL37A ribosomal protein L37a -0.0554595
SOX4 SRY (sex determining region Y)-box 4 -0.0549855
CANX calnexin -0.0545223
RPS12 ribosomal protein S12 -0.0541127
TPT1 tumor protein, translationally-controlled 1 -0.0519572
RPL26 ribosomal protein L26 -0.0519213
RPLP0 ribosomal protein, large, P0 -0.0517859
ENO1 enolase 1, (alpha) -0.0501876
FTL ferritin, light polypeptide -0.0492097
RPL19 ribosomal protein L19 -0.0490277
RPS3 ribosomal protein S3 -0.0485632
RPL31 ribosomal protein L31 -0.0481076
RPL11 ribosomal protein L11 -0.0479252
RPS11 ribosomal protein S11 -0.0479238
TPI1 triosephosphate isomerase 1 -0.0467035
TMSB4X thymosin beta 4, X-linked -0.0447293
CADM2 cell adhesion molecule 2 -0.0440962
RPS27A ribosomal protein S27a -0.0435596
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0434798
RPL32 ribosomal protein L32 -0.0430156
RPL37 ribosomal protein L37 -0.0429215
S100A9 S100 calcium binding protein A9 -0.0423253
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0420455
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0411428
LDHA lactate dehydrogenase A -0.0408159
MT2A metallothionein 2A -0.0405164
KPNB1 karyopherin (importin) beta 1 -0.0400495
RPS4X ribosomal protein S4, X-linked -0.0394718
RPS10 ribosomal protein S10 -0.0394514
RPS25 ribosomal protein S25 -0.0392335
HMGA1 high mobility group AT-hook 1 -0.0387336
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0385093
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0383858
RPS5 ribosomal protein S5 -0.0382115
RPL8 ribosomal protein L8 -0.038044
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0364289
RPL28 ribosomal protein L28 -0.0361381
CBX3 chromobox homolog 3 -0.0359387
TUBB tubulin, beta class I -0.0359164
RPS17 ribosomal protein S17 -0.0355553
RPS16 ribosomal protein S16 -0.0353448
RPL5 ribosomal protein L5 -0.0350712
YBX1 Y box binding protein 1 -0.0340967
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0336087
TPM4 tropomyosin 4 -0.0335751
RPL36A ribosomal protein L36a -0.0335152
RPL7A ribosomal protein L7a -0.0321478
IER3 immediate early response 3 -0.0320722
RPL7 ribosomal protein L7 -0.0319871
RPS29 ribosomal protein S29 -0.0315098
RPS21 ribosomal protein S21 -0.0314201
RPL9 ribosomal protein L9 -0.031379
CALR calreticulin -0.0311399
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0310396
KAZN kazrin, periplakin interacting protein -0.0308257
CENPF centromere protein F, 350/400kDa -0.0301892
RPL27A ribosomal protein L27a -0.0299689
RPS20 ribosomal protein S20 -0.02988
RPS15 ribosomal protein S15 -0.0294489
HMGB1 high mobility group box 1 -0.0293563
RPL30 ribosomal protein L30 -0.0289967
PKM pyruvate kinase, muscle -0.0285318
MKI67 marker of proliferation Ki-67 -0.0285232
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0283205
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0281478
LOC112694756 uncharaterized LOC112694756 -0.0279405
RPL18 ribosomal protein L18 -0.0276332
RPS2 ribosomal protein S2 -0.0275715
RPL35 ribosomal protein L35 -0.0275122
SFTPA2 surfactant protein A2 -0.0273393
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0264363
DEK DEK proto-oncogene -0.0263295
POTEF POTE ankyrin domain family, member F -0.0262802
PFN1 profilin 1 -0.0262539