Mitoxantrone (dihydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMTK2 lemur tyrosine kinase 2 0.0866715
AKAP12 A kinase (PRKA) anchor protein 12 0.0620288
PTK2 protein tyrosine kinase 2 0.0545903
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0536457
EFNA5 ephrin-A5 0.0483996
SMAD3 SMAD family member 3 0.0479344
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0476892
EXT1 exostosin glycosyltransferase 1 0.0437635
ZEB1 zinc finger E-box binding homeobox 1 0.0430135
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0424559
RBM39 RNA binding motif protein 39 0.0423796
HMGA2 high mobility group AT-hook 2 0.0409797
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0387084
HSPA8 heat shock 70kDa protein 8 0.037989
SIK3 SIK family kinase 3 0.0373956
FMNL2 formin-like 2 0.0340789
DOCK5 dedicator of cytokinesis 5 0.0340411
EIF3A eukaryotic translation initiation factor 3, subunit A 0.033638
TRA2A transformer 2 alpha homolog (Drosophila) 0.0322024
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0320177
GREB1L growth regulation by estrogen in breast cancer-like 0.0318953
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0316428
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0311181
PMM2 phosphomannomutase 2 0.0307898
PSD3 pleckstrin and Sec7 domain containing 3 0.0307156
LARP4B La ribonucleoprotein domain family, member 4B 0.030109
IGFBP3 insulin-like growth factor binding protein 3 0.0300757
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0287081
BMP6 bone morphogenetic protein 6 0.027325
PDLIM5 PDZ and LIM domain 5 0.0272359
ZSWIM6 zinc finger, SWIM-type containing 6 0.0267235
PUM2 pumilio RNA-binding family member 2 0.0266477
SGMS2 sphingomyelin synthase 2 0.0265257
ABTB3 ankyrin repeat and BTB domain containing 3 0.0264309
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0256704
GLS2 glutaminase 2 (liver, mitochondrial) 0.0252908
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0252841
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0242216
THSD4 thrombospondin, type I, domain containing 4 0.0239497
TRRAP transformation/transcription domain-associated protein 0.0237306
NAMPT nicotinamide phosphoribosyltransferase 0.0237151
NCOA3 nuclear receptor coactivator 3 0.0236781
VMP1 vacuole membrane protein 1 0.0235646
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0231666
AKAP13 A kinase (PRKA) anchor protein 13 0.023086
NCKAP1 NCK-associated protein 1 0.0230045
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0228558
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0222438
MYOF myoferlin 0.0221842
TRIO trio Rho guanine nucleotide exchange factor 0.0220362
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0217677
MARCHF6 membrane associated ring-CH-type finger 6 0.0215824
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0215448
FNIP1 folliculin interacting protein 1 0.0215352
CANX calnexin 0.0214118
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0213569
AHNAK AHNAK nucleoprotein 0.0209345
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0207945
PPARD peroxisome proliferator-activated receptor delta 0.0207657
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0206711
KDM3A lysine (K)-specific demethylase 3A 0.020666
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0206351
KMT2E lysine (K)-specific methyltransferase 2E 0.0205023
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0204603
CHD1 chromodomain helicase DNA binding protein 1 0.0204026
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0202444
ZFAND3 zinc finger, AN1-type domain 3 0.0200339
SUCO SUN domain containing ossification factor 0.0200326
MAPK8 mitogen-activated protein kinase 8 0.0196554
LPP LIM domain containing preferred translocation partner in lipoma 0.0192911
PDE4D phosphodiesterase 4D, cAMP-specific 0.0192124
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0191642
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.018869
EPS8 epidermal growth factor receptor pathway substrate 8 0.0184886
TRIP12 thyroid hormone receptor interactor 12 0.0183066
SENP5 SUMO1/sentrin specific peptidase 5 0.0182107
ZFC3H1 zinc finger, C3H1-type containing 0.0180005
RASAL2 RAS protein activator like 2 0.0179496
BCAR3 breast cancer anti-estrogen resistance 3 0.0179354
ABI1 abl-interactor 1 0.0178302
MYH9 myosin, heavy chain 9, non-muscle 0.0176454
KLF5 Kruppel-like factor 5 (intestinal) 0.0174303
SEC31A SEC31 homolog A (S. cerevisiae) 0.0173994
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.017256
SAMD4A sterile alpha motif domain containing 4A 0.0171029
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0170389
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.016992
NOP58 NOP58 ribonucleoprotein 0.016905
ANKRD11 ankyrin repeat domain 11 0.0165192
KAT6A K(lysine) acetyltransferase 6A 0.0165087
OGA O-GlcNAcase 0.016268
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0162576
PEAK1 pseudopodium-enriched atypical kinase 1 0.0162479
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0162082
RAB1A RAB1A, member RAS oncogene family 0.0160255
GOLGB1 golgin B1 0.0160138
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0159461
CAMTA1 calmodulin binding transcription activator 1 0.0158767
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0158216
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0157683

decreased expression

Symbol Name Standardized Value
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.228599
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.169841
TMSB10 thymosin beta 10 -0.164518
POTEF POTE ankyrin domain family, member F -0.156983
NDRG1 N-myc downstream regulated 1 -0.153349
PTMA prothymosin, alpha -0.0887599
S100A10 S100 calcium binding protein A10 -0.0885098
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.084842
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0844978
B2M beta-2-microglobulin -0.0783258
VIM vimentin -0.0765972
FLNB filamin B, beta -0.0758303
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0735828
MUC17 mucin 17, cell surface associated -0.0728075
LAMB3 laminin, beta 3 -0.0706619
TPT1 tumor protein, translationally-controlled 1 -0.0698619
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0678259
LDHA lactate dehydrogenase A -0.0671885
S100A11 S100 calcium binding protein A11 -0.0655974
FTL ferritin, light polypeptide -0.0647836
HMGA1 high mobility group AT-hook 1 -0.0646492
F3 coagulation factor III (thromboplastin, tissue factor) -0.0635066
MXD1 MAX dimerization protein 1 -0.0634474
ITGA6 integrin, alpha 6 -0.0621638
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0608049
UBC ubiquitin C -0.0574965
EGR1 early growth response 1 -0.0551737
KLK10 kallikrein-related peptidase 10 -0.0543927
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0528878
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0523126
RPL12 ribosomal protein L12 -0.0521605
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0516044
PERP PERP, TP53 apoptosis effector -0.0511436
SACK1A scaffolding CK1 anchoring protein A -0.0496116
S100A6 S100 calcium binding protein A6 -0.047064
TPM4 tropomyosin 4 -0.0456464
RPS13 ribosomal protein S13 -0.0434916
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0424643
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0414217
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0405004
RPL23 ribosomal protein L23 -0.0390825
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0390572
PFN1 profilin 1 -0.0386398
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0383479
PLAUR plasminogen activator, urokinase receptor -0.0370588
RPS12 ribosomal protein S12 -0.036368
RPL35A ribosomal protein L35a -0.0360812
RPS6 ribosomal protein S6 -0.0357043
RPL31 ribosomal protein L31 -0.0355556
IFI6 interferon, alpha-inducible protein 6 -0.0353571
RPL37A ribosomal protein L37a -0.0352597
LY6E lymphocyte antigen 6 complex, locus E -0.035132
RPLP2 ribosomal protein, large, P2 -0.0350591
SLC38A2 solute carrier family 38, member 2 -0.0344477
JUP junction plakoglobin -0.0342546
RPS21 ribosomal protein S21 -0.0336482
FOSL1 FOS-like antigen 1 -0.0335805
RPS3 ribosomal protein S3 -0.0328491
ADAM9 ADAM metallopeptidase domain 9 -0.0327049
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0320603
CD9 CD9 molecule -0.0319074
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0314963
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0307901
RPS19 ribosomal protein S19 -0.0304604
PKM pyruvate kinase, muscle -0.0302964
ENO1 enolase 1, (alpha) -0.0300211
PRSS3 protease, serine, 3 -0.0299837
LOC112694756 uncharaterized LOC112694756 -0.0298942
TPI1 triosephosphate isomerase 1 -0.0294622
RPS27 ribosomal protein S27 -0.029392
GUK1 guanylate kinase 1 -0.029249
RPL8 ribosomal protein L8 -0.0291289
SLMAP sarcolemma associated protein -0.0288497
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0287418
ESYT2 extended synaptotagmin-like protein 2 -0.0284455
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0284454
RPS23 ribosomal protein S23 -0.028424
RPL34 ribosomal protein L34 -0.0280562
TMEM165 transmembrane protein 165 -0.0279043
RPLP0 ribosomal protein, large, P0 -0.0276431
SLC35F3 solute carrier family 35, member F3 -0.0275608
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0274476
RPS14 ribosomal protein S14 -0.0271651
VEZT vezatin, adherens junctions transmembrane protein -0.027148
FTH1 ferritin, heavy polypeptide 1 -0.0270941
CSTB cystatin B (stefin B) -0.0267668
CD59 CD59 molecule, complement regulatory protein -0.0267179
EIF1 eukaryotic translation initiation factor 1 -0.026446
DSG2 desmoglein 2 -0.026348
SKAP2 src kinase associated phosphoprotein 2 -0.026239
RPL9 ribosomal protein L9 -0.0259537
RPLP1 ribosomal protein, large, P1 -0.0258949
RPL37 ribosomal protein L37 -0.0257695
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0257611
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0255296
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0254508
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.025404
MDK midkine (neurite growth-promoting factor 2) -0.0253569
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0252848
RPS8 ribosomal protein S8 -0.0252596