| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VMP1 | vacuole membrane protein 1 | 0.125991 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.087269 |
| INTS6 | integrator complex subunit 6 | 0.0860975 |
| CLTC | clathrin, heavy chain (Hc) | 0.0841448 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0666518 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0616785 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0610316 |
| YAP1 | Yes-associated protein 1 | 0.0567833 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0542576 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0511489 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0511076 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0505113 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0504873 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0494502 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0492872 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0465765 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0464718 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0464696 |
| DTNA | dystrobrevin, alpha | 0.0455157 |
| CEP250 | centrosomal protein 250kDa | 0.0444855 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0443644 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.044291 |
| ATF6 | activating transcription factor 6 | 0.0436164 |
| NCOA3 | nuclear receptor coactivator 3 | 0.043053 |
| SP100 | SP100 nuclear antigen | 0.04259 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0419837 |
| CDK12 | cyclin-dependent kinase 12 | 0.0419017 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.041754 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0406772 |
| KRT86 | keratin 86, type II | 0.039659 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0396374 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0387465 |
| PLSCR2 | phospholipid scramblase 2 | 0.0385529 |
| PTK2 | protein tyrosine kinase 2 | 0.0385189 |
| STXBP4 | syntaxin binding protein 4 | 0.0383996 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0378826 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0374161 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0368584 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0367391 |
| NEBL | nebulette | 0.0355978 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0354922 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0347648 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0341589 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0338577 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0336964 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0329452 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0328676 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0327083 |
| EFNA5 | ephrin-A5 | 0.0324975 |
| RUNX1 | runt-related transcription factor 1 | 0.0324575 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0324191 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0320455 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0319481 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0317838 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0313807 |
| ATXN1 | ataxin 1 | 0.0313443 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0309228 |
| GOLGB1 | golgin B1 | 0.0306847 |
| SBF2 | SET binding factor 2 | 0.0304644 |
| RCOR1 | REST corepressor 1 | 0.0299843 |
| DUSP16 | dual specificity phosphatase 16 | 0.0298484 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0291029 |
| EGFR | epidermal growth factor receptor | 0.028863 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0287149 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0282509 |
| NABP1 | nucleic acid binding protein 1 | 0.0281077 |
| FAM219A | family with sequence similarity 219, member A | 0.0280657 |
| ZNF638 | zinc finger protein 638 | 0.0280534 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0278003 |
| SMYD3 | SET and MYND domain containing 3 | 0.0277941 |
| DSPP | dentin sialophosphoprotein | 0.0275276 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0273479 |
| GPATCH2L | G patch domain containing 2-like | 0.0269411 |
| RAD51B | RAD51 paralog B | 0.026759 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0267403 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0266889 |
| STOM | stomatin | 0.0266602 |
| MED13 | mediator complex subunit 13 | 0.0266218 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0265609 |
| VCP | valosin containing protein | 0.0265365 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.026144 |
| AEBP2 | AE binding protein 2 | 0.0259114 |
| VCL | vinculin | 0.0255796 |
| CDK13 | cyclin-dependent kinase 13 | 0.025483 |
| EXOC4 | exocyst complex component 4 | 0.0253982 |
| GPHN | gephyrin | 0.0252238 |
| FNIP1 | folliculin interacting protein 1 | 0.0252168 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0250703 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0250571 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0249952 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0249513 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0247655 |
| ATOSA | atos homolog A | 0.0247169 |
| STK4 | serine/threonine kinase 4 | 0.0246961 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0246569 |
| ASPH | aspartate beta-hydroxylase | 0.0246395 |
| LEMD3 | LEM domain containing 3 | 0.0245068 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0243021 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | 0.0242766 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0242751 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL23 | ribosomal protein L23 | -0.311095 |
| RPL19 | ribosomal protein L19 | -0.178826 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.140194 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.129355 |
| PTMA | prothymosin, alpha | -0.118847 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0929263 |
| LASP1 | LIM and SH3 protein 1 | -0.0845467 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.083265 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0757357 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0674443 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0626018 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0600003 |
| TMSB10 | thymosin beta 10 | -0.05775 |
| RPL35A | ribosomal protein L35a | -0.0567255 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0559216 |
| TMSB4X | thymosin beta 4, X-linked | -0.0526069 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0504979 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0498115 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0497976 |
| RPL12 | ribosomal protein L12 | -0.0497123 |
| B2M | beta-2-microglobulin | -0.0490394 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0475512 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0464348 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0435421 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0434756 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0428892 |
| S100A9 | S100 calcium binding protein A9 | -0.0420842 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0416649 |
| ACTG1 | actin gamma 1 | -0.0415165 |
| OSMR | oncostatin M receptor | -0.040498 |
| CCNI | cyclin I | -0.0385388 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.0384513 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.038341 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0378704 |
| HLA-B | major histocompatibility complex, class I, B | -0.0376592 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0372956 |
| S100A8 | S100 calcium binding protein A8 | -0.0372791 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0361766 |
| RPS3 | ribosomal protein S3 | -0.03611 |
| KRT19 | keratin 19, type I | -0.0354472 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0336635 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0326769 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0319653 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.0318769 |
| RPL34 | ribosomal protein L34 | -0.0316982 |
| RPS19 | ribosomal protein S19 | -0.0312044 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0310584 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0308689 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0300094 |
| RPLP1 | ribosomal protein, large, P1 | -0.0294601 |
| PFDN4 | prefoldin subunit 4 | -0.0293845 |
| RPS24 | ribosomal protein S24 | -0.0292462 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.029215 |
| TMC5 | transmembrane channel-like 5 | -0.0288864 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0282019 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0281668 |
| TMEM123 | transmembrane protein 123 | -0.0281157 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0278793 |
| HLA-C | major histocompatibility complex, class I, C | -0.0278035 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0275673 |
| RPS12 | ribosomal protein S12 | -0.0272628 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0272437 |
| RPS6 | ribosomal protein S6 | -0.0272155 |
| GNAS | GNAS complex locus | -0.0271763 |
| LDLR | low density lipoprotein receptor | -0.0270659 |
| RPL8 | ribosomal protein L8 | -0.0270507 |
| TP53INP2 | tumor protein p53 inducible nuclear protein 2 | -0.0269302 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0269138 |
| RPL35 | ribosomal protein L35 | -0.0269097 |
| FASN | fatty acid synthase | -0.026759 |
| RPL26 | ribosomal protein L26 | -0.0265917 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.026073 |
| CFB | complement factor B | -0.0259285 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0258978 |
| RPLP0 | ribosomal protein, large, P0 | -0.0254364 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0253733 |
| KRT8 | keratin 8, type II | -0.0252046 |
| NTN4 | netrin 4 | -0.0251822 |
| CALR | calreticulin | -0.0247298 |
| RPS8 | ribosomal protein S8 | -0.0245527 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0244066 |
| SERF2 | small EDRK-rich factor 2 | -0.0243982 |
| TMEM165 | transmembrane protein 165 | -0.0243461 |
| GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | -0.024295 |
| FDPS | farnesyl diphosphate synthase | -0.0240989 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0240982 |
| CCND1 | cyclin D1 | -0.024057 |
| RPS29 | ribosomal protein S29 | -0.0237263 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0237186 |
| GATA3 | GATA binding protein 3 | -0.0234696 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0234145 |
| KRT18 | keratin 18, type I | -0.0232746 |
| RPS27 | ribosomal protein S27 | -0.0231674 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0230489 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0230392 |
| CBX3 | chromobox homolog 3 | -0.0230056 |
| FADS2 | fatty acid desaturase 2 | -0.0229346 |
| RRBP1 | ribosome binding protein 1 | -0.0228272 |
| RPS13 | ribosomal protein S13 | -0.0224353 |
| INSR | insulin receptor | -0.0224323 |
