Mitoxantrone (dihydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.166524
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.122601
CENPF centromere protein F, 350/400kDa 0.0950035
ZNF608 zinc finger protein 608 0.0775292
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0762632
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0758804
COL5A2 collagen, type V, alpha 2 0.0698951
DSCAM Down syndrome cell adhesion molecule 0.0583501
VCL vinculin 0.0557802
TTC28 tetratricopeptide repeat domain 28 0.0540763
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0529099
CENPE centromere protein E, 312kDa 0.0526106
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0520497
CKAP5 cytoskeleton associated protein 5 0.0510134
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0507699
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0496161
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0470067
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0469064
PTK2 protein tyrosine kinase 2 0.0455855
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0450138
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0444334
SMYD3 SET and MYND domain containing 3 0.0443673
SFPQ splicing factor proline/glutamine-rich 0.0442572
SIK3 SIK family kinase 3 0.0433536
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0427832
CDH18 cadherin 18, type 2 0.0416038
EXOC4 exocyst complex component 4 0.0416008
SRSF4 serine/arginine-rich splicing factor 4 0.0412579
MACF1 microtubule-actin crosslinking factor 1 0.0402752
WWOX WW domain containing oxidoreductase 0.0402489
NCAPG2 non-SMC condensin II complex, subunit G2 0.0400183
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0391939
NFIA nuclear factor I/A 0.0387335
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0382423
WLS wntless Wnt ligand secretion mediator 0.0371638
ASPH aspartate beta-hydroxylase 0.0370127
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0366376
HP1BP3 heterochromatin protein 1, binding protein 3 0.0363865
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0349591
ATAD2 ATPase family, AAA domain containing 2 0.0344274
PNN pinin, desmosome associated protein 0.0341655
ZNF638 zinc finger protein 638 0.0340604
RPL3 ribosomal protein L3 0.0336738
DENND1A DENN/MADD domain containing 1A 0.0331964
MKI67 marker of proliferation Ki-67 0.0328123
TRA2A transformer 2 alpha homolog (Drosophila) 0.0327446
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0323146
KIAA1328 KIAA1328 0.0322244
HELLS helicase, lymphoid-specific 0.0321763
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0320112
JARID2 jumonji, AT rich interactive domain 2 0.0319056
BPTF bromodomain PHD finger transcription factor 0.0313907
CCSER1 coiled-coil serine-rich protein 1 0.0313801
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0312749
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0311103
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0309345
ENO1 enolase 1, (alpha) 0.0304295
MMS22L MMS22-like, DNA repair protein 0.0303829
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0303163
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0302453
KMT2E lysine (K)-specific methyltransferase 2E 0.0299602
CEP192 centrosomal protein 192kDa 0.0299499
PCBP2 poly(rC) binding protein 2 0.0292723
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0291645
SMC1A structural maintenance of chromosomes 1A 0.029163
RCOR1 REST corepressor 1 0.0288033
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.0283856
SRRM2 serine/arginine repetitive matrix 2 0.0282876
HELZ helicase with zinc finger 0.0281286
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0280608
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0279537
ANKRD36 ankyrin repeat domain 36 0.0278507
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0278038
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0275812
PDS5A PDS5 cohesin associated factor A 0.0272583
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0270639
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.027005
SMC5 structural maintenance of chromosomes 5 0.0269227
NRDC nardilysin convertase 0.0269163
CCDC88A coiled-coil domain containing 88A 0.0268903
KIF11 kinesin family member 11 0.0268465
RCC1 regulator of chromosome condensation 1 0.0267021
LPP LIM domain containing preferred translocation partner in lipoma 0.0261906
ZNF609 zinc finger protein 609 0.0261122
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0259688
CEP128 centrosomal protein 128kDa 0.0254988
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0250452
AKAP13 A kinase (PRKA) anchor protein 13 0.0250038
DEK DEK proto-oncogene 0.0249787
YLPM1 YLP motif containing 1 0.0249574
ZZZ3 zinc finger, ZZ-type containing 3 0.0248068
PBX3 pre-B-cell leukemia homeobox 3 0.0246824
PHF3 PHD finger protein 3 0.0246456
NALF1 NALCN channel auxiliary factor 1 0.0246399
PCM1 pericentriolar material 1 0.0246333
RRM2 ribonucleotide reductase M2 0.0245044
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0244905
GSK3B glycogen synthase kinase 3 beta 0.0244885
USP34 ubiquitin specific peptidase 34 0.0244096
WDPCP WD repeat containing planar cell polarity effector 0.0244065

decreased expression

Symbol Name Standardized Value
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.164965
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136792
SLIT2 slit homolog 2 (Drosophila) -0.115225
RAD51B RAD51 paralog B -0.0950117
SOX4 SRY (sex determining region Y)-box 4 -0.0911465
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0853271
PTMA prothymosin, alpha -0.0832845
IFI6 interferon, alpha-inducible protein 6 -0.0831752
RAP1B RAP1B, member of RAS oncogene family -0.0795434
TMSB10 thymosin beta 10 -0.0712664
RPS6 ribosomal protein S6 -0.0680554
ZFP36L1 ZFP36 ring finger protein-like 1 -0.06187
RPLP1 ribosomal protein, large, P1 -0.0613296
LOC112694756 uncharaterized LOC112694756 -0.0612133
RPL34 ribosomal protein L34 -0.059912
NPAS3 neuronal PAS domain protein 3 -0.0578036
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0576053
CADM2 cell adhesion molecule 2 -0.0570436
EGR1 early growth response 1 -0.0569883
RPL23 ribosomal protein L23 -0.056632
RPL12 ribosomal protein L12 -0.0562677
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0554946
ACTG1 actin gamma 1 -0.0533657
RPS24 ribosomal protein S24 -0.0525822
KDM3A lysine (K)-specific demethylase 3A -0.0494864
H1-0 H1.0 linker histone -0.048555
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0485495
SOX2 SRY (sex determining region Y)-box 2 -0.047426
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0464733
LDHA lactate dehydrogenase A -0.0459413
TPI1 triosephosphate isomerase 1 -0.0453429
RPS5 ribosomal protein S5 -0.0446118
B2M beta-2-microglobulin -0.0432641
SHROOM3 shroom family member 3 -0.0430856
RPL35A ribosomal protein L35a -0.0426854
RPL26 ribosomal protein L26 -0.0419257
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0416131
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0415502
TPT1 tumor protein, translationally-controlled 1 -0.0412109
WDR45B WD repeat domain 45B -0.0408277
SLF1 SMC5-SMC6 complex localization factor 1 -0.0404781
CELF2 CUGBP, Elav-like family member 2 -0.0398176
MYL12B myosin, light chain 12B, regulatory -0.0390716
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0388969
GJA1 gap junction protein, alpha 1, 43kDa -0.0385507
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0382773
MCTP1 multiple C2 domains, transmembrane 1 -0.0374609
RPS8 ribosomal protein S8 -0.0374393
RPS4X ribosomal protein S4, X-linked -0.0372018
HLA-B major histocompatibility complex, class I, B -0.0365239
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0363889
RPL36A ribosomal protein L36a -0.0358931
RPL32 ribosomal protein L32 -0.0356337
RIGI RNA sensor RIG-I -0.0355829
RPS19 ribosomal protein S19 -0.0355451
RACK1 receptor for activated C kinase 1 -0.035373
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0351286
TUBB tubulin, beta class I -0.035025
RPS28 ribosomal protein S28 -0.0349124
NAP1L1 nucleosome assembly protein 1-like 1 -0.034779
GRID2 glutamate receptor, ionotropic, delta 2 -0.034591
RPS21 ribosomal protein S21 -0.0344951
ARB2A ARB2 cotranscriptional regulator A -0.0342812
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0340662
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0339635
RPL27A ribosomal protein L27a -0.033605
GNAS GNAS complex locus -0.0335612
CAVIN1 caveolae associated protein 1 -0.0334152
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0330158
TENM3 teneurin transmembrane protein 3 -0.0330092
RPS11 ribosomal protein S11 -0.0328435
ZFP64 ZFP64 zinc finger protein -0.0327575
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.032752
FOXO3 forkhead box O3 -0.032557
RPLP2 ribosomal protein, large, P2 -0.0324109
TMEM41B transmembrane protein 41B -0.0322766
RPL8 ribosomal protein L8 -0.0321025
RPL38 ribosomal protein L38 -0.0320142
FAM162A family with sequence similarity 162, member A -0.0316548
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0315659
HMGB1 high mobility group box 1 -0.0315603
ZNF544 zinc finger protein 544 -0.0314451
RPS29 ribosomal protein S29 -0.0314402
ZFAND3 zinc finger, AN1-type domain 3 -0.0313061
DPYSL2 dihydropyrimidinase-like 2 -0.0304359
RPL28 ribosomal protein L28 -0.0303906
ZNFX1 zinc finger, NFX1-type containing 1 -0.0303752
RPL18 ribosomal protein L18 -0.0302732
RBM25 RNA binding motif protein 25 -0.0298008
TBC1D32 TBC1 domain family, member 32 -0.0297642
EFNA5 ephrin-A5 -0.029406
EIF1 eukaryotic translation initiation factor 1 -0.0293452
WSB1 WD repeat and SOCS box containing 1 -0.0292691
ZNF33A zinc finger protein 33A -0.0283971
SALL4 spalt-like transcription factor 4 -0.0281632
RPL30 ribosomal protein L30 -0.0281106
TOX thymocyte selection-associated high mobility group box -0.027967
DNMBP dynamin binding protein -0.027687
GARS1 glycyl-tRNA synthetase 1 -0.0276628
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0274496