| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.170229 |
| EFNA5 | ephrin-A5 | 0.118652 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.10823 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.10068 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0939823 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0850561 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0817897 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0793282 |
| ASPH | aspartate beta-hydroxylase | 0.075275 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0752301 |
| TGM2 | transglutaminase 2 | 0.0750472 |
| LAMA4 | laminin, alpha 4 | 0.0692678 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.066985 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0597936 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0594986 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0594972 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0565255 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0555524 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0537775 |
| PCBP2 | poly(rC) binding protein 2 | 0.053398 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0510779 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0500558 |
| SGMS2 | sphingomyelin synthase 2 | 0.0497972 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0497838 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0491263 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.049102 |
| TPM3 | tropomyosin 3 | 0.0479731 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0470203 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0467523 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.04482 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0442023 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0434497 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0423273 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0421967 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0417369 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0400783 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0398585 |
| SPAG9 | sperm associated antigen 9 | 0.039194 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0389051 |
| MT2A | metallothionein 2A | 0.038554 |
| EZR | ezrin | 0.0383644 |
| VMP1 | vacuole membrane protein 1 | 0.0382721 |
| OPTN | optineurin | 0.0382283 |
| PLAUR | plasminogen activator, urokinase receptor | 0.038176 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0379948 |
| RTN4 | reticulon 4 | 0.0371796 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0369846 |
| FOSL1 | FOS-like antigen 1 | 0.0369359 |
| NRP1 | neuropilin 1 | 0.0356114 |
| CD44 | CD44 molecule (Indian blood group) | 0.0354301 |
| TFG | TRK-fused gene | 0.0354101 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0352955 |
| DIAPH1 | diaphanous-related formin 1 | 0.034624 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0344358 |
| CCNL1 | cyclin L1 | 0.0341443 |
| HELZ | helicase with zinc finger | 0.0339946 |
| FAM13A | family with sequence similarity 13, member A | 0.0335933 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0335513 |
| DSPP | dentin sialophosphoprotein | 0.0334325 |
| MSN | moesin | 0.0332576 |
| SIK3 | SIK family kinase 3 | 0.0332544 |
| POTEF | POTE ankyrin domain family, member F | 0.0330442 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0329282 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0326082 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0325742 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0320173 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0314575 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0314481 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0308997 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0304856 |
| COPA | coatomer protein complex, subunit alpha | 0.0302965 |
| KYNU | kynureninase | 0.0299848 |
| ITGA6 | integrin, alpha 6 | 0.0299159 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0299045 |
| BRD2 | bromodomain containing 2 | 0.0298263 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0298026 |
| BARX2 | BARX homeobox 2 | 0.0296323 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0290817 |
| MCL1 | myeloid cell leukemia 1 | 0.0288155 |
| MYADM | myeloid-associated differentiation marker | 0.0286423 |
| AREG | amphiregulin | 0.0286244 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0286018 |
| CD2AP | CD2-associated protein | 0.028016 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0277844 |
| STK24 | serine/threonine kinase 24 | 0.0277461 |
| RNF149 | ring finger protein 149 | 0.0272999 |
| USP3 | ubiquitin specific peptidase 3 | 0.0271489 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0270978 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0270476 |
| FAM3C | family with sequence similarity 3, member C | 0.0267513 |
| TXNRD1 | thioredoxin reductase 1 | 0.0267505 |
| SMYD3 | SET and MYND domain containing 3 | 0.0264747 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0262682 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0257758 |
| MX2 | MX dynamin-like GTPase 2 | 0.0255639 |
| PDZD8 | PDZ domain containing 8 | 0.0255554 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0255038 |
| RIOK3 | RIO kinase 3 | 0.0254464 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0252495 |
| YBX1 | Y box binding protein 1 | 0.0251125 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LAMB3 | laminin, beta 3 | -0.150287 |
| HLA-B | major histocompatibility complex, class I, B | -0.132972 |
| TMSB10 | thymosin beta 10 | -0.130669 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.124205 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.110296 |
| CP | ceruloplasmin (ferroxidase) | -0.109433 |
| MMP7 | matrix metallopeptidase 7 | -0.1076 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.101754 |
| AHNAK | AHNAK nucleoprotein | -0.0922877 |
| KLF6 | Kruppel-like factor 6 | -0.0851847 |
| ANXA2 | annexin A2 | -0.0839598 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0835373 |
| DTNA | dystrobrevin, alpha | -0.0818019 |
| LAMC2 | laminin, gamma 2 | -0.0748375 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0744515 |
| TMSB4X | thymosin beta 4, X-linked | -0.0700591 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0663201 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0657059 |
| ACTG1 | actin gamma 1 | -0.0627287 |
| RPL23 | ribosomal protein L23 | -0.0610965 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0605844 |
| RPL34 | ribosomal protein L34 | -0.0587774 |
| GNAS | GNAS complex locus | -0.0583906 |
| PLAU | plasminogen activator, urokinase | -0.0577057 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0546068 |
| S100A6 | S100 calcium binding protein A6 | -0.0538489 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0523387 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0518823 |
| RPS24 | ribosomal protein S24 | -0.0507136 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0505589 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0468145 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0437927 |
| RPL35A | ribosomal protein L35a | -0.0433405 |
| NCKAP5 | NCK-associated protein 5 | -0.0413974 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0411707 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0409698 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0403443 |
| APOL1 | apolipoprotein L, 1 | -0.0396949 |
| HLA-E | major histocompatibility complex, class I, E | -0.0396152 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0395912 |
| ST8SIA6 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 | -0.0395817 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0389388 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0388438 |
| NABP1 | nucleic acid binding protein 1 | -0.0384265 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0378019 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0377603 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0373727 |
| MCU | mitochondrial calcium uniporter | -0.0371811 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0368328 |
| ARF1 | ADP-ribosylation factor 1 | -0.0367164 |
| HLA-C | major histocompatibility complex, class I, C | -0.0366159 |
| IER3 | immediate early response 3 | -0.0360946 |
| RPL31 | ribosomal protein L31 | -0.0360852 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0358731 |
| LASP1 | LIM and SH3 protein 1 | -0.0357288 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0336766 |
| RPLP0 | ribosomal protein, large, P0 | -0.0333578 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0332265 |
| SQSTM1 | sequestosome 1 | -0.032616 |
| TMEM165 | transmembrane protein 165 | -0.032228 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0321817 |
| RPS27A | ribosomal protein S27a | -0.0318995 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0316913 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.031536 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0315315 |
| PTMA | prothymosin, alpha | -0.0312253 |
| RPL19 | ribosomal protein L19 | -0.0308489 |
| CDK6 | cyclin-dependent kinase 6 | -0.0307631 |
| PRKCA | protein kinase C, alpha | -0.0307045 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0305416 |
| RTN3 | reticulon 3 | -0.030391 |
| FOXO3 | forkhead box O3 | -0.0303777 |
| LCN2 | lipocalin 2 | -0.0303098 |
| VCL | vinculin | -0.0299619 |
| CLIC4 | chloride intracellular channel 4 | -0.0298264 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0293887 |
| KRT19 | keratin 19, type I | -0.0291656 |
| RPS8 | ribosomal protein S8 | -0.028878 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0287916 |
| RPLP1 | ribosomal protein, large, P1 | -0.0285848 |
| NUMB | numb homolog (Drosophila) | -0.0284861 |
| TJP1 | tight junction protein 1 | -0.0284791 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.0282612 |
| EREG | epiregulin | -0.027872 |
| INTS6 | integrator complex subunit 6 | -0.0278313 |
| RPS25 | ribosomal protein S25 | -0.0274995 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0271529 |
| RACK1 | receptor for activated C kinase 1 | -0.0271231 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0270995 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0270428 |
| INSIG1 | insulin induced gene 1 | -0.0269274 |
| CFB | complement factor B | -0.0265555 |
| RPS21 | ribosomal protein S21 | -0.0265165 |
| PHF3 | PHD finger protein 3 | -0.026343 |
| RUNX1 | runt-related transcription factor 1 | -0.0262229 |
| SYNRG | synergin, gamma | -0.0261499 |
| NRG1 | neuregulin 1 | -0.0258496 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.02578 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0256307 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.02543 |
