Mitoxantrone (dihydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.186292
TLE4 transducin-like enhancer of split 4 0.137062
VMP1 vacuole membrane protein 1 0.12272
LSAMP limbic system-associated membrane protein 0.115105
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.100801
FMN1 formin 1 0.0993995
EXT1 exostosin glycosyltransferase 1 0.0987294
PTPRD protein tyrosine phosphatase, receptor type, D 0.0970388
ZSWIM6 zinc finger, SWIM-type containing 6 0.0838433
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0828554
ZBTB20 zinc finger and BTB domain containing 20 0.0813006
PRKCA protein kinase C, alpha 0.0809457
LINGO2 leucine rich repeat and Ig domain containing 2 0.077906
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0760926
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0651803
SIK2 salt-inducible kinase 2 0.0628626
KLHL13 kelch-like family member 13 0.0621461
PACS1 phosphofurin acidic cluster sorting protein 1 0.06028
PLAT plasminogen activator, tissue 0.0602311
GREM2 gremlin 2, DAN family BMP antagonist 0.0564883
NRG1 neuregulin 1 0.0563544
MYH9 myosin, heavy chain 9, non-muscle 0.0554329
CALD1 caldesmon 1 0.055101
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0535824
SMYD3 SET and MYND domain containing 3 0.051875
FNDC3B fibronectin type III domain containing 3B 0.0516033
PLPP1 phospholipid phosphatase 1 0.0503552
FNDC3A fibronectin type III domain containing 3A 0.0500734
GLCCI1 glucocorticoid induced 1 0.0491104
TPST1 tyrosylprotein sulfotransferase 1 0.0486061
TPM1 tropomyosin 1 (alpha) 0.0481575
THSD4 thrombospondin, type I, domain containing 4 0.0472465
FERMT2 fermitin family member 2 0.0463134
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0462506
PCBP3 poly(rC) binding protein 3 0.0455148
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0436083
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.042924
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0427167
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0422701
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0420135
ADGRB3 adhesion G protein-coupled receptor B3 0.0417303
MEF2A myocyte enhancer factor 2A 0.0416863
MBD5 methyl-CpG binding domain protein 5 0.0410212
PTPRM protein tyrosine phosphatase, receptor type, M 0.0407218
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0394285
ITPRID2 ITPR interacting domain containing 2 0.0389138
SLIT2 slit homolog 2 (Drosophila) 0.0377851
PDLIM5 PDZ and LIM domain 5 0.0377703
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0362384
ANTXR1 anthrax toxin receptor 1 0.0356004
FBXL17 F-box and leucine-rich repeat protein 17 0.0351911
SLITRK6 SLIT and NTRK-like family, member 6 0.0339011
RAD51B RAD51 paralog B 0.0338414
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0335654
NPAS2 neuronal PAS domain protein 2 0.0332788
PTEN phosphatase and tensin homolog 0.03325
CNTN4 contactin 4 0.032712
ACTN1 actinin, alpha 1 0.0326349
FAM219A family with sequence similarity 219, member A 0.0325856
INTS6 integrator complex subunit 6 0.0322736
AMOTL1 angiomotin like 1 0.0322669
EGR1 early growth response 1 0.032215
STK38L serine/threonine kinase 38 like 0.0321469
AKAP12 A kinase (PRKA) anchor protein 12 0.0321095
KCTD16 potassium channel tetramerization domain containing 16 0.0319308
MACF1 microtubule-actin crosslinking factor 1 0.0318923
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0317391
LPP LIM domain containing preferred translocation partner in lipoma 0.0304659
RSF1 remodeling and spacing factor 1 0.0303857
ARHGAP42 Rho GTPase activating protein 42 0.0302714
FRMD4A FERM domain containing 4A 0.0301901
PBX1 pre-B-cell leukemia homeobox 1 0.0299485
MBTD1 mbt domain containing 1 0.0298906
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.029746
ANKRD17 ankyrin repeat domain 17 0.0297453
FAM107B family with sequence similarity 107, member B 0.0293359
NBEA neurobeachin 0.0290943
BPTF bromodomain PHD finger transcription factor 0.028993
STXBP4 syntaxin binding protein 4 0.028915
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.0286764
PTPRK protein tyrosine phosphatase, receptor type, K 0.0285746
CADM1 cell adhesion molecule 1 0.0284878
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0284363
THBS1 thrombospondin 1 0.0282065
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0281357
PCDH17 protocadherin 17 0.0280206
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0279858
ZCCHC7 zinc finger, CCHC domain containing 7 0.0278889
ZNF148 zinc finger protein 148 0.0275151
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0264573
MAPK8 mitogen-activated protein kinase 8 0.0264464
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0262343
PICALM phosphatidylinositol binding clathrin assembly protein 0.0261844
BCAS3 breast carcinoma amplified sequence 3 0.0261374
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0260334
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0257731
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0257648
TCF12 transcription factor 12 0.0257253
TENT5A terminal nucleotidyltransferase 5A 0.0253201
ADARB1 adenosine deaminase, RNA-specific, B1 0.0252347

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.396737
LPIN1 lipin 1 -0.0948118
PTMA prothymosin, alpha -0.0847563
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0720189
COL1A1 collagen, type I, alpha 1 -0.0689336
TRIB2 tribbles pseudokinase 2 -0.0650494
NDRG1 N-myc downstream regulated 1 -0.0559162
VIM vimentin -0.0541954
LMNA lamin A/C -0.0535658
ACTG1 actin gamma 1 -0.0499783
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0483203
RPS24 ribosomal protein S24 -0.0466527
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0453098
AHNAK AHNAK nucleoprotein -0.0449196
COL3A1 collagen, type III, alpha 1 -0.0437464
OGA O-GlcNAcase -0.0431854
TPT1 tumor protein, translationally-controlled 1 -0.0430009
RPL38 ribosomal protein L38 -0.041657
RPS6 ribosomal protein S6 -0.0398531
RPLP0 ribosomal protein, large, P0 -0.0394383
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0385447
GOLGA4 golgin A4 -0.0356497
RPL23 ribosomal protein L23 -0.0344445
S100A6 S100 calcium binding protein A6 -0.0338163
MAP1B microtubule-associated protein 1B -0.0326003
CCND1 cyclin D1 -0.0320282
ANXA2 annexin A2 -0.0309337
LDHA lactate dehydrogenase A -0.0307529
ZMYM2 zinc finger, MYM-type 2 -0.030658
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.030337
WDR45B WD repeat domain 45B -0.0287754
NAP1L1 nucleosome assembly protein 1-like 1 -0.0284234
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0279773
MATR3 matrin 3 -0.027939
ZNF292 zinc finger protein 292 -0.0277656
UBE2O ubiquitin-conjugating enzyme E2O -0.0276195
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0271855
HMGA1 high mobility group AT-hook 1 -0.027119
GNAS GNAS complex locus -0.0269496
IARS1 isoleucyl-tRNA synthetase 1 -0.0268513
SMAD3 SMAD family member 3 -0.0261338
H3-3B H3.3 histone B -0.0260691
USP3 ubiquitin specific peptidase 3 -0.0258713
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0250779
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0246407
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0243731
SEPTIN2 septin 2 -0.0241985
RPL34 ribosomal protein L34 -0.0239631
AOPEP aminopeptidase O (putative) -0.0238559
WDR43 WD repeat domain 43 -0.0237861
TULP4 tubby like protein 4 -0.0235377
SEPTIN7 septin 7 -0.0234362
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.023415
KDM3A lysine (K)-specific demethylase 3A -0.0230098
LMAN1 lectin, mannose-binding, 1 -0.0229792
NPEPPS aminopeptidase puromycin sensitive -0.0226678
POTEF POTE ankyrin domain family, member F -0.0224936
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0224124
NCAM2 neural cell adhesion molecule 2 -0.0221941
NAMPT nicotinamide phosphoribosyltransferase -0.0221505
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0217991
SEPTIN9 septin 9 -0.0216955
GARS1 glycyl-tRNA synthetase 1 -0.0216348
UBE2Z ubiquitin-conjugating enzyme E2Z -0.0216158
XPO1 exportin 1 -0.0213427
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0212115
CALU calumenin -0.0211067
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0210961
GPHN gephyrin -0.0210949
TARS1 threonyl-tRNA synthetase 1 -0.0210413
RREB1 ras responsive element binding protein 1 -0.0209148
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0208976
CSDE1 cold shock domain containing E1, RNA-binding -0.020805
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0207711
FTH1 ferritin, heavy polypeptide 1 -0.0206534
FKBP10 FK506 binding protein 10, 65 kDa -0.0204247
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0203241
EIF5B eukaryotic translation initiation factor 5B -0.020317
IST1 increased sodium tolerance 1 homolog (yeast) -0.0202994
DDIT4 DNA-damage-inducible transcript 4 -0.020173
SCAF11 SR-related CTD-associated factor 11 -0.0201469
TNPO1 transportin 1 -0.0201098
RPS8 ribosomal protein S8 -0.0200719
GDF15 growth differentiation factor 15 -0.0200257
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0198248
RAD21 RAD21 homolog (S. pombe) -0.0197664
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0196848
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0195315
RPS16 ribosomal protein S16 -0.0193517
RPS25 ribosomal protein S25 -0.0193123
PA2G4 proliferation-associated 2G4, 38kDa -0.0192369
CD36 CD36 molecule (thrombospondin receptor) -0.0191118
HMGB1 high mobility group box 1 -0.0188914
CCDC57 coiled-coil domain containing 57 -0.0188357
LAMC2 laminin, gamma 2 -0.018696
SYNJ2 synaptojanin 2 -0.0186408
RNF213 ring finger protein 213 -0.0186276
ENO1 enolase 1, (alpha) -0.0185228
RPS27A ribosomal protein S27a -0.018381
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0183103