| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GMDS | GDP-mannose 4,6-dehydratase | 0.0944187 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0877865 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0767817 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0719605 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0636977 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0631095 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.062841 |
| SPATA13 | spermatogenesis associated 13 | 0.0608036 |
| SMAD3 | SMAD family member 3 | 0.0602119 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0582054 |
| ERBIN | erbb2 interacting protein | 0.05509 |
| VCL | vinculin | 0.0550588 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0546646 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0542262 |
| VMP1 | vacuole membrane protein 1 | 0.0528733 |
| MAP7 | microtubule-associated protein 7 | 0.0505151 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.048529 |
| PLSCR2 | phospholipid scramblase 2 | 0.0481796 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0476799 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0465241 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0463676 |
| ASPH | aspartate beta-hydroxylase | 0.0454174 |
| NPSR1 | neuropeptide S receptor 1 | 0.0454071 |
| INTS6 | integrator complex subunit 6 | 0.0435307 |
| EPHB2 | EPH receptor B2 | 0.0425401 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0415766 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.041573 |
| LYZ | lysozyme | 0.041182 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0408281 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0397122 |
| LMO7 | LIM domain 7 | 0.0395935 |
| ITGA6 | integrin, alpha 6 | 0.0378871 |
| PHF3 | PHD finger protein 3 | 0.0377765 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0371605 |
| APP | amyloid beta (A4) precursor protein | 0.0364157 |
| MSI2 | musashi RNA-binding protein 2 | 0.0360659 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0359865 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0358904 |
| PRKCA | protein kinase C, alpha | 0.0357476 |
| MX1 | MX dynamin-like GTPase 1 | 0.0354963 |
| SETX | senataxin | 0.0343762 |
| DIAPH1 | diaphanous-related formin 1 | 0.0340751 |
| LAMA4 | laminin, alpha 4 | 0.0338299 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0337999 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0337874 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0331615 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0330187 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0327963 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0327399 |
| RIGI | RNA sensor RIG-I | 0.0327007 |
| TJP1 | tight junction protein 1 | 0.0325782 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0321911 |
| FHIT | fragile histidine triad | 0.0319477 |
| RAB10 | RAB10, member RAS oncogene family | 0.0318892 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0317794 |
| RAD51B | RAD51 paralog B | 0.0311846 |
| SDC4 | syndecan 4 | 0.0308071 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0299813 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0299417 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0296807 |
| ATP11A | ATPase, class VI, type 11A | 0.0294108 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0290313 |
| MCU | mitochondrial calcium uniporter | 0.028941 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0287478 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0282458 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0282208 |
| POF1B | premature ovarian failure, 1B | 0.0278428 |
| FAT1 | FAT atypical cadherin 1 | 0.0272327 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0272263 |
| DGKH | diacylglycerol kinase, eta | 0.027209 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0265203 |
| RNF213 | ring finger protein 213 | 0.0263085 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.026274 |
| BCL2L1 | BCL2-like 1 | 0.0261942 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.026103 |
| SEPTIN9 | septin 9 | 0.0259639 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0257857 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0254361 |
| ANXA2 | annexin A2 | 0.0251227 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0246624 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0243806 |
| TOX3 | TOX high mobility group box family member 3 | 0.0241453 |
| TCF12 | transcription factor 12 | 0.0239901 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0239776 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0239228 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0238278 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0237991 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0233503 |
| FOXO1 | forkhead box O1 | 0.0232247 |
| PRKCE | protein kinase C, epsilon | 0.022967 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | 0.0227924 |
| DIAPH2 | diaphanous-related formin 2 | 0.022526 |
| IFNGR1 | interferon gamma receptor 1 | 0.0222359 |
| TMEM65 | transmembrane protein 65 | 0.021785 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.02177 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0212818 |
| EXOC4 | exocyst complex component 4 | 0.0212798 |
| PDZD8 | PDZ domain containing 8 | 0.0212322 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0211903 |
| CDK13 | cyclin-dependent kinase 13 | 0.0211381 |
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | -0.168972 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.150052 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.134847 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.130071 |
| HLA-B | major histocompatibility complex, class I, B | -0.101668 |
| NDRG1 | N-myc downstream regulated 1 | -0.0964198 |
| LCN2 | lipocalin 2 | -0.094259 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0782999 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0754224 |
| TXNIP | thioredoxin interacting protein | -0.0618272 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0610034 |
| H1-0 | H1.0 linker histone | -0.0571136 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0556545 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0542238 |
| RPL35A | ribosomal protein L35a | -0.0510812 |
| RPS6 | ribosomal protein S6 | -0.0483651 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0475328 |
| RPLP1 | ribosomal protein, large, P1 | -0.0467864 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0461213 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0454334 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0451717 |
| TMSB10 | thymosin beta 10 | -0.0446262 |
| UBC | ubiquitin C | -0.0440859 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0434141 |
| IRF1 | interferon regulatory factor 1 | -0.0424997 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0417921 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0406284 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0403818 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0399822 |
| GNAS | GNAS complex locus | -0.0395984 |
| PTMA | prothymosin, alpha | -0.0390663 |
| HLA-A | major histocompatibility complex, class I, A | -0.0387697 |
| MT2A | metallothionein 2A | -0.0374866 |
| LDHA | lactate dehydrogenase A | -0.0363493 |
| CALR | calreticulin | -0.0362526 |
| RNF149 | ring finger protein 149 | -0.0350205 |
| HLA-C | major histocompatibility complex, class I, C | -0.0344808 |
| RPL12 | ribosomal protein L12 | -0.0343592 |
| EGR1 | early growth response 1 | -0.0343366 |
| RPS19 | ribosomal protein S19 | -0.0336426 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0328638 |
| KRT19 | keratin 19, type I | -0.0324046 |
| RPL34 | ribosomal protein L34 | -0.0323876 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0321123 |
| RBM39 | RNA binding motif protein 39 | -0.0320308 |
| NCKAP5 | NCK-associated protein 5 | -0.0319556 |
| H3-3B | H3.3 histone B | -0.031791 |
| CSTB | cystatin B (stefin B) | -0.0317813 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0316449 |
| DIAPH3 | diaphanous-related formin 3 | -0.0313765 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0308758 |
| AGR2 | anterior gradient 2 | -0.0306296 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0293957 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0292794 |
| MORF4L2 | mortality factor 4 like 2 | -0.0288722 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0288384 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0286549 |
| PERP | PERP, TP53 apoptosis effector | -0.0283222 |
| AHI1 | Abelson helper integration site 1 | -0.028282 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0278829 |
| MKI67 | marker of proliferation Ki-67 | -0.0271938 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0271303 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0270727 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0269359 |
| TPI1 | triosephosphate isomerase 1 | -0.0268901 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0268649 |
| RPL23 | ribosomal protein L23 | -0.0266737 |
| FTL | ferritin, light polypeptide | -0.0266437 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0262729 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0261619 |
| MXD1 | MAX dimerization protein 1 | -0.0257884 |
| RPL26 | ribosomal protein L26 | -0.0255146 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0254423 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0253726 |
| RAB1A | RAB1A, member RAS oncogene family | -0.025356 |
| ENO1 | enolase 1, (alpha) | -0.0251394 |
| SMIM14 | small integral membrane protein 14 | -0.0249703 |
| MT1X | metallothionein 1X | -0.0247407 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0243258 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0241982 |
| S100A10 | S100 calcium binding protein A10 | -0.0240932 |
| ZNF395 | zinc finger protein 395 | -0.0239798 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0239533 |
| RPL19 | ribosomal protein L19 | -0.0238689 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0236108 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0234688 |
| RRBP1 | ribosome binding protein 1 | -0.0232569 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0231201 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0231139 |
| RPL11 | ribosomal protein L11 | -0.0230852 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0229557 |
| RPL9 | ribosomal protein L9 | -0.0229236 |
| SPG11 | spastic paraplegia 11 (autosomal recessive) | -0.0227961 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0227206 |
| CXXC5 | CXXC finger protein 5 | -0.0225 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0224661 |
| ANXA1 | annexin A1 | -0.0222953 |
| HLA-E | major histocompatibility complex, class I, E | -0.0222452 |
| HDLBP | high density lipoprotein binding protein | -0.0221935 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0216868 |
