Mitoxantrone (dihydrochloride)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0702137
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.069084
FTL ferritin, light polypeptide 0.0540419
KYNU kynureninase 0.051265
CXCL8 chemokine (C-X-C motif) ligand 8 0.0505238
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0483323
FAM13A family with sequence similarity 13, member A 0.0442588
FNDC3B fibronectin type III domain containing 3B 0.0397206
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0367177
CENPF centromere protein F, 350/400kDa 0.0342227
SAMD4A sterile alpha motif domain containing 4A 0.030757
HELZ helicase with zinc finger 0.0305722
EEF2 eukaryotic translation elongation factor 2 0.0303097
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0301084
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0286798
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0280409
ZSWIM6 zinc finger, SWIM-type containing 6 0.0279021
UBA6 ubiquitin-like modifier activating enzyme 6 0.0278879
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0277605
YBX1 Y box binding protein 1 0.0259531
MBNL1 muscleblind-like splicing regulator 1 0.0258632
TRA2A transformer 2 alpha homolog (Drosophila) 0.0256758
HDAC9 histone deacetylase 9 0.0241867
CEP128 centrosomal protein 128kDa 0.0236946
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0233514
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0233499
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.023307
TRIO trio Rho guanine nucleotide exchange factor 0.0229724
VMP1 vacuole membrane protein 1 0.0226038
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0225961
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0225452
BRD2 bromodomain containing 2 0.0224209
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0223364
TXNIP thioredoxin interacting protein 0.0221892
NAMPT nicotinamide phosphoribosyltransferase 0.0221138
DGKD diacylglycerol kinase, delta 130kDa 0.0217753
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0215783
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0215583
TPM3 tropomyosin 3 0.0213084
MSN moesin 0.0210467
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0209739
ANKRD28 ankyrin repeat domain 28 0.020958
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0209341
NAV2 neuron navigator 2 0.0207949
AKAP9 A kinase (PRKA) anchor protein 9 0.0201049
SUCO SUN domain containing ossification factor 0.0200186
CHD1 chromodomain helicase DNA binding protein 1 0.0198604
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0197381
ANLN anillin, actin binding protein 0.0196916
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0196178
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0194725
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0193659
WAC WW domain containing adaptor with coiled-coil 0.0193272
DIAPH3 diaphanous-related formin 3 0.0192116
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0190842
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0190431
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0188798
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0188785
TFG TRK-fused gene 0.0187558
METTL15 methyltransferase like 15 0.0187541
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0186717
FXR1 fragile X mental retardation, autosomal homolog 1 0.0183505
FTH1 ferritin, heavy polypeptide 1 0.0182772
GLS2 glutaminase 2 (liver, mitochondrial) 0.0181844
TXNRD1 thioredoxin reductase 1 0.0179646
WNK1 WNK lysine deficient protein kinase 1 0.0178022
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0175198
WDPCP WD repeat containing planar cell polarity effector 0.0172953
PHF21A PHD finger protein 21A 0.0172359
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0171268
ZBTB38 zinc finger and BTB domain containing 38 0.0170378
ATP13A3 ATPase type 13A3 0.0169655
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.016955
SNX13 sorting nexin 13 0.0169417
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0169371
SLC38A2 solute carrier family 38, member 2 0.0167748
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0167729
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0167692
SQSTM1 sequestosome 1 0.016676
ALCAM activated leukocyte cell adhesion molecule 0.0166327
MYOF myoferlin 0.0165497
CCDC102B coiled-coil domain containing 102B 0.0162353
ZCCHC7 zinc finger, CCHC domain containing 7 0.016215
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0161621
BIRC3 baculoviral IAP repeat containing 3 0.0161566
ATP11B ATPase, class VI, type 11B 0.0160988
MCTP1 multiple C2 domains, transmembrane 1 0.0159799
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0159344
PHIP pleckstrin homology domain interacting protein 0.0158629
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0158232
GPATCH2L G patch domain containing 2-like 0.0156054
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0155765
ZNF638 zinc finger protein 638 0.0155561
RRM2 ribonucleotide reductase M2 0.0155134
MAP1B microtubule-associated protein 1B 0.0154632
TPX2 TPX2, microtubule-associated 0.015424
HILPDA hypoxia inducible lipid droplet-associated 0.0152633
ESYT2 extended synaptotagmin-like protein 2 0.0152488
EFNA5 ephrin-A5 0.0150971
TSC22D2 TSC22 domain family, member 2 0.0150749

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.132201
FN1 fibronectin 1 -0.13015
NALF1 NALCN channel auxiliary factor 1 -0.122351
HLA-B major histocompatibility complex, class I, B -0.104713
AHNAK AHNAK nucleoprotein -0.08888
IGFBP3 insulin-like growth factor binding protein 3 -0.0851774
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.080078
COL6A3 collagen, type VI, alpha 3 -0.0794274
VIM vimentin -0.0786941
ASPH aspartate beta-hydroxylase -0.074087
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0670407
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0637856
TGFBI transforming growth factor, beta-induced, 68kDa -0.0622038
GRB10 growth factor receptor-bound protein 10 -0.0579152
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0571777
SDK1 sidekick cell adhesion molecule 1 -0.0568784
TPM4 tropomyosin 4 -0.0547209
TPT1 tumor protein, translationally-controlled 1 -0.0539082
ANTXR2 anthrax toxin receptor 2 -0.0523335
IGF2 insulin-like growth factor 2 -0.0519034
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0513939
MT2A metallothionein 2A -0.0504127
COL5A1 collagen, type V, alpha 1 -0.0503768
S100A6 S100 calcium binding protein A6 -0.0501843
LOX lysyl oxidase -0.0492675
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0490045
IGFBP5 insulin-like growth factor binding protein 5 -0.048835
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0455649
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0444104
HLA-C major histocompatibility complex, class I, C -0.0438421
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0421583
CALD1 caldesmon 1 -0.0409091
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0408767
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0404365
CCND1 cyclin D1 -0.0397989
GNAS GNAS complex locus -0.0390141
CAPN2 calpain 2, (m/II) large subunit -0.038672
PRSS23 protease, serine, 23 -0.0376537
EXT1 exostosin glycosyltransferase 1 -0.037192
LMAN1 lectin, mannose-binding, 1 -0.0371557
CAVIN1 caveolae associated protein 1 -0.0369565
STC1 stanniocalcin 1 -0.035979
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0347957
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0347203
WSB1 WD repeat and SOCS box containing 1 -0.034156
CD44 CD44 molecule (Indian blood group) -0.0340351
NDRG1 N-myc downstream regulated 1 -0.0338135
HLA-A major histocompatibility complex, class I, A -0.0334478
ZNF804A zinc finger protein 804A -0.0330479
BACE2 beta-site APP-cleaving enzyme 2 -0.0329884
CLMP CXADR-like membrane protein -0.0325953
NRXN3 neurexin 3 -0.0325272
INHBA inhibin, beta A -0.031865
RPL35A ribosomal protein L35a -0.0318534
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0308155
OSMR oncostatin M receptor -0.0305448
LOXL2 lysyl oxidase-like 2 -0.0304343
NAV3 neuron navigator 3 -0.0282333
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0281596
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0281446
CALU calumenin -0.0278079
RPS24 ribosomal protein S24 -0.0270731
ENO1 enolase 1, (alpha) -0.0269977
B2M beta-2-microglobulin -0.0264017
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0260735
MACF1 microtubule-actin crosslinking factor 1 -0.0254677
PXDN peroxidasin -0.0253833
RPL34 ribosomal protein L34 -0.0251066
COL6A2 collagen, type VI, alpha 2 -0.024964
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0249458
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0249215
NAV1 neuron navigator 1 -0.0248506
GARS1 glycyl-tRNA synthetase 1 -0.0243317
PLEC plectin -0.0241592
MYLK myosin light chain kinase -0.0241284
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0240671
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -0.0239553
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0237496
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0235623
S100A10 S100 calcium binding protein A10 -0.023258
COL12A1 collagen, type XII, alpha 1 -0.02315
LMNA lamin A/C -0.0227407
NPAS2 neuronal PAS domain protein 2 -0.0225401
TMEM132B transmembrane protein 132B -0.0225097
OXR1 oxidation resistance 1 -0.0225049
CD63 CD63 molecule -0.0223796
EMP1 epithelial membrane protein 1 -0.0222724
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0220535
DTNA dystrobrevin, alpha -0.0219434
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0219237
ZBTB20 zinc finger and BTB domain containing 20 -0.0219222
PYGL phosphorylase, glycogen, liver -0.0218079
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0217482
FAM20C family with sequence similarity 20, member C -0.0217392
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0216015
DST dystonin -0.0215633
SOX5 SRY (sex determining region Y)-box 5 -0.0214022
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0213917
DMD dystrophin -0.0213405
FKBP10 FK506 binding protein 10, 65 kDa -0.0211071