Mitoxantrone (dihydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.092766
INTS6 integrator complex subunit 6 0.0469143
TENM3 teneurin transmembrane protein 3 0.0446369
APLP2 amyloid beta (A4) precursor-like protein 2 0.0441304
ZSWIM6 zinc finger, SWIM-type containing 6 0.0405875
CEMIP2 cell migration inducing hyaluronidase 2 0.0340319
KDM4C lysine (K)-specific demethylase 4C 0.0331974
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.032569
ZNF638 zinc finger protein 638 0.0319405
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.031495
TXNRD1 thioredoxin reductase 1 0.0296963
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0294205
PRELID2 PRELI domain containing 2 0.0288014
EXOC6B exocyst complex component 6B 0.0287993
PDE4D phosphodiesterase 4D, cAMP-specific 0.0279407
GPHN gephyrin 0.0277929
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0274722
ADARB1 adenosine deaminase, RNA-specific, B1 0.0272851
CHRM3 cholinergic receptor, muscarinic 3 0.0272371
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0267947
RUNX1 runt-related transcription factor 1 0.0260035
HELZ helicase with zinc finger 0.0251924
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0245887
BCAS3 breast carcinoma amplified sequence 3 0.0244935
UTRN utrophin 0.0240001
SFPQ splicing factor proline/glutamine-rich 0.0239213
SON SON DNA binding protein 0.0236421
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0231284
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0230343
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0229598
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0226814
PCBP2 poly(rC) binding protein 2 0.0222576
FHIT fragile histidine triad 0.022191
KIAA1217 KIAA1217 0.0221096
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0209784
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0209487
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0205454
HSPA8 heat shock 70kDa protein 8 0.020518
CLU clusterin 0.0203035
ARL15 ADP-ribosylation factor-like 15 0.0200898
HOMER1 homer scaffolding protein 1 0.0197888
GLS2 glutaminase 2 (liver, mitochondrial) 0.0195519
LRRC23 leucine rich repeat containing 23 0.0193931
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0192825
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0192824
PARD3B par-3 family cell polarity regulator beta 0.019164
BBX bobby sox homolog (Drosophila) 0.0188842
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.018664
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0186183
MED13 mediator complex subunit 13 0.0185604
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0185541
DIAPH1 diaphanous-related formin 1 0.0184047
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0183547
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0182767
ATXN1 ataxin 1 0.0179035
TFRC transferrin receptor 0.0176811
RYBP RING1 and YY1 binding protein 0.0176146
PCM1 pericentriolar material 1 0.0174341
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0172447
SGMS2 sphingomyelin synthase 2 0.0171795
SMYD3 SET and MYND domain containing 3 0.017036
FOCAD focadhesin 0.0167951
METTL15 methyltransferase like 15 0.0167402
MYH9 myosin, heavy chain 9, non-muscle 0.0165702
TJP1 tight junction protein 1 0.0165537
CLEC16A C-type lectin domain family 16, member A 0.0164584
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0163703
SH3GL2 SH3-domain GRB2-like 2 0.0163507
IFRD1 interferon-related developmental regulator 1 0.0160736
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0160345
TNRC6A trinucleotide repeat containing 6A 0.0159914
YAP1 Yes-associated protein 1 0.0158984
MYO5A myosin VA (heavy chain 12, myoxin) 0.0157693
ASPH aspartate beta-hydroxylase 0.0157361
NABP1 nucleic acid binding protein 1 0.0157189
FER fer (fps/fes related) tyrosine kinase 0.0156992
LCOR ligand dependent nuclear receptor corepressor 0.0156144
TOR1AIP2 torsin A interacting protein 2 0.0156067
PUM1 pumilio RNA-binding family member 1 0.015486
SCFD1 sec1 family domain containing 1 0.0154486
TAS2R14 taste receptor, type 2, member 14 0.0153338
PTPRG protein tyrosine phosphatase, receptor type, G 0.0153052
WWOX WW domain containing oxidoreductase 0.0153046
PCNX2 pecanex 2 0.0152883
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.015248
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0151715
MACROD2 MACRO domain containing 2 0.0151045
KTN1 kinectin 1 (kinesin receptor) 0.0150283
GAN gigaxonin 0.0149413
ITSN1 intersectin 1 (SH3 domain protein) 0.01465
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0145061
ARHGAP26 Rho GTPase activating protein 26 0.0144552
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0144203
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.014414
CAPRIN2 caprin family member 2 0.0143047
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0142773
BRD2 bromodomain containing 2 0.0140851
UBAP2 ubiquitin associated protein 2 0.014037
AFDN afadin, adherens junction formation factor 0.0137872
PDLIM5 PDZ and LIM domain 5 0.0137194

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.315194
NDRG1 N-myc downstream regulated 1 -0.181768
TPT1 tumor protein, translationally-controlled 1 -0.170018
FAT1 FAT atypical cadherin 1 -0.152606
TMSB10 thymosin beta 10 -0.150961
AHNAK AHNAK nucleoprotein -0.119342
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103303
RPS6 ribosomal protein S6 -0.0882908
MKI67 marker of proliferation Ki-67 -0.0765192
RPS8 ribosomal protein S8 -0.0718614
ENO1 enolase 1, (alpha) -0.0708517
TPM4 tropomyosin 4 -0.0664807
RPL35A ribosomal protein L35a -0.0612358
KRT18 keratin 18, type I -0.0548069
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0533417
PKM pyruvate kinase, muscle -0.0527347
RPS3 ribosomal protein S3 -0.0522759
RPL34 ribosomal protein L34 -0.0519496
SERINC5 serine incorporator 5 -0.0502719
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0501182
RPLP0 ribosomal protein, large, P0 -0.0498626
TUBA1B tubulin, alpha 1b -0.0484946
RPS13 ribosomal protein S13 -0.0483197
S100A6 S100 calcium binding protein A6 -0.047546
RPL26 ribosomal protein L26 -0.0473974
RPL11 ribosomal protein L11 -0.046133
RPL31 ribosomal protein L31 -0.0459956
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0447316
S100A9 S100 calcium binding protein A9 -0.0445769
MT2A metallothionein 2A -0.0439152
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0421937
RPLP2 ribosomal protein, large, P2 -0.0419174
KPNB1 karyopherin (importin) beta 1 -0.0416454
ACTG1 actin gamma 1 -0.0402505
MSI2 musashi RNA-binding protein 2 -0.0394617
KRT19 keratin 19, type I -0.0387551
RPS25 ribosomal protein S25 -0.0381303
RPLP1 ribosomal protein, large, P1 -0.0368913
RPS17 ribosomal protein S17 -0.0363398
RPS27A ribosomal protein S27a -0.0362908
RPS24 ribosomal protein S24 -0.0355744
LDHA lactate dehydrogenase A -0.0354735
RPL37A ribosomal protein L37a -0.035128
TUBB tubulin, beta class I -0.0349729
RPL8 ribosomal protein L8 -0.0346052
TUBB4B tubulin, beta 4B class IVb -0.0339914
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0337693
RPL23 ribosomal protein L23 -0.0336821
RPS19 ribosomal protein S19 -0.0335888
S100A10 S100 calcium binding protein A10 -0.0335121
DLG1 discs, large homolog 1 (Drosophila) -0.0331676
RPL30 ribosomal protein L30 -0.0330059
EPCAM epithelial cell adhesion molecule -0.0327176
RPS14 ribosomal protein S14 -0.0324154
EZR ezrin -0.0321718
RACK1 receptor for activated C kinase 1 -0.0319793
RPS12 ribosomal protein S12 -0.0317484
RPS23 ribosomal protein S23 -0.0313808
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0313734
RPL27A ribosomal protein L27a -0.0309664
HMGA2 high mobility group AT-hook 2 -0.0309413
RPL19 ribosomal protein L19 -0.0307452
POTEF POTE ankyrin domain family, member F -0.0305338
RPS11 ribosomal protein S11 -0.0298566
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0298324
RPS21 ribosomal protein S21 -0.0291942
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0291892
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0291675
RPL18 ribosomal protein L18 -0.0288194
HLA-B major histocompatibility complex, class I, B -0.0281671
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0279002
RPL36A ribosomal protein L36a -0.0278247
EGR1 early growth response 1 -0.0277687
SLC38A2 solute carrier family 38, member 2 -0.0276722
RPL37 ribosomal protein L37 -0.0273863
RPS15 ribosomal protein S15 -0.0268469
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0267348
PGK1 phosphoglycerate kinase 1 -0.0267302
HLA-A major histocompatibility complex, class I, A -0.0266985
RPL32 ribosomal protein L32 -0.0265724
RHOA ras homolog family member A -0.0259144
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0257929
IFITM3 interferon induced transmembrane protein 3 -0.0256436
RAD21 RAD21 homolog (S. pombe) -0.0254108
PFN1 profilin 1 -0.0253973
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0252981
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0249711
RPL15 ribosomal protein L15 -0.0247242
RPS10 ribosomal protein S10 -0.0246759
ITGB4 integrin, beta 4 -0.0246611
RPL9 ribosomal protein L9 -0.0244482
NPEPPS aminopeptidase puromycin sensitive -0.0242773
SERBP1 SERPINE1 mRNA binding protein 1 -0.0241343
LOC112694756 uncharaterized LOC112694756 -0.0241103
SH3BP4 SH3-domain binding protein 4 -0.0240519
EREG epiregulin -0.0239852
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0236469
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0232645
RPL38 ribosomal protein L38 -0.0232555
RPS29 ribosomal protein S29 -0.0232321