| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.109182 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.096496 |
| ITGB8 | integrin, beta 8 | 0.0878684 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0809363 |
| WWC1 | WW and C2 domain containing 1 | 0.0797333 |
| ECT2 | epithelial cell transforming 2 | 0.0768463 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0767062 |
| VCL | vinculin | 0.0722404 |
| ASPH | aspartate beta-hydroxylase | 0.0714201 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0674002 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0665884 |
| VMP1 | vacuole membrane protein 1 | 0.0660027 |
| SMAD3 | SMAD family member 3 | 0.0639739 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0630351 |
| TXNRD1 | thioredoxin reductase 1 | 0.0605284 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0473137 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.046774 |
| APP | amyloid beta (A4) precursor protein | 0.0466831 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0464925 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0463766 |
| ATXN1 | ataxin 1 | 0.0463744 |
| SNX9 | sorting nexin 9 | 0.0463101 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0456674 |
| TJP1 | tight junction protein 1 | 0.0454807 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0450245 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0449394 |
| SPAG9 | sperm associated antigen 9 | 0.0436027 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0435561 |
| SVIL | supervillin | 0.043406 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.042823 |
| SSH2 | slingshot protein phosphatase 2 | 0.0407447 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0406769 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0405598 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0404168 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0398285 |
| SGMS2 | sphingomyelin synthase 2 | 0.0386265 |
| MACROD2 | MACRO domain containing 2 | 0.0377974 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0366763 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.035268 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0344675 |
| AFDN | afadin, adherens junction formation factor | 0.0341017 |
| GDA | guanine deaminase | 0.0339394 |
| CLTC | clathrin, heavy chain (Hc) | 0.0337448 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0336082 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0332315 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0330518 |
| DSPP | dentin sialophosphoprotein | 0.0330193 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0328848 |
| TUSC3 | tumor suppressor candidate 3 | 0.0326893 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0325698 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0324338 |
| ZNF644 | zinc finger protein 644 | 0.0321863 |
| ZNF608 | zinc finger protein 608 | 0.0321366 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0318263 |
| ANO6 | anoctamin 6 | 0.0318229 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0311266 |
| RAB3IP | RAB3A interacting protein | 0.0311229 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0310944 |
| H1-4 | H1.4 linker histone, cluster member | 0.0308923 |
| SLTM | SAFB-like, transcription modulator | 0.0308629 |
| JMJD1C | jumonji domain containing 1C | 0.0306633 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0305286 |
| MED13 | mediator complex subunit 13 | 0.0303003 |
| SIK3 | SIK family kinase 3 | 0.0301769 |
| MMS22L | MMS22-like, DNA repair protein | 0.0301746 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0297234 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0297172 |
| SQSTM1 | sequestosome 1 | 0.0295567 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0295188 |
| DIAPH1 | diaphanous-related formin 1 | 0.0294634 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0294088 |
| USP53 | ubiquitin specific peptidase 53 | 0.0293397 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0292562 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0290585 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0287648 |
| PAPOLA | poly(A) polymerase alpha | 0.0284538 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.028425 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0284098 |
| WWOX | WW domain containing oxidoreductase | 0.0280492 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0279331 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0278529 |
| RUNX1 | runt-related transcription factor 1 | 0.0277972 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0277876 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0276438 |
| SRPK2 | SRSF protein kinase 2 | 0.0273808 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0272973 |
| RASA2 | RAS p21 protein activator 2 | 0.0269418 |
| GOLGB1 | golgin B1 | 0.026854 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0267623 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0265363 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.026514 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0263616 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0260486 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0259123 |
| SETD2 | SET domain containing 2 | 0.0258888 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0258788 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0256359 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0256201 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0255868 |
| INTS6 | integrator complex subunit 6 | 0.0255845 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.177361 |
| NDRG1 | N-myc downstream regulated 1 | -0.148638 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.124192 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.119729 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.117493 |
| AHNAK | AHNAK nucleoprotein | -0.0869276 |
| POTEF | POTE ankyrin domain family, member F | -0.0842705 |
| MT2A | metallothionein 2A | -0.0816539 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0677059 |
| FTL | ferritin, light polypeptide | -0.0661685 |
| HMGA1 | high mobility group AT-hook 1 | -0.0620859 |
| RPS6 | ribosomal protein S6 | -0.0620662 |
| LDHA | lactate dehydrogenase A | -0.0596387 |
| CCND1 | cyclin D1 | -0.0590165 |
| PTMA | prothymosin, alpha | -0.0577734 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0515733 |
| PKM | pyruvate kinase, muscle | -0.0506441 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0500692 |
| KRT7 | keratin 7, type II | -0.0485759 |
| LOC112694756 | uncharaterized LOC112694756 | -0.044909 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0420363 |
| TPM4 | tropomyosin 4 | -0.0419692 |
| S100A6 | S100 calcium binding protein A6 | -0.0401812 |
| TPI1 | triosephosphate isomerase 1 | -0.0393919 |
| ENO1 | enolase 1, (alpha) | -0.0389002 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0387662 |
| KRT19 | keratin 19, type I | -0.0374912 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.037313 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.037111 |
| GNAS | GNAS complex locus | -0.0369563 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0364768 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0361993 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0349017 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0342645 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.033051 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0323052 |
| RPL23 | ribosomal protein L23 | -0.0313957 |
| PFN1 | profilin 1 | -0.0313765 |
| LASP1 | LIM and SH3 protein 1 | -0.0309947 |
| NSRP1 | nuclear speckle splicing regulatory protein 1 | -0.0304257 |
| ANXA2 | annexin A2 | -0.0300124 |
| RPL34 | ribosomal protein L34 | -0.029716 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0290688 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0289195 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0287488 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0284994 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0283133 |
| RPL35A | ribosomal protein L35a | -0.0274089 |
| FLNA | filamin A, alpha | -0.0264563 |
| RPS19 | ribosomal protein S19 | -0.0263367 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0261162 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0255008 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0254812 |
| ZNF609 | zinc finger protein 609 | -0.02513 |
| CD44 | CD44 molecule (Indian blood group) | -0.0247971 |
| CAPNS1 | calpain, small subunit 1 | -0.0247138 |
| RPL28 | ribosomal protein L28 | -0.0242852 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0234986 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0232853 |
| ATG7 | autophagy related 7 | -0.0232673 |
| H1-0 | H1.0 linker histone | -0.0232396 |
| PCED1B | PC-esterase domain containing 1B | -0.0231612 |
| B2M | beta-2-microglobulin | -0.0228888 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0228888 |
| NEK6 | NIMA-related kinase 6 | -0.0225497 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0224193 |
| CDCP1 | CUB domain containing protein 1 | -0.0222747 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0221808 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.022044 |
| KLHL29 | kelch-like family member 29 | -0.0220053 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0219074 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0218825 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | -0.0216051 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0214125 |
| EGR1 | early growth response 1 | -0.0212969 |
| RPS24 | ribosomal protein S24 | -0.0212375 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0211605 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0209477 |
| CALR | calreticulin | -0.0206555 |
| JPT2 | Jupiter microtubule associated homolog 2 | -0.0205917 |
| ITGB4 | integrin, beta 4 | -0.0204233 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | -0.0203669 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0203228 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | -0.0203203 |
| RACK1 | receptor for activated C kinase 1 | -0.0202439 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0200779 |
| ACTG1 | actin gamma 1 | -0.0199927 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0199868 |
| RTN3 | reticulon 3 | -0.0197964 |
| HKDC1 | hexokinase domain containing 1 | -0.0197834 |
| VEGFA | vascular endothelial growth factor A | -0.0196119 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0195846 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0195512 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0194415 |
| RPS11 | ribosomal protein S11 | -0.0192827 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0192662 |
| MROH1 | maestro heat-like repeat family member 1 | -0.0191482 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0191404 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0190195 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0189699 |
