| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD44 | CD44 molecule (Indian blood group) | 0.144694 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.107081 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.10701 |
| DST | dystonin | 0.0994172 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0929828 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0898355 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0877842 |
| GLIS3 | GLIS family zinc finger 3 | 0.0856989 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.084773 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0831224 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.075161 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0719036 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0715647 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0680418 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0666353 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0625385 |
| MYO10 | myosin X | 0.0624132 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0623936 |
| RAI14 | retinoic acid induced 14 | 0.0616433 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0616165 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0576643 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0555666 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.051482 |
| HMGA2 | high mobility group AT-hook 2 | 0.0507644 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0506301 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0496738 |
| NAV1 | neuron navigator 1 | 0.0496149 |
| CENPF | centromere protein F, 350/400kDa | 0.0493474 |
| VMP1 | vacuole membrane protein 1 | 0.0481122 |
| RRM2 | ribonucleotide reductase M2 | 0.0479413 |
| VCL | vinculin | 0.0476576 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0476434 |
| GRAMD1B | GRAM domain containing 1B | 0.0470065 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0456866 |
| WWOX | WW domain containing oxidoreductase | 0.045454 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0449471 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0445652 |
| SMYD3 | SET and MYND domain containing 3 | 0.0437836 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0435447 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0427514 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0427029 |
| PTK2 | protein tyrosine kinase 2 | 0.0425372 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0422673 |
| SMAD3 | SMAD family member 3 | 0.0418673 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0411679 |
| DIAPH2 | diaphanous-related formin 2 | 0.0398278 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0397753 |
| PRKCA | protein kinase C, alpha | 0.0393533 |
| CAPRIN2 | caprin family member 2 | 0.0393031 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0392402 |
| ASPH | aspartate beta-hydroxylase | 0.03895 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0388583 |
| MT2A | metallothionein 2A | 0.0388441 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.038171 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0380695 |
| MSN | moesin | 0.03786 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0377347 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0370995 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0370206 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0354877 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0350807 |
| DNMBP | dynamin binding protein | 0.0342911 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0340401 |
| MAP1B | microtubule-associated protein 1B | 0.0339934 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0339863 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0337008 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0333351 |
| GPC5 | glypican 5 | 0.0333144 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0333075 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0332719 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0330994 |
| RAD51B | RAD51 paralog B | 0.033074 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0329138 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.032338 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0322493 |
| TPM3 | tropomyosin 3 | 0.031555 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0307784 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0306641 |
| DIAPH3 | diaphanous-related formin 3 | 0.0304763 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0304043 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0302702 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0301942 |
| INTS6 | integrator complex subunit 6 | 0.029744 |
| CDK6 | cyclin-dependent kinase 6 | 0.0297069 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0293929 |
| CEP128 | centrosomal protein 128kDa | 0.0290596 |
| SEPTIN9 | septin 9 | 0.0284742 |
| SVIL | supervillin | 0.0284136 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.028045 |
| MLPH | melanophilin | 0.0276789 |
| USP34 | ubiquitin specific peptidase 34 | 0.0276075 |
| ZNF638 | zinc finger protein 638 | 0.0275043 |
| RCOR1 | REST corepressor 1 | 0.02745 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0270281 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0269621 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0266726 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0266088 |
| EXOC4 | exocyst complex component 4 | 0.0265782 |
| EGFR | epidermal growth factor receptor | 0.0265349 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0264388 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.301625 |
| FN1 | fibronectin 1 | -0.256386 |
| VIM | vimentin | -0.146638 |
| NDRG1 | N-myc downstream regulated 1 | -0.145747 |
| TMSB10 | thymosin beta 10 | -0.113828 |
| EGR1 | early growth response 1 | -0.100305 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0958227 |
| CDH13 | cadherin 13 | -0.0857919 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.074041 |
| IGF2 | insulin-like growth factor 2 | -0.0734927 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0549216 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0534006 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0493014 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0485898 |
| INHBA | inhibin, beta A | -0.0476115 |
| LOX | lysyl oxidase | -0.0430694 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0407347 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0387015 |
| ACTG1 | actin gamma 1 | -0.0386238 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0381766 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0368142 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0359591 |
| RPL35A | ribosomal protein L35a | -0.0357793 |
| LAMB3 | laminin, beta 3 | -0.0333228 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0326607 |
| IER3 | immediate early response 3 | -0.0324377 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0323815 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0318248 |
| NGLY1 | N-glycanase 1 | -0.0315758 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0309422 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0309094 |
| WDR45B | WD repeat domain 45B | -0.0305337 |
| GNAS | GNAS complex locus | -0.0304221 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.029852 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0290489 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0283484 |
| RPL23 | ribosomal protein L23 | -0.0272637 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0271643 |
| ZNF292 | zinc finger protein 292 | -0.0262131 |
| LDHA | lactate dehydrogenase A | -0.0252733 |
| ADM | adrenomedullin | -0.0245607 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0240746 |
| GANAB | glucosidase, alpha; neutral AB | -0.0234012 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0229564 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0228973 |
| RTN4 | reticulon 4 | -0.0228859 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0228673 |
| RPLP1 | ribosomal protein, large, P1 | -0.0228172 |
| CD109 | CD109 molecule | -0.0225456 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0224237 |
| S100A6 | S100 calcium binding protein A6 | -0.0223358 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0222955 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0221122 |
| RPL34 | ribosomal protein L34 | -0.0219533 |
| TNNC1 | troponin C type 1 (slow) | -0.0218924 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0218402 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0214887 |
| RPS24 | ribosomal protein S24 | -0.0213946 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0213906 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.021353 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0213477 |
| PTMA | prothymosin, alpha | -0.0212167 |
| FAM13A | family with sequence similarity 13, member A | -0.0211294 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0210402 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0206052 |
| FLNB | filamin B, beta | -0.0204614 |
| COL5A1 | collagen, type V, alpha 1 | -0.0202997 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0199912 |
| CDCP1 | CUB domain containing protein 1 | -0.01989 |
| RPL30 | ribosomal protein L30 | -0.0198141 |
| OGA | O-GlcNAcase | -0.0192889 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0192095 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0190149 |
| USP3 | ubiquitin specific peptidase 3 | -0.0189743 |
| MMP12 | matrix metallopeptidase 12 | -0.0186892 |
| HPCAL1 | hippocalcin-like 1 | -0.0186883 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0186299 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0185444 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0181579 |
| RASA3 | RAS p21 protein activator 3 | -0.0181102 |
| MORF4L2 | mortality factor 4 like 2 | -0.0180104 |
| RACK1 | receptor for activated C kinase 1 | -0.0178696 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0176291 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0175985 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.01715 |
| JUN | jun proto-oncogene | -0.0171467 |
| KLF6 | Kruppel-like factor 6 | -0.0170091 |
| RPS19 | ribosomal protein S19 | -0.0168857 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0166793 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0166768 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.01664 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0166365 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0165918 |
| TRAM2 | translocation associated membrane protein 2 | -0.0165317 |
| RPLP0 | ribosomal protein, large, P0 | -0.0164497 |
| TMEM263 | transmembrane protein 263 | -0.0164173 |
| CCND1 | cyclin D1 | -0.0162918 |
| AGRN | agrin | -0.0162832 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0162469 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.016184 |
