| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.20224 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0998914 |
| CD44 | CD44 molecule (Indian blood group) | 0.0962521 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0836261 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0777244 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0763086 |
| HMGA2 | high mobility group AT-hook 2 | 0.0739813 |
| FN1 | fibronectin 1 | 0.0735607 |
| VIM | vimentin | 0.0718131 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0710832 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0706378 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0636153 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0623028 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0620817 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0619176 |
| SDC2 | syndecan 2 | 0.0575942 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0564622 |
| ATP13A3 | ATPase type 13A3 | 0.0531481 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0528162 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0518367 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0517759 |
| GLIS3 | GLIS family zinc finger 3 | 0.0513901 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0508084 |
| RASA2 | RAS p21 protein activator 2 | 0.0498926 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0492953 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.048759 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0480837 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0465961 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0451154 |
| PTK2 | protein tyrosine kinase 2 | 0.0449997 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0421465 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0421294 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0417133 |
| NAV2 | neuron navigator 2 | 0.0406126 |
| VEGFC | vascular endothelial growth factor C | 0.0396343 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0388356 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0384558 |
| VMP1 | vacuole membrane protein 1 | 0.0367835 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.036724 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0364179 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0354337 |
| TFG | TRK-fused gene | 0.0353102 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0348971 |
| CNTN5 | contactin 5 | 0.034527 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0344639 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0341442 |
| FAT1 | FAT atypical cadherin 1 | 0.0339304 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0333917 |
| MYO10 | myosin X | 0.0333833 |
| SPAG9 | sperm associated antigen 9 | 0.0330029 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0324644 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0316818 |
| MRTFA | myocardin related transcription factor A | 0.0316746 |
| MT2A | metallothionein 2A | 0.0312645 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0312211 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0310542 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0310338 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0309367 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0305814 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0302818 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0301525 |
| JAK2 | Janus kinase 2 | 0.0296154 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0291269 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0289275 |
| IL6ST | interleukin 6 signal transducer | 0.0289062 |
| JAK1 | Janus kinase 1 | 0.0288318 |
| SVIL | supervillin | 0.0281161 |
| VCL | vinculin | 0.0276921 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0273941 |
| JAG1 | jagged 1 | 0.02727 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0270618 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0270351 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0266396 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0265384 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.0263621 |
| HAS2 | hyaluronan synthase 2 | 0.0262271 |
| VCAN | versican | 0.0261839 |
| MED13L | mediator complex subunit 13-like | 0.0257695 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0256076 |
| SQLE | squalene epoxidase | 0.0254926 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0252926 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.025228 |
| ARRDC3 | arrestin domain containing 3 | 0.0249321 |
| SMAD3 | SMAD family member 3 | 0.0248111 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.024622 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0244852 |
| SP100 | SP100 nuclear antigen | 0.0243897 |
| JMJD1C | jumonji domain containing 1C | 0.0242881 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0241929 |
| ITGAV | integrin, alpha V | 0.0241721 |
| VEGFA | vascular endothelial growth factor A | 0.0240909 |
| ASPH | aspartate beta-hydroxylase | 0.0240809 |
| PCM1 | pericentriolar material 1 | 0.0240343 |
| TPM3 | tropomyosin 3 | 0.0236723 |
| MYO1B | myosin IB | 0.0235828 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0234133 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0233568 |
| CALU | calumenin | 0.0233457 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0233149 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0233069 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.303166 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.175483 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.154049 |
| COL1A1 | collagen, type I, alpha 1 | -0.12905 |
| COL5A1 | collagen, type V, alpha 1 | -0.109039 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0970864 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0937346 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0824845 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.077137 |
| TMSB10 | thymosin beta 10 | -0.0706404 |
| COL1A2 | collagen, type I, alpha 2 | -0.0644884 |
| AHNAK | AHNAK nucleoprotein | -0.0589198 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0576503 |
| FBN1 | fibrillin 1 | -0.0556743 |
| CDH13 | cadherin 13 | -0.0544508 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0498365 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0467768 |
| EGFR | epidermal growth factor receptor | -0.0446217 |
| COL7A1 | collagen, type VII, alpha 1 | -0.044311 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0426481 |
| CMIP | c-Maf inducing protein | -0.0395324 |
| CADM1 | cell adhesion molecule 1 | -0.0386249 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0378371 |
| OXR1 | oxidation resistance 1 | -0.0369074 |
| PRELID2 | PRELI domain containing 2 | -0.0362371 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0344542 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0343486 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0341664 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0329448 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.032798 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0324455 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0311232 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0309223 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0308922 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0305015 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0300935 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.029923 |
| SMYD3 | SET and MYND domain containing 3 | -0.0297884 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0292816 |
| BNC2 | basonuclin 2 | -0.0290827 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0284315 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0282076 |
| RUNX1 | runt-related transcription factor 1 | -0.0281645 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0274326 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0272783 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0271425 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0268973 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0262062 |
| LOXL2 | lysyl oxidase-like 2 | -0.0261401 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0259505 |
| FRMD4A | FERM domain containing 4A | -0.0258694 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0257877 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.024875 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0247979 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0247341 |
| BBX | bobby sox homolog (Drosophila) | -0.0243504 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0238273 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | -0.0237511 |
| GANAB | glucosidase, alpha; neutral AB | -0.0236001 |
| CA12 | carbonic anhydrase XII | -0.0235993 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0235808 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0234793 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0234515 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.023317 |
| EPHB1 | EPH receptor B1 | -0.0228609 |
| HM13 | histocompatibility (minor) 13 | -0.0228208 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.02263 |
| IER3 | immediate early response 3 | -0.0224421 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0215331 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0214955 |
| HLA-B | major histocompatibility complex, class I, B | -0.0214714 |
| ACTG1 | actin gamma 1 | -0.0211696 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0208421 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0207917 |
| NCKAP5 | NCK-associated protein 5 | -0.0207361 |
| CLMP | CXADR-like membrane protein | -0.020736 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0206427 |
| EHD2 | EH-domain containing 2 | -0.0205809 |
| ITGA11 | integrin, alpha 11 | -0.0203578 |
| RPL23 | ribosomal protein L23 | -0.0197404 |
| RRBP1 | ribosome binding protein 1 | -0.0197243 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.019684 |
| LMAN1 | lectin, mannose-binding, 1 | -0.019545 |
| RTN3 | reticulon 3 | -0.0194735 |
| ZMAT4 | zinc finger, matrin-type 4 | -0.0193978 |
| RNF220 | ring finger protein 220 | -0.0191117 |
| PDE10A | phosphodiesterase 10A | -0.0189625 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0189617 |
| S100A6 | S100 calcium binding protein A6 | -0.0188874 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0188659 |
| RPL35A | ribosomal protein L35a | -0.0185804 |
| SLC33A1 | solute carrier family 33 (acetyl-CoA transporter), member 1 | -0.0185616 |
| PRSS23 | protease, serine, 23 | -0.0184902 |
| INHBA | inhibin, beta A | -0.0182641 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0182613 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0181812 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0178962 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0177125 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0174532 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0172809 |
