Mitoxantrone (dihydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.297537
ERRFI1 ERBB receptor feedback inhibitor 1 0.201425
SAMD4A sterile alpha motif domain containing 4A 0.123176
DSPP dentin sialophosphoprotein 0.111674
PDLIM5 PDZ and LIM domain 5 0.0991538
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0981851
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0946149
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.09407
VCL vinculin 0.0784571
SVIL supervillin 0.0766439
DST dystonin 0.0763287
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0746646
FAM107B family with sequence similarity 107, member B 0.074629
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0740768
VMP1 vacuole membrane protein 1 0.0729227
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0725158
EXT1 exostosin glycosyltransferase 1 0.0714773
ITGAV integrin, alpha V 0.062945
GPC6 glypican 6 0.0586295
FAT1 FAT atypical cadherin 1 0.057021
LPP LIM domain containing preferred translocation partner in lipoma 0.0548674
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0541103
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0540894
DLC1 DLC1 Rho GTPase activating protein 0.0527408
SLC38A2 solute carrier family 38, member 2 0.0516773
TRIO trio Rho guanine nucleotide exchange factor 0.050769
LRMDA leucine rich melanocyte differentiation associated 0.0487557
LIMS1 LIM and senescent cell antigen-like domains 1 0.0486521
MAML2 mastermind-like 2 (Drosophila) 0.047661
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0465906
GK glycerol kinase 0.0463339
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0461661
MBNL2 muscleblind-like splicing regulator 2 0.0460904
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0460857
MYH9 myosin, heavy chain 9, non-muscle 0.0423718
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0417947
TPM1 tropomyosin 1 (alpha) 0.0409679
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0405124
CEMIP2 cell migration inducing hyaluronidase 2 0.0395982
ENAH enabled homolog (Drosophila) 0.0391966
MACF1 microtubule-actin crosslinking factor 1 0.0391484
ZNF644 zinc finger protein 644 0.0390756
RASA2 RAS p21 protein activator 2 0.0387117
PAWR PRKC, apoptosis, WT1, regulator 0.0386261
LMCD1 LIM and cysteine-rich domains 1 0.0385519
LCOR ligand dependent nuclear receptor corepressor 0.0379116
KYNU kynureninase 0.0378628
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0378432
DIAPH1 diaphanous-related formin 1 0.037463
FERMT2 fermitin family member 2 0.0373003
MBNL1 muscleblind-like splicing regulator 1 0.0358315
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0352708
KIF1B kinesin family member 1B 0.034499
AFF1 AF4/FMR2 family, member 1 0.0342651
GRB10 growth factor receptor-bound protein 10 0.0339184
ATXN1 ataxin 1 0.033804
WWC2 WW and C2 domain containing 2 0.0331268
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.031987
PALLD palladin, cytoskeletal associated protein 0.0319526
DOCK4 dedicator of cytokinesis 4 0.0318264
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0316288
C3 complement component 3 0.0315313
RAD51B RAD51 paralog B 0.0311693
STK17A serine/threonine kinase 17a 0.0305119
SDC4 syndecan 4 0.0301227
ELL2 elongation factor, RNA polymerase II, 2 0.0301014
FMNL2 formin-like 2 0.0294637
INTS6 integrator complex subunit 6 0.0294094
CLIC4 chloride intracellular channel 4 0.0293276
FILIP1L filamin A interacting protein 1-like 0.0288829
KRT23 keratin 23, type I 0.0284576
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0283142
TCIM transcriptional and immune response regulator 0.0280691
SEPTIN9 septin 9 0.0280281
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0278543
UBASH3B ubiquitin associated and SH3 domain containing B 0.0274706
NPAS2 neuronal PAS domain protein 2 0.0273017
MYO1E myosin IE 0.0272909
SMYD3 SET and MYND domain containing 3 0.0272436
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0267693
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0267166
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0266518
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0266091
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0265641
PICALM phosphatidylinositol binding clathrin assembly protein 0.0259072
DUSP16 dual specificity phosphatase 16 0.0257794
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0256355
APLP2 amyloid beta (A4) precursor-like protein 2 0.0255822
TMEM181 transmembrane protein 181 0.0254002
RAI14 retinoic acid induced 14 0.0251752
MCU mitochondrial calcium uniporter 0.0249313
SMAD3 SMAD family member 3 0.024743
USP34 ubiquitin specific peptidase 34 0.0246245
DNAH17 dynein, axonemal, heavy chain 17 0.0242867
CUL3 cullin 3 0.0240151
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0240122
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0239585
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0237069
KIZ kizuna centrosomal protein 0.0234431
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0232641

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.144886
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0869762
GPC3 glypican 3 -0.0793618
RPS24 ribosomal protein S24 -0.0767088
TMSB10 thymosin beta 10 -0.0666075
TM4SF1 transmembrane 4 L six family member 1 -0.058101
IGF2 insulin-like growth factor 2 -0.0578917
RPS6 ribosomal protein S6 -0.0573879
RPL37A ribosomal protein L37a -0.0556398
RPS19 ribosomal protein S19 -0.0551394
RPL35A ribosomal protein L35a -0.0531516
ZMYND8 zinc finger, MYND-type containing 8 -0.0508201
APOA2 apolipoprotein A-II -0.0484699
RPL23 ribosomal protein L23 -0.0475418
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.045496
AKAP12 A kinase (PRKA) anchor protein 12 -0.0442961
RPL34 ribosomal protein L34 -0.0438219
AHSG alpha-2-HS-glycoprotein -0.0433758
TRIM26 tripartite motif containing 26 -0.0417643
PTCHD4 patched domain containing 4 -0.040309
RPLP1 ribosomal protein, large, P1 -0.0402109
RPS8 ribosomal protein S8 -0.0397168
RPL9 ribosomal protein L9 -0.0395964
RPL31 ribosomal protein L31 -0.0385395
RPS21 ribosomal protein S21 -0.038255
AMBP alpha-1-microglobulin/bikunin precursor -0.0354895
CP ceruloplasmin (ferroxidase) -0.0354724
A2M alpha-2-macroglobulin -0.0340009
RPLP2 ribosomal protein, large, P2 -0.033747
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0331433
EML4 echinoderm microtubule associated protein like 4 -0.0328002
HMGA1 high mobility group AT-hook 1 -0.0327271
RPL11 ribosomal protein L11 -0.0326972
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0315786
RPL26 ribosomal protein L26 -0.0300696
RPS12 ribosomal protein S12 -0.0299644
PTMA prothymosin, alpha -0.0295842
LCN2 lipocalin 2 -0.0295066
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0293109
IGFBP1 insulin-like growth factor binding protein 1 -0.027363
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0268992
ISG15 ISG15 ubiquitin-like modifier -0.0268591
RPL37 ribosomal protein L37 -0.0268175
RPLP0 ribosomal protein, large, P0 -0.0264422
NDRG1 N-myc downstream regulated 1 -0.0262317
GDF15 growth differentiation factor 15 -0.0257734
RPS13 ribosomal protein S13 -0.0255913
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0250078
RPL38 ribosomal protein L38 -0.0247578
CTSB cathepsin B -0.0244186
OSMR oncostatin M receptor -0.0239911
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.023488
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0234826
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0234271
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0233332
TMEM51 transmembrane protein 51 -0.0229865
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0227119
HLA-A major histocompatibility complex, class I, A -0.0221145
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0219294
CRLS1 cardiolipin synthase 1 -0.0217329
RPS3 ribosomal protein S3 -0.0216912
GNAS GNAS complex locus -0.0215988
NPR2 natriuretic peptide receptor 2 -0.0211591
RPS29 ribosomal protein S29 -0.0210024
H3-3B H3.3 histone B -0.0206257
FBF1 Fas (TNFRSF6) binding factor 1 -0.0206112
SLC38A1 solute carrier family 38, member 1 -0.0204757
S100A9 S100 calcium binding protein A9 -0.0202954
IFI6 interferon, alpha-inducible protein 6 -0.0202057
RPS27A ribosomal protein S27a -0.0201628
RPL32 ribosomal protein L32 -0.0199985
FTL ferritin, light polypeptide -0.0198823
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0197998
APOE apolipoprotein E -0.0197157
NCOA7 nuclear receptor coactivator 7 -0.019365
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0192515
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0191339
MIDN midnolin -0.0191207
RNF213 ring finger protein 213 -0.0189694
IFI27 interferon, alpha-inducible protein 27 -0.0188764
KDM7A lysine (K)-specific demethylase 7A -0.0188609
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0187356
H1-0 H1.0 linker histone -0.0186993
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0185858
B2M beta-2-microglobulin -0.0184048
EGR1 early growth response 1 -0.0182032
RPL36A ribosomal protein L36a -0.0180043
RPS11 ribosomal protein S11 -0.0178984
RPS27L ribosomal protein S27-like -0.0177481
RNASET2 ribonuclease T2 -0.0175757
RPL30 ribosomal protein L30 -0.0174331
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0174094
RBM39 RNA binding motif protein 39 -0.0172389
RPS25 ribosomal protein S25 -0.0169138
RPL5 ribosomal protein L5 -0.0166413
S100A6 S100 calcium binding protein A6 -0.0165989
CFB complement factor B -0.0165899
COBLL1 cordon-bleu WH2 repeat protein-like 1 -0.0164625
INSR insulin receptor -0.0164334
PTPRF protein tyrosine phosphatase, receptor type, F -0.0162554