Mitoxantrone (dihydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.136691
PDE4D phosphodiesterase 4D, cAMP-specific 0.120094
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.11191
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0746066
PTK2 protein tyrosine kinase 2 0.073476
EXT1 exostosin glycosyltransferase 1 0.0672814
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0660481
HMGA2 high mobility group AT-hook 2 0.0644701
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.062345
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0621856
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.061016
MACF1 microtubule-actin crosslinking factor 1 0.0591881
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0519889
KLF5 Kruppel-like factor 5 (intestinal) 0.0488071
DST dystonin 0.0486227
ZSWIM6 zinc finger, SWIM-type containing 6 0.0481262
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0480131
INTS6 integrator complex subunit 6 0.047263
SIK3 SIK family kinase 3 0.0452879
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0426359
AKAP13 A kinase (PRKA) anchor protein 13 0.0422917
MT2A metallothionein 2A 0.0422793
BCAR3 breast cancer anti-estrogen resistance 3 0.0422145
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0391587
RASAL2 RAS protein activator like 2 0.037211
FNDC3B fibronectin type III domain containing 3B 0.0371823
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0366372
HDAC9 histone deacetylase 9 0.0342753
SLC35F3 solute carrier family 35, member F3 0.033784
RAI14 retinoic acid induced 14 0.0336888
IFI44L interferon-induced protein 44-like 0.033657
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.032028
HSPH1 heat shock 105kDa/110kDa protein 1 0.0320095
RNF217 ring finger protein 217 0.0317142
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0308431
JMJD1C jumonji domain containing 1C 0.0297815
SVIL supervillin 0.028774
EFNA5 ephrin-A5 0.0287197
ASPH aspartate beta-hydroxylase 0.0285562
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.028551
ALCAM activated leukocyte cell adhesion molecule 0.0282493
PDLIM5 PDZ and LIM domain 5 0.0280731
DOK5 docking protein 5 0.0280018
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0278515
ANO1 anoctamin 1, calcium activated chloride channel 0.027786
HSPA8 heat shock 70kDa protein 8 0.027745
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0272716
MBNL2 muscleblind-like splicing regulator 2 0.0264994
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.026152
PSD3 pleckstrin and Sec7 domain containing 3 0.0261114
DPYD dihydropyrimidine dehydrogenase 0.0253203
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0252738
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0246501
SLK STE20-like kinase 0.024604
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0243405
ANKRD28 ankyrin repeat domain 28 0.0241189
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0239464
DGKH diacylglycerol kinase, eta 0.0238437
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0238171
DSPP dentin sialophosphoprotein 0.0235811
TPT1 tumor protein, translationally-controlled 1 0.0233741
MKI67 marker of proliferation Ki-67 0.023341
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0231661
SP100 SP100 nuclear antigen 0.0231376
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0229218
ARHGAP21 Rho GTPase activating protein 21 0.0226498
RIGI RNA sensor RIG-I 0.0225365
LRP1B low density lipoprotein receptor-related protein 1B 0.0225107
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0223823
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0223539
PRSS23 protease, serine, 23 0.0223528
LPP LIM domain containing preferred translocation partner in lipoma 0.0216611
FRMD6 FERM domain containing 6 0.0215206
ESYT2 extended synaptotagmin-like protein 2 0.0214853
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0214519
PEAK1 pseudopodium-enriched atypical kinase 1 0.0214496
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.021422
MED13L mediator complex subunit 13-like 0.0212438
HAS2 hyaluronan synthase 2 0.0212212
MTAP methylthioadenosine phosphorylase 0.0210584
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0209384
EPS8 epidermal growth factor receptor pathway substrate 8 0.0206716
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0206529
UTRN utrophin 0.0205688
IPO7 importin 7 0.0203833
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0202944
MAML3 mastermind-like 3 (Drosophila) 0.0202777
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0201181
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0200431
VEGFC vascular endothelial growth factor C 0.0199141
TXNIP thioredoxin interacting protein 0.0196497
SPIRE1 spire-type actin nucleation factor 1 0.0195882
TSC22D1 TSC22 domain family, member 1 0.0193974
FNIP1 folliculin interacting protein 1 0.0193634
LAMA4 laminin, alpha 4 0.0193234
CALB1 calbindin 1, 28kDa 0.019272
CSNK1A1 casein kinase 1, alpha 1 0.0192559
TENM4 teneurin transmembrane protein 4 0.0192143
MBNL1 muscleblind-like splicing regulator 1 0.0191915
BARX2 BARX homeobox 2 0.0191624

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.22124
NDRG1 N-myc downstream regulated 1 -0.183057
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.089632
CEMIP cell migration inducing protein, hyaluronan binding -0.0795676
EMP1 epithelial membrane protein 1 -0.0726685
LOC112694756 uncharaterized LOC112694756 -0.0714594
NAMPT nicotinamide phosphoribosyltransferase -0.0672516
UBC ubiquitin C -0.0664666
ANXA2 annexin A2 -0.0660811
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0642469
LDHA lactate dehydrogenase A -0.0624479
KRT17 keratin 17, type I -0.0622519
TMSB10 thymosin beta 10 -0.0605955
AHNAK AHNAK nucleoprotein -0.0605568
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0599114
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0557942
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0557739
PGK1 phosphoglycerate kinase 1 -0.0557701
BCL2L1 BCL2-like 1 -0.0549343
ENO1 enolase 1, (alpha) -0.0538392
ANKRD33B ankyrin repeat domain 33B -0.0527763
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0515776
RBM39 RNA binding motif protein 39 -0.0510048
CALU calumenin -0.0499307
FSCN1 fascin actin-bundling protein 1 -0.0494191
HM13 histocompatibility (minor) 13 -0.0491461
FLNA filamin A, alpha -0.0480451
SEC31A SEC31 homolog A (S. cerevisiae) -0.0479944
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0467407
FOXO1 forkhead box O1 -0.0461746
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0461715
NRG1 neuregulin 1 -0.0461013
SULF1 sulfatase 1 -0.0457995
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0451936
HSPG2 heparan sulfate proteoglycan 2 -0.043464
POTEF POTE ankyrin domain family, member F -0.0434598
OSMR oncostatin M receptor -0.0424329
NEK7 NIMA-related kinase 7 -0.0422115
COPA coatomer protein complex, subunit alpha -0.041789
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0411144
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0391959
CANX calnexin -0.0385218
ITCH itchy E3 ubiquitin protein ligase -0.0379456
H1-0 H1.0 linker histone -0.0378898
NCOA3 nuclear receptor coactivator 3 -0.0378689
ACTN4 actinin, alpha 4 -0.0378397
CD99 CD99 molecule -0.0375191
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0374155
OGA O-GlcNAcase -0.0372511
LMAN1 lectin, mannose-binding, 1 -0.0363765
SLC45A4 solute carrier family 45, member 4 -0.0361908
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0354136
GARS1 glycyl-tRNA synthetase 1 -0.0350289
COPB1 coatomer protein complex, subunit beta 1 -0.0349905
PODXL podocalyxin-like -0.0344621
STC1 stanniocalcin 1 -0.034321
PLAT plasminogen activator, tissue -0.0342646
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0340355
TRIO trio Rho guanine nucleotide exchange factor -0.0336513
LDLR low density lipoprotein receptor -0.0334986
GOLGA4 golgin A4 -0.033187
EPHA2 EPH receptor A2 -0.0326787
CUL4B cullin 4B -0.0321291
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0321079
DUSP6 dual specificity phosphatase 6 -0.031884
MORF4L2 mortality factor 4 like 2 -0.0317197
ITGA6 integrin, alpha 6 -0.0315285
RIN2 Ras and Rab interactor 2 -0.0304411
PTMA prothymosin, alpha -0.0302497
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0300323
NPEPPS aminopeptidase puromycin sensitive -0.0297245
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0293211
MARCHF6 membrane associated ring-CH-type finger 6 -0.0292147
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0288293
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0287484
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.028626
MEF2A myocyte enhancer factor 2A -0.0284306
PKM pyruvate kinase, muscle -0.0283376
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0282694
LAMA5 laminin, alpha 5 -0.0280979
HDLBP high density lipoprotein binding protein -0.0277739
SERINC3 serine incorporator 3 -0.0274059
SQLE squalene epoxidase -0.0270333
CD9 CD9 molecule -0.0267909
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0266811
ARF4 ADP-ribosylation factor 4 -0.026403
TPM4 tropomyosin 4 -0.0263613
WASF2 WAS protein family, member 2 -0.02617
RAB22A RAB22A, member RAS oncogene family -0.026072
SDCBP syndecan binding protein (syntenin) -0.0259271
ITSN1 intersectin 1 (SH3 domain protein) -0.0256328
CAVIN1 caveolae associated protein 1 -0.0252238
SRP54 signal recognition particle 54kDa -0.0251968
GOLGA2 golgin A2 -0.0249838
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0249113
EGR1 early growth response 1 -0.0249057
CAPN2 calpain 2, (m/II) large subunit -0.024778
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0247146
COL17A1 collagen, type XVII, alpha 1 -0.0246715
NLRP1 NLR family, pyrin domain containing 1 -0.0244935