Mitoxantrone (dihydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.0952497
TRIO trio Rho guanine nucleotide exchange factor 0.0787324
INTS6 integrator complex subunit 6 0.0719615
ZSWIM6 zinc finger, SWIM-type containing 6 0.0509935
DST dystonin 0.0448666
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0432882
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0410334
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0404786
NAV2 neuron navigator 2 0.0399908
PDLIM5 PDZ and LIM domain 5 0.0392805
FNDC3B fibronectin type III domain containing 3B 0.0390015
ASPH aspartate beta-hydroxylase 0.0374017
ERBIN erbb2 interacting protein 0.0366657
TLE4 transducin-like enhancer of split 4 0.0357979
MYH9 myosin, heavy chain 9, non-muscle 0.0342983
PTK2 protein tyrosine kinase 2 0.0316731
LPP LIM domain containing preferred translocation partner in lipoma 0.0316437
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0295699
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0295553
SMYD3 SET and MYND domain containing 3 0.0271941
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.027001
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0268522
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0261527
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0259105
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0256754
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0255807
SMAD3 SMAD family member 3 0.0254461
PICALM phosphatidylinositol binding clathrin assembly protein 0.0250888
RAD51B RAD51 paralog B 0.0249743
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0247727
VCL vinculin 0.0245233
SLIT2 slit homolog 2 (Drosophila) 0.0245075
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0239771
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0229993
PRELID2 PRELI domain containing 2 0.0226257
RUNX1 runt-related transcription factor 1 0.0223843
MACF1 microtubule-actin crosslinking factor 1 0.0222487
DOCK5 dedicator of cytokinesis 5 0.0217681
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0216786
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0216045
VEGFC vascular endothelial growth factor C 0.0215575
PTPRM protein tyrosine phosphatase, receptor type, M 0.0212903
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0210952
ATXN1 ataxin 1 0.0210172
EFNA5 ephrin-A5 0.0209043
NALF1 NALCN channel auxiliary factor 1 0.0205051
SAMD4A sterile alpha motif domain containing 4A 0.0203978
RIGI RNA sensor RIG-I 0.0203068
WWOX WW domain containing oxidoreductase 0.0201203
FRMD6 FERM domain containing 6 0.0195746
NABP1 nucleic acid binding protein 1 0.0193175
IGF1R insulin-like growth factor 1 receptor 0.0189547
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0188191
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0186716
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0179182
EGFR epidermal growth factor receptor 0.0178855
PTPRG protein tyrosine phosphatase, receptor type, G 0.0178721
TBC1D5 TBC1 domain family, member 5 0.0178373
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0178224
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0177008
TENM3 teneurin transmembrane protein 3 0.0176988
NRIP1 nuclear receptor interacting protein 1 0.0175167
LRMDA leucine rich melanocyte differentiation associated 0.017435
JARID2 jumonji, AT rich interactive domain 2 0.0174002
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0173434
DENND1A DENN/MADD domain containing 1A 0.0173191
PDE4D phosphodiesterase 4D, cAMP-specific 0.0169856
CALD1 caldesmon 1 0.0168566
EXOC4 exocyst complex component 4 0.0168318
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0167869
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0166772
FHIT fragile histidine triad 0.0165227
GLIS3 GLIS family zinc finger 3 0.0164422
PLSCR1 phospholipid scramblase 1 0.0163557
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0162907
CLIC4 chloride intracellular channel 4 0.016156
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0158166
HSPH1 heat shock 105kDa/110kDa protein 1 0.0156615
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0156061
AKAP13 A kinase (PRKA) anchor protein 13 0.0154227
HSPA8 heat shock 70kDa protein 8 0.0153721
MED13L mediator complex subunit 13-like 0.0153158
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0152816
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0152384
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.0151882
MBNL1 muscleblind-like splicing regulator 1 0.015092
BCAR3 breast cancer anti-estrogen resistance 3 0.0149102
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.014547
SEPTIN9 septin 9 0.0145461
KLF12 Kruppel-like factor 12 0.0144862
CUX1 cut-like homeobox 1 0.0143796
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0142197
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0142009
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0141302
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0141038
LMO7 LIM domain 7 0.0140997
RSU1 Ras suppressor protein 1 0.0139796
VMP1 vacuole membrane protein 1 0.01389
TAS2R14 taste receptor, type 2, member 14 0.0138166
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0138164

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.232213
HLA-B major histocompatibility complex, class I, B -0.188179
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.145442
MT2A metallothionein 2A -0.11322
FTL ferritin, light polypeptide -0.110601
MT1X metallothionein 1X -0.0813492
NDRG1 N-myc downstream regulated 1 -0.0804028
IGFBP3 insulin-like growth factor binding protein 3 -0.0784624
FN1 fibronectin 1 -0.0780794
B2M beta-2-microglobulin -0.0734231
TMSB10 thymosin beta 10 -0.0686256
POTEF POTE ankyrin domain family, member F -0.0654722
FTH1 ferritin, heavy polypeptide 1 -0.0654536
ABI3BP ABI family, member 3 (NESH) binding protein -0.0646565
ENO1 enolase 1, (alpha) -0.063376
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0572555
DEK DEK proto-oncogene -0.0569287
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0555045
HLA-A major histocompatibility complex, class I, A -0.0551612
CALR calreticulin -0.0528173
LDHA lactate dehydrogenase A -0.0479325
LOC112694756 uncharaterized LOC112694756 -0.0470713
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0468107
UGCG UDP-glucose ceramide glucosyltransferase -0.0455735
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0422237
PFN1 profilin 1 -0.0419086
PTMA prothymosin, alpha -0.0397379
IFI6 interferon, alpha-inducible protein 6 -0.0395244
TPI1 triosephosphate isomerase 1 -0.0387615
VIM vimentin -0.037488
TMSB4X thymosin beta 4, X-linked -0.0366569
RPL35A ribosomal protein L35a -0.0365544
UBC ubiquitin C -0.036472
S100A6 S100 calcium binding protein A6 -0.0346784
RPS6 ribosomal protein S6 -0.0340371
CTSD cathepsin D -0.0327586
F3 coagulation factor III (thromboplastin, tissue factor) -0.0326994
HLA-E major histocompatibility complex, class I, E -0.0324278
GNAS GNAS complex locus -0.032295
TUBB tubulin, beta class I -0.0316327
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0311754
PDIA3 protein disulfide isomerase family A, member 3 -0.0309416
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0307823
ADM adrenomedullin -0.0302271
GOLGA4 golgin A4 -0.0301808
ATP13A3 ATPase type 13A3 -0.0296715
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0296551
RPL23 ribosomal protein L23 -0.029225
PGK1 phosphoglycerate kinase 1 -0.029153
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0291168
POSTN periostin, osteoblast specific factor -0.0285008
RPLP2 ribosomal protein, large, P2 -0.0284712
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0284516
KPNB1 karyopherin (importin) beta 1 -0.0281215
NAMPT nicotinamide phosphoribosyltransferase -0.0275244
PKM pyruvate kinase, muscle -0.0267993
DLG1 discs, large homolog 1 (Drosophila) -0.0264108
IFITM3 interferon induced transmembrane protein 3 -0.0257432
TPT1 tumor protein, translationally-controlled 1 -0.0255372
RPL12 ribosomal protein L12 -0.025117
S100A10 S100 calcium binding protein A10 -0.0245111
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0244989
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0238322
ANXA2 annexin A2 -0.0237282
LMAN1 lectin, mannose-binding, 1 -0.0235068
MYL12B myosin, light chain 12B, regulatory -0.0234082
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0232245
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0230898
MKI67 marker of proliferation Ki-67 -0.0230871
BZW1 basic leucine zipper and W2 domains 1 -0.0228852
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0226254
HMGB2 high mobility group box 2 -0.0225925
OSMR oncostatin M receptor -0.0217887
EIF1 eukaryotic translation initiation factor 1 -0.021787
RPS13 ribosomal protein S13 -0.0217317
PTPRF protein tyrosine phosphatase, receptor type, F -0.0216288
HMGB1 high mobility group box 1 -0.0215833
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0210654
TUBB4B tubulin, beta 4B class IVb -0.0210573
RPL26 ribosomal protein L26 -0.0208605
CCNL1 cyclin L1 -0.0207933
TXNRD1 thioredoxin reductase 1 -0.0206023
RPS19 ribosomal protein S19 -0.0204995
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0204803
RAD21 RAD21 homolog (S. pombe) -0.0203262
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0201867
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0200211
RPL35 ribosomal protein L35 -0.0199779
AHNAK AHNAK nucleoprotein -0.019711
IFI27 interferon, alpha-inducible protein 27 -0.0192723
PLIN2 perilipin 2 -0.0191808
CBX3 chromobox homolog 3 -0.0191549
TAGLN2 transgelin 2 -0.0191384
RPLP1 ribosomal protein, large, P1 -0.0189631
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0188964
CCDC80 coiled-coil domain containing 80 -0.0187628
RPL19 ribosomal protein L19 -0.0187528
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0186529
KRT7 keratin 7, type II -0.0183849
TUBA1B tubulin, alpha 1b -0.0182387