Mitoxantrone (dihydrochloride)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.159634
DTNA dystrobrevin, alpha 0.0968688
LSAMP limbic system-associated membrane protein 0.0919446
TRIO trio Rho guanine nucleotide exchange factor 0.0868669
NALF1 NALCN channel auxiliary factor 1 0.0834825
PBX3 pre-B-cell leukemia homeobox 3 0.066878
ASPH aspartate beta-hydroxylase 0.0621874
RUNX1 runt-related transcription factor 1 0.061381
MSN moesin 0.057631
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0567061
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0564436
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0547864
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0519372
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0516034
HMGA2 high mobility group AT-hook 2 0.0510301
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0507055
MYO10 myosin X 0.0498649
DST dystonin 0.048098
FMNL2 formin-like 2 0.0438385
EXT1 exostosin glycosyltransferase 1 0.0437367
ZSWIM6 zinc finger, SWIM-type containing 6 0.0422958
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.042139
USP34 ubiquitin specific peptidase 34 0.0413744
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0408185
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0407287
APLP2 amyloid beta (A4) precursor-like protein 2 0.0404207
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0393414
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0392281
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0381366
HDAC9 histone deacetylase 9 0.0376292
MCL1 myeloid cell leukemia 1 0.0349076
ZNF638 zinc finger protein 638 0.0347984
MACF1 microtubule-actin crosslinking factor 1 0.0345732
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0342188
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0336086
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0333943
ERRFI1 ERBB receptor feedback inhibitor 1 0.0331475
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0318398
UBA6 ubiquitin-like modifier activating enzyme 6 0.0315615
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0308988
PICALM phosphatidylinositol binding clathrin assembly protein 0.0305324
FNDC3B fibronectin type III domain containing 3B 0.030145
CD109 CD109 molecule 0.029874
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.029784
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0294407
ANO6 anoctamin 6 0.0293884
GPC6 glypican 6 0.0292387
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0291323
PRKG1 protein kinase, cGMP-dependent, type I 0.0283814
ZCCHC7 zinc finger, CCHC domain containing 7 0.0280337
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0278961
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0275069
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0272626
FNIP1 folliculin interacting protein 1 0.0269588
INTS6 integrator complex subunit 6 0.0268686
FAT1 FAT atypical cadherin 1 0.0268577
GPHN gephyrin 0.0267894
PTK2 protein tyrosine kinase 2 0.0265934
PCBP2 poly(rC) binding protein 2 0.0265273
VMP1 vacuole membrane protein 1 0.0260304
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0256015
MED13L mediator complex subunit 13-like 0.0254979
AKAP12 A kinase (PRKA) anchor protein 12 0.0253745
ARHGAP21 Rho GTPase activating protein 21 0.025287
JUN jun proto-oncogene 0.0252454
KDM4C lysine (K)-specific demethylase 4C 0.025128
SAMD4A sterile alpha motif domain containing 4A 0.0249648
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.024957
JARID2 jumonji, AT rich interactive domain 2 0.0246118
SSH2 slingshot protein phosphatase 2 0.0246044
HSPA8 heat shock 70kDa protein 8 0.0244494
ESYT2 extended synaptotagmin-like protein 2 0.0241158
PRKCE protein kinase C, epsilon 0.0241078
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0236864
MYH9 myosin, heavy chain 9, non-muscle 0.0233416
PTPRD protein tyrosine phosphatase, receptor type, D 0.0231566
CDH13 cadherin 13 0.0228098
AKAP13 A kinase (PRKA) anchor protein 13 0.0227405
CD44 CD44 molecule (Indian blood group) 0.0227096
TPM3 tropomyosin 3 0.0226624
EGR1 early growth response 1 0.0226432
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0225548
GRAMD1B GRAM domain containing 1B 0.0225543
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.02225
LIMCH1 LIM and calponin homology domains 1 0.0217273
TENM2 teneurin transmembrane protein 2 0.0214615
RND3 Rho family GTPase 3 0.0212673
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0210175
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0210035
TTC3 tetratricopeptide repeat domain 3 0.020898
JMJD1C jumonji domain containing 1C 0.0208889
EXOC4 exocyst complex component 4 0.0208378
KDM2A lysine (K)-specific demethylase 2A 0.0207057
YAP1 Yes-associated protein 1 0.0206442
RAD51B RAD51 paralog B 0.0206345
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.020324
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0203036
ITGA6 integrin, alpha 6 0.020136
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0199451
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0195738

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.495823
VIM vimentin -0.202832
TMSB10 thymosin beta 10 -0.168505
RPS6 ribosomal protein S6 -0.109288
ACTG1 actin gamma 1 -0.101693
VCL vinculin -0.101418
PTMA prothymosin, alpha -0.0946758
AHNAK AHNAK nucleoprotein -0.0909148
TPT1 tumor protein, translationally-controlled 1 -0.0883909
MT2A metallothionein 2A -0.0808721
RPL23 ribosomal protein L23 -0.0793272
ADAM19 ADAM metallopeptidase domain 19 -0.0691351
RPL12 ribosomal protein L12 -0.0683634
LOC112694756 uncharaterized LOC112694756 -0.0667813
RAD21 RAD21 homolog (S. pombe) -0.064257
RPL35A ribosomal protein L35a -0.0632739
RPLP1 ribosomal protein, large, P1 -0.0615316
FTL ferritin, light polypeptide -0.0612285
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0545352
RPS19 ribosomal protein S19 -0.0534171
RPLP0 ribosomal protein, large, P0 -0.0532267
EIF1 eukaryotic translation initiation factor 1 -0.0525573
CTSB cathepsin B -0.052246
RPL11 ribosomal protein L11 -0.0498347
CAVIN1 caveolae associated protein 1 -0.0486071
RPLP2 ribosomal protein, large, P2 -0.0485158
RPL26 ribosomal protein L26 -0.0474987
OSMR oncostatin M receptor -0.0470279
RPS24 ribosomal protein S24 -0.0459475
RPS3 ribosomal protein S3 -0.0453425
CFAP251 cilia and flagella associated protein 251 -0.0442273
RPL30 ribosomal protein L30 -0.0437908
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.043329
RPL19 ribosomal protein L19 -0.0432278
RPL8 ribosomal protein L8 -0.0431271
RPS13 ribosomal protein S13 -0.0423755
LDHA lactate dehydrogenase A -0.0419396
RPL34 ribosomal protein L34 -0.0418298
RPS8 ribosomal protein S8 -0.0414227
RPS20 ribosomal protein S20 -0.0409577
NPC1 Niemann-Pick disease, type C1 -0.0408359
GNAS GNAS complex locus -0.0397068
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0396739
RPS27A ribosomal protein S27a -0.0395756
RPL31 ribosomal protein L31 -0.0393385
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0375217
RPL37A ribosomal protein L37a -0.0369367
RPL32 ribosomal protein L32 -0.0366854
ENKUR enkurin, TRPC channel interacting protein -0.0359746
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0359478
BTG1 B-cell translocation gene 1, anti-proliferative -0.035821
RACK1 receptor for activated C kinase 1 -0.0354425
RPL38 ribosomal protein L38 -0.0351893
RPS25 ribosomal protein S25 -0.0350716
NTM neurotrimin -0.0349675
CALD1 caldesmon 1 -0.0342786
H1-0 H1.0 linker histone -0.03425
CDK17 cyclin-dependent kinase 17 -0.0342042
IFI16 interferon, gamma-inducible protein 16 -0.0323473
RPS4X ribosomal protein S4, X-linked -0.0320269
RPL36A ribosomal protein L36a -0.0319842
RPL36 ribosomal protein L36 -0.0318824
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0316928
RPL37 ribosomal protein L37 -0.0311284
RPS21 ribosomal protein S21 -0.0307988
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0306306
TPM4 tropomyosin 4 -0.0302793
KLF6 Kruppel-like factor 6 -0.0301674
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0296167
RPL27A ribosomal protein L27a -0.0293961
KDM3A lysine (K)-specific demethylase 3A -0.0292191
BMAL2 basic helix-loop-helix ARNT like 2 -0.0286169
ALCAM activated leukocyte cell adhesion molecule -0.0285879
RPL5 ribosomal protein L5 -0.028177
WSB1 WD repeat and SOCS box containing 1 -0.0281017
RPS23 ribosomal protein S23 -0.0276711
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0276401
RPL13A ribosomal protein L13a -0.0268325
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0268195
RPS14 ribosomal protein S14 -0.02675
RPL35 ribosomal protein L35 -0.0265465
PCNX4 pecanex 4 -0.0256658
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0256022
ANXA2 annexin A2 -0.0254922
KYNU kynureninase -0.0253126
PGK1 phosphoglycerate kinase 1 -0.0251223
RPS16 ribosomal protein S16 -0.024843
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0246631
KPNB1 karyopherin (importin) beta 1 -0.0246018
HLA-E major histocompatibility complex, class I, E -0.0244382
EMP1 epithelial membrane protein 1 -0.024426
TM4SF1 transmembrane 4 L six family member 1 -0.024376
TPI1 triosephosphate isomerase 1 -0.0234002
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0232277
GLMN glomulin, FKBP associated protein -0.0226062
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0225887
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.022398
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0223929
RPS12 ribosomal protein S12 -0.0223136
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0222555