Mitoxantrone (dihydrochloride)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.233458
LMO7 LIM domain 7 0.114118
GMDS GDP-mannose 4,6-dehydratase 0.111382
FAT1 FAT atypical cadherin 1 0.111084
MYO1E myosin IE 0.0992756
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0977701
ASPH aspartate beta-hydroxylase 0.0842404
CEMIP cell migration inducing protein, hyaluronan binding 0.076063
EXT1 exostosin glycosyltransferase 1 0.0743345
PDLIM5 PDZ and LIM domain 5 0.0608157
VCL vinculin 0.0589325
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0586002
EPS8 epidermal growth factor receptor pathway substrate 8 0.0581096
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0578115
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0559899
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0518684
ANTXR2 anthrax toxin receptor 2 0.049024
ALCAM activated leukocyte cell adhesion molecule 0.0474337
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0462254
MACF1 microtubule-actin crosslinking factor 1 0.0461686
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0455506
MBNL1 muscleblind-like splicing regulator 1 0.0446988
PARD3B par-3 family cell polarity regulator beta 0.0444664
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0443707
SMYD3 SET and MYND domain containing 3 0.0432883
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0420282
LPP LIM domain containing preferred translocation partner in lipoma 0.0418868
MED13 mediator complex subunit 13 0.0416701
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0407627
SMAD2 SMAD family member 2 0.040298
AKAP13 A kinase (PRKA) anchor protein 13 0.0394829
MUC13 mucin 13, cell surface associated 0.0381017
CD44 CD44 molecule (Indian blood group) 0.0380455
CADPS Ca++-dependent secretion activator 0.0375158
MYO5B myosin VB 0.0373351
ARHGAP32 Rho GTPase activating protein 32 0.0368621
VMP1 vacuole membrane protein 1 0.0366813
CCSER1 coiled-coil serine-rich protein 1 0.0366462
GPHN gephyrin 0.0364304
TRIM2 tripartite motif containing 2 0.0355421
PDZD8 PDZ domain containing 8 0.0350429
SLC38A2 solute carrier family 38, member 2 0.0342308
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0338083
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0336494
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0334792
NEBL nebulette 0.033411
CENPF centromere protein F, 350/400kDa 0.0323565
NRXN3 neurexin 3 0.0322879
ECT2 epithelial cell transforming 2 0.0322019
PTPRK protein tyrosine phosphatase, receptor type, K 0.0322003
ITPRID2 ITPR interacting domain containing 2 0.031924
PTBP3 polypyrimidine tract binding protein 3 0.0318201
ITGA6 integrin, alpha 6 0.0317439
ARHGAP26 Rho GTPase activating protein 26 0.0316115
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0315717
PELI1 pellino E3 ubiquitin protein ligase 1 0.030965
MYH9 myosin, heavy chain 9, non-muscle 0.0304083
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.030268
FBXL17 F-box and leucine-rich repeat protein 17 0.0302647
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0302541
KLF5 Kruppel-like factor 5 (intestinal) 0.0301504
SAMD5 sterile alpha motif domain containing 5 0.0299648
ANKRD17 ankyrin repeat domain 17 0.0298788
ARHGAP21 Rho GTPase activating protein 21 0.0294578
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.029083
UBE2H ubiquitin-conjugating enzyme E2H 0.028625
PRELID2 PRELI domain containing 2 0.0280643
FOXP1 forkhead box P1 0.0280562
AFF1 AF4/FMR2 family, member 1 0.0277653
DIAPH2 diaphanous-related formin 2 0.0276227
TSC22D1 TSC22 domain family, member 1 0.0275457
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0273659
CTBP2 C-terminal binding protein 2 0.0272868
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0271616
ZNF644 zinc finger protein 644 0.0271555
LURAP1L leucine rich adaptor protein 1-like 0.0268847
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0266072
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.026494
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.026438
ERRFI1 ERBB receptor feedback inhibitor 1 0.0258566
TGFBR3 transforming growth factor, beta receptor III 0.0258214
FHIT fragile histidine triad 0.0258073
ARHGAP42 Rho GTPase activating protein 42 0.0256555
AREG amphiregulin 0.0256514
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0247695
USP6NL USP6 N-terminal like 0.0246582
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0244524
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.024061
PALLD palladin, cytoskeletal associated protein 0.0240489
ATXN1 ataxin 1 0.0238025
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0237873
USP53 ubiquitin specific peptidase 53 0.0235086
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0234588
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0230798
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0229832
JMJD1C jumonji domain containing 1C 0.022881
WNK1 WNK lysine deficient protein kinase 1 0.02286
FAF1 Fas (TNFRSF6) associated factor 1 0.0224004
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0223885
RAD51B RAD51 paralog B 0.0223687

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108347
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.105533
TMSB10 thymosin beta 10 -0.0973799
NDRG1 N-myc downstream regulated 1 -0.0938239
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0877431
S100A6 S100 calcium binding protein A6 -0.0634292
KRT8 keratin 8, type II -0.0619586
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0609082
RPS6 ribosomal protein S6 -0.0593499
TPT1 tumor protein, translationally-controlled 1 -0.0583047
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0570423
NPSR1 neuropeptide S receptor 1 -0.0555506
ONECUT3 one cut homeobox 3 -0.0505122
RPS19 ribosomal protein S19 -0.0470044
GDF15 growth differentiation factor 15 -0.0458226
KRT19 keratin 19, type I -0.0439718
GCC2 GRIP and coiled-coil domain containing 2 -0.041284
TNS4 tensin 4 -0.040717
FLNB filamin B, beta -0.0389443
LOC112694756 uncharaterized LOC112694756 -0.0370946
RPL23 ribosomal protein L23 -0.0370554
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0364006
ITGB4 integrin, beta 4 -0.0355344
PKM pyruvate kinase, muscle -0.0355144
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0348055
CDPF1 cysteine-rich, DPF motif domain containing 1 -0.0340924
AGR2 anterior gradient 2 -0.0339987
RPL35A ribosomal protein L35a -0.0332578
AHNAK AHNAK nucleoprotein -0.0316985
RPLP1 ribosomal protein, large, P1 -0.0301756
B2M beta-2-microglobulin -0.029593
ANXA2 annexin A2 -0.0291132
S100P S100 calcium binding protein P -0.0283749
RPS8 ribosomal protein S8 -0.0281581
KRT18 keratin 18, type I -0.02809
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0278309
CALR calreticulin -0.0276019
GNAS GNAS complex locus -0.0270579
RPS12 ribosomal protein S12 -0.0268986
RPS27 ribosomal protein S27 -0.0259185
ACTN4 actinin, alpha 4 -0.0257273
FTH1 ferritin, heavy polypeptide 1 -0.0253897
LDHA lactate dehydrogenase A -0.0249947
RPL9 ribosomal protein L9 -0.0246912
RPL26 ribosomal protein L26 -0.0244744
RPS27L ribosomal protein S27-like -0.0242788
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0240408
COL17A1 collagen, type XVII, alpha 1 -0.023586
BACE2 beta-site APP-cleaving enzyme 2 -0.023189
POTEF POTE ankyrin domain family, member F -0.022863
PDIA3 protein disulfide isomerase family A, member 3 -0.022734
MAML2 mastermind-like 2 (Drosophila) -0.0227271
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0225372
CALB1 calbindin 1, 28kDa -0.0219165
WDR45B WD repeat domain 45B -0.0218916
TBC1D22A TBC1 domain family, member 22A -0.0218865
KIAA1217 KIAA1217 -0.0218399
LMNA lamin A/C -0.021589
RPL34 ribosomal protein L34 -0.0215484
RPS24 ribosomal protein S24 -0.0212406
ESYT2 extended synaptotagmin-like protein 2 -0.0211656
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0210135
RPL37A ribosomal protein L37a -0.0207165
IFI27 interferon, alpha-inducible protein 27 -0.0199317
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0194973
BTG1 B-cell translocation gene 1, anti-proliferative -0.0192891
HSPG2 heparan sulfate proteoglycan 2 -0.0189149
RPL31 ribosomal protein L31 -0.0187072
EPHA2 EPH receptor A2 -0.0186563
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0186018
RPL36 ribosomal protein L36 -0.0184336
MUC17 mucin 17, cell surface associated -0.0183714
FAM13A family with sequence similarity 13, member A -0.0181887
RPS11 ribosomal protein S11 -0.0180991
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -0.0178717
XPC xeroderma pigmentosum, complementation group C -0.0178643
S100A10 S100 calcium binding protein A10 -0.0175313
MT2A metallothionein 2A -0.0174322
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0172191
PDIA4 protein disulfide isomerase family A, member 4 -0.0171898
PERP PERP, TP53 apoptosis effector -0.0170768
PNISR PNN-interacting serine/arginine-rich protein -0.0169772
MON2 MON2 homolog (S. cerevisiae) -0.016524
ASTN2 astrotactin 2 -0.0163493
RPS29 ribosomal protein S29 -0.0163398
KDM4B lysine (K)-specific demethylase 4B -0.0159388
RPL38 ribosomal protein L38 -0.0158766
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0158062
SULF2 sulfatase 2 -0.0157739
FTL ferritin, light polypeptide -0.0155391
RPS23 ribosomal protein S23 -0.0155388
RPS13 ribosomal protein S13 -0.0153997
CCND1 cyclin D1 -0.0153419
RPL8 ribosomal protein L8 -0.015087
PTMA prothymosin, alpha -0.0150529
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0150378
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0149942
RREB1 ras responsive element binding protein 1 -0.0149258
H1-0 H1.0 linker histone -0.0148415
ATP5F1B ATP synthase F1 subunit beta -0.0148383