Mitoxantrone (dihydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 0.107981
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0961408
FLNB filamin B, beta 0.0863631
EPS8 epidermal growth factor receptor pathway substrate 8 0.0544036
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0477345
MYOF myoferlin 0.0466545
PDE4D phosphodiesterase 4D, cAMP-specific 0.0441752
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0424012
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0415414
PTPRB protein tyrosine phosphatase, receptor type, B 0.0397138
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0396815
LMO7 LIM domain 7 0.0391612
PTPRK protein tyrosine phosphatase, receptor type, K 0.0368659
P3H2 prolyl 3-hydroxylase 2 0.0367801
MSI2 musashi RNA-binding protein 2 0.0348322
AKAP13 A kinase (PRKA) anchor protein 13 0.033757
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0335117
TC2N tandem C2 domains, nuclear 0.0318644
KLF5 Kruppel-like factor 5 (intestinal) 0.0307819
DSPP dentin sialophosphoprotein 0.0306525
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0285792
TTC3 tetratricopeptide repeat domain 3 0.0279673
CATSPERB catsper channel auxiliary subunit beta 0.0276037
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0266223
FAT1 FAT atypical cadherin 1 0.0260218
MAML2 mastermind-like 2 (Drosophila) 0.0246535
LPP LIM domain containing preferred translocation partner in lipoma 0.0237538
EZR ezrin 0.0237421
RIMKLB ribosomal modification protein rimK-like family member B 0.0229236
RIN2 Ras and Rab interactor 2 0.022817
PELI1 pellino E3 ubiquitin protein ligase 1 0.0223116
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0216562
DSCAM Down syndrome cell adhesion molecule 0.0215255
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0215105
PDLIM5 PDZ and LIM domain 5 0.0212715
LOC105378220 macrophage receptor MARCO-like 0.0210368
EXT1 exostosin glycosyltransferase 1 0.0209817
MYO5B myosin VB 0.0207874
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0207808
TAS2R14 taste receptor, type 2, member 14 0.0203678
KMT2C lysine (K)-specific methyltransferase 2C 0.020267
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0202027
IQGAP2 IQ motif containing GTPase activating protein 2 0.0200981
ITGA6 integrin, alpha 6 0.0199189
OXSR1 oxidative stress responsive 1 0.0198121
SFPQ splicing factor proline/glutamine-rich 0.0196024
MYO6 myosin VI 0.0193601
ZCCHC7 zinc finger, CCHC domain containing 7 0.0192579
RABGAP1L RAB GTPase activating protein 1-like 0.0186346
PCDHB16 protocadherin beta 16 0.0186031
TRIO trio Rho guanine nucleotide exchange factor 0.0183929
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0180038
DMXL1 Dmx-like 1 0.0177615
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0174721
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0174657
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0174568
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0173777
SPAG9 sperm associated antigen 9 0.0173283
PPARG peroxisome proliferator-activated receptor gamma 0.017324
AFDN afadin, adherens junction formation factor 0.0172825
EXOC4 exocyst complex component 4 0.0170029
RANBP17 RAN binding protein 17 0.0170018
TLN2 talin 2 0.0169795
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.016855
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0168543
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 0.0166983
CLTC clathrin, heavy chain (Hc) 0.0166686
FRMD3 FERM domain containing 3 0.0165978
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0162922
NFIA nuclear factor I/A 0.0161784
ZNF638 zinc finger protein 638 0.0160623
UBE3C ubiquitin protein ligase E3C 0.0160101
FMNL2 formin-like 2 0.0159848
CDK13 cyclin-dependent kinase 13 0.0159252
POF1B premature ovarian failure, 1B 0.0158469
DGKD diacylglycerol kinase, delta 130kDa 0.0157801
FBXO11 F-box protein 11 0.0157527
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0157504
HEPH hephaestin 0.0157372
ANKHD1 ankyrin repeat and KH domain containing 1 0.0155468
KIAA1549 KIAA1549 0.0154713
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0153986
ANKRD17 ankyrin repeat domain 17 0.015335
PTK2 protein tyrosine kinase 2 0.0153199
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0152315
IARS1 isoleucyl-tRNA synthetase 1 0.0151896
BACE2 beta-site APP-cleaving enzyme 2 0.0151448
ZFC3H1 zinc finger, C3H1-type containing 0.0151043
CAPRIN2 caprin family member 2 0.0150515
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0150428
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0149758
RHBDD1 rhomboid domain containing 1 0.0147378
SMAD3 SMAD family member 3 0.0147073
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0146456
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0145861
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.014545
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0144202
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0144073
CEMIP cell migration inducing protein, hyaluronan binding 0.0144
CYSTM1 cysteine-rich transmembrane module containing 1 0.0142273

decreased expression

Symbol Name Standardized Value
RPLP1 ribosomal protein, large, P1 -0.228134
RPS6 ribosomal protein S6 -0.225461
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.189612
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.185234
TPT1 tumor protein, translationally-controlled 1 -0.141271
TMSB10 thymosin beta 10 -0.138939
RPS19 ribosomal protein S19 -0.137887
RPL35A ribosomal protein L35a -0.115032
RPS8 ribosomal protein S8 -0.111572
PTMA prothymosin, alpha -0.106306
RPS12 ribosomal protein S12 -0.106148
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.10565
HLA-B major histocompatibility complex, class I, B -0.101804
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.100358
RPL34 ribosomal protein L34 -0.0944948
RPLP2 ribosomal protein, large, P2 -0.0892526
RPS23 ribosomal protein S23 -0.0888843
RPLP0 ribosomal protein, large, P0 -0.0888387
RPL23 ribosomal protein L23 -0.0856072
RPS13 ribosomal protein S13 -0.0828956
RPS25 ribosomal protein S25 -0.0778612
RPL37A ribosomal protein L37a -0.0758784
RPL31 ribosomal protein L31 -0.0741326
PKM pyruvate kinase, muscle -0.0718073
IFI6 interferon, alpha-inducible protein 6 -0.0663511
FRMD5 FERM domain containing 5 -0.0632326
RPS17 ribosomal protein S17 -0.0630447
RPL19 ribosomal protein L19 -0.0616029
RPS14 ribosomal protein S14 -0.0604973
RPS27 ribosomal protein S27 -0.060269
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0599668
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0589454
RPL28 ribosomal protein L28 -0.0588648
RPS29 ribosomal protein S29 -0.0588345
IFI27 interferon, alpha-inducible protein 27 -0.0577626
PDIA3 protein disulfide isomerase family A, member 3 -0.0576723
RPL26 ribosomal protein L26 -0.0569072
RPS3 ribosomal protein S3 -0.0567815
RPS16 ribosomal protein S16 -0.0538639
RPL11 ribosomal protein L11 -0.0517154
RPL37 ribosomal protein L37 -0.0515526
TSPAN8 tetraspanin 8 -0.0511882
RPL12 ribosomal protein L12 -0.0504478
RPL9 ribosomal protein L9 -0.0500057
RPL36 ribosomal protein L36 -0.0496756
RPS11 ribosomal protein S11 -0.0491589
RPL27A ribosomal protein L27a -0.0474276
RPL8 ribosomal protein L8 -0.0473914
RPS21 ribosomal protein S21 -0.0471031
RACK1 receptor for activated C kinase 1 -0.0463639
RPS24 ribosomal protein S24 -0.046245
RPL35 ribosomal protein L35 -0.0444739
RPS20 ribosomal protein S20 -0.0433246
RPL32 ribosomal protein L32 -0.043232
RPL36A ribosomal protein L36a -0.0430726
RPS27A ribosomal protein S27a -0.0424062
RPS5 ribosomal protein S5 -0.0423549
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0406567
EIF1 eukaryotic translation initiation factor 1 -0.0391893
RPS15 ribosomal protein S15 -0.039151
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0388375
RPL13A ribosomal protein L13a -0.0385387
LOC112694756 uncharaterized LOC112694756 -0.0383634
LDHA lactate dehydrogenase A -0.0383624
ENO1 enolase 1, (alpha) -0.0366348
RPL5 ribosomal protein L5 -0.0360407
TPI1 triosephosphate isomerase 1 -0.0359945
ISG15 ISG15 ubiquitin-like modifier -0.0357818
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.035669
HLA-A major histocompatibility complex, class I, A -0.0349099
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0348849
FTL ferritin, light polypeptide -0.0348755
S100A10 S100 calcium binding protein A10 -0.0343899
KRT8 keratin 8, type II -0.0336752
SPON1 spondin 1, extracellular matrix protein -0.0333229
RPL38 ribosomal protein L38 -0.0333127
RPL30 ribosomal protein L30 -0.0330127
S100A6 S100 calcium binding protein A6 -0.0324493
CALB1 calbindin 1, 28kDa -0.0319862
GDF15 growth differentiation factor 15 -0.0318078
RPL18 ribosomal protein L18 -0.0316228
RPS4X ribosomal protein S4, X-linked -0.0312167
WWC1 WW and C2 domain containing 1 -0.0309887
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0309514
RPL7 ribosomal protein L7 -0.0299233
EEF1G eukaryotic translation elongation factor 1 gamma -0.0298831
KTN1 kinectin 1 (kinesin receptor) -0.0287206
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0280326
RNF213 ring finger protein 213 -0.0278016
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0276526
POTEF POTE ankyrin domain family, member F -0.0275917
RPL27 ribosomal protein L27 -0.0271214
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0270392
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0270218
GOLGA4 golgin A4 -0.0269995
S100P S100 calcium binding protein P -0.0264404
RPL7A ribosomal protein L7a -0.0259168
RPL15 ribosomal protein L15 -0.0257415
EGR1 early growth response 1 -0.0253513
YBX1 Y box binding protein 1 -0.0252245