| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | 0.154668 |
| VIM | vimentin | 0.149251 |
| DST | dystonin | 0.119826 |
| CD44 | CD44 molecule (Indian blood group) | 0.095417 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.089482 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0771106 |
| PRELID2 | PRELI domain containing 2 | 0.0650593 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0636856 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0597696 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0597491 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.059328 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0585603 |
| CADM2 | cell adhesion molecule 2 | 0.0570494 |
| CFAP299 | cilia and flagella associated protein 299 | 0.0550356 |
| RAD51B | RAD51 paralog B | 0.0541526 |
| EPHA4 | EPH receptor A4 | 0.0512024 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0468152 |
| HDAC9 | histone deacetylase 9 | 0.04628 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0447031 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0428204 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0424802 |
| SDC4 | syndecan 4 | 0.0410231 |
| FTL | ferritin, light polypeptide | 0.0404969 |
| VEGFC | vascular endothelial growth factor C | 0.0400823 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0395398 |
| RIGI | RNA sensor RIG-I | 0.0390572 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.038895 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0366937 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0364628 |
| FMNL2 | formin-like 2 | 0.0361552 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.034591 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0339928 |
| RUNX1 | runt-related transcription factor 1 | 0.0336855 |
| RNF213 | ring finger protein 213 | 0.0333968 |
| EHBP1 | EH domain binding protein 1 | 0.0331567 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.032561 |
| SP100 | SP100 nuclear antigen | 0.032513 |
| ZNF638 | zinc finger protein 638 | 0.0324686 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0317622 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0317043 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0315127 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0309874 |
| MYOF | myoferlin | 0.0308359 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0302379 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0300067 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0299954 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0299364 |
| EGFR | epidermal growth factor receptor | 0.0293956 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0291269 |
| VCL | vinculin | 0.0288171 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0286671 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0284034 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0283839 |
| JUN | jun proto-oncogene | 0.0282177 |
| NAV2 | neuron navigator 2 | 0.0278441 |
| PDE8A | phosphodiesterase 8A | 0.0273136 |
| PARD3 | par-3 family cell polarity regulator | 0.026951 |
| ENO1 | enolase 1, (alpha) | 0.0266115 |
| RB1 | retinoblastoma 1 | 0.0265671 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0265018 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0261755 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0260582 |
| SMYD3 | SET and MYND domain containing 3 | 0.0259862 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0259778 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0258325 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.025381 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0252869 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0250564 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.024986 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0249286 |
| HDAC8 | histone deacetylase 8 | 0.0248869 |
| ATM | ATM serine/threonine kinase | 0.0247661 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0247258 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0246682 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0246523 |
| B2M | beta-2-microglobulin | 0.0242932 |
| EXOC4 | exocyst complex component 4 | 0.0242927 |
| BPTF | bromodomain PHD finger transcription factor | 0.0242412 |
| H1-0 | H1.0 linker histone | 0.0242351 |
| INTS6 | integrator complex subunit 6 | 0.0237473 |
| PLIN2 | perilipin 2 | 0.0236071 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0234121 |
| TNS3 | tensin 3 | 0.0229764 |
| PDGFC | platelet derived growth factor C | 0.0229226 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0228929 |
| PLK2 | polo-like kinase 2 | 0.0228444 |
| PDE10A | phosphodiesterase 10A | 0.0226248 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | 0.0224683 |
| PRKCE | protein kinase C, epsilon | 0.0222617 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0222253 |
| CUX1 | cut-like homeobox 1 | 0.0217588 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0216371 |
| FTO | fat mass and obesity associated | 0.0214442 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0213123 |
| CEP128 | centrosomal protein 128kDa | 0.0212833 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0212724 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.021066 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0210087 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0210057 |
| ANXA2 | annexin A2 | 0.0208455 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TM4SF1 | transmembrane 4 L six family member 1 | -0.168484 |
| TXNRD1 | thioredoxin reductase 1 | -0.117346 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.112407 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.111125 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0982998 |
| MT2A | metallothionein 2A | -0.0935486 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0864691 |
| POTEF | POTE ankyrin domain family, member F | -0.0773676 |
| RPL26 | ribosomal protein L26 | -0.075096 |
| MT1X | metallothionein 1X | -0.074233 |
| RPS2 | ribosomal protein S2 | -0.0731891 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0725245 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.062698 |
| RAI1 | retinoic acid induced 1 | -0.0607555 |
| CENPF | centromere protein F, 350/400kDa | -0.054508 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0536213 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0520323 |
| RPS12 | ribosomal protein S12 | -0.0519439 |
| CLTC | clathrin, heavy chain (Hc) | -0.051606 |
| TMEM41B | transmembrane protein 41B | -0.0511079 |
| USP34 | ubiquitin specific peptidase 34 | -0.0510726 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0503541 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0486561 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0475011 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0474437 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.047422 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0470828 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0460471 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0455794 |
| FLNB | filamin B, beta | -0.044902 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0441728 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.0433248 |
| RPS6 | ribosomal protein S6 | -0.0432092 |
| RTN4 | reticulon 4 | -0.0429835 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0429264 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0428767 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.0423284 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.042009 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0407793 |
| NUP58 | nucleoporin 58 | -0.0391435 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0390877 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0389605 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0385918 |
| SET | SET nuclear proto-oncogene | -0.0378033 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0368541 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0367717 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.036761 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0364578 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0358143 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0356675 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0354782 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0351107 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0346446 |
| RPLP0 | ribosomal protein, large, P0 | -0.0343213 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.03428 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0340803 |
| RPL12 | ribosomal protein L12 | -0.0337287 |
| RBM39 | RNA binding motif protein 39 | -0.0325451 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.0324002 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0323909 |
| LDHA | lactate dehydrogenase A | -0.0322249 |
| S100A6 | S100 calcium binding protein A6 | -0.032222 |
| RPL36A | ribosomal protein L36a | -0.031553 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0311962 |
| XPO1 | exportin 1 | -0.0310553 |
| RPL37 | ribosomal protein L37 | -0.030938 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0304499 |
| PTMA | prothymosin, alpha | -0.0304291 |
| MKI67 | marker of proliferation Ki-67 | -0.0299234 |
| RPS3 | ribosomal protein S3 | -0.0297194 |
| HPCAL1 | hippocalcin-like 1 | -0.0296593 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.029469 |
| SERINC1 | serine incorporator 1 | -0.0293443 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0292522 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0292336 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0290806 |
| RASAL2 | RAS protein activator like 2 | -0.0290259 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.028457 |
| UBC | ubiquitin C | -0.0284025 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0281709 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.028086 |
| ATP13A3 | ATPase type 13A3 | -0.0278375 |
| RPS23 | ribosomal protein S23 | -0.0278183 |
| BMERB1 | bMERB domain containing 1 | -0.0277417 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0276989 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0276979 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0276478 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0274886 |
| FBXO11 | F-box protein 11 | -0.0274327 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0273989 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0272405 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0272174 |
| MATR3 | matrin 3 | -0.0271416 |
| CDCP1 | CUB domain containing protein 1 | -0.0268704 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0268089 |
| CCDC47 | coiled-coil domain containing 47 | -0.0267945 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0267894 |
| ZFR | zinc finger RNA binding protein | -0.0266708 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0266085 |
| WDR43 | WD repeat domain 43 | -0.0264569 |
