Mitoxantrone (dihydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.212113
THSD4 thrombospondin, type I, domain containing 4 0.146609
LMO7 LIM domain 7 0.134173
PTPRM protein tyrosine phosphatase, receptor type, M 0.103823
SLTM SAFB-like, transcription modulator 0.0996489
EGFR epidermal growth factor receptor 0.0879268
PM20D1 peptidase M20 domain containing 1 0.0858593
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0810756
PDLIM5 PDZ and LIM domain 5 0.080283
DOCK5 dedicator of cytokinesis 5 0.0738821
SCEL sciellin 0.0705537
INTS6 integrator complex subunit 6 0.0701877
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0699531
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0693161
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0680001
AKAP13 A kinase (PRKA) anchor protein 13 0.0657404
EFNA5 ephrin-A5 0.0657343
ERRFI1 ERBB receptor feedback inhibitor 1 0.064341
MCL1 myeloid cell leukemia 1 0.0611245
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0606344
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0593284
ELL2 elongation factor, RNA polymerase II, 2 0.0551132
MYOF myoferlin 0.054667
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0540974
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0516813
RAD51B RAD51 paralog B 0.0511185
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0492265
GRAMD1B GRAM domain containing 1B 0.049118
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0488661
MCTP1 multiple C2 domains, transmembrane 1 0.0476831
CEMIP cell migration inducing protein, hyaluronan binding 0.047372
FNDC3A fibronectin type III domain containing 3A 0.0471728
LPP LIM domain containing preferred translocation partner in lipoma 0.0470103
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0458078
BCAR3 breast cancer anti-estrogen resistance 3 0.0455346
DSPP dentin sialophosphoprotein 0.0453497
DSCAM Down syndrome cell adhesion molecule 0.0450315
VCL vinculin 0.044663
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0441228
TRIP12 thyroid hormone receptor interactor 12 0.0430455
ASPH aspartate beta-hydroxylase 0.0430203
SMYD3 SET and MYND domain containing 3 0.0419478
MACF1 microtubule-actin crosslinking factor 1 0.0417143
ATP11A ATPase, class VI, type 11A 0.0413066
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0411004
MYO1E myosin IE 0.0396277
EXT1 exostosin glycosyltransferase 1 0.0391206
HOMER1 homer scaffolding protein 1 0.0385371
MAML3 mastermind-like 3 (Drosophila) 0.0385218
ZSWIM6 zinc finger, SWIM-type containing 6 0.0383801
LAMA4 laminin, alpha 4 0.0372741
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0371484
VEGFC vascular endothelial growth factor C 0.0369952
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0364673
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0359333
SPAG9 sperm associated antigen 9 0.0358279
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0353872
SLC38A2 solute carrier family 38, member 2 0.0349566
SMAD2 SMAD family member 2 0.0341424
USP34 ubiquitin specific peptidase 34 0.0335773
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.032347
VMP1 vacuole membrane protein 1 0.0322376
SAMD4A sterile alpha motif domain containing 4A 0.031881
DOCK1 dedicator of cytokinesis 1 0.0315314
ANXA1 annexin A1 0.0311845
CCSER1 coiled-coil serine-rich protein 1 0.0309997
SIK3 SIK family kinase 3 0.0309735
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0309106
HSPA8 heat shock 70kDa protein 8 0.030584
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0304337
ATF6 activating transcription factor 6 0.0303206
NSUN6 NOP2/Sun domain family, member 6 0.0298174
SUMF1 sulfatase modifying factor 1 0.0297259
TRAPPC9 trafficking protein particle complex 9 0.0296815
MYO1D myosin ID 0.0295558
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0291959
FAF1 Fas (TNFRSF6) associated factor 1 0.0289044
FNDC3B fibronectin type III domain containing 3B 0.0288863
EXOC6B exocyst complex component 6B 0.0285972
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0285443
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.027759
FOXP1 forkhead box P1 0.027528
BIRC3 baculoviral IAP repeat containing 3 0.0274714
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0267167
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0263278
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like 0.0261674
CAV1 caveolin 1, caveolae protein, 22kDa 0.0257828
PTK2 protein tyrosine kinase 2 0.0255182
BMP6 bone morphogenetic protein 6 0.0253101
FBXL17 F-box and leucine-rich repeat protein 17 0.0252629
JMJD1C jumonji domain containing 1C 0.0251895
IGF1R insulin-like growth factor 1 receptor 0.0250604
MBNL1 muscleblind-like splicing regulator 1 0.0248944
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0246373
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.024564
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0243904
TBC1D5 TBC1 domain family, member 5 0.0243479
MIPOL1 mirror-image polydactyly 1 0.024274
BABAM2 BRISC and BRCA1 A complex member 2 0.0242167
RABGAP1L RAB GTPase activating protein 1-like 0.0241971

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.159451
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.156655
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.133994
NDRG1 N-myc downstream regulated 1 -0.101134
TMSB10 thymosin beta 10 -0.0859926
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0762857
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.066335
AKR1C1 aldo-keto reductase family 1, member C1 -0.0644962
NAMPT nicotinamide phosphoribosyltransferase -0.0597412
LOC112694756 uncharaterized LOC112694756 -0.0584832
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0581557
TBC1D22A TBC1 domain family, member 22A -0.0569669
TPT1 tumor protein, translationally-controlled 1 -0.0539535
H1-0 H1.0 linker histone -0.0495553
PKM pyruvate kinase, muscle -0.0484129
SEC61G Sec61 gamma subunit -0.0480415
TMEM165 transmembrane protein 165 -0.0456708
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.041462
FTH1 ferritin, heavy polypeptide 1 -0.0400637
PTMA prothymosin, alpha -0.0393464
SLC38A1 solute carrier family 38, member 1 -0.0387837
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0380722
B2M beta-2-microglobulin -0.03608
EIF1 eukaryotic translation initiation factor 1 -0.0359969
TPI1 triosephosphate isomerase 1 -0.0356316
LAMC2 laminin, gamma 2 -0.0353038
FTL ferritin, light polypeptide -0.035282
RPL35A ribosomal protein L35a -0.0339004
HLA-B major histocompatibility complex, class I, B -0.0338803
PGK1 phosphoglycerate kinase 1 -0.0338225
ZMYND8 zinc finger, MYND-type containing 8 -0.0328329
RPLP1 ribosomal protein, large, P1 -0.0294807
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.029008
RAB1A RAB1A, member RAS oncogene family -0.0288315
BZW1 basic leucine zipper and W2 domains 1 -0.0287999
RPL34 ribosomal protein L34 -0.0282809
PDIA3 protein disulfide isomerase family A, member 3 -0.0278398
RPS24 ribosomal protein S24 -0.0274908
S100A9 S100 calcium binding protein A9 -0.027442
RPS3 ribosomal protein S3 -0.0270575
KRT18 keratin 18, type I -0.0264398
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0254032
KDM2A lysine (K)-specific demethylase 2A -0.0252666
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0244512
ANKRD10 ankyrin repeat domain 10 -0.0243692
WDR45B WD repeat domain 45B -0.0241558
CAMTA1 calmodulin binding transcription activator 1 -0.0241207
IFI6 interferon, alpha-inducible protein 6 -0.0240167
HM13 histocompatibility (minor) 13 -0.023979
RPL37A ribosomal protein L37a -0.0239486
LAMB3 laminin, beta 3 -0.0235257
BTG1 B-cell translocation gene 1, anti-proliferative -0.0234417
RPS12 ribosomal protein S12 -0.0234391
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0234117
EGR1 early growth response 1 -0.0225068
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0224033
ENO1 enolase 1, (alpha) -0.0220459
AGR2 anterior gradient 2 -0.021946
KDM3A lysine (K)-specific demethylase 3A -0.0218721
RPS8 ribosomal protein S8 -0.0218698
LPCAT2 lysophosphatidylcholine acyltransferase 2 -0.0216372
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0216027
S100A10 S100 calcium binding protein A10 -0.0213533
S100A11 S100 calcium binding protein A11 -0.0210688
RPL23 ribosomal protein L23 -0.02034
UBC ubiquitin C -0.0196069
HDLBP high density lipoprotein binding protein -0.0194822
RPS6 ribosomal protein S6 -0.0194814
CST3 cystatin C -0.019236
RPS21 ribosomal protein S21 -0.0192171
KRT8 keratin 8, type II -0.019209
GM2A GM2 ganglioside activator -0.0191516
S100A6 S100 calcium binding protein A6 -0.0189935
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0189708
PRRC2C proline-rich coiled-coil 2C -0.0188837
KRT7 keratin 7, type II -0.0188169
RSF1 remodeling and spacing factor 1 -0.0188076
CANX calnexin -0.0188051
NGLY1 N-glycanase 1 -0.0187558
SEPTIN2 septin 2 -0.0187151
KDM5B lysine (K)-specific demethylase 5B -0.0185677
GNAS GNAS complex locus -0.018509
WSB1 WD repeat and SOCS box containing 1 -0.0183949
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0183263
RPS25 ribosomal protein S25 -0.0183217
BBX bobby sox homolog (Drosophila) -0.0182035
RAP1B RAP1B, member of RAS oncogene family -0.018188
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0175008
BRWD1 bromodomain and WD repeat domain containing 1 -0.0173078
HOOK2 hook microtubule-tethering protein 2 -0.0172959
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0172379
IER3 immediate early response 3 -0.0171926
OGA O-GlcNAcase -0.0171727
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0170026
HLA-A major histocompatibility complex, class I, A -0.0168819
RAB6A RAB6A, member RAS oncogene family -0.0167791
NDE1 nudE neurodevelopment protein 1 -0.0166088
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0166018
CP ceruloplasmin (ferroxidase) -0.0165817
YEATS2 YEATS domain containing 2 -0.0164963