| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.104895 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0991832 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0939916 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0669117 |
| NTN4 | netrin 4 | 0.0662006 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0648605 |
| INTS6 | integrator complex subunit 6 | 0.0643705 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0609231 |
| AADAC | arylacetamide deacetylase | 0.0607995 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0599625 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0588928 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0530532 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.051361 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0505945 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0505489 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0497707 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0496688 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0473072 |
| HMGA2 | high mobility group AT-hook 2 | 0.0446499 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0423657 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.041885 |
| SMAD3 | SMAD family member 3 | 0.0412517 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0409917 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0403445 |
| MYO10 | myosin X | 0.0379264 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0370846 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0356551 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0356043 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0352426 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0347648 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0343091 |
| ZNF638 | zinc finger protein 638 | 0.0337418 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0330493 |
| RCOR1 | REST corepressor 1 | 0.0324152 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0322621 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0318924 |
| SVIL | supervillin | 0.0313296 |
| SEPTIN9 | septin 9 | 0.0310462 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0310102 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0302293 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0298375 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0297388 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0289148 |
| STK38L | serine/threonine kinase 38 like | 0.0286644 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0283378 |
| YBX1 | Y box binding protein 1 | 0.0283072 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0282908 |
| EXT1 | exostosin glycosyltransferase 1 | 0.028033 |
| VMP1 | vacuole membrane protein 1 | 0.0278476 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0276015 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0275828 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0275759 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0273324 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0271021 |
| NAV2 | neuron navigator 2 | 0.0269792 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0269145 |
| RHCG | Rh family, C glycoprotein | 0.0268899 |
| TGFB1 | transforming growth factor, beta 1 | 0.0267382 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0265742 |
| OXSR1 | oxidative stress responsive 1 | 0.0263875 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.025966 |
| KSR1 | kinase suppressor of ras 1 | 0.0257613 |
| QKI | QKI, KH domain containing, RNA binding | 0.0257356 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0255489 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.025524 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0252294 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0250931 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0247074 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0246874 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0244535 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.024093 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0239861 |
| COPA | coatomer protein complex, subunit alpha | 0.0239792 |
| NOTCH2 | notch 2 | 0.0236923 |
| CRY1 | cryptochrome circadian clock 1 | 0.0235939 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0234684 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0234639 |
| EFNA5 | ephrin-A5 | 0.0234389 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0232069 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0231257 |
| ANO6 | anoctamin 6 | 0.0230529 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0230059 |
| ANKRD33B | ankyrin repeat domain 33B | 0.022711 |
| VCL | vinculin | 0.022046 |
| CTBP2 | C-terminal binding protein 2 | 0.0220125 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0218401 |
| NABP1 | nucleic acid binding protein 1 | 0.0218262 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0217884 |
| FERMT2 | fermitin family member 2 | 0.0215645 |
| PCBP2 | poly(rC) binding protein 2 | 0.0215088 |
| NHSL1 | NHS-like 1 | 0.0213337 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.0212327 |
| GPR176 | G protein-coupled receptor 176 | 0.0209527 |
| CAPRIN2 | caprin family member 2 | 0.0209509 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0208144 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0207888 |
| ATF7 | activating transcription factor 7 | 0.0206492 |
| IL1R1 | interleukin 1 receptor, type I | 0.0204187 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0204152 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0202098 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | -0.262781 |
| TMSB10 | thymosin beta 10 | -0.223695 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.133937 |
| OSMR | oncostatin M receptor | -0.126478 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.108673 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.101042 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0973201 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0960663 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0875668 |
| NRP1 | neuropilin 1 | -0.0802406 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0760775 |
| CDCP1 | CUB domain containing protein 1 | -0.0722703 |
| STC1 | stanniocalcin 1 | -0.0707196 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0706212 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0691477 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0684847 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0679911 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0676313 |
| S100A6 | S100 calcium binding protein A6 | -0.0656592 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0644653 |
| VIM | vimentin | -0.0625082 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0624401 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0622758 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0607495 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0604383 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0589122 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0558029 |
| GLCCI1 | glucocorticoid induced 1 | -0.0545253 |
| GPC6 | glypican 6 | -0.0539637 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.052259 |
| B2M | beta-2-microglobulin | -0.0512404 |
| ETV6 | ets variant 6 | -0.0504248 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0495531 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.049332 |
| RBM39 | RNA binding motif protein 39 | -0.0485917 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0473941 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0465918 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0460001 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0457758 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0448526 |
| NDRG1 | N-myc downstream regulated 1 | -0.0447863 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0443305 |
| POTEF | POTE ankyrin domain family, member F | -0.0426413 |
| USP34 | ubiquitin specific peptidase 34 | -0.0409921 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0394859 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0390055 |
| TMEM165 | transmembrane protein 165 | -0.0386439 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0365801 |
| RPS21 | ribosomal protein S21 | -0.0365519 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0364556 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0361479 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0355443 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0354786 |
| HLA-B | major histocompatibility complex, class I, B | -0.0347617 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0342581 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0338788 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0338749 |
| KLF6 | Kruppel-like factor 6 | -0.0336355 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0334952 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0333629 |
| TMSB4X | thymosin beta 4, X-linked | -0.0329153 |
| RNF149 | ring finger protein 149 | -0.0328689 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0326163 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0325492 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0324713 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0324234 |
| RPL35A | ribosomal protein L35a | -0.0323026 |
| DOCK5 | dedicator of cytokinesis 5 | -0.032212 |
| PCNX1 | pecanex 1 | -0.032041 |
| CAB39 | calcium binding protein 39 | -0.031949 |
| HMGA1 | high mobility group AT-hook 1 | -0.0318959 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0316427 |
| IL1B | interleukin 1, beta | -0.0314738 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0314715 |
| TPM4 | tropomyosin 4 | -0.0310914 |
| SYNJ2 | synaptojanin 2 | -0.0310164 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.030863 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.0307559 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0306423 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0305279 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0305042 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0304708 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.030327 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0302031 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0298868 |
| RPL34 | ribosomal protein L34 | -0.0296974 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0295773 |
| ANXA10 | annexin A10 | -0.0291033 |
| RAD51B | RAD51 paralog B | -0.0290429 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0287984 |
| PRELID2 | PRELI domain containing 2 | -0.0287826 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0286774 |
| ADD3 | adducin 3 (gamma) | -0.028653 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0285402 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0283547 |
| ENOSF1 | enolase superfamily member 1 | -0.0281583 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0279889 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0279778 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0279729 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0278868 |
