| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.26999 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.265441 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.105383 |
| WWOX | WW domain containing oxidoreductase | 0.0833233 |
| TXNRD1 | thioredoxin reductase 1 | 0.0790747 |
| GRAMD1B | GRAM domain containing 1B | 0.0684827 |
| ASPH | aspartate beta-hydroxylase | 0.0630619 |
| KYNU | kynureninase | 0.0624023 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.056187 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0561139 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0560883 |
| PDE10A | phosphodiesterase 10A | 0.0504446 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0489368 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0477323 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0437772 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0419397 |
| GLIS3 | GLIS family zinc finger 3 | 0.0405495 |
| FAM107B | family with sequence similarity 107, member B | 0.0395179 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0392216 |
| FHIT | fragile histidine triad | 0.0390425 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0384154 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0372221 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0367184 |
| VMP1 | vacuole membrane protein 1 | 0.0365624 |
| RAD51B | RAD51 paralog B | 0.0362406 |
| MYOF | myoferlin | 0.0344862 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0322075 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0314774 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0309289 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0307488 |
| SPAG9 | sperm associated antigen 9 | 0.0302084 |
| BMP6 | bone morphogenetic protein 6 | 0.0301859 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0301107 |
| RTN4 | reticulon 4 | 0.0297952 |
| SMAD2 | SMAD family member 2 | 0.0296392 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0294428 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0293802 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0286478 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0285545 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0282658 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.028217 |
| ATF6 | activating transcription factor 6 | 0.0277332 |
| AHR | aryl hydrocarbon receptor | 0.0275129 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0274663 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.026656 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0264009 |
| DST | dystonin | 0.0262834 |
| TPM3 | tropomyosin 3 | 0.0261356 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0261146 |
| UTRN | utrophin | 0.026049 |
| EFNA5 | ephrin-A5 | 0.025942 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0254399 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0253562 |
| WDR43 | WD repeat domain 43 | 0.0250375 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0248741 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0247965 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0244191 |
| ATXN1 | ataxin 1 | 0.0241278 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0239763 |
| CLTC | clathrin, heavy chain (Hc) | 0.0239465 |
| EXOC6B | exocyst complex component 6B | 0.0235494 |
| CENPF | centromere protein F, 350/400kDa | 0.0234686 |
| PRKD1 | protein kinase D1 | 0.0230148 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0227989 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.022751 |
| IGF1R | insulin-like growth factor 1 receptor | 0.022677 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.022423 |
| YAP1 | Yes-associated protein 1 | 0.0223877 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0223742 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0221808 |
| EXOC4 | exocyst complex component 4 | 0.0218676 |
| GPHN | gephyrin | 0.0214307 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0214111 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0214072 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0213315 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0213207 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0211715 |
| INTS6 | integrator complex subunit 6 | 0.0209997 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0209359 |
| NRG1 | neuregulin 1 | 0.0208133 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0206632 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0206441 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0205742 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0205618 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0204866 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0204762 |
| OLA1 | Obg-like ATPase 1 | 0.0200825 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0199777 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0198122 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0198103 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0196261 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0193994 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.019311 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0192894 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0190967 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.0190515 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0186957 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0186155 |
| PRELID2 | PRELI domain containing 2 | 0.018552 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0184757 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.166924 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.16673 |
| TMSB10 | thymosin beta 10 | -0.133479 |
| VIM | vimentin | -0.104878 |
| MT2A | metallothionein 2A | -0.104827 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0881325 |
| RPL23 | ribosomal protein L23 | -0.060497 |
| PYGL | phosphorylase, glycogen, liver | -0.058655 |
| ACTG1 | actin gamma 1 | -0.0573254 |
| POTEF | POTE ankyrin domain family, member F | -0.0573185 |
| FLNB | filamin B, beta | -0.0572766 |
| IGF2 | insulin-like growth factor 2 | -0.0567664 |
| S100A6 | S100 calcium binding protein A6 | -0.0542819 |
| HLA-B | major histocompatibility complex, class I, B | -0.0503075 |
| RPLP1 | ribosomal protein, large, P1 | -0.0499733 |
| RPS21 | ribosomal protein S21 | -0.0470458 |
| RPS8 | ribosomal protein S8 | -0.0436674 |
| NDRG1 | N-myc downstream regulated 1 | -0.0429505 |
| PTMA | prothymosin, alpha | -0.0422327 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0419604 |
| RPL19 | ribosomal protein L19 | -0.0403671 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0397691 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0380586 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0354514 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0351294 |
| TPI1 | triosephosphate isomerase 1 | -0.0345949 |
| EGFR | epidermal growth factor receptor | -0.0344902 |
| RPL37A | ribosomal protein L37a | -0.0343769 |
| CAVIN1 | caveolae associated protein 1 | -0.0334079 |
| RPS12 | ribosomal protein S12 | -0.0322321 |
| RPS29 | ribosomal protein S29 | -0.0319468 |
| STC1 | stanniocalcin 1 | -0.0318852 |
| HLA-A | major histocompatibility complex, class I, A | -0.0314812 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0303384 |
| RPS6 | ribosomal protein S6 | -0.0296249 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0294547 |
| RPL31 | ribosomal protein L31 | -0.0286508 |
| RPL35A | ribosomal protein L35a | -0.0282745 |
| CMIP | c-Maf inducing protein | -0.0277319 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0271497 |
| RPS19 | ribosomal protein S19 | -0.0268479 |
| PKM | pyruvate kinase, muscle | -0.0259406 |
| RPL37 | ribosomal protein L37 | -0.0257755 |
| S100A11 | S100 calcium binding protein A11 | -0.0252816 |
| ZFHX3 | zinc finger homeobox 3 | -0.0252281 |
| CTBP2 | C-terminal binding protein 2 | -0.0250212 |
| RPL36 | ribosomal protein L36 | -0.0249983 |
| RPL36A | ribosomal protein L36a | -0.0249394 |
| GNAS | GNAS complex locus | -0.0249159 |
| PRR16 | proline rich 16 | -0.0247908 |
| RPL36AL | ribosomal protein L36a-like | -0.0246782 |
| RPL34 | ribosomal protein L34 | -0.0244763 |
| RPS27A | ribosomal protein S27a | -0.0237535 |
| S100A10 | S100 calcium binding protein A10 | -0.0235537 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0232285 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0231567 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.022899 |
| TPM4 | tropomyosin 4 | -0.022572 |
| S100A9 | S100 calcium binding protein A9 | -0.0225689 |
| RPL9 | ribosomal protein L9 | -0.0223799 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.022253 |
| RPS24 | ribosomal protein S24 | -0.0220071 |
| KIFC3 | kinesin family member C3 | -0.02181 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0217118 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0215953 |
| RPS13 | ribosomal protein S13 | -0.0215582 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0213075 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0213014 |
| ACTN1 | actinin, alpha 1 | -0.0211875 |
| RPS27 | ribosomal protein S27 | -0.0211245 |
| RPS3 | ribosomal protein S3 | -0.0211012 |
| RPS17 | ribosomal protein S17 | -0.0210496 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0208106 |
| AHNAK | AHNAK nucleoprotein | -0.0205094 |
| ASTN2 | astrotactin 2 | -0.0204154 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | -0.020317 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0199975 |
| SERF2 | small EDRK-rich factor 2 | -0.0199166 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0198002 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0197804 |
| RPS23 | ribosomal protein S23 | -0.0196786 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0196501 |
| RPL28 | ribosomal protein L28 | -0.0195031 |
| HLA-E | major histocompatibility complex, class I, E | -0.0194071 |
| RPL26 | ribosomal protein L26 | -0.0193643 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0193133 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0190335 |
| RPS25 | ribosomal protein S25 | -0.0190061 |
| RAP1GAP2 | RAP1 GTPase activating protein 2 | -0.018698 |
| THBS1 | thrombospondin 1 | -0.0186627 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0186189 |
| RPS14 | ribosomal protein S14 | -0.0185566 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.0181681 |
| HMGA1 | high mobility group AT-hook 1 | -0.0181469 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0179266 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.017717 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0176247 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0174713 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0174058 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0173737 |
