| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYO1E | myosin IE | 0.243793 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.183955 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.138853 |
| GRAMD1B | GRAM domain containing 1B | 0.1193 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.110161 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.100619 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0879047 |
| EFNA5 | ephrin-A5 | 0.0875584 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0871212 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0870023 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0852246 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0847585 |
| MYOF | myoferlin | 0.0845746 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0832915 |
| PDE10A | phosphodiesterase 10A | 0.0800559 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0798707 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.079681 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0787349 |
| LMO7 | LIM domain 7 | 0.0762736 |
| SMAD2 | SMAD family member 2 | 0.0759307 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0733722 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0707237 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0697571 |
| KYNU | kynureninase | 0.0697436 |
| FAM107B | family with sequence similarity 107, member B | 0.0684499 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0680643 |
| VMP1 | vacuole membrane protein 1 | 0.0677036 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0661743 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0646261 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0643841 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0631793 |
| USP15 | ubiquitin specific peptidase 15 | 0.0625959 |
| SMYD3 | SET and MYND domain containing 3 | 0.0612435 |
| TXNRD1 | thioredoxin reductase 1 | 0.0607695 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0602336 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0600573 |
| FHIT | fragile histidine triad | 0.0582921 |
| LAMB3 | laminin, beta 3 | 0.0579088 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0573516 |
| RAD51B | RAD51 paralog B | 0.0572925 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0571931 |
| NABP1 | nucleic acid binding protein 1 | 0.0565625 |
| INTS6 | integrator complex subunit 6 | 0.0551486 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0539308 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0521817 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0516838 |
| SIK3 | SIK family kinase 3 | 0.0500121 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0495635 |
| AEBP2 | AE binding protein 2 | 0.0485448 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.048295 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0471989 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0467177 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0462569 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0457013 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0456956 |
| VCL | vinculin | 0.0449214 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0447877 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0443135 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0432966 |
| HPCAL1 | hippocalcin-like 1 | 0.0430472 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0425192 |
| SVIL | supervillin | 0.0423779 |
| RCOR1 | REST corepressor 1 | 0.0414442 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0414097 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0413231 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0407559 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0404313 |
| CLMP | CXADR-like membrane protein | 0.039227 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0388518 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0388004 |
| CUX1 | cut-like homeobox 1 | 0.038513 |
| PARD3 | par-3 family cell polarity regulator | 0.0378017 |
| HMGA2 | high mobility group AT-hook 2 | 0.0377577 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0376725 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.037594 |
| OSMR | oncostatin M receptor | 0.0371275 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0365833 |
| CTBP2 | C-terminal binding protein 2 | 0.0361919 |
| FMNL2 | formin-like 2 | 0.0360342 |
| TUSC3 | tumor suppressor candidate 3 | 0.0359143 |
| CLTC | clathrin, heavy chain (Hc) | 0.0354454 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0353497 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0353032 |
| USP34 | ubiquitin specific peptidase 34 | 0.0349021 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0347856 |
| EHBP1 | EH domain binding protein 1 | 0.0346024 |
| ANXA1 | annexin A1 | 0.0341891 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0341123 |
| DTNA | dystrobrevin, alpha | 0.0340337 |
| DENND1A | DENN/MADD domain containing 1A | 0.0338176 |
| SBF2 | SET binding factor 2 | 0.033365 |
| FUS | FUS RNA binding protein | 0.0330906 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0330206 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0329332 |
| SEPTIN10 | septin 10 | 0.0327545 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.032733 |
| BCL2L1 | BCL2-like 1 | 0.0323782 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | 0.032302 |
| RNF213 | ring finger protein 213 | 0.0322276 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0320986 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IFIH1 | interferon induced with helicase C domain 1 | -0.118518 |
| FN1 | fibronectin 1 | -0.107129 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.090667 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0833152 |
| NDRG1 | N-myc downstream regulated 1 | -0.0821369 |
| KRT17 | keratin 17, type I | -0.0790002 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0716628 |
| TMSB10 | thymosin beta 10 | -0.0704716 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0666974 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0639209 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0636771 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0623338 |
| TMEM165 | transmembrane protein 165 | -0.0594677 |
| ATOSA | atos homolog A | -0.0590884 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0587897 |
| B2M | beta-2-microglobulin | -0.055623 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0555302 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0547007 |
| FNIP1 | folliculin interacting protein 1 | -0.0541337 |
| STC1 | stanniocalcin 1 | -0.0537073 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0532952 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0517777 |
| SLMAP | sarcolemma associated protein | -0.0505411 |
| S100A11 | S100 calcium binding protein A11 | -0.0492723 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0487022 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0485904 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0478836 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0477714 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0469042 |
| KLHL24 | kelch-like family member 24 | -0.0464772 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0462603 |
| COPA | coatomer protein complex, subunit alpha | -0.0455978 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0454129 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0451554 |
| RPL37 | ribosomal protein L37 | -0.0447474 |
| MXD1 | MAX dimerization protein 1 | -0.0447225 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0433726 |
| RPS6 | ribosomal protein S6 | -0.0431807 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0430351 |
| EZR | ezrin | -0.0429816 |
| PKM | pyruvate kinase, muscle | -0.042743 |
| RPL31 | ribosomal protein L31 | -0.041218 |
| INHBA | inhibin, beta A | -0.0404661 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0404354 |
| ANXA2 | annexin A2 | -0.0402747 |
| FLNB | filamin B, beta | -0.0398584 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0395946 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0390742 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0390726 |
| SQSTM1 | sequestosome 1 | -0.0389114 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0388426 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0387288 |
| NBAS | neuroblastoma amplified sequence | -0.0384395 |
| MUC16 | mucin 16, cell surface associated | -0.0378031 |
| TPM4 | tropomyosin 4 | -0.0371645 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0370102 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0367259 |
| RPL15 | ribosomal protein L15 | -0.0364452 |
| GNAS | GNAS complex locus | -0.0363869 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0363227 |
| RPL9 | ribosomal protein L9 | -0.0362467 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0362321 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0354547 |
| MROH1 | maestro heat-like repeat family member 1 | -0.0343559 |
| QKI | QKI, KH domain containing, RNA binding | -0.0339077 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0338261 |
| JUP | junction plakoglobin | -0.0337884 |
| MORC3 | MORC family CW-type zinc finger 3 | -0.033748 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0334772 |
| GOLGA4 | golgin A4 | -0.0334428 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0329783 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0321004 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0318736 |
| CDK13 | cyclin-dependent kinase 13 | -0.0317857 |
| DENND2C | DENN/MADD domain containing 2C | -0.0316988 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0316971 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0316164 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0313342 |
| WDFY3 | WD repeat and FYVE domain containing 3 | -0.0306697 |
| MEF2A | myocyte enhancer factor 2A | -0.0305677 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0305055 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0304997 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.030443 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0301999 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0301765 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0299861 |
| RND3 | Rho family GTPase 3 | -0.0299469 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0298525 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.029849 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0297406 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.0297132 |
| KIF13B | kinesin family member 13B | -0.0295801 |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | -0.0295407 |
| GLG1 | golgi glycoprotein 1 | -0.0294989 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.0292743 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0292355 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0291604 |
| MYO9A | myosin IXA | -0.0291006 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0288583 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | -0.0287865 |
