| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.14192 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.124825 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.106358 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0988656 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0934592 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0878235 |
| GRAMD1B | GRAM domain containing 1B | 0.0865368 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0828648 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0828237 |
| TXNRD1 | thioredoxin reductase 1 | 0.0812816 |
| MCL1 | myeloid cell leukemia 1 | 0.0741601 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0720527 |
| VCL | vinculin | 0.0702648 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0692468 |
| INTS6 | integrator complex subunit 6 | 0.0670106 |
| YBX3 | Y box binding protein 3 | 0.0644793 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0640189 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.063948 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.062588 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0599146 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0556759 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0542708 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0529933 |
| HOMER1 | homer scaffolding protein 1 | 0.0524567 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0520762 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0510118 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0497698 |
| RBM39 | RNA binding motif protein 39 | 0.0492938 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0487752 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0480093 |
| YAP1 | Yes-associated protein 1 | 0.0474819 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0430733 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0428828 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0421033 |
| SMYD3 | SET and MYND domain containing 3 | 0.0410156 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.040539 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0405143 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0395213 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0387539 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0386837 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0383969 |
| RAD51B | RAD51 paralog B | 0.0377329 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0376109 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0371126 |
| NABP1 | nucleic acid binding protein 1 | 0.0364254 |
| VMP1 | vacuole membrane protein 1 | 0.0363651 |
| JMJD1C | jumonji domain containing 1C | 0.0360807 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0353854 |
| TRIM59 | tripartite motif containing 59 | 0.0353484 |
| RRM2 | ribonucleotide reductase M2 | 0.0348483 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0335039 |
| BRD2 | bromodomain containing 2 | 0.0332932 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0332121 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0327949 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0322758 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.031794 |
| PUM2 | pumilio RNA-binding family member 2 | 0.031496 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0306009 |
| EXOC6B | exocyst complex component 6B | 0.0303498 |
| PHF3 | PHD finger protein 3 | 0.0300733 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.03004 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0300221 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0297057 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0297024 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0292881 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0292604 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0292123 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0287727 |
| CDK17 | cyclin-dependent kinase 17 | 0.0286721 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0277578 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0273092 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.027278 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0271103 |
| FBXO11 | F-box protein 11 | 0.0268996 |
| USP34 | ubiquitin specific peptidase 34 | 0.0268938 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0266906 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0264014 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.025776 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0256984 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0255499 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0254016 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0253771 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0253728 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.025027 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0249871 |
| R3HDM2 | R3H domain containing 2 | 0.0248445 |
| GPHN | gephyrin | 0.0248311 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0247602 |
| THADA | thyroid adenoma associated | 0.0247093 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0245 |
| LRRC23 | leucine rich repeat containing 23 | 0.0243353 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0243163 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0241274 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0240159 |
| CHCHD3 | coiled-coil-helix-coiled-coil-helix domain containing 3 | 0.0238935 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0236287 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0236103 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0232387 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0231757 |
| CMIP | c-Maf inducing protein | 0.0231476 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.185033 |
| TMSB10 | thymosin beta 10 | -0.127663 |
| TPI1 | triosephosphate isomerase 1 | -0.108893 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0749799 |
| POTEF | POTE ankyrin domain family, member F | -0.0634136 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0585654 |
| PFN1 | profilin 1 | -0.0542932 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0518284 |
| VIM | vimentin | -0.0509103 |
| HLA-B | major histocompatibility complex, class I, B | -0.049924 |
| EGR1 | early growth response 1 | -0.0445295 |
| OSMR | oncostatin M receptor | -0.0436667 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0415802 |
| TMEM165 | transmembrane protein 165 | -0.0410988 |
| RYR3 | ryanodine receptor 3 | -0.0404093 |
| BBX | bobby sox homolog (Drosophila) | -0.0399632 |
| BSG | basigin (Ok blood group) | -0.0397298 |
| RSF1 | remodeling and spacing factor 1 | -0.03951 |
| GNAS | GNAS complex locus | -0.0390495 |
| TPM2 | tropomyosin 2 (beta) | -0.0379694 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0376304 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0326463 |
| RPL23 | ribosomal protein L23 | -0.0323718 |
| RPS21 | ribosomal protein S21 | -0.0316545 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0315677 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0313646 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0297982 |
| PTMS | parathymosin | -0.0296014 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0295496 |
| IGF2 | insulin-like growth factor 2 | -0.0291458 |
| ZNF292 | zinc finger protein 292 | -0.0290595 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0288971 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.0284492 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0282121 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0281477 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0281219 |
| CCND2 | cyclin D2 | -0.0280993 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0276215 |
| PHF21A | PHD finger protein 21A | -0.0272277 |
| SEPTIN7 | septin 7 | -0.0269254 |
| CBX3 | chromobox homolog 3 | -0.0265861 |
| PTMA | prothymosin, alpha | -0.026569 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0263307 |
| TPM4 | tropomyosin 4 | -0.0257224 |
| UBXN4 | UBX domain protein 4 | -0.0256457 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0255355 |
| EHBP1 | EH domain binding protein 1 | -0.0254853 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0253265 |
| TAGLN2 | transgelin 2 | -0.025279 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0252086 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0250144 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0249221 |
| PRELID2 | PRELI domain containing 2 | -0.0248951 |
| S100A11 | S100 calcium binding protein A11 | -0.024872 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0246887 |
| HELZ | helicase with zinc finger | -0.0242217 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0240687 |
| MT2A | metallothionein 2A | -0.0239074 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0236829 |
| HLA-A | major histocompatibility complex, class I, A | -0.023471 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0233946 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0233849 |
| HDGF | hepatoma-derived growth factor | -0.0233499 |
| ATXN1 | ataxin 1 | -0.0229094 |
| S100A6 | S100 calcium binding protein A6 | -0.0228115 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0224553 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0223055 |
| PFKP | phosphofructokinase, platelet | -0.0220327 |
| NUP58 | nucleoporin 58 | -0.0220091 |
| GORASP2 | golgi reassembly stacking protein 2, 55kDa | -0.0219676 |
| ICAM1 | intercellular adhesion molecule 1 | -0.021899 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0217181 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0215704 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0215534 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0215052 |
| RBM25 | RNA binding motif protein 25 | -0.0214798 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0214183 |
| RPS19 | ribosomal protein S19 | -0.0214055 |
| FMN1 | formin 1 | -0.021388 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0212764 |
| LDHA | lactate dehydrogenase A | -0.0211913 |
| MTA3 | metastasis associated 1 family, member 3 | -0.0211389 |
| RNF213 | ring finger protein 213 | -0.0211278 |
| RPL37 | ribosomal protein L37 | -0.0211002 |
| SET | SET nuclear proto-oncogene | -0.0210115 |
| YBX1 | Y box binding protein 1 | -0.0206361 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0205615 |
| S100A10 | S100 calcium binding protein A10 | -0.0205609 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0203471 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0202657 |
| RNF38 | ring finger protein 38 | -0.020145 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0201204 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0200591 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.0199855 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0197551 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0197063 |
| KDM2B | lysine (K)-specific demethylase 2B | -0.0194984 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0194308 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0194019 |
| CALR | calreticulin | -0.0193728 |
