Mitoxantrone (dihydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0416477
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0402676
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0388701
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.036327
INTS6 integrator complex subunit 6 0.0359894
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0338376
TSC22D2 TSC22 domain family, member 2 0.0327088
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0314485
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0288363
FNDC3B fibronectin type III domain containing 3B 0.0283773
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0270299
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0267346
EPS8 epidermal growth factor receptor pathway substrate 8 0.0266958
ALCAM activated leukocyte cell adhesion molecule 0.0264883
MCL1 myeloid cell leukemia 1 0.0250804
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0248775
ZSWIM6 zinc finger, SWIM-type containing 6 0.0244302
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0242553
VGLL3 vestigial-like family member 3 0.023906
CCNL1 cyclin L1 0.0238128
NABP1 nucleic acid binding protein 1 0.0235831
RYBP RING1 and YY1 binding protein 0.0235135
RAB7A RAB7A, member RAS oncogene family 0.0233276
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0233039
DST dystonin 0.0232093
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.023091
AKAP13 A kinase (PRKA) anchor protein 13 0.0226384
PTK2 protein tyrosine kinase 2 0.0225982
NTN4 netrin 4 0.0224553
IFRD1 interferon-related developmental regulator 1 0.022377
KIAA1217 KIAA1217 0.022115
CHD1 chromodomain helicase DNA binding protein 1 0.0220319
SGMS2 sphingomyelin synthase 2 0.0217047
G0S2 G0/G1 switch 2 0.0215636
MBNL1 muscleblind-like splicing regulator 1 0.0215115
HSPA8 heat shock 70kDa protein 8 0.0213838
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0211861
FXR1 fragile X mental retardation, autosomal homolog 1 0.0209939
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0208915
SSBP2 single-stranded DNA binding protein 2 0.0208732
BRD2 bromodomain containing 2 0.0207274
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0204866
MEF2A myocyte enhancer factor 2A 0.0203549
FHIT fragile histidine triad 0.0199668
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0197666
DENND4A DENN/MADD domain containing 4A 0.0194616
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0192458
TRA2B transformer 2 beta homolog (Drosophila) 0.0190312
TUFT1 tuftelin 1 0.0188398
SEPTIN11 septin 11 0.0185613
EGR1 early growth response 1 0.0185123
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0183638
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0182216
GRAMD2B GRAM domain containing 2B 0.0180296
BIRC3 baculoviral IAP repeat containing 3 0.0178506
NPTN neuroplastin 0.017681
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0176442
RNF145 ring finger protein 145 0.0176418
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0175598
USP53 ubiquitin specific peptidase 53 0.0171603
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0171557
VMP1 vacuole membrane protein 1 0.0170566
C3ORF52 chromosome 3 open reading frame 52 0.01693
PPARD peroxisome proliferator-activated receptor delta 0.0169296
RASA2 RAS p21 protein activator 2 0.0169192
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0168655
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0168505
PLEC plectin 0.0168188
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0166286
TRAF3 TNF receptor-associated factor 3 0.016547
BHLHE40 basic helix-loop-helix family, member e40 0.016489
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0162765
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.016183
CHKA choline kinase alpha 0.0161159
WWC1 WW and C2 domain containing 1 0.0159731
RHEB Ras homolog enriched in brain 0.0157218
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.015651
PPARG peroxisome proliferator-activated receptor gamma 0.0154582
IARS1 isoleucyl-tRNA synthetase 1 0.0154405
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0153271
PAPOLA poly(A) polymerase alpha 0.0151815
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0151453
GLS2 glutaminase 2 (liver, mitochondrial) 0.0150454
LHFPL2 lipoma HMGIC fusion partner-like 2 0.015044
COL8A1 collagen, type VIII, alpha 1 0.014847
USP15 ubiquitin specific peptidase 15 0.0147989
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0147506
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0147464
NCKAP1 NCK-associated protein 1 0.0146606
SMC4 structural maintenance of chromosomes 4 0.0146393
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0145509
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0144932
WNK1 WNK lysine deficient protein kinase 1 0.0144911
SETD5 SET domain containing 5 0.0144337
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.014335
DMXL1 Dmx-like 1 0.0141451
TMEM131L transmembrane 131 like 0.0141167
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0140941
GLCCI1 glucocorticoid induced 1 0.0140584
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 0.0140255

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.222948
TMSB10 thymosin beta 10 -0.208462
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182556
S100A6 S100 calcium binding protein A6 -0.147641
ACTG1 actin gamma 1 -0.129462
TMSB4X thymosin beta 4, X-linked -0.127351
IFI27 interferon, alpha-inducible protein 27 -0.122014
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.121956
PTMA prothymosin, alpha -0.115665
SOX4 SRY (sex determining region Y)-box 4 -0.114693
LIMCH1 LIM and calponin homology domains 1 -0.113935
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.104473
IGFBP3 insulin-like growth factor binding protein 3 -0.0987798
FBXO32 F-box protein 32 -0.0964283
LPP LIM domain containing preferred translocation partner in lipoma -0.0933397
NDRG1 N-myc downstream regulated 1 -0.088637
POTEF POTE ankyrin domain family, member F -0.0768069
LAMB3 laminin, beta 3 -0.0748612
NPEPPS aminopeptidase puromycin sensitive -0.0717295
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0715684
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0712444
IFI6 interferon, alpha-inducible protein 6 -0.0687362
RPL34 ribosomal protein L34 -0.0670331
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.06628
LMO7 LIM domain 7 -0.062461
CSTB cystatin B (stefin B) -0.0621854
LY6E lymphocyte antigen 6 complex, locus E -0.0609726
ISG15 ISG15 ubiquitin-like modifier -0.0605062
CD2AP CD2-associated protein -0.0596652
S100A10 S100 calcium binding protein A10 -0.0558937
FAM3C family with sequence similarity 3, member C -0.0553969
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0546393
IFI16 interferon, gamma-inducible protein 16 -0.0546166
TMEM165 transmembrane protein 165 -0.0534003
TPI1 triosephosphate isomerase 1 -0.0532363
TOP1 topoisomerase (DNA) I -0.0523578
RPS19 ribosomal protein S19 -0.0518535
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0514238
IFITM1 interferon induced transmembrane protein 1 -0.0505115
BASP1 brain abundant, membrane attached signal protein 1 -0.0495396
ZFP36L1 ZFP36 ring finger protein-like 1 -0.049461
PGK1 phosphoglycerate kinase 1 -0.0486567
WSB1 WD repeat and SOCS box containing 1 -0.0485688
ENO1 enolase 1, (alpha) -0.0479132
FTH1 ferritin, heavy polypeptide 1 -0.0470696
EIF1 eukaryotic translation initiation factor 1 -0.0467834
LOC112694756 uncharaterized LOC112694756 -0.0462927
RPLP1 ribosomal protein, large, P1 -0.0457848
BZW1 basic leucine zipper and W2 domains 1 -0.045736
F3 coagulation factor III (thromboplastin, tissue factor) -0.0457301
IFITM3 interferon induced transmembrane protein 3 -0.0449076
RPL8 ribosomal protein L8 -0.0448559
MDK midkine (neurite growth-promoting factor 2) -0.0447063
GNAS GNAS complex locus -0.0444364
TPM4 tropomyosin 4 -0.0437268
RPL23 ribosomal protein L23 -0.0434742
UBC ubiquitin C -0.0433604
S100A9 S100 calcium binding protein A9 -0.0422002
AHNAK AHNAK nucleoprotein -0.0421422
TM4SF1 transmembrane 4 L six family member 1 -0.0418594
ITCH itchy E3 ubiquitin protein ligase -0.0407657
STRN3 striatin, calmodulin binding protein 3 -0.0406177
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0406019
EPCAM epithelial cell adhesion molecule -0.0404217
TPT1 tumor protein, translationally-controlled 1 -0.0400946
RPL12 ribosomal protein L12 -0.0400651
RPL32 ribosomal protein L32 -0.0399711
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0391675
HLA-A major histocompatibility complex, class I, A -0.0386644
LMNA lamin A/C -0.0382142
CALR calreticulin -0.0377747
RPS21 ribosomal protein S21 -0.0376577
CANX calnexin -0.0373178
LDHA lactate dehydrogenase A -0.0372043
CCND1 cyclin D1 -0.0370085
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0369695
LMAN1 lectin, mannose-binding, 1 -0.0366752
RPLP2 ribosomal protein, large, P2 -0.03586
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0353286
TMEM123 transmembrane protein 123 -0.0351734
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0338692
CTSB cathepsin B -0.0336424
MRPS6 mitochondrial ribosomal protein S6 -0.0331118
KRT8 keratin 8, type II -0.0329201
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0324719
RPL19 ribosomal protein L19 -0.0323645
HLA-E major histocompatibility complex, class I, E -0.0315146
C15ORF48 chromosome 15 open reading frame 48 -0.0314779
KRT18 keratin 18, type I -0.0314679
RPS6 ribosomal protein S6 -0.0314181
HLA-B major histocompatibility complex, class I, B -0.0312299
ANTXR2 anthrax toxin receptor 2 -0.0310413
CTSD cathepsin D -0.0308271
ARRDC3 arrestin domain containing 3 -0.0308054
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0305077
H1-0 H1.0 linker histone -0.0302999
HDLBP high density lipoprotein binding protein -0.0301278
HSPB1 heat shock 27kDa protein 1 -0.0296008
SFTPA2 surfactant protein A2 -0.0290489
RPL26 ribosomal protein L26 -0.0284477