Mitoxantrone (dihydrochloride)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.0842881
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0679204
PDE10A phosphodiesterase 10A 0.0642829
KYNU kynureninase 0.0591218
DST dystonin 0.0584133
EFNA5 ephrin-A5 0.0481035
TRIO trio Rho guanine nucleotide exchange factor 0.0476253
COL8A1 collagen, type VIII, alpha 1 0.0474329
PDLIM5 PDZ and LIM domain 5 0.0436453
GDA guanine deaminase 0.0411189
ELL2 elongation factor, RNA polymerase II, 2 0.0404027
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0341584
MYOF myoferlin 0.032768
SPTBN1 spectrin, beta, non-erythrocytic 1 0.030826
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0303545
FMNL2 formin-like 2 0.0275296
SMOC1 SPARC related modular calcium binding 1 0.027441
NAMPT nicotinamide phosphoribosyltransferase 0.0273608
GRAMD1B GRAM domain containing 1B 0.0266866
SAMD4A sterile alpha motif domain containing 4A 0.0263831
NEK7 NIMA-related kinase 7 0.0261439
CXCL8 chemokine (C-X-C motif) ligand 8 0.0258466
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0254749
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0253287
TGFBR1 transforming growth factor, beta receptor 1 0.0249593
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0212987
ERRFI1 ERBB receptor feedback inhibitor 1 0.0209797
LIMCH1 LIM and calponin homology domains 1 0.0203148
SMAD2 SMAD family member 2 0.0200161
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0198813
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0198436
CTIF CBP80/20-dependent translation initiation factor 0.0196508
DOCK4 dedicator of cytokinesis 4 0.0191821
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0184875
ZSWIM6 zinc finger, SWIM-type containing 6 0.0179474
CHD1 chromodomain helicase DNA binding protein 1 0.0176631
EPHA4 EPH receptor A4 0.0175786
ESYT2 extended synaptotagmin-like protein 2 0.017491
PDE7B phosphodiesterase 7B 0.0173714
AGTPBP1 ATP/GTP binding protein 1 0.0171401
HELZ helicase with zinc finger 0.0168037
DNER delta/notch-like EGF repeat containing 0.0166981
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0165018
HSPA8 heat shock 70kDa protein 8 0.0164041
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0158163
USP9X ubiquitin specific peptidase 9, X-linked 0.0157156
PSME4 proteasome (prosome, macropain) activator subunit 4 0.015484
TXNRD1 thioredoxin reductase 1 0.0154244
NBAS neuroblastoma amplified sequence 0.0152503
LAMA1 laminin, alpha 1 0.0146474
CDC73 cell division cycle 73 0.0144464
PTEN phosphatase and tensin homolog 0.0142707
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0141353
NUP58 nucleoporin 58 0.0135767
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0135118
COL4A6 collagen, type IV, alpha 6 0.0134668
COL4A5 collagen, type IV, alpha 5 0.0133992
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0133388
NCKAP1 NCK-associated protein 1 0.0130902
PTPRM protein tyrosine phosphatase, receptor type, M 0.0130672
PUM2 pumilio RNA-binding family member 2 0.0130283
FLNB filamin B, beta 0.0129553
RNF145 ring finger protein 145 0.0128717
FAM13A family with sequence similarity 13, member A 0.0127812
ZEB2 zinc finger E-box binding homeobox 2 0.0127673
ZNF638 zinc finger protein 638 0.0125098
PLCB4 phospholipase C, beta 4 0.0124633
ATP13A3 ATPase type 13A3 0.0124505
SPAG9 sperm associated antigen 9 0.0124463
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0123801
CARD16 caspase recruitment domain family, member 16 0.0122861
ZC3H11A zinc finger CCCH-type containing 11A 0.0121849
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0121702
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0121077
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0120917
MARCHF1 membrane associated ring-CH-type finger 1 0.011981
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.011905
FNDC3B fibronectin type III domain containing 3B 0.0118499
INTS6 integrator complex subunit 6 0.0117691
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0116665
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0116582
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0116257
BDNF brain-derived neurotrophic factor 0.0116233
WAC WW domain containing adaptor with coiled-coil 0.0113051
PDE4D phosphodiesterase 4D, cAMP-specific 0.0112467
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0110062
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.011002
CLTC clathrin, heavy chain (Hc) 0.0109302
MBNL1 muscleblind-like splicing regulator 1 0.0109037
ECT2 epithelial cell transforming 2 0.0108391
ANTXR1 anthrax toxin receptor 1 0.0107544
BCAR3 breast cancer anti-estrogen resistance 3 0.010568
MALT1 MALT1 paracaspase 0.0105105
TSC22D2 TSC22 domain family, member 2 0.0104711
CUL3 cullin 3 0.0103674
CSNK1A1 casein kinase 1, alpha 1 0.0102973
EZR ezrin 0.0102843
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0098988
PSD3 pleckstrin and Sec7 domain containing 3 0.0098787
ARHGAP29 Rho GTPase activating protein 29 0.0098538

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.188266
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.184551
TPT1 tumor protein, translationally-controlled 1 -0.161495
TMSB10 thymosin beta 10 -0.149995
PTMA prothymosin, alpha -0.135513
RPS6 ribosomal protein S6 -0.120703
RPLP1 ribosomal protein, large, P1 -0.104609
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0961074
RPL35A ribosomal protein L35a -0.0946948
RPL31 ribosomal protein L31 -0.0907296
FN1 fibronectin 1 -0.0904301
RPS8 ribosomal protein S8 -0.0896084
RPL37A ribosomal protein L37a -0.0893291
RPS24 ribosomal protein S24 -0.0860372
FTL ferritin, light polypeptide -0.0770404
RPL26 ribosomal protein L26 -0.0769097
RPS12 ribosomal protein S12 -0.0765255
RPS19 ribosomal protein S19 -0.0755526
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0716017
RPL12 ribosomal protein L12 -0.0702879
RPS23 ribosomal protein S23 -0.0668738
HLA-B major histocompatibility complex, class I, B -0.0653724
RPL9 ribosomal protein L9 -0.063828
RPL36A ribosomal protein L36a -0.0626288
RPL34 ribosomal protein L34 -0.0619658
RPL19 ribosomal protein L19 -0.0604025
RPLP2 ribosomal protein, large, P2 -0.0575011
RPS29 ribosomal protein S29 -0.0574239
RPS27A ribosomal protein S27a -0.0562742
RPS3 ribosomal protein S3 -0.0560237
RPL23 ribosomal protein L23 -0.055416
B2M beta-2-microglobulin -0.055252
RPL7A ribosomal protein L7a -0.0551124
RPS13 ribosomal protein S13 -0.0550518
S100A6 S100 calcium binding protein A6 -0.0550516
RPL37 ribosomal protein L37 -0.054771
RPS21 ribosomal protein S21 -0.0511799
RPLP0 ribosomal protein, large, P0 -0.0504727
RPS25 ribosomal protein S25 -0.0504436
RPL11 ribosomal protein L11 -0.0494638
RPS14 ribosomal protein S14 -0.0492893
HLA-A major histocompatibility complex, class I, A -0.0486924
CTSL cathepsin L -0.0472119
RPL38 ribosomal protein L38 -0.0452565
EIF1 eukaryotic translation initiation factor 1 -0.0444593
RPL36 ribosomal protein L36 -0.0443915
ACTG1 actin gamma 1 -0.0443768
RPS16 ribosomal protein S16 -0.0439445
RPS27 ribosomal protein S27 -0.043779
RPS17 ribosomal protein S17 -0.0427872
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0409903
WARS1 tryptophanyl-tRNA synthetase 1 -0.0408849
SOX4 SRY (sex determining region Y)-box 4 -0.0407223
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0392773
RACK1 receptor for activated C kinase 1 -0.0391813
TM4SF1 transmembrane 4 L six family member 1 -0.0391296
GNAS GNAS complex locus -0.0390899
S100A10 S100 calcium binding protein A10 -0.0382001
TFPI2 tissue factor pathway inhibitor 2 -0.0379881
POTEF POTE ankyrin domain family, member F -0.0377992
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.035987
STC1 stanniocalcin 1 -0.0351973
ENO1 enolase 1, (alpha) -0.0347194
RPL13A ribosomal protein L13a -0.0335507
RPS11 ribosomal protein S11 -0.0332348
RPL32 ribosomal protein L32 -0.0330405
RPL35 ribosomal protein L35 -0.0330357
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0330195
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0320269
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0314294
RPS4X ribosomal protein S4, X-linked -0.0304292
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0293169
RPS10 ribosomal protein S10 -0.0290248
PGK1 phosphoglycerate kinase 1 -0.0289585
MT2A metallothionein 2A -0.0289495
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0286737
LMNA lamin A/C -0.0286359
RPL30 ribosomal protein L30 -0.0282521
PRSS23 protease, serine, 23 -0.0282448
NAP1L1 nucleosome assembly protein 1-like 1 -0.0275205
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0271687
TPM4 tropomyosin 4 -0.0270595
WSB1 WD repeat and SOCS box containing 1 -0.027057
RPS15 ribosomal protein S15 -0.0269907
RPL8 ribosomal protein L8 -0.0269732
RPL27A ribosomal protein L27a -0.0269192
RPL27 ribosomal protein L27 -0.0267297
RPS5 ribosomal protein S5 -0.0266646
RPS28 ribosomal protein S28 -0.0264145
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0258694
KPNB1 karyopherin (importin) beta 1 -0.025837
RPL28 ribosomal protein L28 -0.0255929
SRGN serglycin -0.0254713
TPI1 triosephosphate isomerase 1 -0.0252983
IFIH1 interferon induced with helicase C domain 1 -0.0251225
INHBA inhibin, beta A -0.0248108
RPL5 ribosomal protein L5 -0.0245801
VDAC1 voltage-dependent anion channel 1 -0.0240614
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0234092
ATP5F1E ATP synthase F1 subunit epsilon -0.0233977