Mitoxantrone (dihydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

128 genes differentially expressed following the Mitoxantrone (dihydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLTM SAFB-like, transcription modulator 0.1767
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.146255
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.136184
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.133776
ZBTB20 zinc finger and BTB domain containing 20 0.119781
GRAMD1B GRAM domain containing 1B 0.114655
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.10851
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.101222
ZFAND3 zinc finger, AN1-type domain 3 0.0998667
TNS3 tensin 3 0.0981328
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0924474
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0875288
DOCK5 dedicator of cytokinesis 5 0.0858547
EEF2 eukaryotic translation elongation factor 2 0.0827218
EGFR epidermal growth factor receptor 0.0804082
JMJD1C jumonji domain containing 1C 0.0797774
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0797368
ASPH aspartate beta-hydroxylase 0.0783846
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0749294
AKAP9 A kinase (PRKA) anchor protein 9 0.0735862
PTPRG protein tyrosine phosphatase, receptor type, G 0.0734512
RPS16 ribosomal protein S16 0.0731942
ANXA2 annexin A2 0.070265
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0698856
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0681793
BCAR3 breast cancer anti-estrogen resistance 3 0.0679513
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0671175
ZEB1 zinc finger E-box binding homeobox 1 0.0670259
SPAG9 sperm associated antigen 9 0.0657599
DSCAM Down syndrome cell adhesion molecule 0.063212
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0617574
AKAP12 A kinase (PRKA) anchor protein 12 0.0613184
EIF1 eukaryotic translation initiation factor 1 0.0606431
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0593624
SFTPA2 surfactant protein A2 0.0587607
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0534218
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0511516
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.049488
RPL35A ribosomal protein L35a 0.0486014
PTK2 protein tyrosine kinase 2 0.0480175
TULP4 tubby like protein 4 0.0475498
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0442169
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0441026
LMO7 LIM domain 7 0.0410563
FTL ferritin, light polypeptide 0.0406932
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0359741
FNDC3B fibronectin type III domain containing 3B 0.0359081
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0325112
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0275845
STC1 stanniocalcin 1 0.0250697
SBF2 SET binding factor 2 0.0229299
KTN1 kinectin 1 (kinesin receptor) 0.0220518
RPLP0 ribosomal protein, large, P0 0.021402
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0201289
CD44 CD44 molecule (Indian blood group) 0.0199326
RPS12 ribosomal protein S12 0.0126087
MYO1E myosin IE 0.011966
RPS24 ribosomal protein S24 0.00831804
MON2 MON2 homolog (S. cerevisiae) 0.00816712
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.00814713
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00730514
PDE4D phosphodiesterase 4D, cAMP-specific 0.00602786
SDC4 syndecan 4 0.00454756
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0038887
RPS8 ribosomal protein S8 0.00302031
DST dystonin 0.00183683

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.273231
FN1 fibronectin 1 -0.189616
EXT1 exostosin glycosyltransferase 1 -0.189384
TRIO trio Rho guanine nucleotide exchange factor -0.186788
NDRG1 N-myc downstream regulated 1 -0.169088
MT2A metallothionein 2A -0.118922
TPT1 tumor protein, translationally-controlled 1 -0.118608
HMGA2 high mobility group AT-hook 2 -0.117391
VIM vimentin -0.111868
TMSB10 thymosin beta 10 -0.110544
PARD3 par-3 family cell polarity regulator -0.104578
LDHA lactate dehydrogenase A -0.102682
NALF1 NALCN channel auxiliary factor 1 -0.0975219
IGFBP3 insulin-like growth factor binding protein 3 -0.0893469
RPL12 ribosomal protein L12 -0.0882724
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0873069
EFNA5 ephrin-A5 -0.0841964
PSD3 pleckstrin and Sec7 domain containing 3 -0.0832252
CDH13 cadherin 13 -0.0809614
MAML3 mastermind-like 3 (Drosophila) -0.073808
MYOF myoferlin -0.060558
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0557127
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0553483
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.05373
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0508094
RPL23 ribosomal protein L23 -0.0484285
COL6A3 collagen, type VI, alpha 3 -0.0466124
SMYD3 SET and MYND domain containing 3 -0.0439347
ENO1 enolase 1, (alpha) -0.0427532
THSD4 thrombospondin, type I, domain containing 4 -0.0413697
SAMD4A sterile alpha motif domain containing 4A -0.04135
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0407481
WSB1 WD repeat and SOCS box containing 1 -0.0403831
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0389556
PGK1 phosphoglycerate kinase 1 -0.038649
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0374373
MED13L mediator complex subunit 13-like -0.0361602
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0350623
NPAS2 neuronal PAS domain protein 2 -0.0345199
INHBA inhibin, beta A -0.034142
KMT2E lysine (K)-specific methyltransferase 2E -0.032827
NAV2 neuron navigator 2 -0.0319099
RPL19 ribosomal protein L19 -0.0306548
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0299784
COL6A1 collagen, type VI, alpha 1 -0.0291021
IGFBP5 insulin-like growth factor binding protein 5 -0.0259537
PDLIM5 PDZ and LIM domain 5 -0.0210383
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0200114
PDE10A phosphodiesterase 10A -0.0196179
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0178992
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0169222
IGF2 insulin-like growth factor 2 -0.0150336
GPC6 glypican 6 -0.0135253
OGA O-GlcNAcase -0.0124898
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.010856
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.00918665
ESYT2 extended synaptotagmin-like protein 2 -0.00908327
B2M beta-2-microglobulin -0.00795004
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.00695469
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.00594748
RPS6 ribosomal protein S6 -0.00515975
PTMA prothymosin, alpha -8.86968E-4