Mitoxantrone (dihydrochloride)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.0984219
NTM neurotrimin 0.0853108
TENM3 teneurin transmembrane protein 3 0.0697729
COL11A1 collagen, type XI, alpha 1 0.0685895
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0524242
INTS6 integrator complex subunit 6 0.0479267
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0452681
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0437655
TSC22D2 TSC22 domain family, member 2 0.0435033
PDGFC platelet derived growth factor C 0.0407991
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0392952
NSUN6 NOP2/Sun domain family, member 6 0.0385992
KMT2C lysine (K)-specific methyltransferase 2C 0.0380811
HMGA2 high mobility group AT-hook 2 0.0377001
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0367902
GARS1 glycyl-tRNA synthetase 1 0.0363012
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0360728
DOCK5 dedicator of cytokinesis 5 0.0350229
PARD3B par-3 family cell polarity regulator beta 0.0348142
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0346985
GLS2 glutaminase 2 (liver, mitochondrial) 0.0341088
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0336512
DSCAM Down syndrome cell adhesion molecule 0.0334692
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0334027
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0333741
ZNF608 zinc finger protein 608 0.0330032
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0321386
ZSWIM6 zinc finger, SWIM-type containing 6 0.032119
CSMD3 CUB and Sushi multiple domains 3 0.0312729
UTRN utrophin 0.0310796
ZC3H12B zinc finger CCCH-type containing 12B 0.0310311
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0305698
NRXN1 neurexin 1 0.0303997
CSRNP3 cysteine-serine-rich nuclear protein 3 0.0302973
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0301779
PBX3 pre-B-cell leukemia homeobox 3 0.0298912
FAT1 FAT atypical cadherin 1 0.0293012
PLCB4 phospholipase C, beta 4 0.0292579
EXT1 exostosin glycosyltransferase 1 0.0289462
CDK6 cyclin-dependent kinase 6 0.0283608
SFPQ splicing factor proline/glutamine-rich 0.0283398
MCTP1 multiple C2 domains, transmembrane 1 0.0279919
TRA2A transformer 2 alpha homolog (Drosophila) 0.0275498
LOC102724023 ES1 protein homolog, mitochondrial 0.0274232
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.027311
CNTN6 contactin 6 0.0272648
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0268144
CDH19 cadherin 19, type 2 0.0262414
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.026209
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0261517
NPAS3 neuronal PAS domain protein 3 0.02613
PSPC1 paraspeckle component 1 0.0258392
SERTAD2 SERTA domain containing 2 0.0255793
NLGN1 neuroligin 1 0.0254859
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0253344
YBX1 Y box binding protein 1 0.0248696
CADM2 cell adhesion molecule 2 0.0246384
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0245641
BTBD9 BTB (POZ) domain containing 9 0.0245175
CLOCK clock circadian regulator 0.024425
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0244073
ANKRD17 ankyrin repeat domain 17 0.0243492
TOX thymocyte selection-associated high mobility group box 0.0242249
PCLO piccolo presynaptic cytomatrix protein 0.0238859
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.023848
CLTC clathrin, heavy chain (Hc) 0.0238305
TEX14 testis expressed 14 0.0233309
SOX5 SRY (sex determining region Y)-box 5 0.0231431
SATB2 SATB homeobox 2 0.0226719
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0225943
TOP1 topoisomerase (DNA) I 0.0224802
ELP4 elongator acetyltransferase complex subunit 4 0.0224602
USP53 ubiquitin specific peptidase 53 0.022402
CECR2 cat eye syndrome chromosome region, candidate 2 0.0219597
PEAK1 pseudopodium-enriched atypical kinase 1 0.0217395
ATF6 activating transcription factor 6 0.0215818
STK31 serine/threonine kinase 31 0.021562
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0215327
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0213279
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0213029
DPYD dihydropyrimidine dehydrogenase 0.021247
DNAH14 dynein, axonemal, heavy chain 14 0.021114
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0210712
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0210707
KDM6A lysine (K)-specific demethylase 6A 0.0210259
PCDH11Y protocadherin 11 Y-linked 0.0208803
FOXO1 forkhead box O1 0.0208223
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0207626
CRY1 cryptochrome circadian clock 1 0.0204487
EPHA5 EPH receptor A5 0.0202733
ADGRL2 adhesion G protein-coupled receptor L2 0.0202226
METTL15 methyltransferase like 15 0.0201955
NFIB nuclear factor I/B 0.0200342
TMEM64 transmembrane protein 64 0.0200065
SLIT2 slit homolog 2 (Drosophila) 0.0197784
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0197021
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0194118
GPHN gephyrin 0.0191988
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0191119
HSPA4 heat shock 70kDa protein 4 0.0190985

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.195149
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.150343
GPC3 glypican 3 -0.137174
COL3A1 collagen, type III, alpha 1 -0.134635
COL1A2 collagen, type I, alpha 2 -0.128532
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103624
PTMA prothymosin, alpha -0.0959088
TMSB10 thymosin beta 10 -0.0944225
PGK1 phosphoglycerate kinase 1 -0.0895732
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0815145
MDK midkine (neurite growth-promoting factor 2) -0.081475
GNAS GNAS complex locus -0.0780247
PHIP pleckstrin homology domain interacting protein -0.0772794
WSB1 WD repeat and SOCS box containing 1 -0.0754402
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0705877
LDHA lactate dehydrogenase A -0.0695762
RPS8 ribosomal protein S8 -0.0690201
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0685322
RPS16 ribosomal protein S16 -0.0666059
RPS6 ribosomal protein S6 -0.0639178
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0638253
ENO1 enolase 1, (alpha) -0.0637932
FST follistatin -0.0633178
ACTG1 actin gamma 1 -0.061681
ITGAV integrin, alpha V -0.0591636
ZFAND3 zinc finger, AN1-type domain 3 -0.0589841
SOX2 SRY (sex determining region Y)-box 2 -0.0574511
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0560865
PEG10 paternally expressed 10 -0.055685
LRRC4C leucine rich repeat containing 4C -0.0531503
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0523365
RPL35A ribosomal protein L35a -0.0510368
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0508945
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0502317
MYL12B myosin, light chain 12B, regulatory -0.0484511
MAP4 microtubule-associated protein 4 -0.047547
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0469556
UBE2K ubiquitin-conjugating enzyme E2K -0.0469202
APOE apolipoprotein E -0.0463134
B2M beta-2-microglobulin -0.0462699
ANKRD12 ankyrin repeat domain 12 -0.0462094
NRG1 neuregulin 1 -0.0424801
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0421789
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0416668
HSPB1 heat shock 27kDa protein 1 -0.0413185
ZFP64 ZFP64 zinc finger protein -0.0403298
RPS19 ribosomal protein S19 -0.0403247
MKI67 marker of proliferation Ki-67 -0.0402918
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.040143
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0399994
RPL31 ribosomal protein L31 -0.038879
RAD21 RAD21 homolog (S. pombe) -0.0379897
RAI1 retinoic acid induced 1 -0.0379554
BMPR1A bone morphogenetic protein receptor, type IA -0.0376261
NACA nascent polypeptide-associated complex alpha subunit -0.0374469
MED12L mediator complex subunit 12-like -0.037355
SPAG9 sperm associated antigen 9 -0.0371572
RAD51B RAD51 paralog B -0.0368765
LOC112694756 uncharaterized LOC112694756 -0.0367348
TUT4 terminal uridylyl transferase 4 -0.0366934
SAMD4B sterile alpha motif domain containing 4B -0.0363581
GSE1 Gse1 coiled-coil protein -0.0361806
FGF13 fibroblast growth factor 13 -0.0361124
RPS13 ribosomal protein S13 -0.0355707
RPS24 ribosomal protein S24 -0.0355649
TNRC6B trinucleotide repeat containing 6B -0.0353333
FTL ferritin, light polypeptide -0.0351493
SQSTM1 sequestosome 1 -0.0351199
CAVIN1 caveolae associated protein 1 -0.0350279
H1-0 H1.0 linker histone -0.0349496
TUBA1B tubulin, alpha 1b -0.0348665
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0346557
ISG15 ISG15 ubiquitin-like modifier -0.0344775
GARRE1 granule associated Rac and RHOG effector 1 -0.034049
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0340238
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0335929
PFN1 profilin 1 -0.0330826
GPATCH8 G patch domain containing 8 -0.0330226
FBXO17 F-box protein 17 -0.0329287
RFPL4B ret finger protein-like 4B -0.0329223
THOC2 THO complex 2 -0.0326406
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0325996
PCDH9 protocadherin 9 -0.0323806
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0321914
SCAF11 SR-related CTD-associated factor 11 -0.0319914
HNRNPR heterogeneous nuclear ribonucleoprotein R -0.0318831
RASAL2 RAS protein activator like 2 -0.0317114
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0315965
RPL34 ribosomal protein L34 -0.0315546
SERF2 small EDRK-rich factor 2 -0.0314431
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0312713
RPS21 ribosomal protein S21 -0.0311893
SREBF2 sterol regulatory element binding transcription factor 2 -0.0309824
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.030864
CALR calreticulin -0.0308398
WASF2 WAS protein family, member 2 -0.0306958
ZMYND8 zinc finger, MYND-type containing 8 -0.0304607
CBX3 chromobox homolog 3 -0.0303465
CEP350 centrosomal protein 350kDa -0.0302995
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0302813