Mitoxantrone (dihydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.247479
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.17542
TRIO trio Rho guanine nucleotide exchange factor 0.156828
FNDC3B fibronectin type III domain containing 3B 0.143321
DST dystonin 0.106883
MACF1 microtubule-actin crosslinking factor 1 0.0895053
PTK2 protein tyrosine kinase 2 0.0836956
AHNAK AHNAK nucleoprotein 0.0805933
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0800201
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0735648
SMAD3 SMAD family member 3 0.0695299
SEPTIN9 septin 9 0.0645631
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0645163
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.062972
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0627948
ANKRD11 ankyrin repeat domain 11 0.0617023
MYH9 myosin, heavy chain 9, non-muscle 0.059111
AFAP1 actin filament associated protein 1 0.0580722
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0567564
MYOF myoferlin 0.0555746
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0530881
CENPF centromere protein F, 350/400kDa 0.052799
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0525511
FMNL2 formin-like 2 0.0523538
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0505721
PRELID2 PRELI domain containing 2 0.0505595
NAV2 neuron navigator 2 0.0503171
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.050081
ASPH aspartate beta-hydroxylase 0.0497831
SBF2 SET binding factor 2 0.0494573
APLP2 amyloid beta (A4) precursor-like protein 2 0.0475137
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0467928
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0460286
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0450494
SLC35F3 solute carrier family 35, member F3 0.0444177
SDK1 sidekick cell adhesion molecule 1 0.0443942
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0436281
UTRN utrophin 0.0432201
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0428927
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0422847
SMYD3 SET and MYND domain containing 3 0.0420267
LPP LIM domain containing preferred translocation partner in lipoma 0.0410862
EFNA5 ephrin-A5 0.0404864
RAD51B RAD51 paralog B 0.0396582
WNK1 WNK lysine deficient protein kinase 1 0.0391915
YAP1 Yes-associated protein 1 0.0390581
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0389701
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0387089
CANX calnexin 0.038688
TXNRD1 thioredoxin reductase 1 0.038539
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0383788
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.0382144
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0379835
THSD4 thrombospondin, type I, domain containing 4 0.03796
MED13L mediator complex subunit 13-like 0.0374091
NHSL1 NHS-like 1 0.0369572
CDK6 cyclin-dependent kinase 6 0.0369211
AKAP13 A kinase (PRKA) anchor protein 13 0.0367721
EXOC4 exocyst complex component 4 0.0367352
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0364712
HSPA8 heat shock 70kDa protein 8 0.0361234
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.036042
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0355406
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0354413
FAF1 Fas (TNFRSF6) associated factor 1 0.0354071
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0353797
ZNF638 zinc finger protein 638 0.0351871
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0351063
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0348327
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0346827
PGK1 phosphoglycerate kinase 1 0.0346396
ENO1 enolase 1, (alpha) 0.034436
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0341881
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0336291
BIRC3 baculoviral IAP repeat containing 3 0.0335185
TNS3 tensin 3 0.0334882
TRIP12 thyroid hormone receptor interactor 12 0.0328748
CKAP5 cytoskeleton associated protein 5 0.0328047
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0327066
GOLGB1 golgin B1 0.0321451
APP amyloid beta (A4) precursor protein 0.0320141
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.031757
CTBP2 C-terminal binding protein 2 0.0316981
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0315858
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0314141
ATXN1 ataxin 1 0.0307339
RNF220 ring finger protein 220 0.0306443
ZNF292 zinc finger protein 292 0.0303185
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.030131
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0300096
SAMD4A sterile alpha motif domain containing 4A 0.0299392
IGF1R insulin-like growth factor 1 receptor 0.0298449
MYO10 myosin X 0.029842
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0294184
GPHN gephyrin 0.0293978
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0287094
HMGA2 high mobility group AT-hook 2 0.0285399
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0282601
USP34 ubiquitin specific peptidase 34 0.0280709
FAT1 FAT atypical cadherin 1 0.0280316

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.225039
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.172896
VCL vinculin -0.101601
EGR1 early growth response 1 -0.0806058
TMSB10 thymosin beta 10 -0.0792833
ZFP36 ZFP36 ring finger protein -0.0712857
RPL35A ribosomal protein L35a -0.063052
VIM vimentin -0.050151
S100A6 S100 calcium binding protein A6 -0.0479314
RPLP2 ribosomal protein, large, P2 -0.0432615
PTMA prothymosin, alpha -0.0424197
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0404826
RPLP1 ribosomal protein, large, P1 -0.039681
FTL ferritin, light polypeptide -0.0395901
NCEH1 neutral cholesterol ester hydrolase 1 -0.03723
RPL36A ribosomal protein L36a -0.037163
RTN4 reticulon 4 -0.0369109
RPLP0 ribosomal protein, large, P0 -0.0364128
RPL23 ribosomal protein L23 -0.0328825
EIF1 eukaryotic translation initiation factor 1 -0.0319877
TMEM41B transmembrane protein 41B -0.0314289
RPS24 ribosomal protein S24 -0.0305489
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0299019
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0291409
RPS13 ribosomal protein S13 -0.0290526
RPL12 ribosomal protein L12 -0.0284867
KLF6 Kruppel-like factor 6 -0.0275667
RPS12 ribosomal protein S12 -0.0272015
RPS5 ribosomal protein S5 -0.0268739
LOC102724023 ES1 protein homolog, mitochondrial -0.0268264
FHL2 four and a half LIM domains 2 -0.0262624
RPL34 ribosomal protein L34 -0.0261519
RPL28 ribosomal protein L28 -0.0258754
RPS8 ribosomal protein S8 -0.0258291
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0254906
RPS19 ribosomal protein S19 -0.0243358
RPL26 ribosomal protein L26 -0.0237038
RPS25 ribosomal protein S25 -0.0234255
RPS3 ribosomal protein S3 -0.0221087
LOC112694756 uncharaterized LOC112694756 -0.0218118
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0216881
TPT1 tumor protein, translationally-controlled 1 -0.0214519
RPL27A ribosomal protein L27a -0.0211598
RPL8 ribosomal protein L8 -0.0211402
RPL31 ribosomal protein L31 -0.0203318
RPL9 ribosomal protein L9 -0.020295
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0199209
ACTG1 actin gamma 1 -0.0196585
RPS14 ribosomal protein S14 -0.0193328
PFN1 profilin 1 -0.0191311
NPC1 Niemann-Pick disease, type C1 -0.0190607
RPS23 ribosomal protein S23 -0.0187494
H1-0 H1.0 linker histone -0.0183812
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0182517
MAP1B microtubule-associated protein 1B -0.0182194
GARS1 glycyl-tRNA synthetase 1 -0.0181313
CTSD cathepsin D -0.0176913
RPS21 ribosomal protein S21 -0.0171594
HLA-B major histocompatibility complex, class I, B -0.0169672
RPL36 ribosomal protein L36 -0.0166187
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0165392
FOSL1 FOS-like antigen 1 -0.0165127
ASTN2 astrotactin 2 -0.0163381
RPS27 ribosomal protein S27 -0.0162838
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.015895
RPS4X ribosomal protein S4, X-linked -0.0158443
RPL11 ribosomal protein L11 -0.0155806
S100A10 S100 calcium binding protein A10 -0.0154069
RPS6 ribosomal protein S6 -0.0152986
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0150428
CCN2 cellular communication network factor 2 -0.0150233
RPL39 ribosomal protein L39 -0.0148913
RAP1B RAP1B, member of RAS oncogene family -0.0147408
RPS20 ribosomal protein S20 -0.0147089
RPL30 ribosomal protein L30 -0.0146452
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0146132
WASF2 WAS protein family, member 2 -0.0141068
ARHGAP29 Rho GTPase activating protein 29 -0.0137833
RPL32 ribosomal protein L32 -0.0136534
ATP5F1B ATP synthase F1 subunit beta -0.0135897
RACK1 receptor for activated C kinase 1 -0.0134313
BMP6 bone morphogenetic protein 6 -0.0132881
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.013286
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0130909
NABP1 nucleic acid binding protein 1 -0.0127174
DDIT3 DNA-damage-inducible transcript 3 -0.0126632
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0126538
LIMA1 LIM domain and actin binding 1 -0.0124481
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0123738
RPL38 ribosomal protein L38 -0.0123475
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0123296
CIB1 calcium and integrin binding 1 (calmyrin) -0.0121341
RPL35 ribosomal protein L35 -0.0120993
SERF2 small EDRK-rich factor 2 -0.0120783
RPS28 ribosomal protein S28 -0.0120491
MCL1 myeloid cell leukemia 1 -0.0119926
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0119381
BLZF1 basic leucine zipper nuclear factor 1 -0.0119335
S100A9 S100 calcium binding protein A9 -0.0118683
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0118334