Mitoxantrone (dihydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mitoxantrone (dihydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INTS6 integrator complex subunit 6 0.107934
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.090704
ZSWIM6 zinc finger, SWIM-type containing 6 0.0761982
RIMKLB ribosomal modification protein rimK-like family member B 0.0761315
TJP1 tight junction protein 1 0.0692472
NAV2 neuron navigator 2 0.0638998
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.062043
SMAD3 SMAD family member 3 0.0599016
LMO7 LIM domain 7 0.0569875
BCAR3 breast cancer anti-estrogen resistance 3 0.0558735
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0543523
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0517205
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0449921
TSC22D2 TSC22 domain family, member 2 0.0449268
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0436658
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0423067
LOC102724023 ES1 protein homolog, mitochondrial 0.0416349
ANKRD33B ankyrin repeat domain 33B 0.0416066
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.040823
ARHGAP26 Rho GTPase activating protein 26 0.040728
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0387941
TRA2A transformer 2 alpha homolog (Drosophila) 0.0387075
AREG amphiregulin 0.0385695
AKAP13 A kinase (PRKA) anchor protein 13 0.0374164
APLP2 amyloid beta (A4) precursor-like protein 2 0.0370485
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0369452
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0360261
BIRC3 baculoviral IAP repeat containing 3 0.0357721
PCLO piccolo presynaptic cytomatrix protein 0.0354921
FNDC3B fibronectin type III domain containing 3B 0.0352664
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0349137
CCNL1 cyclin L1 0.0348992
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0341261
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0340747
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0335018
PPARD peroxisome proliferator-activated receptor delta 0.0334703
SEPTIN9 septin 9 0.0323558
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.031287
SDC4 syndecan 4 0.0307998
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0304755
DSPP dentin sialophosphoprotein 0.0298221
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0297923
TRIO trio Rho guanine nucleotide exchange factor 0.0290202
SGMS2 sphingomyelin synthase 2 0.0286922
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0283454
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0281911
DIAPH1 diaphanous-related formin 1 0.0279097
IRS2 insulin receptor substrate 2 0.027747
BRD2 bromodomain containing 2 0.0276445
SMOC1 SPARC related modular calcium binding 1 0.0275734
GOLGA4 golgin A4 0.027417
CTBP2 C-terminal binding protein 2 0.0272657
FMNL2 formin-like 2 0.0272611
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0270897
NABP1 nucleic acid binding protein 1 0.0270735
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0270368
OXSR1 oxidative stress responsive 1 0.0268612
SPAG9 sperm associated antigen 9 0.026809
CENPF centromere protein F, 350/400kDa 0.0266755
ELL2 elongation factor, RNA polymerase II, 2 0.0262022
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0261469
ZBTB38 zinc finger and BTB domain containing 38 0.0257289
SLC38A2 solute carrier family 38, member 2 0.025696
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0255475
MAST4 microtubule associated serine/threonine kinase family member 4 0.0255351
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0254291
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0253533
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0250841
MYH9 myosin, heavy chain 9, non-muscle 0.0245928
MYO6 myosin VI 0.0245107
NCEH1 neutral cholesterol ester hydrolase 1 0.0244852
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0244532
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0243021
ECT2 epithelial cell transforming 2 0.0242854
IFRD1 interferon-related developmental regulator 1 0.024271
SIK3 SIK family kinase 3 0.0242685
MYO5B myosin VB 0.0241498
ELOVL5 ELOVL fatty acid elongase 5 0.0241243
SHB Src homology 2 domain containing adaptor protein B 0.0240555
TBC1D5 TBC1 domain family, member 5 0.0232092
DSCAM Down syndrome cell adhesion molecule 0.0231017
CEMIP2 cell migration inducing hyaluronidase 2 0.0230718
PELI1 pellino E3 ubiquitin protein ligase 1 0.0227416
FAM3C family with sequence similarity 3, member C 0.0226147
SAMD4A sterile alpha motif domain containing 4A 0.022476
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0223449
KMT2E lysine (K)-specific methyltransferase 2E 0.022097
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0219698
TRA2B transformer 2 beta homolog (Drosophila) 0.0218164
RASA2 RAS p21 protein activator 2 0.0217068
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0216201
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0215741
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0213819
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0209669
SMYD3 SET and MYND domain containing 3 0.0208007
RB1 retinoblastoma 1 0.0207321
VMP1 vacuole membrane protein 1 0.0205316
ANO6 anoctamin 6 0.0204595
USP9X ubiquitin specific peptidase 9, X-linked 0.0203883
SMC4 structural maintenance of chromosomes 4 0.0203592

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.106969
IGFBP3 insulin-like growth factor binding protein 3 -0.0987255
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0959507
HLA-B major histocompatibility complex, class I, B -0.0938257
AHNAK AHNAK nucleoprotein -0.0924809
TPM4 tropomyosin 4 -0.09162
TMSB4X thymosin beta 4, X-linked -0.0869853
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0745904
EMP1 epithelial membrane protein 1 -0.0703885
F3 coagulation factor III (thromboplastin, tissue factor) -0.068789
MAML2 mastermind-like 2 (Drosophila) -0.0683742
PTMA prothymosin, alpha -0.0678665
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0630455
ACTG1 actin gamma 1 -0.0616405
TMSB10 thymosin beta 10 -0.0607436
CD2AP CD2-associated protein -0.0584882
DSG2 desmoglein 2 -0.0573665
FTH1 ferritin, heavy polypeptide 1 -0.0571715
RPS6 ribosomal protein S6 -0.0548401
H1-0 H1.0 linker histone -0.0535621
HLA-E major histocompatibility complex, class I, E -0.0534148
MUC4 mucin 4, cell surface associated -0.0520978
HLA-A major histocompatibility complex, class I, A -0.0506634
PLAT plasminogen activator, tissue -0.0496582
RPL19 ribosomal protein L19 -0.0489546
KRT7 keratin 7, type II -0.0488107
RACK1 receptor for activated C kinase 1 -0.0477073
RPL23 ribosomal protein L23 -0.0467563
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.046393
HLA-C major histocompatibility complex, class I, C -0.0462866
TPT1 tumor protein, translationally-controlled 1 -0.0461959
RPS19 ribosomal protein S19 -0.0442508
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0440117
RPLP1 ribosomal protein, large, P1 -0.0434784
LAMC2 laminin, gamma 2 -0.0431749
B2M beta-2-microglobulin -0.0431174
ARHGAP5 Rho GTPase activating protein 5 -0.0420248
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0418404
SOX4 SRY (sex determining region Y)-box 4 -0.0408709
SULF2 sulfatase 2 -0.0408292
CANX calnexin -0.0406831
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0406521
MX1 MX dynamin-like GTPase 1 -0.0395275
OSMR oncostatin M receptor -0.039195
S100A6 S100 calcium binding protein A6 -0.0390773
RPL37A ribosomal protein L37a -0.0390645
SYT14 synaptotagmin XIV -0.0389185
RNF213 ring finger protein 213 -0.0387809
IFI27 interferon, alpha-inducible protein 27 -0.037548
EIF1 eukaryotic translation initiation factor 1 -0.0370958
RPL12 ribosomal protein L12 -0.0362566
PLSCR1 phospholipid scramblase 1 -0.0362542
RPL37 ribosomal protein L37 -0.0354131
LOC112694756 uncharaterized LOC112694756 -0.0353662
TMEM123 transmembrane protein 123 -0.0351772
RPS12 ribosomal protein S12 -0.0349458
IFITM1 interferon induced transmembrane protein 1 -0.0347975
SORBS2 sorbin and SH3 domain containing 2 -0.0347437
HMGA1 high mobility group AT-hook 1 -0.0344168
PGK1 phosphoglycerate kinase 1 -0.0343095
ANKRD10 ankyrin repeat domain 10 -0.0339146
MUC16 mucin 16, cell surface associated -0.033893
KPNB1 karyopherin (importin) beta 1 -0.0338424
ASS1 argininosuccinate synthase 1 -0.0326439
RPS29 ribosomal protein S29 -0.0323655
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0317444
RPL8 ribosomal protein L8 -0.0315193
RPL30 ribosomal protein L30 -0.0315004
RPS17 ribosomal protein S17 -0.0310557
INHBA inhibin, beta A -0.0308219
ANXA2 annexin A2 -0.0304701
RPS27 ribosomal protein S27 -0.0303758
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0300512
SVIL supervillin -0.0299492
RPS15 ribosomal protein S15 -0.0298515
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0295235
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.029511
ACTN4 actinin, alpha 4 -0.0294295
LDHA lactate dehydrogenase A -0.029329
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0293199
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0292445
RPS3 ribosomal protein S3 -0.029202
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0289543
ADGRF1 adhesion G protein-coupled receptor F1 -0.0288406
RPL34 ribosomal protein L34 -0.0287708
IL1RAP interleukin 1 receptor accessory protein -0.0285096
RPS24 ribosomal protein S24 -0.0283239
WARS1 tryptophanyl-tRNA synthetase 1 -0.0282505
NT5C2 5'-nucleotidase, cytosolic II -0.0282017
NPEPPS aminopeptidase puromycin sensitive -0.0280269
RPS13 ribosomal protein S13 -0.0279913
RPS14 ribosomal protein S14 -0.0277383
STS steroid sulfatase (microsomal), isozyme S -0.0274978
RPL10A ribosomal protein L10a -0.0273489
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0272674
NRP1 neuropilin 1 -0.0272459
RPS23 ribosomal protein S23 -0.0271969
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0271598
RPL31 ribosomal protein L31 -0.0269547
ZMYND8 zinc finger, MYND-type containing 8 -0.0268799