| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Mitoxantrone (dihydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Mitoxantrone (dihydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0850681 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0714335 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0650302 |
| FN1 | fibronectin 1 | 0.0583154 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0557993 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0543946 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0509732 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0503368 |
| SMAD3 | SMAD family member 3 | 0.0457313 |
| MYOF | myoferlin | 0.0453552 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0451789 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0429511 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0424346 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.042299 |
| GOLGA4 | golgin A4 | 0.0418658 |
| NPTN | neuroplastin | 0.04131 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0408478 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0406747 |
| NAV2 | neuron navigator 2 | 0.0397433 |
| ANXA2 | annexin A2 | 0.0396025 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0394482 |
| HMGA2 | high mobility group AT-hook 2 | 0.0392674 |
| RBM39 | RNA binding motif protein 39 | 0.0392249 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0384887 |
| ANKRD11 | ankyrin repeat domain 11 | 0.037939 |
| DST | dystonin | 0.0379237 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0376145 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0374887 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0372061 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0369653 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0364133 |
| OXSR1 | oxidative stress responsive 1 | 0.0355644 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0355044 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0353355 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0352675 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0350938 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0350594 |
| APP | amyloid beta (A4) precursor protein | 0.0350259 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0346155 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.034493 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0339957 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0336683 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.033601 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0333306 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0319868 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0317159 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0315523 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0310448 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0309973 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0307082 |
| FMNL2 | formin-like 2 | 0.0298368 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0295441 |
| H1-0 | H1.0 linker histone | 0.0291605 |
| CDK13 | cyclin-dependent kinase 13 | 0.0290407 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.029028 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0289787 |
| RYBP | RING1 and YY1 binding protein | 0.0288156 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0285956 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0284814 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0283641 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0283561 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0282157 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0281456 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0281044 |
| BZW2 | basic leucine zipper and W2 domains 2 | 0.0280253 |
| COL4A2 | collagen, type IV, alpha 2 | 0.0277762 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0274658 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0269866 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.026795 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0267249 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0266547 |
| CALD1 | caldesmon 1 | 0.0266219 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0264971 |
| FAT1 | FAT atypical cadherin 1 | 0.0264272 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0260915 |
| CD44 | CD44 molecule (Indian blood group) | 0.026074 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0259326 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0257106 |
| ACTN1 | actinin, alpha 1 | 0.025706 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0256034 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0254695 |
| FNIP1 | folliculin interacting protein 1 | 0.0254112 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0253373 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0252877 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0251084 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0247294 |
| DIDO1 | death inducer-obliterator 1 | 0.0246978 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0244693 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0243423 |
| TEX10 | testis expressed 10 | 0.0243223 |
| CD109 | CD109 molecule | 0.0242604 |
| ACTN4 | actinin, alpha 4 | 0.0240211 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0238934 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0237176 |
| JUN | jun proto-oncogene | 0.023452 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0234438 |
| ERBIN | erbb2 interacting protein | 0.023361 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0233506 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.023286 |
| RUNX1 | runt-related transcription factor 1 | 0.0232661 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.194247 |
| HLA-B | major histocompatibility complex, class I, B | -0.134987 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.127086 |
| B2M | beta-2-microglobulin | -0.125334 |
| VIM | vimentin | -0.0932891 |
| TMSB10 | thymosin beta 10 | -0.0923095 |
| COL1A2 | collagen, type I, alpha 2 | -0.0898367 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0827357 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0714156 |
| NDRG1 | N-myc downstream regulated 1 | -0.0676656 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0627798 |
| FTL | ferritin, light polypeptide | -0.0621885 |
| IL1B | interleukin 1, beta | -0.0587824 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0562054 |
| MT2A | metallothionein 2A | -0.0544739 |
| HLA-C | major histocompatibility complex, class I, C | -0.0544679 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -0.0531751 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0514232 |
| FRMD4A | FERM domain containing 4A | -0.0497735 |
| CDH13 | cadherin 13 | -0.0488097 |
| INHBA | inhibin, beta A | -0.0487366 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0485559 |
| POTEF | POTE ankyrin domain family, member F | -0.0481763 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0471753 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0468345 |
| HLA-A | major histocompatibility complex, class I, A | -0.0459276 |
| HM13 | histocompatibility (minor) 13 | -0.0443041 |
| COL1A1 | collagen, type I, alpha 1 | -0.044049 |
| RPL37A | ribosomal protein L37a | -0.0426416 |
| RPLP1 | ribosomal protein, large, P1 | -0.0419349 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0409488 |
| RPL23 | ribosomal protein L23 | -0.0407314 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0405534 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0403966 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0389377 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.037824 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0371377 |
| EGR1 | early growth response 1 | -0.0360069 |
| ZNF395 | zinc finger protein 395 | -0.0359641 |
| EML5 | echinoderm microtubule associated protein like 5 | -0.0354407 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0353668 |
| VEGFA | vascular endothelial growth factor A | -0.0352489 |
| RPS17 | ribosomal protein S17 | -0.0350008 |
| STC1 | stanniocalcin 1 | -0.0349591 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0347647 |
| RPS13 | ribosomal protein S13 | -0.0346465 |
| RPS6 | ribosomal protein S6 | -0.034572 |
| RPL34 | ribosomal protein L34 | -0.0345433 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.034469 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.033414 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.032652 |
| RPS12 | ribosomal protein S12 | -0.0313939 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0304068 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0303671 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0302681 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.030066 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0297327 |
| RPL36 | ribosomal protein L36 | -0.0295045 |
| RPS25 | ribosomal protein S25 | -0.0294665 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0292229 |
| S100A6 | S100 calcium binding protein A6 | -0.0291062 |
| RTN4 | reticulon 4 | -0.0291055 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0290977 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0290704 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0284769 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0283125 |
| POU2F2 | POU class 2 homeobox 2 | -0.0280824 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0280103 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0278382 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0271233 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0271221 |
| RPS8 | ribosomal protein S8 | -0.026771 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0259261 |
| NRP1 | neuropilin 1 | -0.0257324 |
| RPS21 | ribosomal protein S21 | -0.0256178 |
| CDCP1 | CUB domain containing protein 1 | -0.0252881 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0249273 |
| RPL35A | ribosomal protein L35a | -0.0245615 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0244574 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0242993 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | -0.0242653 |
| RPL31 | ribosomal protein L31 | -0.0242324 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0241554 |
| COL5A1 | collagen, type V, alpha 1 | -0.0241123 |
| RPS23 | ribosomal protein S23 | -0.0240357 |
| RPLP0 | ribosomal protein, large, P0 | -0.0240093 |
| CLMP | CXADR-like membrane protein | -0.0239955 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0233223 |
| EGFR | epidermal growth factor receptor | -0.0231234 |
| MMP12 | matrix metallopeptidase 12 | -0.0229967 |
| LPAR1 | lysophosphatidic acid receptor 1 | -0.0229598 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0227218 |
| ITGA1 | integrin, alpha 1 | -0.0226499 |
| SERF2 | small EDRK-rich factor 2 | -0.0225829 |
| RPS16 | ribosomal protein S16 | -0.0223931 |
| ACTG1 | actin gamma 1 | -0.0223515 |
| RPL9 | ribosomal protein L9 | -0.0222503 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0221388 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0220372 |
| RPL26 | ribosomal protein L26 | -0.0214535 |
